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Effect of Pyroligneous Liquor on Lipid Metabolism in Serum of CD Rats  

Cho, Weon-Ki (Clinical Dualism Research Institute, Choa Pharmacy Co. Ltd.)
Choi, Jin-Ho (Laboratory of Biochemistry, Faculty of Food Science and Biotechnology, Pukyong National University)
Publication Information
Journal of Nutrition and Health / v.40, no.1, 2007 , pp. 24-30 More about this Journal
Abstract
This study was designed to investigate the effects of pyroligneous liquor on lipid metaboilsm in serum of SPF/VAF Cri/Bgi CD rats. Male CD rats were fed basic diet prepared in our Lab., and PL-0 (control), PL-1, PL-25, PL-50, PL-75 groups were prepared with pyroligneous liquor (35% of Choa Co. Ltd.) of 0%, 1%, 25%, 50% and 75% in purified water per day for 8 weeks. Body weights and food intakes almost did not change in these five groups, and triglyceride (TG) levels were significantly decreased (20.5% and 19.5%, respectively) in these PL-25 and PL-50 groups compared with control group. Total and LDL-cholesterol levels were markedly decreased (20.7%, 16.3% and 20.3%, 116.9%, respectively) in these PL-25 and PL-50% groups, but HDL-cholesterol levels were significantly increased about 36.4% and 25.5% in serum of PL-25 and PL-50 groups compared with control group. Atherogenic indices were also remarkedly decreased (63.0%, and 50%, respectively) in these PL-25 and PL-50 groups compared with control group. These results suggest that long term administration orally of pyroligneous liquor in 25 to 50% may inhibit chronic degenerative disease through improving of lipid metabolism of lower TG & LDL-cholesterol and higher HDL-cholesterol, and lower AJ.
Keywords
SPF/VAF Cri/Bgi CD rats; choa pyroligneous liquor; triglyceride (TG); LDL and HDL-cholesterols; atherogenic index (AI);
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