• Progress in Superconductivity and Cryogenics
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• v.25 no.3
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• pp.49-55
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• 2023

This paper presents the design of a re-liquefaction system as a BOG (boil-off gas) handling process in liquid hydrogen transport vessels. The total capacity of the re-liquefaction system was assumed to be 3 ton/day, with a BOR (boil-off rate) of 0.2 %/day inside the cargo. The re-liquefaction cycle was devised using the He-Brayton Cycle, incorporating considerations of BOG capacity and operational stability. The primary components of the system, such as compressors, expanders, and heat exchangers, were selected to meet domestically available specifications. Case studies were conducted based on the specifications of the components to determine the optimal design parameters for the re-liquefaction system. This encompassed variables such as helium mass flow rate, the number of compressors, compressor inlet pressure and compression ratio, as well as the quantity and composition of expanders. Additionally, an analysis of exergy destruction and exergy efficiency was carried out for the components within the system. Remarkably, while previous design studies of BOG re-liquefaction systems for liquid hydrogen vessels were confined to theoretical and analytical realms, this research distinguishes itself by accounting for practical implementation through equipment and system design.

• Korean Journal of Food Science and Technology
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• v.41 no.5
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• pp.552-559
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• 2009

In this study, the anticancer activity of the water extract at $100^{\circ}C$ was compared to that of the callus extracts via a ultrasonification extraction process. All the extracts were utilized to evaluate cytotoxicity, antioxidant and immune activities. The callus extracted via ultrasonification extraction showed relatively low cytotoxicity on normal human cell lines, HEK293 and HEL299, showing 13.17% and 21.78%, respectively. The callus extract has 59.82% which was similar to 61.70% for water extracts. It was also found that callus extract yielded higher nitric oxide secretion form macrophage than other extracts. The growths of both human stomach adenocarcinoma (AGS) cell and human lung carcinoma (A549) were inhibited up to 70% by adding 1.0 mg/mL of the callus extracts with ultrasonification extraction. This inhibition ratio (70%) was almost close to that of water extract. Human hepatoma carcinoma (HEP3B) cell growth was most significantly inhibited up to 75% by adding 1.0 mg/mL of callus extracts, and its selectivity was highest compared to other extracts. It indicates that the callus extracts could selectively inhibit growth of digestive system-related cancer cells. It can be also concluded from the results of this study that the callus extracts associated with ultrasonification extraction process have the potential for anticancer activity.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2159-2165
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• 2013

Cancer registries help to establish and maintain cancer incidence reporting system, serve as a resource for investigation of cancer and its causes, and provide information for planning and evaluation of preventive and control programs. However, their wider role in directly enhancing oncology drug access has not been fully explored. We examined the value of cancer registries in oncology drug access in the Asia-Pacific region on three levels: (1) specific registry variable types; (2) macroscopic strategies on the national level; and (3) a regional cancer registry network. Using literature search and proceedings from an expert forum, this paper covers recent cancer registry developments in eight economies in the Asia-Pacific region - Australia, China, Hong Kong, Malaysia, Singapore, South Korea, Taiwan, and Thailand - and the ways they can contribute to oncology drug access. Specific registry variables relating to demographics, tumor characteristics, initial treatment plans, prognostic markers, risk factors, and mortality help to anticipate drug needs, identify high-priority research area and design access programs. On a national level, linking registry data with clinical, drug safety, financial, or drug utilization databases allows analyses of associations between utilization and outcomes. Concurrent efforts should also be channeled into developing and implementing data integrity and stewardship policies, and providing clear avenues to make data available. Less mature registry systems can employ modeling techniques and ad-hoc surveys while increasing coverage. Beyond local settings, a cancer registry network for the Asia-Pacific region would offer cross-learning and research opportunities that can exert leverage through the experiences and capabilities of a highly diverse region.

• The Korean Journal of Food And Nutrition
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• v.25 no.4
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• pp.779-786
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• 2012

Rhodiola sachalinensis fermentates by lactic acid bacteria were prepared using the adsorption process, and were investigated for changes of the main compounds and anti-oxidative activities during the adsorption and fermentation process. While the R. sachalinensis extract (RSE), which did not go through the adsorption process, showed little change in pH during fermentation and a significant reduction in the number of lactic acid bacteria, the pre-preparatory adsorption process was found to be helpful for promoting fermentation and for maintenance of bacterial numbers. The contents of total phenolic compounds mostly decreased during the adsorption process, but showed an increasing tendency to rebound during the fermentation process. The contents of salidroside and p-tyrosol in the RSE were 1153.3 mg% and 185.0 mg% respectively, and they did not significantly change after treatment with acid clay or bentonite as adsorbents, which were 1093.0 and 190.5 mg% by acid clay, and 882.2 and 157.3 mg% by bentonite. When the extract was fermented after treatment with acid clay or bentonite, the salidroside contents were decreased by 282.7 and 505.0 mg% respectively, but the p-tyrosol contents were increased by 714.0 and 522.4 mg% respectively. Compared to the DPPH radical scavenging activity of the RSE (66.8%) at the conc. of 0.1%, that of the fermented RSE, which went through adsorption process with acid clay or bentonite, was significantly increased to 79.4 and 72.7% respectively at the same concentration (p<0.05). Though fermentation by lactic acid bacteria was suppressed in the RSE, the results suggested that the adsorption process may promote fermentation without any change in the content of major active compounds. It is expected that fermentation by lactic acid bacteria could improve the antioxidant activity and various associated functionalities of R. sachalinensis.

• Journal of Life Science
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• v.9 no.4
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• pp.439-452
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• 1999

This study was designed to investigate the effects of sea tangle (Laminaria japonica) extract and fucoidan components on anti-aging action. Sprague-Dawley(SD) male rats (210$\pm$5g) were fed experimental diets Dasi-Ex group: sea tangle extract powder of 4.0% added to control diet; Fuco-I, II and III groups: funcoidan powder of 1, 2 and 3% added to Dasi-Ex group for 45 days. Hydroxyl radical (.OH) formations were significantly inhibited (10-20% and 25-30%) in serum and brain mitochondria of Dasi-Ex and Fuco-I, II and III groups compared with control group. Significant differences in .OH formations of brain mitochondria in Dasi-Ex and Fuco-I groups could not be obtained, but.OH formations of brain microsomes resulted in a significant decrease (15-20%) in Fuco-II and III groups compared with control group. Basal oxygen radical (BOR) formations were significantly decreased about 10% and 13-15% in brain mitochondria of Dasi-Ex and Fuco-I group, and Fuco-II, III groups, and also decreased about 10% and 15-20% in brain microsomes of Dasi-Ex and Fuco-I groups, and Fuco-II, III groups. LPO levels of brain mitochondria and microsomes were significantly inhibited about 10% in Dasi-Ex and Fuco-I, II groups and 15% in Fuco-III groups. Oxidized proteins (>C=O) were significantly inhibited about 10% in serum of Dasi-Ex and Fuco-I, II, III groups and brain mitochondria of Dasi-Ex group, while remarkably inhibited (30~35%) in brain mitochondria of Fuco-I, II and III groups. Nitric oxide (NO) levels were significantly inhibited (12~15%) in serum of Fuco-I, II and III groups, but there no significant difference in serum NO levels of Dasi-Ex group. Superoxide dismutase (SOD) activities were remarkably increased (30~ 60%) in serum of Fuco-I, II and III groups, but there were no significant differences in SOD activities in serum of Dasi-Ex group. Catalase (CAT) activities were significantly increased about 20% in serum of Dasi-Ex and Fuco-I, II, III groups. Mn-SOD activities in brain mitochondria were significantly increased about 17% in Dasi-Ex group, while remarkably increased 26~36% in Fuco-I, II, III groups. Cu,Zn-SOD activities in brain cytosol were dose-dependently of fucoidan increased 10%, 12% and 18%, respectively, compared with control group. These results suggest that anti-aging effects of fucoidan may play a pivotal role in attenuating a various age-related changes such as chronic degenerative disease and senile dementia.

• Journal of Digital Convergence
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• v.12 no.2
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• pp.119-128
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• 2014

This Study investigated the differences of risk assessment tool and personality assessment inventory (PAI) by recidivism types of juvenile delinquents, the psychological factors that have a influence of juvenile behaviors. 268 incipient Juvenile criminals who had committed crime in the areas of Seoul, were categorized in the three degree of recidivism types. The result showed the significant differences among risk assessment tool, such as family functioning risk factor, school risk factor, away-from-home risk factor, delinquent risk factor, and personal risk factor. PAI scores among the recidivism type showed the significant differences on SOM, DEP, PAR, SCZ, BOR, ANT, ALC, DRG, AGG, SUI, STR, NON, DOM, and WRM. The predictor variables explained a risk assessment tool were STR, ALC, DEP, DOM and WRM in PAI scales. And the interventions and preventions about juvenile delinquents discussed in psychological aspects.

• Korean Journal of Environmental Biology
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• v.22 no.1
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• pp.66-74
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• 2004

In order to clarify intra-and inter-specific variation of Korean Rana species, the partial DNA sequences of mitochondrial 16S rDNA gene were determined from 6 Korean and 1 Japanese Rana species, DNA sequences from Korean and Japanese species were comparison-analysed within, and also with the sequences from three species of Japanese brown frogs. DNA similarities were calculated as 91.3∼97.3％ among brown frog (R. amurensis coreana, R. dybowskii and R. huanrenensis), as 96.11∼97.26％ among pond frogs (R. nigromaculata and R. planeyi chosenica). Genetic distance of pond frog and wrinkle fyog (R. rugosa) were near than that of pond frog and brown frog. Two clusters were formed brown frogs and the other group by neigh-bor-joining and maximum-likelihood analysis, also the populations of R. nigromaculata were well distinguished between Korean peninsula and Korean island. But result from maximum-likelihood analysis slightly differed from neighbor-joining to cluster of R. rugosa. Further analyses for their population will be necessary to study the phylogenetic status.

• Korean Chemical Engineering Research
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• v.55 no.4
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• pp.456-466
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• 2017

This work investigated the particle morphology change to difference in milling media in a metal based composite fabrication process using a stirred ball mill with ball behavior of DEM simulation. A simulation of the three dimensional motion of grinding media in the stirred ball mill for the research of grinding mechanism to clarify the force, kinetic energy, and medium velocity of grinding media were calculated. In addition, the rotational speed of the stirred ball mill was changed to the experimental conditions for the composite fabrication, and change of the input energy was also calculated while changing the ball material, the flow velocity, and the friction coefficient under the same conditions. As the rotating speed of the stirred ball mill increased, the impact energy between the grinding media to media, media to wall, and media and the stirrer increased quantitatively. Also, we could clearly analyze the change of the particle morphology under the same experimental conditions, and it was found that the ball behavior greatly influences in the particle morphology changes.

• Korean Journal of Medicinal Crop Science
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• v.15 no.6
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• pp.411-416
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• 2007

This study was performed to investigate the reduction of toxicity and improvement of anticancer activities from R. sachalinensis by ultra high pressure extracts process. The cytotoxicity on human kidney cell (HEK293) and human lung cell (HEL299) was showed below 20.4% and 21.6% as compare to normal extracts in adding 1.0 $mg/m{\ell}$ concentration. This showed that toxic materials through ultra high pressure processing is broken or degraded. Because bond such as hydrogen bond, electrostatic bond, Van der waals bond, the hydrophobic bond, can be broken by high pressure. The anticancer activity was also increased in over 7% by high pressure processing in A549, AGS, MCF-7 and Hep3B cells. The result showed that extraction by high pressure have low cytotoxicity and high anticancer activity. So, the high pressure extraction technology can play an important role in eruption of new material with high biological activity.

• Animal Bioscience
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• v.36 no.4
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• pp.609-618
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• 2023

Objective: TLRI 211-1 is a novel Bacillus subtilis strain. This experiment was to investigate dietary supplementation of TLRI 211-1 on laying performance, egg quality and blood characteristics of layers. Methods: One hundred and twenty 65-wk-old Leghorn layers were divided into four treatment groups for 8 weeks experiment. Each treatment had three replicates. The basal diet was formulated as control group with crude protein 17% and metabolizable energy 2,850 kcal/kg and supplemented with TLRI 211-1 0.1%, 0.3%, and commercial Bacillus amyloliquefaciens 0.1% as treatment 2, 3 and 4 groups, respectively. Both TLRI 211-1 and commercial Bacillus amyloliquefaciens were adjusted to contain 1×10⁹ colony-forming unit (CFU)/mL (g), hence the 0.1% supplemental level was 1×10⁹ CFU/kg. Results: The results showed that TLRI 211-1 0.3% and commercial B. amyloliquefaciens groups had higher weight gain than the other groups; TLRI 211-1 0.1% group had better feed to eggs conversion ratio than the control and commercial B. amyloliquefaciens groups (p<0.05). Bacillus subtilis supplementation increased yolk weight (p<0.05). In egg quality during storage, TLRI 211-1 0.1% had higher breaking strength than the control group at the second week of storage (p<0.05). At the third week of storage, TLRI 211-1 0.3% had higher Haugh unit (p<0.05). Hens fed diets supplemented with TLRI 211-1 0.3% significantly decreased blood triglyceride levels and increased blood calcium levels (p<0.05). TLRI 211-1 0.3% group had lower H₂S (p<0.05) and hence had less unpleasant odor in excreta of hens. Conclusion: In conclusion, supplementation with 0.1% TLRI 211-1 can significantly improve feed to eggs conversion ratio. TLRI 211-1 supplementation also can maintain eggs at their optimum quality level during storage. The study showed that B. subtilis TLRI 211-1 can be used as feed additives for improving egg production performance and egg quality.