• East Asian mathematical journal
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• v.22 no.2
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• pp.207-213
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• 2006

Using the notion of nilpotent elements, the concept of nil subsets is introduced, and related properties are investigated. We show that a nil subset on a subalgebra (resp. (closed) ideal) is a subalgebra (resp. (closed) ideal). We also prove that in a nil algebra every ideal is a subalgebra.

• Journal of applied mathematics & informatics
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• v.40 no.5_6
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• pp.1105-1115
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• 2022

The main objective of this paper is to introduce the notion of AMR-algebra and its generalization, and to compare them with other algebras such as BCK, BCI, BCH, · · ·, etc. We show moreover that the K-part of AMR-algebra is an abelian group, and the weak AMR-algebra is also an abelian group and generalizes many known algebras like BCI, BCH, and G.

• Parasites, Hosts and Diseases
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• v.51 no.4
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• pp.421-426
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• 2013

Several studies have shown the mechanisms and importance of immune responses against Toxoplasma gondii infection and the notable role of cholinesterases in inflammatory reactions. However, the association between those factors has not yet been investigated. Therefore, the aim of this study was to evaluate the acetylcholinesterase (AChE) activity in blood and lymphocytes and the activity of butyrylcholinesterase (BChE) in serum of rats experimentally infected with T. gondii during the acute phase of infection. For that, an in vivo study was performed with evaluations of AChE and BChE activities on days 5 and 10 post-infection (PI). The activity of AChE in blood was increased on day 5 PI, while in lymphocytes its activity was enhanced on days 5 and 10 PI (P<0.05). No significant difference was observed between groups regarding to the activity of BChE in serum. A positive (P<0.01) correlation was observed between AChE activity and number of lymphocytes. The role of AChE as an inflammatory marker is well known in different pathologies; thus, our results lead to the hypothesis that AChE has an important role in modulation of early immune responses against T. gondii infection.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.6
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• pp.879-888
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• 1999

A Study on the ARQ scheme of data error control is important for more reliable information transmission. Since performance difference is large by the long transmission delay time in satellite communication, the performances of SR ARQ and conventional type-I hybrid ARQ with fixed code rate are investigated by using the parameters of packet length, channel capacity, BER, and transmission delay time especially. BCH code is used in type-I hybrid ARQ for FEC method. This paper presents the throughput analyses according to such various parameters as BCH code rate, window size, data rate and round-trip delay time. Especially we derive a performance equation of type-I hybrid ARQ with the factor of the transmission delay time using the equation of SAW ARQ. Also, the performance of type-I hybrid ARQ specially considering transmission delay time is analyzed through numerical analysis and computer simulation so we can get a important characteristics variation.

• The Korean Journal of Physiology and Pharmacology
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• v.21 no.6
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• pp.599-607
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• 2017

Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly expressed in many tumor cells and presumed to support their increased growth and proliferation. This study examined the effects of JPH203, a selective LAT1 inhibitor, on cell growth and its mechanism for cell death in Saos2 human osteosarcoma cells. FOB human osteoblastic cells and Saos2 cells expressed LAT1 and LAT2 together with their associating protein 4F2 heavy chain, but the expression of LAT2 in the Saos2 cells was especially weak. JPH203 and BCH, a non-selective L-type amino acid transporter inhibitor, potently inhibited L-leucine uptake in Saos2 cells. As expected, the intrinsic ability of JPH203 to inhibit L-leucine uptake was far more efficient than that of BCH in Saos2 cells. Likewise, JPH203 and BCH inhibited Saos2 cell growth with JPH203 being superior to BCH in this regard. Furthermore, JPH203 increased apoptosis rates and formed DNA ladder in Saos2 cells. Moreover, JPH203 activated the mitochondria-dependent apoptotic signaling pathway by upregulating pro-apoptotic factors, such as Bad, Bax, and Bak, and the active form of caspase-9, and downregulating anti-apoptotic factors, such as Bcl-2 and Bcl-xL. These results suggest that the inhibition of LAT1 activity via JPH203, which may act as a potential novel anti-cancer agent, leads to apoptosis mediated by the mitochondria-dependent intrinsic apoptotic signaling pathway by inducing the intracellular depletion of neutral amino acids essential for cell growth in Saos2 human osteosarcoma cells.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.7
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• pp.1118-1130
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• 1999

In this paper, error performance of DS/FH CDMA system has been analyzed in a radio channel which is characterized by near-far problem and multi-path fading. The DS/FH CDMA system adopts Maximum Ratio Combining(MRC) diversity and BCH(Bose-Chau dhuri-Hocquenghem) coding techniques to enhance system performance. Using the derived error probability equation, the error performance of DS/FH CDMA system has been evaluated and shown in figures to discuss as a function of PN code length(N), hopping rate(q), number of diversity branch(M), coding rate($\gamma$) and bit energy per noise power ratio ${E_b/N_o}$. The results show that DS/FH system is more effective to restrain the affection of near-far problem and multi-path fading than DS system. And there is a substantial enhancement in performance by employing an MRC diversity or BCH coding techniques. Consequently, we expected that proposed system structure is reliable to the voice communication system in near-far problem and multi-path fading channel.

• Journal of Life Science
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• v.12 no.1
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• pp.32-42
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• 2002

It was researched to react horse serum-BChE with hefanoylthiocholine chosen among choline esters. According as number of carbon of acyl group in choline esters was increased, reactivity was decreased but strength of ES complex was increased (Km=0,140mM). The pH-V/K profile for BChE-catalyzed hydrolysis of hexanoylthiocholine yields a p $K_{a}$ =4.974$\pm$0.028. This value is equal to recent literature that shows systematic shift from dependence of activity on the basic form fo a residue that huts a p $K_{a}$ =6.2~6.4 to catalysis by a residue or residues that has a p $K_{a}$ =4.7~5.0. The resulting kinetic solvent isotope effect of hexanoylthiocholine is $^{D/V}$K=1.18. The magnitude of the isotope effect suggests that proton transfer is not an element of transition-state stabilization.n.

• Journal of Information Processing Systems
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• v.13 no.5
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• pp.1229-1242
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• 2017

In this paper, an interference aware distributed multi-channel MAC (IDMMAC) protocol is proposed for wireless sensor and actor networks (WSANs). The WSAN consists of a huge number of sensors and ample amount of actors. Hence, in the IDMMAC protocol a lightweight channel selection mechanism is proposed to enhance the sensor's lifetime. The IDMMAC protocol divides the beacon interval into two phases (i.e., the ad-hoc traffic indication message (ATIM) window phase and data transmission phase). When a sensor wants to transmit event information to the actor, it negotiates the maximum packet reception ratio (PRR) and the capacity channel in the ATIM window with its 1-hop sensors. The channel negotiation takes place via a control channel. To improve the packet delivery ratio of the IDMMAC protocol, each actor selects a backup cluster head (BCH) from its cluster members. The BCH is elected based on its residual energy and node degree. The BCH selection phase takes place whenever an actor wants to perform actions in the event area or it leaves the cluster to help a neighbor actor. Furthermore, an interference and throughput aware multi-channel MAC protocol is also proposed for actor-actor coordination. An actor selects a minimum interference and maximum throughput channel among the available channels to communicate with the destination actor. The performance of the proposed IDMMAC protocol is analyzed using standard network parameters, such as packet delivery ratio, end-to-end delay, and energy dissipation, in the network. The obtained simulation results indicate that the IDMMAC protocol performs well compared to the existing MAC protocols.

• Natural Product Sciences
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• v.28 no.3
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• pp.138-142
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• 2022

Alzheimer's disease (AD) is the most common age-related neurodegenerative disease in industrialized countries. It is estimated that about 47 million people living with dementia and the number of cases will be tripled by 2050. However, the exact mechanism of AD is not known, and full therapy has still not been found. Various tryptophan-derived alkaloids have been reported as promising agents for the treatment of AD. In the present study, a series of tryptophan-derived alkaloids were isolated and characterized from the methanol extract of Hedera rhombea fruit. Based on the analysis of their observed and reported spectroscopic data, their structures were identified as N-[4'-hydroxy-(E)-cinnamoyl]-L-tryptophan (1), N-[3',4'-dihydroxy-(E)-cinnamoyl]-L-tryptophan (2), N-[4'-hydroxy-(E)-cinnamoyl]-L-tryptophan methyl ester (3), and N-[3',4'-dihydroxy-(E)-cinnamoyl]-L-tryptophan methyl ester (4). These compounds were screened for anti-Alzheimer activity via their inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes in vitro. As a result, compounds 3 and 4 showed moderate BChE inhibition with IC₅₀ values of 86.9 and 78.4 μM, respectively, compared to those of the positive control [berberine (IC₅₀ = 11.5 μM)]. However, all four compounds did not show significant inhibition of the AChE enzyme. This is the first time, the AChE and BChE inhibitory activities of these tryptophan-derived alkaloids were investigated and reported.

• Journal of Applied Biological Chemistry
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• v.66
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• pp.165-170
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• 2023

Isolation of the culture broth of a marine-derived Acremonium sp. CNQ-049 guided by HPLC-UV yielded compound 1 (3-phenethyl-2-phenylquinazolin-4(3H)-one), and its inhibitory activities against monoamine oxidases (MAOs), cholinesterases (ChEs), and β-secretase 1 (BACE1) were evaluated. Compound 1 was an effective selective MAO-B inhibitor with an IC₅₀ value of 9.39 µM and a selectivity index (SI) value of 4.26 versus MAO-A. In addition, compound 1 showed a potent selective butyrylcholinesterase (BChE) inhibition with an IC₅₀ value of 7.99 µM and an SI value of 5.01 versus acetylcholinesterase (AChE). However, compound 1 showed weak inhibitions against MAO-A, AChE, and BACE1. The Ki value of compound 1 for MAO-B was 5.22±1.73 µM with competitive inhibition, and the Ki value of compound 1 for BChE was 3.00±1.81 µM with mixed-type inhibition. Inhibitions of MAO-B and BChE by compound 1 were recovered by dialysis experiments. These results suggest that compound 1 is a dual-functional reversible inhibitor of MAO-B and BChE, that can be used as a treatment agent for neurological disorders.