• 한국지반신소재학회논문집
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• 제16권1호
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• pp.31-39
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• 2017

본 연구에서는 중금속 오염지반을 정화하기 위한 향상제로 친환경 재료인 나노버블수를 적용하기 위한 기초 연구를 수행하였다. 수소 나노버블을 제조하여 입도분석과 제타 포텐셜 측정을 통해 장기 생존성을 평가하였다. 제조된 나노버블수를 회분식 탈착실험에 적용하여 구리 오염토양에 대한 나노버블수의 정화 효과를 증류수와 비교하여 분석하였다. 가압용해식 나노버블 제조 장치를 통해 제조한 나노버블은 최소 14일간 존재함을 알 수 있었다. 또한 구리 오염 토양에 대한 회분식 탈착실험을 수행한 결과, 토양 종류에 관계없이 나노버블수의 제거효율은 전반적으로 증류수보다 높았으며 고액비와 반응시간에 비례하여 증가하였다. pH 변화에 따라 사질토는 산성 측에서 제거 효율이 높게 나타났으나 점성토는 그 차이가 다소 낮았다. 실험 결과를 통해 나노버블의 구리 탈착 효과는 나노버블의 큰 비표면적과 제타 포텐셜에 기인하여 전반적으로 우수하게 나타난 것으로 판단된다. 따라서 본 연구를 바탕으로 나노버블수의 중금속 제거 효과를 확인하였으며 이를 토양정화의 향상제로 적용하여 친환경적인 정화공법으로 활용될 수 있을 것으로 기대된다.

• 대한환경공학회지
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• 제27권3호
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• pp.293-301
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• 2005

재생골재를 교각안정용 쇄석으로 재활용하기 위하여 다양한 용출방법을 이용하여 미량원소를 포함한 무기이온들의 용출특성을 연구하였다. 본 연구에 적용한 방법은 연속 회분식 용출시험(Continuous batch leaching test: DIN 38414-S4), 가용용출시험(Availability test, NEN 7341), pH 유지 시험(pH-stat test: CEN/TC 292/WG6) 그리고 탱크 확산시험(Tank diffusion test: NEN 7345)등 이다. 기존에 많이 적용되온 EPA의 TCLP와 국내 공정시험법의 경우 빠르고 경제적인 방법으로 고형폐기물의 단기간 용출특성을 파악할 수 있으나 다양한 용출환경에서 장기간 일어나는 용출특성을 판단하기 어려운 점이 있었다. 본 시험에 적용된 방법들은 이러한 제한을 극복하고 보다 다양한 환경에서 일어날 수 있는 용출특성을 평가하고자 하였다. 본 연구에 적용된 시험들은 별도의 위해성 판단 기준이 없다. 그러나 본 시험의 결과들을 위해성 판단을 위해 많이 쓰이는 TCLP와 국내폐기물 공정시험방법의 기준에 비교할 때 접촉시간, pH 조건 등의 용출조건이 더 가혹한 조건에서 이루어졌음에도 두 시험의 위해성 기준에 훨씬 못 미치고 있다. 이는 재생골재를 교각안정용 쇄석으로 활용할 경우 환경위해 정도가 우려할 수준 이하일 것임을 시사한다. 특히 교각안정용 쇄석이 사용될 하천은 물이 정지되지 않고 늘 흐르는 곳으로써 용출된 원소들은 그 자리에 축적되지 않고 분산, 희석되어 그 영향정도는 더 낮아질 것으로 생각된다.

• 전자공학회논문지B
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• 제30B권5호
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• pp.82-89
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• 1993

In this paper, we proposed the autonomous algorithm of pseudo-exhaustive testing for the multi-level combinational logic circuits. For the processing of shared-circuit that existed in each cone-circuit when it backtracked the path from PO to PI of CUT at the conventional verification testing, the dependent relation of PI-P0 is presented by a dependence matrix so it easily partitioned the sub-circuits for the pseudo-exhaustive testing. The test pattern of sub-circuit's C-inputs is generated using a binary counter and the test pattern of I-inputs is synthesized using a singular cover and consistency operation. Thus, according to the test patterns presented with the recipe cube, the number of test pattrens are reduced and it is possible to test concurrently each other subcircuits. The proposed algorithm treated CUT's net-list to the source file and was batch processed from the sub-circuit partitioning to the test pattern generation. It is shown that the range of reduced ration of generated pseudo-exhaustive test pattern exhibits from 85.4% to 95.8% when the average PI-dependency of ISACS bench mark circuits is 69.4%.

• Journal of Biosystems Engineering
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• 제37권4호
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• pp.233-244
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• 2012

Purpose: The kinetic evaluation was performed for swine manure (SM) degradation and biogas generation. Methods: The SM was anaerobically digested using batch digesters at feed to inoculum ratio (F/I) of 1.0 under mesophilic conditions ($36.5^{\circ}C$). The specific gas yield was expressed in terms of gram total chemical oxygen demand (mL/g TCOD added) and gram volatile solids added (mL/g VS added) and their effectiveness was discussed. The biogas and methane production were predicted using first order kinetic model and the modified Gompertz model. The critical hydraulic retention time for biomass washout was determined using Chen and Hashimoto model. Results: The biogas and methane yield from SM was 346 and 274 mL/ TCOD added, respectively after 100 days of digestion. The average methane content in the biogas produced from SM was 79% and $H_2S$ concentration was in the range of 3000-4108 ppm. It took around 32-47 days for 80-90% of biogas recovery and the TCOD removal from SM was calculated to be 85%. When the specific biogas and methane yield from SM (with very high TVFA concentration) was expressed in terms of oven dried volatile solids (VS) basis, the gas yield was found to be over estimated. The difference in the measured and predicted gas yield was in the range of 1.2-1.5% when using first order kinetic model and 0.1% when using modified Gompertz model. The effective time for biogas production ($T_{Ef}$) from SM was calculated to be in the range of 30-45 days and the critical hydraulic retention time ($HRT_{Critical}$) for biomass wash out was found to be 9.5 days. Conclusions: The modified Gompertz model could be better in predicting biogas and methane production from SM. The HRT greater than 10 days is recommended for continuous digesters using SM as feedstock.

• Journal of Pharmaceutical Investigation
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• 제34권1호
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• pp.57-71
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• 2004

The objective of this study was to provide a better understanding of SUPAC-IR and its application in handling postapproval changes to immediate release solid oral dosage forms. Originally, SUPAC-IR was aimed at reducing the regulator burdern of the industry when they were making postapproval changes, but still at maintaining the formulation quality and performance of a drug product. The postapproval changes that were covered under SUPAC-IR included variations in the components ad composition of formulation, the site of manufacturing, batch size, manufacturing equipment, and manufacturing process. The guidance defined levels of changes, based on the likelihood of risk ocurrence and potential impact of postapproval changes upon the safety and efficacy of a drug product I suggested what a type of fing report should be submitted to the FDA for each level of change. Chemist, manufacturing, and control tests to be executed were also recommended for each change level The important tests specified in the guidance included batch release, stability, in vitro dissolution, and in vivo bioequivalence tests. However, there have been strong demands on revising the current SUPAC-IR in order to resolve some issues and to improve its usefulness in evaluating postapproval changes to immediate release solid oral dosage forms. In particular, the rigorous requirement of case C dissolution test and the definition of batch size were challenged by both academia and the industry. A revision work was in progress to reflect these inputs and to expand the utility of SUPAC-IR. As a result of these concerted efforts, an updated 2nd version of SPAC-IR would be likely to be issued ver soon to the public.

• 한국습지학회지
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• 제13권1호
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• pp.129-137
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• 2011

본 연구의 목적은 미량오염물질인 클린다마이신(Clindamycin) 항생제의 생분해성을 질산화 슬러지내 에서 평가하는 것이다. 우선 단기간 배치 실험(Batch)을 통한 10ppb의 클린다마이신 생분해 실험결과, 클린다마이신이 반으로 줄어드는 시간 ($t_{0.5}$)은 질산화 슬러지내에서는 9.1시간으로 측정되었으나, 질산화가 저해된 슬러지내에서는 $t_{0.5}$ 시간이 26.1시간으로 증가하였다. 본 실험을 통해, 클린다마이신 분해산물이 질산화 슬러지내에서 발견되었고 이는 clindamycin-sulfoxide (m/z 441)인 것으로 추정되었다. 이 분해산물은 항생 능력이 있는 것으로 판단되었다. 이 클린다마이신 분해산물은 장기간 배치실험을 통해서도 줄어들지 않는 것으로 관찰되었다. 따라서, 활성슬러지를 통한 클린다마이신의 완전 생분해는 쉽지 않은 것으로 판단되었다.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제8권4호
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• pp.79-86
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• 2019

본 논문에서 인공 신경망을 이용한 시계열 데이터 예측 사례에 대해 서술한다. 본 연구에서는 텐서 플로우 라이브러리를 사용하여 배치 기반의 인공 신경망과 스타케스틱 기반의 인공신경망을 구현하였다. 실험을 통해, 구현된 각 신경망에 대해 훈련 에러와 시험에러를 측정하였다. 신경망 훈련과 시험을 위해서 미국의 인디아나주의 공식 웹사이트로부터 8개월간 수집된 세금 데이터를 사용하였다. 실험 결과, 배치 기반의 신경망 기법이 스타케스틱 기법보다 좋은 성능을 보였다. 또한, 좋은 성능을 보인 배치 기반의 신경망을 이용하여 약 7개월 간 종합 세수 예측을 수행하고 예측된 결과와 실제 데이터를 수집하여 비교 실험을 진행 하였다. 실험 결과, 예측된 종합 세수 금액 결과가 실제값과 거의 유사하게 측정되었다.

• 한국물환경학회지
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• 제36권6호
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• pp.581-591
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• 2020

In this study, two types of reactors were operated to examine the properties of methanol uptake under the high-rate denitrification process. In a sequencing batch reactor, the denitrifying activity was enriched up to 0.80 g-N/g-VSS-day for 72 days. Then, the enriched denitrifying sludge was transferred to a completely stirred tank reactor (CSTR). At the final phase on Day 46-50, the nitrogen removal efficiency was around 100% and the total nitrogen removal rate reached 0.097±0.003 kg-N/㎥-day. During the continuous process, the sludge settling index (SVI30) was stabilized as 118.3 mL/g with the biomass concentration of 1,607 mg/L. The continuous denitrifying process was accelerated by using a sequencing batch reactor (SBR) with a total nitrogen removal rate of 0.403±0.029 kg-N/㎥-day with a high biomass concentration of 8,433 mg-VSS/L. Because the reactor was open to ambient air with the dissolved oxygen range of 0.2-0.5 mg-O2/L, an increased organic carbon requirement of 5.58±0.70 COD/NO3--N was shown for the SBR in comparison to the value of 4.13±0.94 for the test of the same biomass in a completely anaerobic batch reactor. The molecular analysis based on the 16S rRNA gene showed that Methyloversatilis discipulorum and Hyphomicrobium zavarzinii were the responsible denitrifiers with the sole organic carbon source of methanol.

• 한국의학물리학회지:의학물리
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• 제32권4호
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• pp.179-184
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• 2021

This study aimed to determine the optimal thickness of the active layer and scan mode for a flexible radiochromic film (F-RCF) based on the active lithium salt of pentacosa-10,12-diynoic acid (LiPCDA). F-RCFs of 90, 120, 140, and 170-㎛ thickness were fabricated using LiPCDA. Several pieces of the F-RCFs were exposed to doses ranging from 0 to 3 Gy. Transmission and reflection modes were used to scan the irradiated F-RCFs. Their dose-response curves were obtained using a second-order polynomial equation. Their sensitivity was evaluated for both scanning modes, and the uniformity of the batch was also examined. For both the transmission and reflection modes, the sensitivity increased as the film thickness increased. For the reflection mode, the dose response increased dramatically under 1 Gy. The value of the net optical density varied rapidly as the thickness of the film increased. However, the dose-response curves showed a supralinear-curve relationship at doses greater than 2 Gy. The sensitivity of the reflection scan at doses greater than 2 Gy was higher than that of the reflection scan within 0-2 Gy. The sensitivity steadily decreased with increasing doses, and the sensitivity of the two modes was within 0.1 to 0.2 at 2 Gy and was saturated beyond that. For the transmission scan, the sensitivity was approximately 0.2 at 3 Gy. For the intra-batch test result, the maximum net optical density difference of the intra-batch was 5.5% at 2 Gy and 7.4% at 0.2 Gy in the transmission and reflection scans, respectively. In the low-dose range, film thickness of more than 120-㎛ was proper in the transmission mode. In contrast, the transmission mode showed a better result compared to the reflection mode. Therefore, the proper scan mode should be selected according to the dose range.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2004년도 춘계 학술발표회 제16권1호
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• pp.560-563
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• 2004

This study reports the site application of concrete using AE Water Reducing Agent of Early-Strength Type. According to the lab test results, we have made plans of batch plant pilot test, and we have analyzed the erly aged compressive strength and workability of the concrete. We applied the early-strength development concrete to the construction site. We accomplished the slump test in order to evaluate the workablity and air contents, we made site curing mold to evaluate the early strength of members. As a result, we judgeed the superior property of early strength development of the concrete, and thought that we can reduce the time of form stripping more $40\%$ than ordinary strength concrete. We thought that we can reduce the term of works and finally we can accomplish the economical construction.