• YAKHAK HOEJI
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• v.46 no.6
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• pp.416-425
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• 2002

A comparative study to validate the reliability of a fully automated docking program, FlexiDock, was carried out to predict the binding modes of DHFR-inhibitor complex. The inhibitors were extracted from the crystallographically determined DHFR-NADP$^{+}$(H)-inhibitor ternary complexes of human, Escherichia coli and Candida albicans and then docked back into the remaining DHFR-NADP$^{+}$(H) binary complexes using FlexiDock. The resulting conformations and orientations were compared to the original crystal complex structures for reproducibility. Then, folate, the substrate, and known inhibitors such as methotrexate, piritrexim and trimethoprim were docked into the wild-type human DHFR and their binding modes were compared with X-ray crystallographic or other modeling data. The root mean square deviations (RMSDs) for ligands ranged from 1.14 to 1.57$\AA$, and the protein backbone RMSDs from 0.94 to 1.26$\AA$. FlexiDock reproduced the orientations and binding modes of all seven ligands in good agreement with the crystal structures. It proved to be a reliable and efficient program in studying binding modes of DHFR-inhibitor complexes of different species, and the information obtained from this work may provide additional insight into the design of new agents with improved activity.ity.

• Journal of the Korean Geotechnical Society
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• v.18 no.1
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• pp.127-132
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• 2002

Shaking table tests are performed on model group piles to investigate the mechanics of dynamic pile-soil interaction, and to evaluate the dynamic group pile effect. Tests are executed on a single pile as well as group piles($3\times3$) by varying a pile spacing from 3D to 8D. A lumped mass is located on top of piles to simulate a superstructure. Dynamic p-y curves of the single pile and the group piles are obtained from the tests and compared with the backbone slopes of API cyclic p-y curves. From the comparisons, dynamic pile group effects are evaluated in terms of a pile spacing, a shaking frequency, and a shaking intensity.

• Korean Management Science Review
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• v.11 no.3
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• pp.129-151
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• 1994

This paper focuses on method of setting priorities for telecommunications Standardization in which usually includes prioritization, resource allocation, standardization schedule for each SWA is based on prioritization of SWAs. We mainly used the Analytic Hierarchy Process(AHP) and a modified Delphi technique as a method for planning process. Recently, rapid technology evolution in telecommunications fields increases the necessity of developing more and more new standards. Also increased complexity of technologies makes standards more complicated, more specified and more thick than the past ones. As a result, the number of SWAa(Standardization Work Areas) and SWIs(Standardization Work Iterms) is being increased continuously. Furthermore, rapid telecommunication environment changes such as deregulation, liberalization, privatization, regionalization, and globalization surrounding telecommunications standardization grows increasingly important. To cope with these challenges and to make the more efficient use of the limited standardization resources, i.e., time, financial, personal resources, we will suggest logical and rational approach that is a backbone of strategic plan for telecommunication standardization. The telecommunication standardization planning process involves a MCDM(Multi-Criteria Decision Making) process. The Analytic Hierarchy Process(AHP) is a kind of MCDM approach. Our method is based on a combination of a modified Delphi technique and an application of AHP(spreadsheet model). Analyzed data from Delphi technique is used as inputs to AHP. In addition we also focus on the technique how to combine group judgments and to handle a large number of comparisons.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.7B
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• pp.1261-1267
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• 1999

Frame relay (FR) service via an FR interface over a common asynchronous transfer mode (ATM) backbone network requires an FR-to-ATM interworking unit (IWU), the functionality of which directly impacts the engineering of the overall network in terms of capacity required, quality of service (QoS), and the interference among different types of services. This paper presents performance analysis of frame relay traffic in IWU. Additionally frame relay traffic policing using leaky bucket algorithm in this traffic model is carried out through computer simulation. Three measurements, the percentage of frames accepted as committed, the percentage of frames that accepted but marked eligible for diacard, and the percentage of frames that accepted that are discarded because of insufficient number of credits, are simulated variously in this paper.

• Journal of Electrical Engineering and Technology
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• v.9 no.6
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• pp.1995-2003
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• 2014

Power semiconductor devices have been the major backbone for high-power electronic devices. One of important parameters in view of power semiconductor devices often characterize with a high breakdown voltage. Therefore, many efforts have been made, since the development of the Insulated Gate Bipolar Transistor (IGBT), toward having higher level of breakdown voltage, whereby the typical design thereof is focused on the structure using the field ring. In this study, in an attempt to make up more optimized field-ring structure, the characteristics of the field ring were investigated with the use of theoretical arithmetic model and methodologically the design of experiments (DOE). In addition, the IGBT having the field-ring structure was designed via simulation based on the finding from the above, the result of which was also analyzed. Lastly, the current study described the trench field-ring structure taking advantages of trench-etching process having the improved field-ring structure, not as simple as the conventional one. As a result of the simulation, it was found that the improved trench field-ring structure leads to more desirable voltage divider than relying on the conventional field-ring structure.

• Journal of Microbiology and Biotechnology
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• v.16 no.11
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• pp.1784-1790
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• 2006

Bacillus anthracis is a causative agent of anthrax. Anthrax toxins are composed of a protective antigen (PA), lethal factor (LF), and edema factor (EF), in which the PA is a central mediator for the delivery of the two enzymatic moieties LF and EF. Therefore, the PA has been an attractive target in the prevention and vaccinization for anthrax toxin. Recently, it has been reported that the molecule consisting of multiple copies of PA-binding peptide, covalently linked to a flexible polymer backbone, blocked intoxification of anthrax toxin in an animal model. In the present study, we have screened novel diverse peptides that bind to PA with a high affinity (picomolar range) from an M13 peptide display library and characterized the binding regions of the peptides. Our works provide a basis to develop novel potent inhibitors or diagnostic probes with a diverse polyvalence.

• Proceedings of the KIEE Conference
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• 2005.11b
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• pp.30-34
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• 2005

Due to old Toshiba EMS's database size limit and hardware old aging, KPX(Korea Power Exchange) had introduced New EMS from AREVA(old ALSTOM) in July 2002. After then KPX had committed many man power and time to normalize EMS NA(Network Analysis) functions for using real power system. At initial stage, to normalize State Estimator which is the backbone of all other NA functions and DTS(Dispatcher Training Simulator}, KPX had corrected numerous topology errors, network model errors, non-scanned and wrongly scanned SCADA measured errors. After SE function study, running test and tuning, State Estimator could finally have been run properly and stably from June 2003. Based on SE running, KPX had normalized real time Contingency Analysis, and study mode Power Flow, STNET and DTS. From early 2004, dispatchers have been trained to use NA and DTS for the purpose of stable SE running, NA operation & results reading and urgent equipment outage reviewing. EMS NA have been greatly contributed to operate real time power system stably. Above NA normal operation by KPX own efforts under the no experience of NA running, KPX made a good precedent. This paper is intended to introduce EMS NA normalization process, operation status, and etc in Korea power system operation.

• Journal of the Korea Institute of Military Science and Technology
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• v.18 no.6
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• pp.797-807
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• 2015

The low-altitude PAC-2 Patriot missile system is the backbone of ROK air defense for intercepting enemy aircraft. Currently there is no missile interceptor which can defend against the relatively high velocity ballistic missile from North Korea which may carry nuclear, biological or chemical warheads. For ballistic missile defense, Korea's air defense systems are being evaluated. In attempting to intercept ballistic missiles at high altitude the most effective means is through a multi-layered missile defense system. The missile defense problem has been studied considering a single interception system or any additional capability. In this study, we seek to establish a mathematical model that's available for multi-layered missile defense and minimize total interception fail probability and proposes a solution based on genetic algorithms. We perform computational tests to evaluate the relative speed and solution of our GA algorithm in comparison with the commercial optimization tool GAMS.

• KDI Journal of Economic Policy
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• v.36 no.1
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• pp.107-126
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• 2014

The core of the neoclassical growth theory is the capital investment. Solow proposed that the diminishing return is key to such growth process in establishing the stability of the equilibrium growth path. This key postulation has critical implications on the sustainable and effective development policies, emphasizing the importance of productivity growth not only for the steady-state growth but also for the transitional growth from capital accumulation. This paper suggests a novel way to test the diminishing return, the backbone assumption of Solow model, and confirms its strong presence using the Penn World Tables version 8.0 data, hence validates Solow's implications on effective development policies.

• Journal of the Earthquake Engineering Society of Korea
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• v.21 no.1
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• pp.41-48
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• 2017

Columns in existing reinforced concrete structures that are designed and constructed without considering seismic loads generally exhibit widely spaced transverse reinforcements without using seismic hooks. Due to the insufficient reinforcement details in columns compared to the reinforcement requirements specified in modern seismic codes, brittle shear failure is likely to occur. This may lead to sudden collapse of entire structure during earthquakes. Adequate retrofit strategy is required for these columns to avoid such catastrophic event. In order to do so, behavior of columns in existing reinforced concrete structures should be accurately predicted through computational analysis. In this study, an analytical model is proposed for accurately simulating the cyclic behavior of shear critical columns. The parameters for backbone, as well as pinching and cyclic deterioration in strength and stiffness are calibrated using test data of column specimens failed by shear.