• International Journal of Stem Cells
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• 제16권1호
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• pp.52-65
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• 2023

Background and Objectives: Epithelial-Mesenchymal transition (EMT) is one of the origins of myofibroblasts in renal interstitial fibrosis. Mesenchymal stem cells (MSCs) alleviating EMT has been proved, but the concrete mechanism is unclear. To explore the mechanism, serum-free MSCs conditioned medium (SF-MSCs-CM) was used to treat rat renal tubular epithelial cells (NRK-52E) fibrosis induced by transforming growth factor-β1 (TGF-β1) which ameliorated EMT. Methods and Results: Galectin-3 knockdown (Gal-3 KD) and overexpression (Gal-3 OE) lentiviral vectors were established and transfected into NRK-52E. NRK-52E fibrosis model was induced by TGF-β1 and treated with the SF-MSCs-CM for 24 h after modelling. Fibrosis and autophagy related indexes were detected by western blot and immunocytochemistry. In model group, the expressions of α-smooth muscle actin (α-SMA), fibronectin (FN), Galectin-3, Snail, Kim-1, and the ratios of P-Akt/Akt, P-GSK3β/GSK3β, P-PI3K/PI3K, P-mTOR/mTOR, TIMP1/MMP9, and LC3B-II/I were obviously increased, and E-Cadherin (E-cad) and P62 decreased significantly compared with control group. SF-MSCs-CM showed an opposite trend after treatment compared with model group. Whether in Gal-3 KD or Gal-3 OE NRK-52E cells, SF-MSCs-CM also showed similar trends. However, the effects of anti-fibrosis and enhanced autophagy in Gal-3 KD cells were more obvious than those in Gal-3 OE cells. Conclusions: SF-MSCs-CM probably alleviated the EMT via inhibiting Galectin-3/Akt/GSK3β/Snail pathway. Meanwhile, Gal-3 KD possibly enhanced autophagy via inhibiting Galectin-3/Akt/mTOR pathway, which synergistically ameliorated renal fibrosis. Targeting galectin-3 may be a potential target for the treatment of renal fibrosis.

• 한국식생활문화학회지
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• 제23권5호
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• pp.605-615
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• 2008

The principal objective of this study was to categorize service attributes on the basis of the asymmetric and non-linear relationship existing between service attributes and customer satisfaction. Researchers generally assume that service attribute performances and customer satisfaction are both symmetrical and linear. That is to say, improvements in attribute performance will inevitably result in increased customer satisfaction. However, this is not always the case. Certain attributes have been shown not to create satisfaction even when improved, and others do not create dissatisfaction even when their performance ratings become negative. Understanding this relationship is crucial not only to researchers, but also to service managers. Service managers can arrange their priorities with regard to which attributes must be improved or promoted first, in an environment of limited technical, financial, and human resources. Many studies into this asymmetric and non-linear relationship have recently been conducted, beginning with Herzberg's motivation-hygiene theory (1976) and the disconfirmation theory, which was eventually developed into Kano's model (1984). This study attempted to determine the impact level of service attributes on incidents of satisfaction or dissatisfaction. It used 30 service attributes generated by Park (2008) in the CIT research into family restaurants. The data were collected from 600 participants, 300 incidences of satisfaction and 300 incidents of dissatisfaction, via an online survey. The t-test was used to confirm the difference between the satisfaction group's and dissatisfaction group's attributes. 11 attributes were found to be significant at a level of p>0.05. This indicates that the 11 attributes exerted different impacts on satisfaction and dissatisfaction, which confirmed the asymmetric and non-linear relationship. 14 attributes were categorized into the core service, 1 attribute into the quality service, 7 attributes into the basic service, and 8 attributes into the neutral service. Strategic customer service management was recommended for the 'A' family restaurant as an example, on the basis of the asymmetric and non-linear relationship and the characteristics of the four service factors.

• Asia pacific journal of information systems
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• 제19권2호
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• pp.73-94
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• 2009

The general aspects for the future warfare shows that the concept of firepower and maneuver centric warfare has been replacing with that of information and knowledge centric warfare. Thus, some developed countries are now trying to establish the information systems to perform intelligent warfare and innovate defense operations. The C4I(Command, Control, Communication, Computers and Intelligence for the Warrior) systems make it possible to do modern and systematic war operations. The basic idea of this study is to investigate how TAM(Technology Acceptance Model) can explain the acceptance behavior in military organizations. Because TAM is inadequate in explaining the acceptance processes forcomplex technologies and strict organizations, a revised research model based upon TAM was developed in order to assess the usage of the C4I system. The purpose of this study is to investigate factors affecting the usage of C4I in the Korean Army. The research model, based upon TAM, was extended through a belief construct such as self-efficacy as one of mediating variables. The self-efficacy has been used as a mediating variable for technology acceptance, and the variable was included in the research model. The external variables were selected on the basis of previous research. The external variables can be classified into following: 1) technological, 2) organizational, and 3) environmental factors on the basis of TOE(Technology-Organization-Environment) framework. The technological factor includes the information quality and the task-technology fitness. The organizational factor includes the influence of senior colleagues. The environmental factor includes the education/train data. The external variables are considered very important for explaining the behavior patterns of information technology or systems. A structured questionnaire was developed and administrated to those who were using the C4I system. Total 329 data were used for statistical data analyses. A confirmatory factor analysis and structured equation model were used as main statistical methods. Model fitness Indexes for measurement and structured models were verified before all 18 hypotheses were tested. This study shows that the perceived usefulness and the self-efficacy played their roles more than the perceived ease of use did in TAM. In military organizations, the perceived usefulness showed its mediating effects between external variables and dependent variable, but the perceived ease of use did not. These results imply that the perceived usefulness can explain the acceptance processes better than the perceived ease of use in the army. The self-efficacy was also used as one of the three mediating variables, and showed its mediating effects in explaining the acceptance processes. Such results also show that the self-efficacy can be selected as one possible belief construct in TAM. The perceived usefulness was influenced by such factors as senior colleagues, the information quality, and the task-technology fitness. The self-efficacy was affected by education/train and task-technology fitness. The actual usage of C4I was influenced not by the perceived ease of use but by the perceived usefulness and selfefficacy. This study suggests the followings: (1) An extended TAM can be applied to such strict organizations as the army; (2) Three mediation variables are included in the research model and tested at real situations; and (3) Several other implications are discussed.

• 지질공학
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• 제14권4호
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• pp.451-460
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• 2004

사면안정해석에 일반적으로 이용되는 2차원 한계평형해석에서는 활동면의 강도를 활동면 전체에 동일하게 설정한다. 그러나 사면의 활동면에서 저면부와 가장자리부의 강도는 다른 경우가 대부분이다. 4가지 절취모델을 이용한 3차원 사면안정해석의 결과에 따르면 활동면내에서 가장자리부의 저항력이 사면의 안정성에 크게 영향을 미치는 것으로 나타났다. 3차원 사면안정해석에서 활동면 강도를 저면부와 가장자리부로 구분하여 설정함으로써 지금까지 고려하지 못했던 사면 가장자리부의 전단강도가 사면안정에 미치는 영향을 정량적으로 파악할 수 있었다. 활동 저면부의 저항력이 낮은 경우에는 사면의 측부 절토에 의하여 안전율이 크게 저하되며, 저항력이 높은 경우에는 말단부 절토에 의하여 안전율이 저하되고 두부 절토에 의하여 안전율이 향상된다.

• Asia Pacific Journal of Business Review
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• 제1권2호
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• pp.37-62
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• 2017

To analyze the effects of R&D expenditure on the firm value of Korean firms, we classified portfolios based on R&D activity levels. After that, we conducted a time-series analysis to assess excess returns from the portfolios. To carry out such an analysis, an empirical analysis of excess returns in the capital market was performed by using the monthly earning rate of stocks from 2000 to 2013. The purpose of this research is to provide basic data on investment to stakeholders in the capital market by analyzing the effects of R&D on the firm value and to overcome scholarly limitations by offering a new model of analysis. The criteria for classifying the portfolios were based on R&D expenditure levels. The analysis models follow the Fama-French Three-Factor Model and the Carhart Four-Factor Model. The analyses results are as follows. Extrapolating monthly profit rates based on R&D expenditure levels, portfolios with low R&D expenditures showed higher earning rates than those with high R&D expenditures. This suggests that high R&D expenditures did not translate into high earning rates. The investor depreciates the R&D expenditures related profitability and the possibility of success in the market, leading to falls in stock prices and a failure to give a positive effect on the firm value. Our research differs from the previous investigations as we carried out an empirical analysis based on the actual investors' attitudes about R&D expenditures and how these can generate excess earnings. Our research results show that the data related to R&D expenditure are not reflected fully in the market.

• 기술혁신학회지
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• 제12권1호
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• pp.113-136
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• 2009

국가 연구개발사업의 효율성과 생산성을 제고하기 위하여, 정부에서는 '국가연구개발사업 등의 성과 평가 및 성과관리에 관한 법률'을 제정하여 정부 각 부처의 연구개발 사업 성과의 효율성을 증대시키고 있다. 본 논문은 국방연구개발사업 자체평가시스템 측면에서 메타평가를 실시하기 위하여 요인분석(Factor Analysis)을 통한 계층분석적 의사결정기법(AHP, Analytic Hierarchy Process)을 사용한 평가지표를 개발한 결과이다. 국방연구개발사업의 메타평가를 위한 평가요소로서 평가상황, 평가투입, 평가수행, 평가결과 등 4요소로 구분하여 평가지표를 개발하였다. 평가항목 선정을 위하여 평가요소 및 평가지표간 요인분석을 실시하여 Cronbach's ${\alpha}$ 값을 측정한 결과, 평가상황요소는 0.877, 평가투입요소는 0.755, 평가결과요소는 0.792, 평가결과요소는 0.906으로 내적일관성을 고려한 신뢰성은 있는 것으로 나타났다. 그리고 평가요소 및 평가항목별 가중치 산정은 AHP기법을 사용하여 분석하였다. 분석결과 조사자의 전체 일관성 지수는 0.09로 조사자의 일관성은 있는 것으로 분석되었다.

• 한국치위생학회지
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• 제21권2호
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• pp.171-182
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• 2021

Objectives: Recently, subjective career success has been used as a criterion for evaluating career success. The purpose of this study was to develop and evaluate a simplified subjective career success inventory for dental hygienists. Methods: Subfactors of the subjective career success inventory consisted of career satisfaction, employability, and job satisfaction. The validity and reliability of the existing tools were evaluated through the basic items composition, content validity index (CVI), preliminary survey, and main survey process according to dental hygienists. The preliminary survey was composed of 35 questions by verifying the content validity twice from the existing 63 questions, and the main survey was conducted with a total of 12 questions. Samples were conveniently extracted from dental hygienists with a clinical career of ≥3 years and surveyed online from March 12, 2020 to June 30, 2020. Data of 320 people were collected, of which 284 were finally analyzed. The validity and reliability were analyzed using SPSS 18.0 and AMOS 18.0 (p<0.05). Results: The subjective career success was a shortened inventory composed of nine questions, and the overall reliability was Cronbach's α=0.841. Using exploratory factor analysis, three factors were extracted. As a result of the confirmatory factor analysis, each measurement variable significantly explained the latent factor, and the fit of the model was appropriate. The fit of the model was appropriate for the structural equation model. Among the sub-factors of subjective career success, career satisfaction and job satisfaction had a significant effect on intention to stay (p<0.05). Conclusions: The simplified subjective career success inventory developed for dental hygienists was found was found to be a useful tool in terms of reliability and validity.

• 한국ITS학회 논문지
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• 제20권1호
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• pp.54-69
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• 2021

도로교통법이 개정되며 개인형 이동수단(특히, 전동킥보드) 이용에 대한 정책적인 개선방안이 제시되고 있다. 하지만 많은 기기들이 보도 위에 방치되는 등 이용상의 문제점을 해결하고자 하는 논의는 부족한 실정이다. 이에 따라 본 연구에서는 서울시를 200m 격자로 구분하여 공유 전동킥보드의 대여량과 반납량에 영향을 미치는 요인을 분석하고자 한다. 특정공간을 기준으로 집계된 자료의 특성을 반영하기 위해 공간자기상관모형인 공간시차모형과 공간오차모형, 공간더빈모형, 공간더빈오차모형을 구축하였으며, 최종모형으로 공간더빈모형을 선정하였다. 영향요인 분석결과, 인구지표, 토지이용지표, 교통시설지표가 통계적으로 유의하게 영향을 미치는 것으로 분석되었다. 본 연구의 결과는 평일과 주말의 이용특성을 고려한 효율적인 운영방안을 위한 기초자료로 활용될 수 있을 것으로 기대된다.

• 대한토목학회논문집
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• 제26권5D호
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• pp.763-769
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• 2006

중력모형은 출발 존의 유출통행량과 도착존의 유입통행량, 그리고 출발존 중심에서 도착존 중심까지의 교통저항을 이용하여 장래 분포통행을 예측한다. 중력모형에서 존내통행 예측의 경우 교통저항이 "0"로 산정되기 때문에 중력모형에 의해 예측하지 못하고 성장율법과 같은 타 방법에 의해 예측을 행해야 하는 어려움이 존재했다. 본 연구에서는 중력모형에 의한 분포통행 예측시 구축된 중력모형을 이용하여 존내 분포통행을 예측하는 방법을 제안하였는데, 제안한 방법은 기준연도의 존내 분포통행량과 유출, 유입통행량을 존간통행에서 구축된 중력모형식에 대입하여 존내 교통저항을 산출하고 이를 다시 중력 모형에 대입하여 장래 존내 분포통행 예측을 행하는 것이다. 1988년 O-D표를 기준연도 O-D로 하고, 본 연구에서 제안한 방법과 기존의 방법인 성장률법과 회귀모형법의 1992년과 2004년 예측결과들을 실제 O-D와 $x^2$, RMSE, 상관계수 등으로 비교 분석해 본 결과, 본 연구에서 제안한 방법이 우수한 결과를 나타내었다.

• 한국식품저장유통학회지
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• 제5권3호
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• pp.239-246
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• 1998

폴리이미드 고분자막을 사용한 질소부하 장치를 설계하고, 이를 CA 저장에 활용하기 위한 기술적 기본 데이터를 제시하였다. 순수 산소 및 질소의 투과특성은 dual-mode sorption 모델로서 설명될 수 있었으며, 공기 중의 산소의 투과율은 공기 중에 존재하는 질소의 영향으로 순수 산소의 투과율에 비해 크게 감소하나, 공기 중의 질소의 투과율은 산소의 영향으로 순수 질소의 투과율에 비해 증가하였다. 수행한 압력 및 온도 범위 내에서 이상분리인자는 5에서 6 사이의 값을 나타내었으며, 공기의 분리인자는 이상분리인자보다 작은 값을 나타내었다. 산소의 투과활성화에너지가 질소의 투과 활성화에너지보다 커서 이상분리인자는 온도가 증가함에 따라 증가하였다. 제품회수율이 증가함에 따라 농축부의 질소농도는 급격히 감소하였으며, 이로부터 제품회수율은 CA 저장고에서 요구되는 질소농도를 얻기 위한 주요 조업인자임을 알 수 있었다. Polyimide 막 시스템을 이용한 CA 저장 공정의 가상적인 모형을 설정하고, 시스템의 조업시간에 따른 저장고의 질소농도를 예측할 수 있는 관계식을 제시하였다.