• Journal of the Korean housing association
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• v.28 no.2
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• pp.67-74
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• 2017

The purpose of this study is to present basic data of basic concept that planners should consider in planning process. For this purpose, we have proposed the determinant factors of basic concept. In particular, this study focuses on the physical planning elements among the various planning elements that determine the basic concept. The research method is the case study and analysis for the competitions of LH for the past four years. After dividing the residential environment area, the planning elements was derived and the planning direction is arranged for the case district. The determinants factor were determined by the structure of each area. Three area, including the degree of urban context, were found to be the main determinants of the basic idea. The results of the study are as follows. (1) The degree of reflection of urban context, the degree of effort to resolve environmental influences are determinant factors of basic concept. (2) The degree of connection between urban and site area, the degree of overlapping of the boundaries, and street are determinant factors of basic concept. (3) The degree of appropriateness of the residential layout, the degree of rationality of the moving plan, the adequacy of the community space plan are determinant factors of basic concept.

• Archives of Pharmacal Research
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• v.10 no.4
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• pp.245-249
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• 1987

Cardiovascular disease is at present the leading cause of deth in the United States and other in dustrilized countries. A major contributing factor of cardiovascular disease is essential hypertension. Untreated, essential hypertension is considered a risk factor for sudden death due to myocardial infarctions, as well as a risk factor for cerebral vascular disease, renal failure and congestive heart failure. During the last decade, significant progress has been made in the basic knowledge of the pathogenesis of hypertension as well as in the development of new antihypertensive drugs.

• Journal of the Korea Society of Computer and Information
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• v.23 no.10
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• pp.143-149
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• 2018

The purpose of this study was to construct and validate a middle - aged exercise adherence model. The model was designed based on self - determination theory. Participants were 215 middle-aged men and women aged 40-60 who had been exercising for more than six months. Data was collected from four big cities of Seoul, Busan, Gwangju and Daejeon in Korea, using a questionnaire consisting of basic psychological needs, intrinsic motivation, social support, and exercise adherence. Data were analyzed with SPSS 19.0 and AMOS 20.0. Social support and exercise adherence of the questionnaire were partially revised and verified by confirmatory factor analysis. The results of the study were as follows. The model's fit indices: GFI = .938, AGFI) = .915, NFI = .912, CFI = .941, and RMSEA = 0.041. The model satisfied the model fit of the structural model equation. This study model based on self - determination theory was confirmed that basic psychological needs, intrinsic motivation, and social support were important factors for the middle - aged's exercise adherence. Basic psychological need and intrinsic motivation had a direct influence on the adherence of exercise, and social support indirectly influenced the exercise adherence through intrinsic motivation. Both basic psychological needs and social support directly affected internal motivation. The most influential factor in the middle - aged's exercise adherence was intrinsic motivation. In conclusion, it was found that intrinsic motivation such as interest and fun is important for the middle - aged to continue the exercise. Also, the basic psychological needs were important for middle aged's exercise adherence. The results of this study will provide basic data for restoring or maintaining health by continuing exercise. Strategies that enhance intrinsic motivation are needed when a chronic ill person needs to continue long-term exercising.

• Bulletin of the Korean Chemical Society
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• v.33 no.6
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• pp.1890-1894
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• 2012

Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) have been implicated in the pathogenesis of rheumatoid arthritis, which is angiogenesis dependent. Antibody-based molecular imaging improves targeting, and antibody radiolabeling is useful for monitoring biological events $in$ $vivo$ $via$ PET or SPECT. We investigated the potential of molecular imaging to diagnose arthritis with VEGFR-2 $in$ $vivo$. The $^{123}I$-VEGFR-2 antibody was prepared by the iodogen tube method. The radioligand was injected into arthritic mice, and micro SPECT/CT was performed. The arthritic mice were examined by 4.7-T MRI and immunohistochemistry. The $^{123}I$-VEGFR-2 antibody showed high uptake in the arthritic region at 1 h postinjection on SPECT/CT but no uptake in the control animals after radioligand injection. In MR images, the arthritic tissue of the mice was correlated with regions labeled by the $^{123}I$-VEGFR-2 antibody. Immunohistochemical localization showed markedly increased expression of VEGFR-2 in the endothelial cells, fibroblasts, and macrophages of the arthritic mice.

• The Korean Journal of Pain
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• v.35 no.3
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• pp.271-279
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• 2022

Background: Inflammation is known to underlie the pathogenesis in neuropathic pain. This study investigated the anti-inflammatory and neuroprotective mechanisms involved in antinociceptive effects of co-administration of acetaminophen and L-carnosine in chronic constriction injury (CCI)-induced peripheral neuropathy in male Wistar rats. Methods: Fifty-six male Wistar rats were randomly divided into seven experimental groups (n = 8) treated with normal saline/acetaminophen/acetaminophen + L-carnosine. CCI was used to induce neuropathic pain in rats. Hyperalgesia and allodynia were assessed using hotplate and von Frey tests, respectively. Investigation of spinal proinflammatory cytokines and antioxidant system were carried out after twenty-one days of treatment. Results: The results showed that the co-administration of acetaminophen and L-carnosine significantly (P < 0.001) increased the paw withdrawal threshold to thermal and mechanical stimuli in ligated rats compared to the ligated naïve group. There was a significant (P < 0.001) decrease in the levels of nuclear factor kappa light chain enhancer B cell inhibitor, calcium ion, interleukin-1-beta, and tumour necrotic factor-alpha in the spinal cord of the group coadministered with acetaminophen and L-carnosine compared to the ligated control group. Co-administration with acetaminophen and L-carnosine increased the antioxidant enzymatic activities and reduced the lipid peroxidation in the spinal cord. Conclusions: Co-administration of acetaminophen and L-carnosine has anti-inflammatory effects as a mechanism that mediate its antinociceptive effects in CCI-induced peripheral neuropathy in Wistar rat.

• Journal of the Korea Fashion and Costume Design Association
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• v.22 no.3
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• pp.99-110
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• 2020

In terms of junior high school girls' growth patterns during early adolescence, are unlike childhood when relatively balanced growth patterns are found and high school years in which the normal adult body type is nearly reached, growth patterns displayed are imbalanced and rapid. In fact, diverse size changes by body part growth occur significantly different from individual to individual. Therefore, it has been hard for junior high school students to select their proper size when buying school uniforms. This study attempted to acquire basic data needed to address adolescent body shapes and school uniform patterns for junior high school girls, using the data from the 7th Size Korea Survey (2015). Specifically, it provides basic data for the development of school uniform patterns through the classification of their body into particular types, After extracting body shape components and a cluster analysis using ANOVA. According to a factor analysis conducted to determine body shape components, six factors were obtained: Factor 1: bulk and horizontal size, Factor 2: body height and length, Factor 3: shoulder shape and length, Factor 4: shape of upper body, Factor 5: lower drop, Factor 6: upper drop with a variance of 81.46%. To classify junior high school girls' body shape and determine their characteristics, a cluster analysis was performed with the variables obtained using factor analysis. Body shape was classified into three different types: Type 1 accounted for 30.7%. This was a short, slender body with the smallest bulk, size, and upper drop. Type 2 accounted for 24.9%. This was the largest in bulk and horizontal size and highest and length as well. Type 3 accounted for 44.5%. This type was close to average in terms of horizontal size, length and height, and high drop values. To develop school uniforms with great accuracy and body fit for junior high school students, there should be further studies on changes in body shape and their causes. The study results can serve as basic data for comparing branded school uniform patterns for junior high school girls and developing school uniform patterns based on body shape, using 3D virtual clothing simulations.

• BMB Reports
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• v.38 no.1
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• pp.1-8
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• 2005

Transforming growth factor-$\beta$ is a pleiotropic growth factor that has enthralled many investigators for approximately two decades. In addition to many reports that have clarified the basic mechanism of transforming growth factor-$\beta$ signal transduction, numerous laboratories have published on the clinical implication/application of transforming growth factor-$\beta$. To name a few, dysregulation of transforming growth factor-$\beta$ signaling plays a role in carcinogenesis, autoimmunity, angiogenesis, and wound healing. In this report, we will review these clinical implications of transforming growth factor-$\beta$.

• Journal of Technologic Dentistry
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• v.31 no.2
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• pp.15-22
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• 2009

This study examined and analyzed the demographical characteristics of the study target and their expectancy level on the factors in selecting dental medical institutes (basic elements of dental clinics, traffic convenience, physical environment of dental clinic and explicit qualification of dentist) with the questionnaire survey method with 222 questionnaires answered and returned (return rate 88.8%) out of 250 copies distributed to the 1st, 2nd and 3rdyear college students attending technical colleges located in Cheongwon-Gun, Chungbuk, Korea from March 26 to April 7, 2009. The results of this study are as follows: 1. The demographical characteristics of the study target group consisting of 225 college students include 92.3% of age 20s (205 students); 123 males (55.4%) and 99 females (44.6%); the number of those who had at least one experience to visit dental clinic was 199 (89.6%) and 23 (10.4%) of those with no-visiting experience. 2. The descriptive statistics for the selection factor showed that basic elements, traffic convenience, physical environment and explicit qualification of dentist were regarded important as in order. In particular, the factors considered in selecting dental clinic was ordered from most to least in their importance beginning with cleanness of dental clinic as the most important factor, dentist's trustworthiness, kindness of medical staffs, low medical fee, dentist's knowledge level, modernized medical equipments and convenience in using medical facilities as the least. On the contrary, brand name of dental clinic, age, college, sex and appearance of dentist were rated low in order in terms of their importance in selecting dental clinic. 3. As for the difference in the selection factors across demographical characteristics, while male students placed importance on traffic convenience and physical environment of dental clinic, female students placed more importance on dentist's qualification and basic elements of dental clinic. With respect to the difference in the selection factors across the visiting experiences, while those with visiting experience regard traffic convenience more importantly, those without visiting experience regarded physical environment of dental clinic, dentist's qualification and basic elements of dental clinic. 4. In terms of pearson correlation coefficient, the result showed that all aspects in selecting dental clinic were positively correlated. Particularly, the correlation between physical environment of dental clinic and dentist's explicit qualification were correlated highest. Significant positive correlations were found high in traffic convenience, physical environment of dental clinic, dentist's explicit qualification and basic elements of dental clinic in order.

• Journal of Korea Technology Innovation Society
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• v.4 no.2
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• pp.127-142
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• 2001

This paper presents an econometric model for measuring basic research capacity index(BRCI) of each OECD countries and analyses the gap in terms of time lag measured and forecasted in connection with factor analysis and BRCI progress function. Based on the analysis, gross domestic expenditure on R&D(GERD), total R&D personnel higher education expenditure on R&D(HERD) and number of science and technical papers based on SCI are more effective than other factors to BRCI. Also, BRCI progress function shows that 29 years is needed for Korea to catch up the level of German's BRCI of year 1998. But, it's impossible for Korea to catch up US and Japan. Therefore, with restricted scientific resources, Korea's own strategy for strengthening basic research capacity is going to be more important in 21st century.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2001.05a
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• pp.473-492
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• 2001

This paper presents an econometric model for measuring basic research capacity index(BRCI) of each OECD countries and analyses the gap in terms of time lag measured and forecasted in connection with factor analysis and BRCI progress function. Based on the analysis, gross domestic expenditure on R&D(GERD), total R&D personnel, higher education expenditure on R&D(HERD) and number of science and technical papers based on SCI are more effective than other factors to BRCI. Also, BRCI progress function shows that 29 years is needed for Korea to catch up the level of German's BRCI of year 1998. But, it's impossible for Korea to catch up US and Japan. Therefore, with restricted scientific resources, Korea's own strategy for strengthening basic research capacity is going to be more important in 21st century.