• 전기화학회지
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• 제15권3호
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• pp.135-148
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• 2012

Ionic liquids are steadily attracting interests throughout a recent decade and their application is expanding into various fields including electrochemistry due to their unique properties such as non-volatility, inflammability, low toxicity, good ionic conductivity, wide electrochemical potential window and so on. These features make ionic liquids become an alternative solution for electrodeposition of metals that cannot be electroplated in aqueous electrolytes. In this review, we classify investigated metals into three categories, which are light (Li, Mg), refractory (Ti, Ta) and noble (Pd, Pt, Au) metals, rather than covering the exhaustive list of metals and try to update the recent development in this area. In electrodeposition of light metals, granular fine Li particles were successfully obtained while the passivation of electrodeposited Mg layers is an obstacle to reversible deposition-dissolution process of Mg. In the case of refractory metals, the quality of Ta and Ti deposit particles was effectively improved with addition of LiF and pyrrole, respectively. In noble metal category, EMIM TFSA ionic liquid as an electrolyte for Au electrodeposition was proven to be effective and BMP TFSA ionic liquid developed a smooth Pd deposit. Pt nanoparticle production from ionic liquid droplet in aqueous solution can be cost-effective and display an excellent electrocatalytic activity.

• 한국한의학연구원논문집
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• 제10권1호
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• pp.1-14
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• 2004

As entering the information age of the 21st century, Korea is actively processing many digitalizing businesses related to information source of the Korean academic science at the government level based on the Korean advanced digital technologies, which makes them more evolved through the internet networks in Korea. The definition of 'Newly found ideographs(新出漢字)' are made by researching and extracting from the old Chinese documents through the digitalizing process and they are not registered yet among the block of Unicode & extended Chinese characters those are existent international standard. Presently Korea is in the middle of brisk developing computerized old documents in the huge scale. Meanwhile, the international standard of Chinese characters in mostly Asian countries where using them is processing and developing by IRG. Therefore, Korean processing works is very important which are included extracting precisely 'Newly found ideographs' founded from building its database, organizing as an international standard code, submitting the International organization and finally registering as the best standard code.

• 한국컴퓨터정보학회논문지
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• 제20권7호
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• pp.41-47
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• 2015

The bandwidth minimization problem (BMP) has been classified as NP-complete because the polynomial time algorithm to find the optimal solution has been unknown yet. This paper suggests polynomial time heuristic algorithm is to find the solution of bandwidth minimization problem. To find the minimum bandwidth ${\phi}^*=_{min}{\phi}(G)$, ${\phi}(G)=_{max}\{{\mid}f(v_i)-f(v_j):v_i,v_j{\in}E\}$ for given graph G=(V,E), m=|V|,n=|E|, the proposed algorithm sets the maximum degree vertex $v_i$ in graph G into global central point (GCP), and labels the median value ${\lceil}m+1/2{\rceil}$ between [1,m] range. The graph G is partitioned into subgroup, the maximum degree vertex in each subgroup is set to local central point (LCP), and we adjust the label of LCP per each subgroup as possible as minimum distance from GCP. The proposed algorithm requires O(mn) time complexity for label to all of vertices. For various twelve graph, the proposed algorithm can be obtains the same result as known optimal solution. For one graph, the proposed algorithm can be improve on known solution.

• 대한조선학회논문집
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• 제35권3호
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• pp.46-53
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• 1998

본 논문에서는 부유식 해양구조물의 보다 신뢰성 있고 정도 높은 구조안전성 평가를 위한 직접 구조해석시스템을 개발한다. 본 시스템은, 3차원 패널법에 기초한 강체운동해석 모듈, 자동하중변환기능(LOADGEN)과 범용 유한요소해석 프로그램(NASTRAN)이 결합된 구조해석 모듈, 그리고 장단기 스펙트럼해석에 기초한 통계해석 모듈 등의 3 주요모듈로 구성되어 있다. 본 논문에서는 시설계과정에 있는 PILOT 부유식 해상플랜트에 개발된 시스템을 적용하고, 그 결과를 2차원 스트립법에 기초한 해석결과에 비교/검토함으로써 본 해석법의 유용성을 확인하고자 한다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2012년도 학술발표회
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• pp.539-539
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• 2012

최근 미국 환경부에서는 국가 환경 정책으로써 LID(Low Impact Development)를 대안 책으로 제시하고 있으며 우리나라에서도 최근 LID기법 연구가 활발히 진행 되고 있다. LID란 기존의 집중식 BMP처럼 유출 발생 후 처리를 다루는 방식의 기법이 아닌 발생원 단계에서의 처리에 초점을 맞춘 기법이다. 환경적 측면에서 다양한 기능을 가능하게 할 수 있는 LID기법 적용에 따른 효과를 알아보기 위해 전 세계적으로 SWMM 모형이 많이 사용되고 있지만 SWMM 모형 내 유량 및 수질에 따른 자동 보정 툴이 존재하지 않고 유역에 적합한 최적의 LID 기법 구조물의 설계 기준을 정할 수 있는 툴이 존재하지 않기 때문에 보다 효율적인 유역의 수문 보정 및 LID 기법 적용에 따른 효과 모의를 제공하지 못한다. 따라서 본 연구에서는 SWMM 5.0 버전 내 SWMM LID auto-calibration tool을 PARASOL 알고리즘을 기반으로 개발하였다. 또한 개발된 PARASOL 알고리즘 기반 SWMM LID auto-calibration tool을 이용하여 경기도 경안천 유역에 적용하였고 2011년 일별 실측 수문자료와 비교 분석 하였으며 경기도 경안천 유역에 맞는 최적의 LID기법을 산정하였다. 본 연구에서 개발 된 SWMM auto-calibration tool은 SWMM 모형의 유량 및 수질을 자동으로 보정하기 때문에 보다 효율적인 모형의 보정을 사용자에게 제공해 줄 수 있을 것이며 유역에 적합한 최적의 LID 기법 구조물 설계를 제시해 줄 수 있기 때문에 향후 LID 기법을 이용한 도시개발 계획에 유용하게 사용될 수 있을 것으로 판단된다. 향후 PARASOL 알고리즘 뿐만이 아닌 GLUE, SUFI-2, GA 등 다양한 알고리즘이 추가된 SWMM LID auto-calibration tool 을 개발 중에 있다.

• BMB Reports
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• 제50권6호
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• pp.308-317
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• 2017

Bone morphogenetic protein type 2 receptor (BMPR2) is one of the transforming growth $factor-{\beta}$ ($TGF-{\beta}$) superfamily receptors, performing diverse roles during embryonic development, vasculogenesis, and osteogenesis. Human BMPR2 consists of 1,038 amino acids, and contains functionally conserved extracellular, transmembrane, kinase, and C-terminal cytoplasmic domains. Bone morphogenetic proteins (BMPs) engage the tetrameric complex, composed of BMPR2 and its corresponding type 1 receptors, which initiates SMAD proteins-mediated signal transduction leading to the expression of target genes implicated in the development or differentiation of the embryo, organs and bones. In particular, genetic alterations of BMPR2 gene are associated with several clinical disorders, including representative pulmonary arterial hypertension, cancers, and metabolic diseases, thus demonstrating the physiological importance of BMPR2. In this mini review, we summarize recent findings regarding the molecular basis of BMPR2 functions in BMP signaling, and the versatile roles of BMPR2. In addition, various aspects of experimentally validated pathogenic mutations of BMPR2 and the linked human diseases will also be discussed, which are important in clinical settings for diagnostics and treatment.

• 한국발생생물학회지:발생과생식
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• 제25권4호
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• pp.279-291
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• 2021

Hair loss is one of the most common chronic diseases, with a detrimental effect on a patient's psychosocial life. Hair loss results from damage to the hair follicle (HF) and/or hair regeneration cycle. Various damaging factors, such as hereditary, inflammation, and aging, impair hair regeneration by inhibiting the activation of hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs). Formyl peptide receptor 2 (FPR2) regulates the inflammatory response and the activity of various types of stem cells, and has recently been reported to have a protective effect on hair loss. Given that stem cell activity is the driving force for hair regeneration, we hypothesized that FPR2 influences hair regeneration by mediating HFSC activity. To prove this hypothesis, we investigated the role of FPR2 in hair regeneration using Fpr2 knockout (KO) mice. Fpr2 KO mice were found to have excessive hair loss and abnormal HF structures and skin layer construction compared to wild-type (WT) mice. The levels of Sonic hedgehog (Shh) and β-catenin, which promote HF regeneration, were significantly decreased, and the expression of bone morphogenetic protein (Bmp)2/4, an inhibitor of the anagen phase, was significantly increased in Fpr2 KO mice compared to WT mice. The proliferation of HFSCs and DPCs was significantly lower in Fpr2 KO mice than in WT mice. These findings demonstrate that FPR2 impacts signaling molecules that regulate HF regeneration, and is involved in the proliferation of HFSCs and DPCs, exerting a protective effect on hair loss.

• Molecules and Cells
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• 제37권5호
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• pp.406-411
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• 2014

The initial step of atrioventricular (AV) valve development involves the deposition of extracellular matrix (ECM) components of the endocardial cushion and the endocardialmesenchymal transition. While the appropriately regulated expression of the major ECM components, Versican and Hyaluronan, that form the endocardial cushion is important for heart valve development, the underlying mechanism that regulates ECM gene expression remains unclear. We found that zebrafish crip2 expression is restricted to a subset of cells in the AV canal (AVC) endocardium at 55 hours post-fertilization (hpf). Knockdown of crip2 induced a heart-looping defect in zebrafish embryos, although the development of cardiac chambers appeared to be normal. In the AVC of Crip2-deficient embryos, the expression of both versican a and hyaluronan synthase 2 (has2) was highly upregulated, but the expression of bone morphogenetic protein 4 (bmp4) and T-box 2b (tbx2b) in the myocardium and of notch1b in the endocardium in the AVC did not change. Taken together, these results indicate that crip2 plays an important role in AV valve development by downregulating the expression of ECM components in the endocardial cushion.

• Journal of Veterinary Science
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• 제24권5호
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• pp.69.1-69.11
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• 2023

Background: Kalkitoxin (KT) is an active lipopeptide isolated from the cyanobacterium Lyngbya majuscula found in the bed of the coral reef. Although KT suppresses cell division and inflammation, KT's mechanism of action in vascular smooth muscle cells (VSMCs) is unidentified. Therefore, our main aim was to investigate the impact of KT on vascular calcification for the treatment of cardiovascular disease. Objectives: Using diverse calcification media, we studied the effect of KT on VSMC calcification and the underlying mechanism of this effect. Methods: VSMC was isolated from the 6 weeks ICR mice. Then VSMCs were treated with different concentrations of KT to check the cell viability. Alizarin red and von Kossa staining were carried out to examine the calcium deposition on VSMC. Thoracic aorta of 6 weeks mice were taken and treated with different concentrations of KT, and H and E staining was performed. Real-time polymerase chain reaction and western blot were performed to examine KT's effect on VSMC mineralization. Calcium deposition on VSMC was examined with a calcium deposition quantification kit. Results: Calcium deposition, Alizarin red, and von Kossa staining revealed that KT reduced inorganic phosphate-induced calcification phenotypes. KT also reduced Ca⁺⁺-induced calcification by inhibiting genes that regulate osteoblast differentiation, such as runtrelated transcription factor 2 (RUNX-2), SMAD family member 4, osterix, collagen 1α, and osteopontin. Also, KT repressed Ca²⁺-induced bone morphogenetic protein 2, RUNX-2, collagen 1α, osteoprotegerin, and smooth muscle actin protein expression. Likewise, Alizarin red and von Kossa staining showed that KT markedly decreased the calcification of ex vivo ring formation in the mouse thoracic aorta. Conclusions: This experiment demonstrated that KT decreases vascular calcification and may be developed as a new therapeutic treatment for vascular calcification and arteriosclerosis.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권3호
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• pp.247-255
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• 2007

The bone morphogenic protein(BMP) can promote migration and growth of mesenchymal cells and initiate process for bone and cartilage formation. Cartilage-derived morphogenic protein(CDMP)-1 and -2 belong to the bone morphogenetic protein family in the transforming growth factor(TGF)-${\beta}$ superfamily. Although pleomorphic adenoma of the salivary glands is an epithelial tumor, it frequently shows ectopic cartilaginous formation with biomolecular studies. The mechanism of pathogenesis in cartilaginous formation is still controversy. We examined the expression and localization of CDMP-1 and -2, in comparison with the localization of cartilaginous matrix proteins, in human normal salivary glands and 20 cases of pleomorphic adenoma using immunohistochemical methods. The results were followed. 1. CMP-1 was immunolocalized in the striated ducts and the intercalated ducts, but not expressed in excretory duct, CDMP-2 was not expressed in the normal salivary glands. 2. CMP-1 was immunolocalized in the ductal cell and cuboidal neoplastic myoepithelial cells around the chondroid areas of the pleomorphic adenomas, whereas these molecules were not localized in the spindle-shaped neoplastic myoepithelial cells of the myxoid element in these tumors. CDMP-2 was expressed neither in normal salivary glands nor in any elements of the pleomorphic adenomas. 3. In transmission electron microscopic view, the tumor cells are composed of modifed myoepithelial cells between hyaline and myxoid stroma. 4. In Immuno-blot analysis, strong overexpression of CDMP-1 was frequently seen in pleomorphic adenomas, but the level of CDMP-2 was expressed minimally in pleomorphic adenoma. From the these results, it should be suggested that undifferentiated neoplastic myoepithelial cells around the chondroid areas expressed CDMP-1 and suggested that this molecule may play a role in the differentiation of neoplastic myoepithelial cells in pleomorphic adenoma, but not CDMP-2.