• International Journal of Precision Engineering and Manufacturing
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• 제9권3호
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• pp.68-71
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• 2008

Transdermal and topical drug delivery with minimal tissue damage has been an area of vigorous research for a number of years. Our research team has initiated the development of an effective method for delivering drug particles across the skin (transdermal) for systemic circulation, and to localized (topical) areas. The device consists of a micro particle acceleration system based on laser ablation that can be integrated with endoscopic surgical techniques. A layer of micro particles is deposited on the surface of a thin metal foil. The rear side of the foil is irradiated with a laser beam, which generates a shockwave that travels through the foil. When the shockwave reaches the end of the foil, it is reflected as an expansion wave and causes instantaneous deformation of the foil in the opposite direction. Due to this sudden deformation, the microparticles are ejected from the foil at very high speeds, and therefore have sufficient momentum to penetrate soft body tissues. We have demonstrated this by successfully delivering cobalt particles $3\;{\mu}m$ in diameter into gelatin models that represent soft tissue with remarkable penetration depth.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1998년도 춘계학술발표회논문집(2)
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• pp.951-956
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• 1998

The beam extraction system for the KOMAC[1] (Korea Multi-purpose Accelerator Complex) project is to be designed to partially extract H￣ beam at both 100 and 260 MeV This paper describes a simulation study of charge changing extraction with a stripper magnet and a possible design of a H$^{0}$ extractor by utilizing the simulation study The method consists of converting the negative hydrogen (H￣) ion beam from the linac to a chosen intensity (0-100%) of neutral hydrogen (H$^{0}$ ) beam having an acceptable omittance and drifting it directly onto a stripper foil followed by a downstream beamline.

• Applied Microscopy
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• 제50권
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• pp.22.1-22.6
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• 2020

In-situ transmission electron microscopy (TEM) holders that employ a chip-type specimen stage have been widely utilized in recent years. The specimen on the microelectromechanical system (MEMS)-based chip is commonly prepared by focused ion beam (FIB) milling and ex-situ lift-out (EXLO). However, the FIB-milled thin-foil specimens are inevitably contaminated with Ga⁺ ions. When these specimens are heated for real time observation, the Ga⁺ ions influence the reaction or aggregate in the protection layer. An effective method of removing the Ga residue by Ar⁺ ion milling within FIB system was explored in this study. However, the Ga residue remained in the thin-foil specimen that was extracted by EXLO from the trench after the conduct of Ar⁺ ion milling. To address this drawback, the thin-foil specimen was attached to an FIB lift-out grid, subjected to Ar⁺ ion milling, and subsequently transferred to an MEMS-based chip by EXLO. The removal of the Ga residue was confirmed by energy dispersive spectroscopy.

• Nuclear Engineering and Technology
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• 제23권4호
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• pp.426-437
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• 1991

SNU 1.5-MV 직렬형 반데그라프 가속기의 $He^{++}$ 빔 수송계를 이온광학적으로 분석하였다. 각 이온광학요소의 최적운전조건을 결정하고, 이온빔 수송을 모사하기 위하여 프로그램 OPTRANS를 개발하였다. 일차행렬법을 사용하였으며, 공간전하효과는 무시하였다. 프로그램 OPTRANS를 사용하여 0.5~3.0 MeV $He^{++}$ 빔 수송을 위한 최적운전조건을 결정하였다. 초기 이온빔의 방사면량은 인출전극의 구조와 이온빔 인출실험에 의해 0.5$\times$80.0 mm.mrad으로 가정하였다. 운전조건의 변화에 따른 각 이온광학요소의 이온빔 수송 특성을 검토하였으며, 각 Slit과 Stripping Foil, 그리고 표적에서 빔 크기가 최소로 되도록 하는 운전조건을 계산하였다. 이온빔 수송 실험으로부터 얻어진 최적운전조건은 계산된 값과 오차 범위 15% 내에서 일치하였다. 이온빔 수송 모사와 실험을 통해, 계산된 최적운전조건의 타당성 및 프로그램 OPTRANS의 유용성을 입증하였다.

• 한국안전학회지
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• 제26권6호
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• pp.64-70
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• 2011

In this study, the applicability of PVDF films for measurements of dynamic strain in a structure was investigated. A relationship between the strain and the voltage response of a PVDF film was analytically derived. Free vibration test on a steel cantilever beam was performed and vibration response of the beam was measured both by a convential foil strain gauge and a PVDF film. Strain-voltage relationship obtained from the experiment was compared with the analytic relationship. Good agreement between the analytic and experimental relationships was observed. It was found that a tailored PVDF film can measure the dynamic strain of a structure as accurate as a conventional foil strain gauge.

• 한국전기화학회:학술대회논문집
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• 한국전기화학회 1999년도 제3회 총회 및 추계학술발표회
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• pp.50-50
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• 1999

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.566-569
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• 2008

Recently, the biolistic process is emerging as an effective needle-free drug delivery technique to transfer adequate concentrations of pharmacologic agents to soft living tissues with minimum side effects. We have started developing an effective method for delivering drug coated particles using laser ablation. A thin metal foil with deposited micro-particles on one side is irradiated with laser beam on the opposite side so that a shock wave is generated. This shock wave travels through the foil and is reflected, which causes and instantaneous deformation of the foil. Due to such a sudden deformation, the micro-particles are ejected at a very high speed. Here we present the experimental results of direct and confined laser ablation, which correspond to the initial stage of the whole experiment.

• Tribology and Lubricants
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• 제21권2호
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• pp.71-76
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• 2005

This paper compares of mechanical tensile properties of 6 kinds of copper foil. The beam lead made with copper foil. Different from other package type such as plastic package, Chip Size Package has a reliability problem in beam lead rather than solder joint in board level. A new tensile loading system was developed using voice-coil actuator. The new tensile loading system has a load cell with maximum capacity of 20 N and a non-contact position measuring system based on the principle of capacitance micrometry with 0.1nm resolution for displacement measurement. Strain was calculated from the measured displacement using FE analysis. The comparison of mechanical properties helps designer of package to choose copper for ensuring reliability of beam lead in early stage of semiconductor development.

• Journal of Radiation Protection and Research
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• 제42권3호
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• pp.141-145
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• 2017

Background: The concrete walls inside the vaults of cyclotron facilities are activated by neutrons emitted by the targets during radioisotope production. Reducing the amount of radioactive waste created in such facilities is very important in case they are decommissioned. Thus, we proposed a strategy of reducing the neutron activation of the concrete walls in cyclotrons during operation. Materials and Methods: A polyethylene plate and B-doped Al sheet (30 wt% of B and 2.5 mm in thickness) were placed in front of the wall in the cyclotron room of a radioisotope production facility for pharmaceutical use. The target was Xe gas, and a Cu block was utilized for proton dumping. The irradiation time, proton energy, and beam current were 8 hours, 30 MeV, and $125{\mu}A$, respectively. To determine a suitable thickness for the polyethylene plate set in front of the B-doped Al sheet, the neutron-reducing effects achieved by inserting such sheets at several depths within polyethylene plate stacks were evaluated. The neutron fluence was monitored using an activation detector and 20-g on de Au foil samples with and without 0.5-mm-thick Cd foil. Each Au foil sample was pasted onto the center of a polyethylene plate and B-doped Al sheet, and the absolute activity of one Au foil sample was measured as a standard using a Ge detector. The resulting relative activities were obtained by calculating the ratio of the photostimulated luminescence of each foil sample to that of the standard Au foil. Results and Discussion: When the combination of a 4-cm-thick polyethylene plate and B-doped Al sheet was employed, the thermal neutron rate was reduced by 78%. Conclusion: The combination of a 4-cm-thick polyethylene plate and B-doped Al sheet effectively reduced the neutron activation of the investigated concrete wall.

• 소음진동
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• 제7권3호
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• pp.511-519
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• 1997

For a number of years it has been known that flexural vibration in a beam and plate can be damped by the application of layer of damping (viscoelastic) material that is in turn constrained by a backing layer or foil. In this study, a quantitative analysis of damping of the sandwich beam has been performed by using impact test. The damping is characterized by the loss factor .etha. in which the damping is normalized by imaginary part of the complex bending stiffiness of the beam. Results show that the relative thickness of the sandwich beam gives more effect on the riatural-frequencies and loss factor than the variation of width does. It is also shown that the Ross-Kerwin-Ungar equation and impact test can be effectively used to identify the damping characteristic of the sandwich beam and viscoelastic material.