• Journal of Genetic Medicine
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• v.12 no.2
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• pp.61-65
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• 2015

Whole genome sequencing (WGS)-based noninvasive prenatal test (NIPT) is the first method applied in the clinical setting out of various NIPT techniques. Several companies, such as Sequenom, BGI, and Illumina offer WGS-based NIPT, each with different technical and bioinformatic approaches. Sequenom, BGI, and Illumina utilize z-, t-, and L-scores, as well as normalized chromosome values, respectively, for trisomy detection. Their outstanding performance has been demonstrated in clinical studies of more than 100,000 pregnancies. The sensitivity and specificity for detection of trisomies 13, 18, and 21 were above 98%, as reported by all three companies. Unlike other techniques, WGS-based NIPT can detect other trisomies as well as clinically significant segmental duplications/deletions within a chromosome, which could expand the scope of NIPT. Incorrect results could be due to low fetal fraction, fetoplacental mosaicism, confined placental mosaicism or maternal copy number variation (CNV). Among those, maternal CNV is a significant contributor of false positive results and therefore genome wide scanning plays an important role in preventing the occurrence of false positives. In this article, the bioinformatic techniques and clinical performance of three major companies are comprehensively reviewed.

• Korean Journal of Microbiology
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• v.23 no.2
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• pp.138-146
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• 1985

A Bacillus licheniformis ATCC31667 gene coding for a glucose isomerase has been cloned and expressed in glucose isomerase negative mutant of Escherichia coli. A recombinant plasmid, constructed by ligation of a EcoRI fragment of B.licheniformis chromosomal DNA to vector plasmid pBR322, was expressed glucose isomerase positive in E.coli LE392-6 with growth on minimal medium containing xylose as a sole carbon source. This recombinant plasmid, designated pBGI6, had the insery of 4.1Kb of Bacillus gene in EcoRI site, and restriction map of the plasmid was established. The plasmid pBG16 was very stable after 10days of serial transfer to a fresh medium. The activity of glucose isomerase from the transformed cell containing pBGI6 was increased about 20 fold than its wild type of host.

• Ecology and Resilient Infrastructure
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• v.7 no.1
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• pp.15-25
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• 2020

We've compared and conceptually evaluated the newly emerging concept of nature-based solutions (NbS's), in the aspect of water management, and existing similar solutions of different naming, all of which are based on ecosystem functions. In this study, it is found that NbS's seem significant and meaningful both educationally and understandably in the aspect that it can comprehensively cover and include the existing methodologies and solutions using the functions of natural ecosystem to socio-environmental challenges. It, however, seems not quite different from the broad-meaning of green infra, including Eco-DRR, in terms of the approaching methodologies in water management. The conceptual and spatial hierarchy of each practice in water management considered in this study can be expressed in the narrowing order of NbS-(EE)-BGI-(CRT)-GI-LID. Last, the term LID, which is the best management practice for storm water management in the development project, can be replaced with the term GI for clarification and less confusion both in academia and practice.

• The Plant Pathology Journal
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• v.29 no.2
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• pp.193-200
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• 2013

Trichoderma asperellum SKT-1 is a microbial pesticide that is very effective against various diseases. Our study was undertaken to evaluate T. asperellum SKT-1 for induction of resistance against yellow strain of Cucumber mosaic virus (CMV-Y) in Arabidopsis plants. Disease severity was rated at 2 weeks post inoculation (WPI). CMV titre in Arabidopsis leaves was determined by indirect enzyme-linked immunosorbent assay (ELISA) at 2 WPI. Our results demonstrated that among all Arabidopsis plants treated with barley grain inoculum (BGI) of SKT-1 NahG and npr1 plants showed no significant reduction in disease severity and CMV titre as compared with control plants. In contrast, disease severity and CMV titre were significantly reduced in all Arabidopsis plants treated with culture filtrate (CF) of SKT-1 as compared with control plants. RT-PCR results showed increased expression levels of SA-inducible genes, but not JA/ET-inducible genes, in leaves of BGI treated plants. Moreover, expression levels of SA- and JA/ET-inducible genes were increased in leaves of CF treated plants. In conclusion, BGI treatment induced systemic resistance against CMV through SA signaling cascade in Arabidopsis plants. While, treatment with CF of SKT-1 mediated the expression of a majority of the various pathogen related genes, which led to the increased defense mechanism against CMV infection.

• Journal of the Korean Data and Information Science Society
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• v.25 no.2
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• pp.349-356
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• 2014

In baseball, sabermetric batting statistics are used to compare an offensive performance of players. There exist dozens of sabermetric statistics, but baseball fans don't like the complexity of an abundance of measures. This paper provides a batting grade index (BGI) using principal component based on eight batting statistics. These are OPS, ISO, SECA, TA, RC, RC/27, wOBA and XR. We show that how standardized batting statistics are aggregated and weighted to arrive at a single composite measure of BGI. Also our result allows for segmentation of players into groups using the K-means clustering algorithm.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.09a
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• pp.533-538
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• 2010

This study was performed for evaluate permeability in base of development material and existing grouting. And examined durability by age strength when devide seawater and fresh water that water curing. Executed permeability test to choose base to produce pouring in specimen. About 5 grouting material, produced pouring in specimen. Seawater strength of all grouting materials except BGI decreased gradually as result that divide seawater and fresh water that water curing.

• Journal of Nutrition and Health
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• v.40 no.1
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• pp.24-30
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• 2007

This study was designed to investigate the effects of pyroligneous liquor on lipid metaboilsm in serum of SPF/VAF Cri/Bgi CD rats. Male CD rats were fed basic diet prepared in our Lab., and PL-0 (control), PL-1, PL-25, PL-50, PL-75 groups were prepared with pyroligneous liquor (35% of Choa Co. Ltd.) of 0%, 1%, 25%, 50% and 75% in purified water per day for 8 weeks. Body weights and food intakes almost did not change in these five groups, and triglyceride (TG) levels were significantly decreased (20.5% and 19.5%, respectively) in these PL-25 and PL-50 groups compared with control group. Total and LDL-cholesterol levels were markedly decreased (20.7%, 16.3% and 20.3%, 116.9%, respectively) in these PL-25 and PL-50% groups, but HDL-cholesterol levels were significantly increased about 36.4% and 25.5% in serum of PL-25 and PL-50 groups compared with control group. Atherogenic indices were also remarkedly decreased (63.0%, and 50%, respectively) in these PL-25 and PL-50 groups compared with control group. These results suggest that long term administration orally of pyroligneous liquor in 25 to 50% may inhibit chronic degenerative disease through improving of lipid metabolism of lower TG & LDL-cholesterol and higher HDL-cholesterol, and lower AJ.

• Asia pacific journal of information systems
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• v.19 no.4
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• pp.149-176
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• 2009

In the recent e-learning environment, avatars are often used to help learners get familiar with the contents, which is ultimately to motivate them to study more. Therefore, it is important to investigate whether avatars have actually the desirable effect on users of e-learning materials. Surprisingly, however, no extensive study has been conducted on this crucial issue Accordingly, main objectives this study are summarized as follows. First, we need to gain better understanding of how much learners' trust towards avatars (termed as "avatar trust") is transferred to learners' trust towards e-learning contents (termed as "contents trust"). Second, we need to investigate how much learners' personal relationships with avatars as well as learning behaviors change depending on avatar types (attractive vs. professional) and contents complexity (easy vs. difficult). As described in the study objectives, in order for us to analyze empirical data more systematically, we classified avatar types into two: "attractive" and "professional;" the contents are categorized as either "easy" or "difficult." Therefore, it is essential for this study to build a prototype e-learning website on which our research purpose can be realized and tested effectively with proper avatar types and e-learning contents. For this purpose, we built a prototype e-learning website, in which avatars are invited from currently working avatar instructors used in real-world e-learning websites, and e-learning contents are adapted from real-world contents about Java programming topic, which have been proved to have shown high quality and reliability. Our research method includes questionnaire survey by inviting a number of valid respondents comprised of office workers who are believed to have high demands for the e-learning contents as well as those who have previous experience with avatar instructors. Respondents were given one of the four e-learning experiment conditions (2 avatar types x 2 contents types) on a random basis. Each experimental e-learning condition is framed to have the same quality but different avatar type and content complexity. Then the respondents are asked to fill out the survey form which has questions about avatar trust, contents trust, personal relationships with avatar, and learning behavior, among others. Regarding the constructs used in research model, we based them rigorously on previous studies. For example, we used six constructs such as behavior to give information (BGI), behavior to obtain information (BOI), need for inclusion wanted, need for control wanted, contents trust, and avatar trust. To measure them, 7-Likert scales were used in the questionnaire. E-learning performance was measured indirectly through two constructs such as BGI and BOI. Six constructs used in the research model were adopted and revised from the FIRO-B model suggested by Schutz. Empirical results are as follows: First, professional avatars are more effective for difficult contents, while attractive avatars were not as effective for easy contents. Second, our study results ascertained that avatar trust transfers to contents trust regardless of avatar types and contents complexity.

• The Journal of Advanced Prosthodontics
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• v.7 no.1
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• pp.62-68
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• 2015

PURPOSE. The purpose of this research was to evaluate the amount of reosseointegration after counter torquing (reverse torque) and transposing the installed implants at different times. MATERIALS AND METHODS. This study was done on ten tibiae of five cross-bred dogs. At the first day one implant was installed in each tibia. After one week half of the implants were randomly counter torqued (1WCT) and the other half were explanted and reimplanted in a new juxtaposition site (transposed)(1WT). At the same time three new implants were installed in each dog, one of them was considered as one week control (1WC) and remaining two as 8 week groups (8WCT&8WT). After eight weeks the 1WCT and 1WT implants were loosened by counter torque and the quantity of needed force for liberation was measured with the digital device (BGI). At the same time one implant was installed in each dog as eight week control (8WC) and the same protocol was repeated for 8 week groups after another 8 weeks. RESULTS. All implants were osseointegrated. Mean quantities of osseointegration in case groups indicated better amounts rather than control groups. CONCLUSION. Counter torque or transposition of the installed implants one week or eight weeks after the implantation did lead to osseointegration.

• Journal of Industrial Technology
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• v.29 no.B
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• pp.73-80
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• 2009

This paper is to investigate effect of B.G.I (Best Grouting Innovation) method on reinforcing ground. In this thesis, extensive literature review was performed to summarize theoretical backgrounds of grouting and to compare the applicability of different grouting methods. Unconfined compression test with specimen prepared by injecting different grouts of B.G.I, S.G.R and L.W methods and by changing the curing time were carried out to figure out characteristics of initial unconfined compression strength mobilized in the early stage. As results of test, the compression strength increases with curing times and specimen prepared with grouts of B.G.I method show greater values than others. On the other hands, the measured values of pH are in the range of 7-10 during tests. In field, preliminary construction to main construction at several sites were performed to confirm the effect of reinforcing the ground by application of B.G.I method. From the results of permeability test in field, SPT test and phenol reaction test, it was found that N values after grouting are greater than those before grouting and values of permeability in grouted ground is reduced significantly.