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http://dx.doi.org/10.3347/kjp.2013.51.4.421

Influence of Toxoplasma gondii Acute Infection on Cholinesterase Activities of Wistar Rats  

Tonin, Alexandre Alberto (Department of Small Animal, Universidade Federal de Santa Maria)
da Silva, Aleksandro Schafer (Department of Animal Science, Universidade do Estado de Santa Catarina)
Thorstenberg, Maria Luiza (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria)
Castilhos, Livia Gelain (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria)
Franca, Raqueli Teresinha (Department of Small Animal, Universidade Federal de Santa Maria)
Leal, Daniela Bitencourt Rosa (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria)
Duarte, Marta Maria Medeiros Frescura (Department of Preventive Veterinary Medicine, Universidade Federal de Santa Maria)
Vogel, Fernanda Silveira Flores (Department of Preventive Veterinary Medicine, Universidade Federal de Santa Maria)
de La Rue, Mario L. (Department of Microbiology and Parasitology, Universidade Federal de Santa Maria)
dos Anjos Lopes, Sonia Terezinha (Department of Small Animal, Universidade Federal de Santa Maria)
Publication Information
Parasites, Hosts and Diseases / v.51, no.4, 2013 , pp. 421-426 More about this Journal
Abstract
Several studies have shown the mechanisms and importance of immune responses against Toxoplasma gondii infection and the notable role of cholinesterases in inflammatory reactions. However, the association between those factors has not yet been investigated. Therefore, the aim of this study was to evaluate the acetylcholinesterase (AChE) activity in blood and lymphocytes and the activity of butyrylcholinesterase (BChE) in serum of rats experimentally infected with T. gondii during the acute phase of infection. For that, an in vivo study was performed with evaluations of AChE and BChE activities on days 5 and 10 post-infection (PI). The activity of AChE in blood was increased on day 5 PI, while in lymphocytes its activity was enhanced on days 5 and 10 PI (P<0.05). No significant difference was observed between groups regarding to the activity of BChE in serum. A positive (P<0.01) correlation was observed between AChE activity and number of lymphocytes. The role of AChE as an inflammatory marker is well known in different pathologies; thus, our results lead to the hypothesis that AChE has an important role in modulation of early immune responses against T. gondii infection.
Keywords
Toxoplasma gondii; acute toxoplasmosis; acetylcholinesterase (AchE); butyrylcholinesterase (BchE);
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