Measurement of Optical Parameters of Biological Tissues by Using the Frequency-Domain Spectroscopy

주파수 영역 분광법을 이용한 생체의 광학계수 측정법 연구

  • Jeon, K.J. (Biomedical Engineering Research Center, Samsung Biomedical Research Institute) ;
  • Yoon, G. (Biomedical Engineering Research Center, Samsung Biomedical Research Institute) ;
  • Kim, H.S. (Biomedical Engineering Research Center, Samsung Biomedical Research Institute) ;
  • Kim, W.K. (Biomedical Engineering Research Center, Samsung Biomedical Research Institute) ;
  • Yi, J.H. (Medical Electronics Lab., Samsung Advanced Institute of Technology) ;
  • Park, S.H. (Department of Physics, Yonsei University) ;
  • Kim, U. (Department of Physics, Yonsei University)
  • 전계진 (삼성생명과학연구소 임상의공학연구센터) ;
  • 윤길원 (삼성생명과학연구소 임상의공학연구센터) ;
  • 김홍식 (삼성생명과학연구소 임상의공학연구센터) ;
  • 김원기 (삼성생명과학연구소 임상의공학연구센터) ;
  • 이정한 (삼성종합기술원 의료기기연구실) ;
  • 박승한 (연세대학교 이과대학 물리학과) ;
  • 김웅 (연세대학교 이과대학 물리학과)
  • Published : 1997.05.23

Abstract

A method for measuring optical properties of biological medium was investigated by using the frequency domain spectroscopy. When amplitude-modulated light with the frequency of several tens up to several hundred MHz propagates through a scattering medium, the phase lag and the amplitude reduction occur. The phase lag depends on the average of optical path lengths. The amplitude reduction with respect to the radial distance is influenced by the penetration depth. The mean of optical path length and penetration depth are related to optical coefficients. The phase lag and the amplitude reduction were measured based on the heterodyne detection method. The experimental data were fitted with the theoretical curves derived from diffusion theory and the absorption and scattering coefficients were calculated.

Keywords