• Journal of Dental Anesthesia and Pain Medicine
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• 제22권2호
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• pp.97-105
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• 2022

Background: The pentadecapeptide BPC-157 has been shown to have anti-inflammatory and wound healing effects on multiple target tissues and organs. Peptides have potent anti-inflammatory effects on periodontal tissues in rats with periodontitis. Few studies have investigated the effect of BPC-157 on pain after dental procedures or oral surgeries. The purpose of the present study was to investigate the antinociceptive effects of BPC-157 on postoperative incisional pain in rats. Methods: Sprague-Dawley rats were randomly divided into five groups: control (saline with the same volume), BPC10 (10 ㎍/kg of BPC-157), BPC20 (20 ㎍/kg of BPC-157), BPC40 (40 ㎍/kg of BPC-157), and morphine (5 mg/kg of morphine). A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats. Withdrawal responses were measured using von Frey filaments at 0, 2, 6 h and 4, 7 d after incision. The formalin test was also performed to differentiate its anti-nociceptive effect from an inflammatory reaction or central sensitization. Pain behavior was quantified periodically in phases 1 and 2 by counting the number of flinches in the ipsilateral paw after injection with 30 µL of 5% formalin. Results: The threshold of mechanical allodynia was significantly increased in the BPC10, BPC20, BPC40 and morphine groups compared with that in the control group at 2 h. These increasing thresholds then returned to the levels of the control group. The BPC-157 group showed a much higher threshold at 4 days after incision than the control group. The thresholds of the BPC groups, except the morphine group, were normalized 7 days after incision. The flinching numbers of the BPC10, BPC20, BPC40 and morphine groups were significantly decreased in phase 1, but there was no decrease in the BPC-157 groups except the morphine group in phase 2. Conclusions: BPC-157 was effective only for a short period after incision. It was also effective during phase 1 but not during phase 2, as determined by the formalin test. BPC-157 might have a short antinociceptive effect, even though it has anti-inflammatory and wound healing effects.

• 한국정보시스템학회지:정보시스템연구
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• 제20권4호
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• pp.49-72
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• 2011

Business Process Change(BPC) is regarded as a salient factor to improve an organizations' efficiency in the current fast-changing business environment. Despite the tremendous popularity and great potential, the field of BPC adoption is littered with remarkable failures. Consequently, there have been many studies that have tried to identify the environmental factors that lead to successful BPC. However, most of them have not considered the effect of the interaction between the environmental factors on BPC success. According to Klempa(1995), the fit between environmental factors of a company may have the impact on its BPC success. Under this background, this paper empirically examines the effects of the fit between the type of BPC and the organization's culture on the success of BPC. Organization's cultures, organizational learning, as well as knowledge sharing are the dominant causes that have impact on the innovation characters of organization. Whether an organization has safety-oriented homogeneous culture or it has the change-oriented heterogeneous culture may have impact on its implementation of BPC. Also the implementation of BPC may be affected by whether the organization adopts the improvement project which accompanies only small changes or it adopts the innovation project which leads to critical changes. Thus, we analyzed the effect of the fit between the organization's culture and its BPC type on BPC success by using the survey data collected from the companies that have adopted BPC. The findings presented in this paper show that the organization having heterogeneous culture practicing innovation project and the organization having homogeneous culture practicing the improvement project resulted in the excellent BPC success.

• 디지털산업정보학회논문지
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• 제7권2호
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• pp.127-145
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• 2011

According to Klempa(1995), the fit between environmental factors of a company may have the impact on its BPC success. Under this background, this paper empirically examines the effects of the fit between the organizational culture and the organizational learning the success of BPC. Organizational cultures, organizational learning, as well as knowledge sharing are the dominant causes that have impact on the innovation characters of organization. Whether an organization has safety-oriented homogeneous culture or it has the change-oriented heterogeneous culture may have impact on its implementation of BPC. Also the implementation of BPC may be affected by whether an organizational learning type has adaptive-oriented learning is single loop or it has the innovative-oriented learning is double loop. Thus, we analyzed the effect of the fit between the organization's culture and organizational learning type on BPC success by using the survey data collected from the companies that have adopted BPC. The findings presented in this paper show that the organization having heterogeneous culture practicing double loop learning the improvement project resulted in the excellent BPC success. These findings provide the perceptive guidelines for managers of organizations contemplating the implementation of BPC project.

• Fisheries and Aquatic Sciences
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• 제24권4호
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• pp.153-162
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• 2021

In this study, a fish metabolic accelerator (a combination of butaphosphan and cyanocobalamin [BPC]) was injected into the muscle of the olive flounder, Paralichthys olivaceus, to investigate its effect on immunity and stress in fish maintained at low temperatures. A single dose of BPC was injected (100 mg/kg body weight) into the olive flounder, and its immunity and stress were observed after one and two weeks. Immunity tests revealed the presence of lysozyme (LZM), nitroblue tetrazolium (NBT), myeloperoxidase (MPO), anti-protease (AP), glutathione peroxidase (GPx), and total immunoglobulin (TIg). BPC injection was found to increase immunity activity compared to the control group. In particular, there was significantly high GPx activity. There was similarly high activity for MPO and GPx in the first week following the injection, followed by significant differences between the BPC-injected and control groups in the second week. There was a reduced low water-temperature stress response in the BPC-injected fish, as evidenced by the cortisol and glucose levels of the control and BPC groups. Lower levels were also observed in the BPC group than the control group during the second week. Cortisol levels were significantly lower in the BPC group than the control group. Histological examinations were conducted in the first and second weeks after the intramuscular injection of the recommended BPC dose to confirm the safety of BPC in aquaculture. There were no abnormalities observed in any tissue samples. This study confirms that the injection of BPC is safe even when used in a culture situation. BPC helps relieve stress and improves non-specific immune responses (innate immunity) in the olive flounder.

• Korean Chemical Engineering Research
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• 제45권3호
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• pp.286-290
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• 2007

청정 용매로 주목받고 있는 이온성 액체를 촉매로 유리지방산을 에스테르화하여 알킬에스터로 전환하는 반응 특성에 대해 조사하였다. 본 연구에서 사용한 강산성 이온성 촉매는 BPC[$AlCl_3$], BMIM[$Bf_4$], BMIM[$Pf_6$], EMIM[$Ntf_2$], BMIM[Otf] 등 5종이었으며 이러한 이온성 액체 촉매 중 BPC[$AlCl_3$]가 본 반응에서 가장 높은 활성을 갖는 것으로 나타났다. BPC[$AlCl_3$]는 모사 폐식용유를 원료로 한 에스테르화 반응 시 원료에 포함된 유리지방산의 90% 이상을 반응시작 2시간 내에 에스테르로 전환시키는 것으로 나타났다. 이러한 높은 반응 효율과 반응 후 촉매의 회수의 용이성 및 처리 후 재사용이 가능하다는 장점을 고려할 때 BPC[$AlCl_3$]를 이용하여 유리지방산이 다량 함유된 폐유지의 전처리 촉매로 활용 가능성이 높은 것으로 나타났다.

• 한국산학기술학회논문지
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• 제10권1호
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• pp.146-150
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• 2009

차세대 정지영상 압축방식인 JPEG2000의 엔트로피 코더는 컨텍스트 추출부(BPC)와 산술부호화기(AC)로 구성되는데 본 논문에서는 효율적인 컨텍스트 추출부 설계에 새로운 알고리즘을 제안하였고, 설계하였다. BPC(Bit Plane Coding)는 context 기반의 부호화기를 사용하였고, 현재의 SigStage register의 값과 상위 비트 플랜의 column 값을 가공한 데이터와 현재의 column 값을 이용하여 코딩패스를 미리 예측하는 기법을 사용하여, 각 bit plane에서 사용되어지는 상태 정보 레지스터와 이 상태 정보 레지스터를 접속하는 Access time을 줄일 수 있다. 본 논문에서 제안된 방법으로 설계된 Bit Plane Coding은 Verilog HDL 모델링후 Xilinx FPGA technology를 이용하여 합성한 후 동작을 검증하였다.

• 대한화장품학회지
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• 제34권1호
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• pp.43-50
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• 2008

세라마이드는 콜레스테롤, 지방산과 함께 각질층을 구성하는 주요성분으로 각질층의 피부장벽 기능에 중요한 역할을 하며, 아토피 피부염, 건선, 건성습진, 주부습진 등과 같은 염증성 피부질환 방지에 도움이 되는 것으로 알려져 있다. 본 연구에서 2-(2-amino-ethylamino)-ethanol(AEEA)을 출발물질로 하여 신규 유사세라마이드 BPC-16을 합성하고, 그 물리화학적 성질과 화장품의 신규 소재로 활용하기 위하여 세포독성, 보습, 각질제거효능 등을 평가하였다. 합성된 BPC-16을 이용하여 콜레스테롤, 스테아린산을 포함하는 에멀젼을 제조했고, 편광현미경에서 'Maltese Cross'를 확인함으로써 BPC-1이 라멜라 에멀젼을 형성함을 확인하였다. 단층배양세포와 삼차원배양세포에서의 세포독성 실험에서 BPC-16은 보습과 피부손상회복 효과를 보이는 10 mM 이하의 농도에서 독성이 없음을 확인하였다. BPC-16의 보습효능을 확인하기 위하여 Vapormeter와 Corneometer를 이용하여 임상실험을 실시하였으며, 우수한 효과를 확인할 수 있었다. 또한, 피부손상에 대한 회복효과와 Visioscan을 이용한 각질량의 변화 실험에서도 우수한 효과를 확인하였다.

• 한국환경과학회지
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• 제30권1호
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• pp.69-76
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• 2021

The purposes of this study were to evaluate the removal characteristics of COD, Ni, and P and to derive appropriate operating conditions for the plating wastewater according to NaOCl reaction time and pH operating conditions in the BPC unit process during the plating wastewater treatment process. As a results of evaluating the removal characteristics for raw wastewater by each BPC unit process, the removal efficiencies of COD, Ni and P in BPC 1-1 unit process were 72.8%, 99.1%, and 100.0%. Therefore, the proper reaction time of NaOCl was derived as 21.1 minutes. In order to maintain the +800 mV ORP and the reaction time of 20 minutes, the temporary injection and continuous injection of NaOCl in the BPC unit process were 13.7 mL and 18.7 mL, respectively. It was found that the temporary injection method of NaOCl reduced the chemical cost by 36.5% compared to the continuous injection method. Also, Ni showed the highest removal efficiency of 97.8% at pH 10.5. On the other hand, P showed a removal efficiency of 57.4% at pH 10.0.

• 대한전자공학회논문지SP
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• 제46권3호
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• pp.37-43
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• 2009

차세대 정지영상 압축방식인 JPEG2000은 DWT와 EBCOT로 구성 되어 있다. EBCOT는 컨텍스트 추출부(BPC)와 산술부호화기(AC)로 구성되는데 본 논문에서는 효율적인 EBCOT 설계에 새로운 알고리즘을 적용하여 설계하였다. BPC(Bit Plane Coding)는 context 기반의 부호화기를 사용하였고, 현재의 SigStage register의 값과 상위 비트 플랜의 column 값을 가공한 데이터와 현재의 column 값을 이용하여 코딩패스를 미리 예측하는 기법을 사용하였다. BAC(Binary Arimethic Coder)에는 4단계 pipeline을 적용하였다. 설계된 EBCOT은 Verilog HDL 모델링후 Xilinx FPGA technology를 이용하여 합성한 후 동작을 검증하였다.

• Macromolecular Research
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• 제15권7호
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• pp.640-645
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• 2007

The phase behavior of branched polycarbonate (BPC) blends with poly(ethylene terephthalate-co-1,4-dimethyl cyclohexane terephthalate) copolyesters (PECT), as well as their rheological properties, were assessed. Even though BPC blends with PECT prepared by solvent casting proved to be immiscible, BPC and PECT copolyesters containing 1,4-dimethyl cyclohexane (CHDM) from 32 to 80 mole% formed homogeneous mixtures upon heating. The homogenization temperatures of the blends decreased with increasing CHDM content in PECT. The interaction energies of the BPC-PECT pairs calculated from the phase boundary in accordance with the lattice-fluid theory were positive and also decreased with increasing CHDM content in PECT. It was shown that the phase homogenization of these blends occurs upon heating when the combinatorial entropy term, which is favorable for miscibility, overcomes unfavorable energetic terms at elevated temperatures. A novel product, which is not limited by the drawbacks of linear polycarbonate (PC) and evidences processability superior to that of the PC/PECT blends, can be developed via the blending of BPC and PECT.