• 대한소아치과학회지
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• 제29권4호
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• pp.519-528
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• 2002

임상에서 설비의 노후나 고장 등으로 인해 고속 핸드피스의 물 분사에 의한 냉각이 종종 불완전하게 일어날 수 있다. 또한 성인에 비해 치료에 관한 공포가 심하여 비협조적인 소아환자의 경우에는 물의 분사나 고속 흡인기의 사용을 거부하거나 지극히 혐오하는 경우도 드물지 않다. 이처럼 냉각이 충분히 이뤄지지 않은 상황에서 시행되는 다양한 술식은 치수조직에 치명적인 손상을 가할 수 있다. 본 연구의 목적은 임상 수복 술식을 시행하는 동안 각 치아표면에서 발생되는 열이 치수 내부로 전달되는 양상을 조사하기 위함이었다. 석고 블록에 식립된 90개의 하악 제2유구치를 대상으로 수종의 수복 술식을 시행하였고, 해당 치아표면에서 발생되는 열의 온도를 적외선 카메라와 thermography를 이용하여 측정하고, 이를 토대로 유한요소 분석을 통한 치질내 열전도에 관한 평가를 시행하였다. 본 연구에서 시행된 임상 술식의 주수 하 최고 표면 온도는 $30.8^{\circ}C{\sim}43.6^{\circ}C$, 비 주수 하에서는 $51.2^{\circ}C{\sim}103.4^{\circ}C$의 범위를 보였다. 술식 중에서는 치관 형성과정이 가장 높은 온도를, 아말감 제거 과정이 가장 낮은 표면온도를 보였다. 동일 술식 내에서의 주수와 비 주수 조건간에는 모든 술식이 유의한 차를 나타냈다(p<0.05). 유한요소 분석에서 나타난 치수각의 온도변화는 모든 비 주수 조건에서는 큰 폭으로 상승한 반면, 주수 하에서는 전반적으로 미약한 변화를 보였다. 이상의 결과는 고속 절삭기를 사용한 수복 과정에 주수에 의한 충분한 냉각이 치수 생활력의 유지를 위해서 필수적임을 시사해준다. 향후 보다 다양한 술식과 조건을 부여한 유사 분야의 연구가 추천된다.

• Nutrition Research and Practice
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• 제1권3호
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• pp.184-188
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• 2007

The major goal in the treatment of diabetes mellitus is to achieve near-normal glycemic control. To optimize both fasting blood glucose and postprandial glucose levels is important in keeping blood glucose levels as close to normal as possible. ${\alpha}-Glucosidase$ is the enzyme that digests dietary carbohydrate, and inhibition of this enzyme could suppress postprandial hyperglycemia. The purpose of this study was to test the inhibitory activity of methanol extract of Euonymus alatus on ${\alpha}-glucosidase$ in vitro and in vivo to evaluate its possible use as an anti-diabetic agent. Yeast ${\alpha}-glucosidase$ inhibitory activities of methanol extract of E. alatus were measured at concentrations of 0.50, 0.25, 0.10, and 0.05 mg/ml. The ability of E. alatus to lower postprandial glucose was studied in streptozotocin-induced diabetic rats. A starch solution (1 g/kg) with and without E. alatus extract (500 mg/kg) was administered to diabetic rats by gastric intubation after an overnight fast. Plasma glucose levels were measured at 30, 60, 90, 120, 180, and 240 min. Plasma glucose levels were expressed in increments from baseline, and incremental areas under the response curve were calculated. Extract of E. alatus, which had an $IC_{50}$ value of 0.272 mg/ml, inhibited yeast ${\alpha}-glucosidase$ activity in a concentration-dependent manner. A single oral dose of E. alatus extract significantly inhibited increases in blood glucose levels at 60 and 90 min (p<0.05) and significantly decreased incremental response areas under the glycemic response curve (p<0.05). These results suggest that E. alatus has an antihyperglycemic effect by inhibiting ${\alpha}-glucosidase$ activity in this animal model of diabetes mellitus.

• The Korean Journal of Pain
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• 제22권1호
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• pp.16-20
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• 2009

Background: Zaprinast is an inhibitor of phosphodiesterase 5, 6 and 9. Phosphodiesterase inhibitors could produce anti-nociceptive effects by promoting the accumulation of cGMP. We hypothesized that intrathecal zaprinast could attenuate the allodynia induced by chronic constriction injury of the sciatic nerve in rat. Methods: Sprague-Dawley rats were prepared with four loose ligations of the left sciatic nerve just proximal to the trifurcation into the sural, peroneal and tibial nerve branches. Tactile allodynia was measured by applying von Frey filaments to the lesioned hindpaw. The thresholds for the withdrawal responses were assessed. Zaprinast ($3-100{\mu}g$) was administered intrathecally by the direct lumbar puncture method to obtain the dose-response curve and the 50% effective dose ($ED_{50}$). Measurements were taken before and 15, 30, 45, 60, 90, 120, and 180 min after the intrathecal doses of zaprinast. The side effects were also observed. Results: Intrathecal zaprinast resulted in a dose-dependent antiallodynic effect. The maximal effects occurred within 15-30 min and then they gradually decreased down to the baseline level over time in all the groups. There was a dose dependent increase in the magnitude and duration of the effect. The $ED_{50}$ value was $17.4{\mu}g$ (95% confidence intervals; $14.7-20.5{\mu}g$). No severe motor weakness or sedation was observed in any of the rats. Conclusions: Intrathecally administered zaprinast produced a dose-dependent antiallodynic effect in the chronic constriction injury neuropathic pain model. These findings suggest that spinal phosphodiesterase 5, 6 and 9 may play an important role in the modulation of neuropathic pain.

• 한국도로학회논문집
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• 제20권1호
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• pp.35-45
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• 2018

PURPOSES : This study examines the performance changes of road networks according to the strength of a disaster, and proposes a method for estimating the quantitative resilience according to the road-network performance changes and damage scale. This study also selected high-influence road sections, according to disasters targeting the road network, and aimed to analyze their hazard resilience from the network aspect through a scenario analysis of the damage recovery after a disaster occurred. METHODS : The analysis was conducted targeting Sejong City in South Korea. The disaster situation was set up using the TransCAD and VISSIM traffic-simulation software. First, the study analyzed how road-network damage changed the user's travel pattern and travel time, and how it affected the complete network. Secondly, the functional aspects of the road networks were analyzed using quantitative resilience. Finally, based on the road-network performance change and resilience, priority-management road sections were selected. RESULTS : According to the analysis results, when a road section has relatively low connectivity and low traffic, its effect on the complete network is insignificant. Moreover, certain road sections with relatively high importance can suffer a performance loss from major damage, for e.g., sections where bridges, tunnels, or underground roads are located, roads where no bypasses exist or they exist far from the concerned road, including entrances and exits to suburban areas. Relatively important roads have the potential to significantly degrade the network performance when a disaster occurs. Because of the high risk of delays or isolation, they may lead to secondary damage. Thus, it is necessary to manage the roads to maintain their performance. CONCLUSIONS : As a baseline study to establish measures for traffic prevention, this study considered the performance of a road network, selected high-influence road sections within the road network, and analyzed the quantitative resilience of the road network according to scenarios. The road users' passage-pattern changes were analyzed through simulation analysis using the User Equilibrium model. Based on the analysis results, the resilience in each scenario was examined and compared. Sections where a road's performance loss had a significant influence on the network were targeted. The study results were judged to become basic research data for establishing response plans to restore the original functions and performance of the destroyed and damage road networks, and for selecting maintenance priorities.

• 대한기계학회논문집A
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• 제37권3호
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• pp.325-331
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• 2013

본 논문에서는 상용 프로그램 ABAQUS를 이용하여 브레이크 시스템의 불안정 모드를 알아보기 위한 복소고유치해석을 수행하였다. 또한 전체 시스템의 불안정 복소 고유모드에서 가장 진동에너지가 큰 부품을 알아보기 위한 기여도해석과 전체 복소 고유모드와 해당 부품의 부품모드간의 기여도해석을 통해 모드 연성의 가능성이 높은 모드를 알아보았다. 본 연구에서는 디스크 로터의 2차 굽힘모드와 토크멤버의 3차 축방향 횡모드의 연성에 의해 1.4kHz의 불안정 모드가 발생하는 것을 알 수 있었다. 이러한 모드 연성을 차단하기 위해 불안정성을 유발하는 토크멤버에서 해당모드의 주파수 변화에 대한 감도 해석을 실시하였다. 감도 해석 결과를 토대로 질량 가중에 의한 구조물 동특성 변경을 수행한 결과 저주파 영역에서 불안정 모드가 발생하지 않아 본 연구에서 제시된 저감방법의 유효성을 확인할 수 있었다.

• Journal of Preventive Medicine and Public Health
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• 제25권1호
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• pp.53-63
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• 1992

There are increasing interest and need for information on health care consumer with the significance of hospital marketing and strategic planning being increasingly emphasized. This study was conducted to investigate the criteria for selection of medical facilities according to the characteristics of health care consumer by the types of medical services on a sample of 1,500 population aged 20 years and above. Major findings are as follows ; 1. When considering the criteria for selection of medical facilities into two factors, namely, quality or convenience factors, convenience factor was the major contributor for outpatient and dental services whereas it was quality factor for inpatient services. 2. Females and those residing in large cities selected medical facilities based on convenience factor in the outpatient services. In the case of inpatient service, persons who considered their present health status to be good and whose ages were 50 years old and above choose medical facilities based on quality factor. 3. Persons who considered medical facilities to be profit-making tended to choose medical facilities based on convenience factor for outpatient services. There were no differences in the cases of inpatient and dental services. 4. There was no significant difference on the criteria for selection of medical facilities according to the decision maker for selection or trust on medical facilities. On the use of health service information, selection of medical facilities was based on quality factor for those who made more use of the information in the cases of outpatient and dental services. 5. Analysis using the logistic regression model on the criteria for the selection of medical facilities with the characteristics of health care consumer as independent variables was performed. The selection of medical facilities was significantly related with residential area, sex, and use of information on medical facilities for outpatient services and with age, average monthly income, and perception of health status for inpatient services. For dental services significant association with residential area and use of information on medical facilities was seen. The results of this study, despite some limitations, can be used as baseline data for marketing and strategic planning of hospital management.

• 한국치위생학회지
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• 제12권1호
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• pp.145-156
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• 2012

Objectives : By analyzing the affects of the mother's oral care to the caries experiences of the elementary school children, To looking for the way to prevent dental caries in the primary school, to provide baseline data to perform the associated oral health education. Methods : Between the 3,676 children's dental check-up data and the 2,934 survey of parents from 9 elementary schools in the the Gyeonggi Province, the exactly matching data of 2,358 pairs, children versus mothers, were analyzed during the period, 2009 May 4 to July 20, By using the PASW 18(SPSS-PC 18), Frequency analysis of the collected data, and cross-analysis, ANOVA, Bonferroni post-analysis was performed. Results : The findings of the study were as follows. 1. In children, the ratio(DMF rate)of the dental caries experience in permanent teeth, appeared higher for men than women. Divided by grade level, the ratio of caries experience in the permanent teeth(DMF rate) generally appear higher in older than young. Thus between the child's gender and grade level by the ratio of caries experience in the permanent teeth(DMF rate) showed the statistically significant differences (p<0.05). 2. Between the socioeconomic characteristics of mothers and the children's level of dental caries experiences, not showed the statistically significant difference.(p>0.05). 3. The significant difference showed between the dental caries levels of the children and the mother's oral health care behavior - a toothbrush replacement period, mother's broken teeth, mothers guidances of the brushing after snacks for children(p<0.05). Conclusions : The mother's oral health attitudes and behaviors can affect to their children's oral care habits. Therefore The mother themselves should have the right proper habit of oral health care, so that in oral health care mothers should be the model for their children. Institutionally more systematic and detailed oral health educational program in conjunction with the family is needed.

• 대한지역사회영양학회지
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• 제20권2호
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• pp.129-140
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• 2015

Objectives: We examined the association between the adherence to dietary guidelines for breast cancer survivors and health-related quality of life in a cross-sectional study of Korean breast cancer survivors. Methods: A total of 157 women aged 21 to 79 years who had been diagnosed with stage I to III breast cancers according to the American Joint Committee on Cancer (AJCC) and had breast cancer surgery at least 6 months before the baseline were included. We used a Korean version of the Core 30 (C30) and Breast cancer 23 (BR23) module of the European Organization for Research and Treatment Cancer Quality of Life Questionnaire (EORTC-QLQ), both of which have been validated for Koreans. Participants were asked about their adherence to dietary guidelines for breast cancer survivors, suggested by the Korean breast cancer society, using a 5-point Likert scale. We summed dietary guideline adherence scores for each participant and calculated the least squares means of health-related quality of life according to dietary guideline adherence scores using the generalized linear model. Results: Breast cancer survivors who had higher adherence to dietary guidelines for breast cancer survivors had lower constipation scores than those with lower adherence (p for trend=0.01). When we stratified by the stage at diagnosis, this association was limited to those who had been diagnosed with stage II or III breast cancers. Also, sexual functioning scores increased significantly with increasing adherence scores of dietary guidelines among those with stage II or III breast cancers (p for trend < 0.001). However, among those who had been diagnosed with stage I, higher scores of dietary guidelines were associated with higher scores of pain (p for trend=0.03) and breast symptoms (p for trend=0.05). Conclusions: Our study suggested that the health-related quality of life levels of breast cancer survivors are associated with the adherence to dietary guidelines and may differ by the stage of the breast cancer.

• 한국식품위생안전성학회지
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• 제18권3호
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• pp.101-106
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• 2003

냉장식품의 주요한 변패원일균으로서 저온세균인 Pseudomonas aeruhinosa를 최소 전처리한 후 신속히 검출할 수 있는 비표지 면역센서 시스템을 개발하였다. 수정결정전극상으로의 생물요소인 항체의 고정화는 이형이기능성 가교화제인 sulfosuccinimidyl 6-[3-(2-pyridyldithio)propionamido] hexanoate를 사용하여 항체를 티올화시킨 후 티올화된 항체를 화학흡착하여 행하였고, P. aeruginosa flagella에 대한 단클론항체를 사용하였을 때 다클론항체를 사용한 경우보다 센서감응이 우수한 것으로 나타났다. 항체가 고정화된 센서 chip과 flow형 quart crystal microbalance 계측 시스템을 이용하여 균 첨가 및 증균을 행한 10종의 모델시료에 대한 계측을 행하였다. 이 때, 시료자체에 의한 진동수변화가 52~89 Hz 범위인 반면 균 첨가 시에 나타난 진동수변화는 108~200 Hz이었고 증균시료에 의한 진동수변화는 162~222 Hz 범위로 나타났다. 시스템 안정화, 시료주입 및 정상상태이 센서반응 획득, 시스템 세척으로 이루어지는 한 주기의 센서계측에 소요된 시간은 모든 시료에 있어 30분 이내였다.

• 한국콘텐츠학회논문지
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• 제15권5호
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• pp.375-385
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• 2015

본 연구는 의사결정나무 분석을 활용하여 청소년의 우울 보호요인을 예측하여 우울 예방과 조기발견 및 중재 방안을 마련하고자 시도된 서술적 조사연구이다. 연구대상은 G광역시에 소재한 청소년 총 485명이고, 자료 수집은 2013년 9월 23일부터 9월 26일 사이에 이루어졌다. 자료 분석은 SPSS 20.0 프로그램을 이용하여 빈도, 백분율, 평균과 표준편차 및 ${\chi}^2$-test, t-test, 의사결정나무 분석으로 분석하였다. 본 연구 결과, 4개의 경로, 총 12노드가 구축되었고 가족 결속력, 부모 자녀간 의사소통과 또래와의 의사소통이 청소년 우울 보호요인이었다. 우울의 보호요인 예측 정확도에서 분석용은 특이도 76.0%, 민감도 65.4%이었고, 검정용은 특이도 78.2%, 민감도 63.7%이었으며, 전체 분류 정확도는 분석용 70.1%, 검정용 69.7%이었다. 이에 본 연구 결과가 학교와 지역사회에서 청소년 정신보건을 담당하는 전문가들에게 우울을 예방을 위한 프로그램 개발의 기초자료로 제공되고, 나아가 청소년들이 자신들의 목소리를 되찾고 힘차게 성장하기 위한 보호요인 강화를 위한 우울예방 정책 전략에 활용되기를 기대해 본다.