• 대한의용생체공학회:의공학회지
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• 제20권2호
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• pp.213-220
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• 1999

본 연구는 쥐의 뇌, 심장, 간, 근육 및 근육부위의 종양조직과 인간의 뇌 조직과 뇌 종양 조직의 광학적 흡수계수를 500nm~900nm 범위의 파장에서 측정하고 비교분석하였다. 광학적 흡수계수는 물질마다 가지고 있는 고유한 성질을 나타내므로 생체조직의 광학계수를 측정하면, 생체 조직의 고유한 특성을 나타낼 수 있다. Spectrograph monometer와 PDA를 이용하여, 동결절편으로 제작한 시편에 대하여 실험하였다. 실험결과, 쥐 조직과 인체의 뇌 조직의 흡수계수는 정상적인 일반 조직과 종양 조직에서 차이가 분명하게 있음을 알 수 있었다. 정상 뇌 조직의 흡수계수는 파장이 변화함에 따라 0.1~0.2$cm^{-1}$사이의 비교적 균일한 값을 보이는데 반하여, 뇌종양 조직의 흡수계수는 파장에 따라서 크게는 약 0.4~0.5$cm^{-1}$정도의 변화가 있다. 본 실험 결과들은 다양한 조직에서의 광학계수 중에서 흡수계수를 측정함으로써, 생체조직의 흡수계수의 변화를 감지하여 질병진단의 지표로 삼을 수 있다.

• 대한의용생체공학회:의공학회지
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• 제18권4호
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• pp.499-505
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• 1997

본 연구에서는 생체조직의 흡수계수와 산란계수를 비침습적으로 측정하는 방법에 관하여 연구하였다. 피코초 영역의 펄스폭을 갖는 레이저광으로 조직을 조사하고 산란반사된 빛을 시간상관 단일 광자 계수법을 이용하여 피코초 시간영역에서 측정하였다. 측정된 시간분해 반사율의 최대치에 이르는 시간 및 나중소멸부분의 점근선의 기울기로부터 계산되는 값과 디컨블루션방법에 의한 곡선맞춤으로 얻은 값을 비교하여 서로 잘 일치함을 확인하였다. 매질의 산란이 커질수록 흡수가 작을수록 근사식은 더 잘 맞으므로 가시광선부터 근적외선의 파장영역에서 흡수에 비해 산란이 매우 큰 생체조직의 광특성을 비침습적으로 측정하는 중요한 방법이 될 수 있다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1994년도 추계학술대회
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• pp.147-150
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• 1994

To predict light propagation in biological tissues irradiated by laser, the optical properties such as absorption and scattering coefficients are required. There have been various techniques for measuring these coefficients. One method requires tissue samples, often a slab of thin tissue, is invasive. On the other hand, non-invasive method usually measures back-scattered light from a subject with no physical intervent ions. Advantages and disvantages of using different methods are investigated. A careful attention should be made in order to select the best method for a given experimental condition since, even either for invasive or non-invasive method, accuracy is subject to governing models and sample preparations.

• 대한의용생체공학회:의공학회지
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• 제28권2호
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• pp.229-234
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• 2007

Diffuse optical tomography (DOT) is a relatively new medical imaging modality which uses near infrared light to image large-sized tissues noninvasively. We constructed a frequency-domain DOT system to measure the optical properties of optical phantoms and human tissues. The FD-DOT uses the intensity-modulated infrared light source that illuminates the biological tissues. The phase shift and modulation changes at each detector site are separately processed to measure the optical properties. The absorption and scattering coefficients are separately estimated using inverse algorithms.

• 반도체디스플레이기술학회지
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• 제9권2호
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• pp.33-39
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• 2010

The moisture absorption properties such as diffusion coefficient and moisture content ratio of liquid type epoxy resin systems with the filler were investigated. Bisphenol A type and Bisphenol F type epoxy resin, Kayahard MCD as hardener and 2-methylimidazole as catalyst were used in these epoxy resin systems. The nano-sized spherical type fused silica as filler were used in order to study the moisture absorption properties of these liquid type epoxy encapsulant according to the change of filler size. The temperature of glass transition (Tg) of these epoxy resin systems was measured using Dynamic Scanning Calorimeter (DSC), and the moisture absorption properties of these epoxy resin systems according to the change of time were observed at $85^{\circ}C$ and 85% relative humidity condition using a thermo-hygrostat. The diffusion coefficients in these systems were calculated in terms of modified Crank equation based on Ficks' law. An increase of Tg and diffusion coefficient with filler size in these systems can be observed, which are attributed to the increase of free volume with Tg. The change of maximum moisture absorption ratio according to the filler size and filler content cannot be observed; however, the diffusion coefficients of these systems decreased with filler content. The diffusion via free volume is dominant in the epoxy resin systems with low nano-sized filler content; however, the diffusion with the interaction of absorption according the increase of the filler surface area is dominant in the liquid type epoxy encapsulant with high nano-sized filler content.

• 약학회지
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• 제15권2호
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• pp.41-52
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• 1971

Cu(II) chelates of several sulfanilamide derivatives (Sulfa-Cu) were prepared and their effects on solubility, absorptivity in intestinal lumen, biding tendency with serum protein and erythrocytes, concentration in rabbit blood, and acetylation rate were studied in comparison with their free ligand forms. For solubility concerned, the partition coefficients of Sulfa-Cu are decreased as following order: Sulfadimethoxine Copper chelate (SDM-Cu), Sulfamethoxypyridazine Copper chelate (SD-Cu), Sulfamerazine Copper chelate (SM-Cu), Sulfaisoxazole Copper chelate (SIX-Cu). The partition coefficients of SDM-Cu and ST-Cu were much greater than those of ligands. this phenomenone acounts for the rapid absorption of SDM-Cu and ST-Cu in the rat small intestine (in situ). The Sulfa-Cu were absorbed at the intestinal lumen of a rat in the rate of first order and there was no difference between long acting sulfa drugs and their Cu0chelates in biological half lives. In binding experiments, sulfa-Cu binded with serum protein in lower ratio than their ligands except SIX-Cu. On other hand, acetylation rates of sulfa-Cu were higher than those of free sulfa drugs and the acetylation rate were higher than those of free sulfa drugs and powder. In a experiment on Sulfa-Cu concentration in rabbit blood, the half lives of SD-Cu, SIX-cu, ST-Cu, and SM-Cu were longer than those of their ligands. Above all, the half life of SD-Cu appeared to be approximately 3.5 times logner than that of corresponding ligand, SD. When absorption of sulfa drugs or sulfa-Cu at the small intestinal lumen of a rat and the concentration in rabbit blood after absorption were compared, it was found that there was not always conrrelated.

• 한국광학회지
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• 제10권5호
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• pp.357-363
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• 1999

다중산란매질의 광학계수를 측정하기 위하여 광세기의 변화와 위상차이를 동시에 측정하는 주파수 영역 분광장치를 구성하고, 산란과 흡수가 다른 매질 조건하에서 진폭 변조된 광을 입사시킨 후 후방 산란광의 교류 및 위상지연 성분을 heterodyne 검지 방법을 이용하여 측정하였다. 실험을 통하여 산란자와 흡수체의 농도가 증가함에 따라 흡수계수와 수송산란 계수는 선형적으로 증가함을 확인할 수 있었으며, 흡수계수와 수송산란계수를 확산이론을 이용하여 구할 수 있었다. 광원과 검출기의 거리, 변조주파수에 따라 측정 가능한 광학계수의 범위를 분석하였다. 레이저 다이오드를 사용하는 소형화된 이 장치는 생체조직과 같은 다중 산란매질의 비침습적 광학계수 측정에 이용될수 있으리라 기대된다.

• Korean Chemical Engineering Research
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• 제54권5호
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• pp.648-652
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• 2016

본 연구에서는 구아니딘계 초염기인 1,1,3,3-테트라메틸 구아니딘(TMG)과 에틸렌 글라이콜로 구성된 비수계 흡수제를 충진탑에 적용하여 이산화탄소 흡수특성을 고찰하였다. 흡수탑은 내경이 1 in이고 높이는 0.6 m이며 탑 내부는 $0.16in{\times}0.16in$의 규격을 갖는 다공 충진물로 채웠다. 흡수탑에서의 이산화탄소 제거 효율에 대한 흡수제 농도, 조업온도 등의 영향 뿐 아니라 이들이 물질전달 저항에 미치는 영향을 고찰하였다. 이산화탄소에 대한 TMG의 로딩값은 약 ${\alpha}=1.0mol_{CO2}/mol_{TMG}$에 달하였으며 이산화탄소가 적게 로딩된 흡수제에서는 총괄 물질전달 계수가 TMG의 농도에 비례하였으나 ${\alpha}=0.5$ 이상의 로딩값에서는 총괄 물질전달계수가 오히려 감소하였다. 이는 흡수제의 이산화탄소에 대한 로딩값에 따른 흡수제 점도 증가로 인한 액체상에서의 물질전달 저항 증가로 해석할 수 있다.

• Bulletin of the Korean Chemical Society
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• 제34권10호
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• pp.2937-2941
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• 2013

Fluorescence imaging is considered as one of the most powerful techniques for monitoring biomolecule activities in living systems. Near-infrared (NIR) light is advantageous for minimum photodamage, deep tissue penetration, and minimum background autofluorescence interference. Herein, we have developed a new NIR fluorescent dye, namely, RB-1, based on the Rhodamine B scaffold. RB-1 exhibits excellent photophysical properties including large absorption extinction coefficients, high fluorescence quantum yields, and high photostability. In particular, RB-1 displays both absorption and emission in the NIR region of the "biological window" (650-900 nm) for imaging in biological samples. RB-1 shows absorption maximum at 614 nm (500-725 nm) and emission maximum at 712 nm (650-825 nm) in ethanol, which is superior to those of traditional rhodamine B in the selected spectral region. Furthermore, applications of RB-1 for fluorescence imaging in living cells and small animals were investigated using confocal fluorescence microscopy and in vivo imaging system with a high signal-to-noise ratio (SNR = 10.1).

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.379-382
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• 1997

A method for measuring optical properties of biological medium was investigated by using the frequency domain spectroscopy. When amplitude-modulated light with the frequency of several tens up to several hundred MHz propagates through a scattering medium, the phase lag and the amplitude reduction occur. The phase lag depends on the average of optical path lengths. The amplitude reduction with respect to the radial distance is influenced by the penetration depth. The mean of optical path length and penetration depth are related to optical coefficients. The phase lag and the amplitude reduction were measured based on the heterodyne detection method. The experimental data were fitted with the theoretical curves derived from diffusion theory and the absorption and scattering coefficients were calculated.