• Journal of the Optical Society of Korea
• /
• v.20 no.1
• /
• pp.22-28
• /
• 2016

The monitoring and measurement of the motion of a human joint is very important in screening for degenerative brain diseases and tracking the rehabilitation process. Since there are various medical fields to benefit from angular motion measurement, the necessity for monitoring of human joint movement is increasing. In this study, the optical sensor is composed of a light emission unit with a red LED and an optical fiber, and a reception unit with an arrangement of three photodiodes. The angular detection range was widened with the use of multiple photodiodes and the developed algorithm. The result will be useful for designing an effective angular sensor with low cost and small size.

• Proceedings of the KIEE Conference
• /
• 2015.07a
• /
• pp.1407-1408
• /
• 2015

현재에는 과거와 달리 표면상 비춰지는 외모의 중요성이 강조되어 치아 교정을 해서 미적 욕구를 충족시키려는 사람들이 증가하고 있다. 특히나 치아를 교정할 때 사용되는 치아교정용 브라켓은 부착되는 위치가 치아 앞면이기 때문에 미관상의 중요성은 치아교정장치 중 가장 크다. 이러한 이유 때문에 미적인 부분을 고려하여 치아색과 유사한 브라켓이 개발되었는데, 이 브라켓은 레진 브라켓이다. 이는 치아 교정에 도움을 주면서 심미성이 우수한 장점이 있지만 음식을 섭취할 때 음식의 색소에 의해 브라켓의 색 변화가 일어난다는 단점이 있다. 본 연구에서는 사람들이 자주 섭취하는 음식이나 음료에 치아교정용 브라켓을 착색시켜 색이 변하는 정도의 차이를 컬러센서를 이용해 측정하였다. 이렇게 측정된 브라켓의 RGB 값은 객관적이고 정량적인 값을 나타낼 수 있다. 이는 브라켓의 변색 뿐만 아니라 치아 미백 치료에도 적용되어 사용될 수 있을 것이다.

• Proceedings of the Korean Environmental Sciences Society Conference
• /
• 2016.10a
• /
• pp.251-251
• /
• 2016

• Biomolecules & Therapeutics
• /
• v.22 no.2
• /
• pp.122-128
• /
• 2014

The stiffness of cancer cells is attributable to intermediate filaments such as keratin. Perinuclear reorganization via phosphorylation of specific serine residue in keratin is implicated in the deformability of metastatic cancer cells including the human pancreatic carcinoma cell line (PANC-1). 12-O-Tetradecanoylphorbol-13-acetate (TPA) is a potent tumor promoter and protein kinase C (PKC) activator. However, its effects on phosphorylation and reorganization of keratin 8 (K8) are not well known. Therefore, we examined the underlying mechanism and effect of TPA on K8 phosphorylation and reorganization. TPA induced phosphorylation and reorganization of K8 and transglutaminase-2 (Tgase-2) expression in a time- and dose-dependent manner in PANC-1 cells. These effects peaked after 45 min and 100 nM of TPA treatment. We next investigated, using cystamine (CTM), Tgase inhibitor, and Tgase-2 gene silencing, Tgase-2's possible involvement in TPA-induced K8 phosphorylation and reorganization. We found that Tgase-2 gene silencing inhibited K8 phosphorylation and reorganization in PANC-1 cells. Tgase-2 gene silencing, we additionally discovered, suppressed TPA-induced migration of PANC-1 cells and Tgase-2 overexpression induced migration of PANC-1 cells. Overall, these results suggested that TPA induced K8 phosphorylation and reorganization via Tgase-2 expression in PANC-1 cells.

• Proceedings of the KIEE Conference
• /
• 2015.07a
• /
• pp.1409-1410
• /
• 2015

현대기술의 발달로 인해 인간의 삶 중 많은 부분을 기계가 차지하고 있다. 특히 로봇공학 분야는 위험하거나 혹은 매우 정밀함을 요하는 일, 단순반복 등 인간이 기피하거나 하기 어려운 일을 대신 해줌으로서 많은 관심을 받고 있다. 이에 우리는 우리 생활에 가장 깊숙히 들어와 있는 로봇팔분야에 대해 말하고자 한다. 현재 로봇팔은 산업용은 물론, 의료용, 재해용 등 다양한 분야에서 사용되고 있다. 하지만 매우 정밀하고 정확한 작업을 위해 만들어져 있음에도 불구하고, 약간의 충격에도 이상이 생긴다거나, 기기의 이음세 부분의 잦은 회전으로 마모가 발생하게 되고 그에 따라 미세한 오차가 발생한다. 그런 상황을 방지하고자, 우리는 PSD(Position Sensitive Detecter)센서를 이용해 실시간으로 굽힘각을 측정 및 감시하여 보다 정확한 구동을 유도하려 한다. 이는 단순한 로봇팔만이 아닌 휴머노이드나 다른 회전을 이용하는 기기라면 어디든 쉽게 적용 할 수 있을 것이다.

• Proceedings of the KIEE Conference
• /
• 2015.07a
• /
• pp.1405-1406
• /
• 2015

본 논문에서는 비교적 가격이 저렴하면서 전자기장의 영향을 적게 받는 광학 소자를 이용하여 각도를 측정하는 연구에 대해 다루고 있다. 보다 측정 범위를 넓히기 위해 빛을 수광하는 포토트랜지스터를 3개 사용하였고, 발광부의 빛을 효과적으로 전달하기 위해 광섬유를 사용하였으며, 이 광섬유의 끝을 여러 각도로 가공하였다. 그 결과 포토트랜지스터를 1개 사용한 경우보다 측정 범위가 넓어지고, 광섬유의 끝을 가공함으로써 측정 신호의 비대칭성과 피크점이 이동하는 것을 확인하였다. 본 연구는 각도 측정을 요하는 다양한 분야에서 활용될 수 있는 측정 기술에 기반이 될 것으로 판단된다.

• Biomolecules & Therapeutics
• /
• v.22 no.3
• /
• pp.207-212
• /
• 2014

Skin hyperpigmentation is one of the most common skin disorders caused by abnormal melanogenesis. The mechanism and key factors at play are not fully understood. Previous reports have indicated that cystamine (CTM) inhibits melanin synthesis, though its molecular mechanism in melanogenesis remains unclear. In the present study, we investigated the effect of CTM on melanin production using ELISA reader and the expression of proteins involved in melanogenesis by Western blotting, and examined the involvement of transglutaminase-2 (Tgase-2) in SK-MEL-2 human melanoma cells by gene silencing. In the results, CTM dose-dependently suppressed melanin production and dendrite extension in a-MSH-induced melanogenesis of SK-MEL-2 human melanoma cells. CTM also suppressed a-MSH-induced chemotactic migration as well as the expressions of melanogenesis factors TRP-1, TRP-2 and MITF in a-MSH-treated SK-MEL-2 cells. Meanwhile, gene silencing of Tgase-2 suppressed dendrite extension and the expressions of TRP-1 and TRP-2 in a-MSH-treated SK-MEL-2 cells. Overall, these findings suggested that CTM suppresses a-MSH-induced melanogenesis via Tgase-2 inhibition and that therefore, Tgase-2 might be a new target in hyperpigmentation disorder therapy.

• Korean Journal of Veterinary Research
• /
• v.56 no.2
• /
• pp.129-131
• /
• 2016

Five eastern great egrets with a history of ataxia, wry neck, and wet feathers were submitted to the Veterinary Diagnostic Center for pathologic examination. Slightly enlarged livers with diffuse white-grayish nodules were observed. Microscopically, the hepatic and lung parenchyma contained granulomatous lesions consisting of central necrosis. Some hearts showed myofiber necrosis with infiltration of histiocytes and heterophils. Partial 16SrRNA and gyrB gene sequences of all isolates showed high similarities (99-100%) to those of Salmonella (S.) enterica subsp. enterica. Based on pathological and molecular biological results, S. enterica subsp. enterica systemic infections were diagnosed in eastern great egrets of Korea.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.64 no.5
• /
• pp.792-798
• /
• 2015

Joint angle generally can be measured to check the recovery process in rehabilitation field. This paper suggests to measure joint angle with Infrared sensor based on triangulation principle. We performed various experiments to find the optimal condition of the sensor’s attached distance, height, and angle. The results were compared with commercial goniometer for accuracy. The proposed infrared joint angle sensor can be effectively used in rehabilitation and sport science fields.

• Journal of Veterinary Clinics
• /
• v.33 no.2
• /
• pp.131-134
• /
• 2016

A 4-year-old intact female Maltese was referred to the Animal Medical Center of Chonbuk National University with a history of consistent fecal incontinence over 4 months following sacculectomy surgery. We suspected that anal sacculectomy resulted in loss of the external anal sphincter. On physical examination, the external anal sphincter muscle on the left side was intact, while the external anal sphincter muscle on the right side could not be detected and exhibited severe laceration. To repair the defect, the left semitendinosus muscle was transposed around the anus. The left semitendinosus muscle was isolated and transected near the stifle, reflected dorsally and passed around the ventral rectum into the pararectal fossa. Care was taken to preserve the integrity of the vasculature and nerve supply. The muscle was secured dorsally with simple interrupted sutures to the levator ani and coccygeus muscles to simulate the external anal sphincter. Nine days after surgery, the dog was defecating normally with no evidence of incontinence. The use of semitendinosus muscle flaps is a good option for the treatment of fecal incontinence secondary to loss of sphincter muscle in dogs.