• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.3
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• pp.429-436
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• 2013

This study considers how the fatigue behavior and probabilistic properties of SAE1055 steel are related to its hardness level. SAE1055 steel was heat-treated using induction hardening. Five types of specimens were prepared (A: base material, B: through hardened material with HV390, C: through hardened material with HV510, D: through hardened material with HV700, and E: surface hardened material with HV700). Fatigue tests were performed under a stress ratio of R = -1 using a 4-point rotary bending fatigue tester. The fatigue behaviors were greatly influenced by the hardness, but the fatigue limit did not increase over a hardness of HV510. In addition, the effect of the hardness level on the failure mechanism was evaluated using a scanning electron microscope. The probabilistic properties of the fatigue life were investigated using a probabilistic S-N approach, and the effect of the hardness level on these properties was evaluated using a residue analysis.

• Transactions of the Society of Information Storage Systems
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• v.5 no.2
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• pp.96-101
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• 2009

In recent years, the demand for portable digital devices such as cellular phone, digital camera, and MP3 player has been largely increased. To meet the requirements of such portable applications the information storage devices with smaller size, higher capacity, and lower power consumption are needed. A small form factor (SFF) HDD using a load/unload (L/UL) system is one of the appropriate alternatives to satisfy these requirements. Due to complexity of L/UL process and mechanism, it is required to investigate for better understanding the effects of design parameters. Among the various design parameters, flexible cable and friction force on the L/UL ramp become important to the dynamic characteristics of L/UL process as the system is miniaturized. The program for L/UL simulation which considers the effect of flexible cable and L/UL ramp is needed. Unfortunately, there is hardly any commercial program for the L/UL simulation except the Computer Mechanics Laboratory (CML) air bearing design program and the CML L/UL simulation code. Furthermore, the design parameters such as flexible cable and the L/UL ramp are not considered in the CML L/UL simulation code. So we embody the L/UL simulation considering flexible cable and an L/UL ramp by using the ANSYS/LS-DYNA. In this thesis, the effects of flexible cable and friction force on the dynamic characteristics and the performances of the L/UL process are studied. Numerical simulation and related experiments are carried out and compared each other.

• Geomechanics and Engineering
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• v.20 no.2
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• pp.87-101
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• 2020

The construction of combined pile-raft foundations is considered as the main option in designing foundations in high-rise buildings, especially in soils close to the ground surface which do not have sufficient bearing capacity to withstand building loads. This paper deals with the geotechnical report of the Northern Fereshteh area of Tabriz, Iran, and compares the characteristics of the single pile foundation with the two foundations of pile group and geogrid. Besides, we investigate the effects of five principal parameters including pile diameter and length, the number of geogrid layers, the depth of groundwater level, and pore water pressure on vertical consolidation settlement and pore water pressure changes over a year. This study assessed the mechanism of the failure of the soil under the foundation using numerical analysis as well. Numerical analysis was performed using the two-dimensional finite element PLAXIS software. The results of fifty-four models indicate that the diameter of the pile tip, either as a pile group or as a single pile, did not have a significant effect on the reduction of the consolidation settlement in the soil in the Northern Fereshteh Street region. The optimum length for the pile in the Northern Fereshteh area is 12 meters, which is economically feasible. In addition, the construction of four-layered ten-meter-long geogrids at intervals of 1 meter beneath the deep foundation had a significant preventive impact on the consolidation settlement in clayey soils.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.28 no.4
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• pp.202-211
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• 2016

This study aims to analyze seismic responses of suction foundations for offshore wind turbine. For this purpose, dynamic centrifuge model tests were carried out. The skirt length of the suction foundation is a critical element for bearing mechanism against environmental loads. Thus, dynamic centrifuge model tests were performed and analyzed for three suction foundation models with the ratios of skirt length to suction foundation diameter of 0.5, 0.75, and 1 installed in dense sand. As results, the acceleration amplification at the suction foundation, residual settlement, and residual tilting angle were compared.

• Metals and materials international
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• v.24 no.6
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• pp.1376-1385
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• 2018

Ultrasonic melt treatment (UST) was applied to an A390 hypereutectic Al-Si alloy in a temperature range of $750-800^{\circ}C$ and its influence on the solidification structure and the consequent increase in strength was investigated. UST at such a high temperature, which is about $100^{\circ}C$ above the liquidus temperature, had little effect on the grain refinement but enhanced the homogeneity of the microstructure with the uniform distribution of constituent phases (e.g. primary Si, ${\alpha}-Al$ and intermetallics) significantly refined. With the microstructural homogeneity, quantitative analysis confirmed that UST was found to suppress the formation of Cu-bearing phases, i.e., $Q-Al_5Cu_2Mg_8Si_6$, $Al_2Cu$ phases that form in the final stage of solidification while notably increasing the average Cu contents in the matrix from 1.29 to 2.06 wt%. A tensile test exhibits an increase in the yield strength of the as-cast alloy from 185 to 208 MPa, which is mainly associated with the solute increment within the matrix. The important role of UST in the microstructure evolution during solidification is discussed and the mechanism covering the microstructure-strengthening interrelationship of the ultrasonically treated A390 alloy is proposed.

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.63-70
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• 2019

Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a heterogeneous cell population frequently observed in cancer, infection, and autoimmune disease. Immune checkpoint molecules, such as programmed death 1 (PD-1) expressed on T cells and its ligand (PD-L1) expressed on tumor cells or antigen-presenting cells, have received extensive attention in the past decade due to the dramatic effects of their inhibitors in patients with various types of cancer. In the present study, we investigated the expression of PD-1 on MDSCs in bone marrow, spleen, and tumor tissue derived from breast tumor-bearing mice. Our studies demonstrate that PD-1 expression is markedly increased in tumor-infiltrating MDSCs compared to expression in bone marrow and spleens and that it can be induced by LPS that is able to mediate $NF-{\kappa}B$ signaling. Moreover, expression of PD-L1 and CD80 on $PD-1^+$ MDSCs was higher than on $PD-1^-$ MDSCs and proliferation of MDSCs in a tumor microenvironment was more strongly induced in $PD-1^+$ MDSCs than in $PD-1^-$ MDSCs. Although we could not characterize the inducer of PD-1 expression derived from cancer cells, our findings indicate that the study on the mechanism of PD-1 induction in MDSCs is important and necessary for the control of MDSC activity; our results suggest that $PD-1^+$ MDSCs in a tumor microenvironment may induce tumor development and relapse through the modulation of their proliferation and suppressive molecules.

• BMB Reports
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• v.54 no.9
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• pp.470-475
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• 2021

Low-dose metronomic chemotherapy has been introduced as a less toxic and effective strategy to inhibit tumor angiogenesis, but its anti-angiogenic mechanism on endothelial progenitor cells (EPCs) has not been fully elucidated. Here, we investigated the functional role of regulated in development and DNA damage response 1 (REDD1), an endogenous inhibitor of mTORC1, in low-dose doxorubicin (DOX)-mediated dysregulation of EPC functions. DOX treatment induced REDD1 expression in bone marrow mononuclear cells (BMMNCs) and subsequently reduced mTORC1-dependent translation of endothelial growth factor (VEGF) receptor (Vegfr)-2 mRNA, but not that of the mRNA transcripts for Vegfr-1, epidermal growth factor receptor, and insulin-like growth factor-1 receptor. This selective event was a risk factor for the inhibition of BMMNC differentiation into EPCs and their angiogenic responses to VEGF-A, but was not observed in Redd1-deficient BMMNCs. Low-dose metronomic DOX treatment reduced the mobilization of circulating EPCs in B16 melanoma-bearing wild-type but not Redd1-deficient mice. However, REDD1 overexpression inhibited the differentiation and mobilization of EPCs in both wild-type and Redd1-deficient mice. These data suggest that REDD1 is crucial for metronomic DOX-mediated EPC dysfunction through the translational repression of Vegfr-2 transcript, providing REDD1 as a potential therapeutic target for the inhibition of tumor angiogenesis and tumor progression.

• Computers and Concrete
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• v.26 no.6
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• pp.547-563
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• 2020

In this paper, the influence of axial compression ratio on the mechanical properties of new type joints of side span of rectangular concrete-filled steel tubular column-H-type steel beam is studied. Two new types of side-span joints of rectangular concrete-filled steel tubular column-H-type steel beam are designed and quasi-static tests of five new type joints with 1:2 scale reduction ratios are performed. The axial compression ratio of joint JD1 is 0.3, 0.4 and 0.5, and the axial compression ratio of joint JD2 is 0.3 and 0.5. In the joint test, different axial forces were applied to the top of the column according to different axial compression ratios, and low-cyclic reciprocating load was applied on the beam. The stress and strain distribution, beam and column deformation, limit state, failure process, failure mechanism, stiffness degradation, ductile deformation and energy dissipation capacity of the joint were measured and analyzed. The results show that: with the increase of axial compression ratio, the ultimate bearing capacity of the joint decreases slightly, the plastic deformation decreases, and the stiffness and ductility decrease. According to the energy dissipation curve of the specimen, the equivalent damping coefficient also increases with the increase of axial compression ratio in a certain range, indicating that the increase of axial compression ratio can improve the seismic performance of the joint to a certain extent. The finite element method is used to simulate the joint test, and the test results are in good agreement with the simulation results.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.3
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• pp.149-158
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• 2022

As a bridge ages, its mechanical properties and structural performance deteriorate, degrading its seismic performance during a strong earthquake. In this study, the aging of piers and bridge bearings was quantified in several stages and reflected in the analysis model, enabling the evaluation of the member-level seismic fragility of these bearings. Moreover, by assuming that the failure mechanism of a bridge system is a series system, a method for evaluating the system-level seismic fragility based on the member-level seismic fragility analysis result is formulated and proposed. For piers with rubber and lead-rubber bearings (members vulnerable to aging effects), five quantitative degrees of aging (0, 5, 10, 25, and 40%) are assumed to evaluate the member-level seismic fragility. Then, based on the result, the system-level seismic fragility evaluation was implemented. The pier rather than the bridge bearing is observed to have a dominant effect on the system-level seismic fragility. This means that the seismic fragility of more vulnerable structural members has a dominant influence on the seismic fragility of the entire bridge system.

• Resources Recycling
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• v.31 no.2
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• pp.49-55
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• 2022

In the present study, the thermodynamic evaluation of the sulfate-roasting process was conducted to extract vanadium from the Korean vanadium titano-magnetite ore. The leaching efficiency of vanadium and other impurities was analyzed for varying roasting temperatures and addition of Na₂SO₄. In the case of sulfate roasting, the roasting temperature was 200 ℃ higher than that previously observed Na₂CO₃ roasting. However, the higher leaching efficiency of vanadium and lower leaching efficiency of other impurities, such as aluminum and silicon, were observed. The high selectivity for the extraction of vanadium in sulfate roasting would result from the reaction mechanism between SO₂ gas and vanadium concentrate.