• Journal of Applied Biological Chemistry
• /
• v.64 no.3
• /
• pp.291-298
• /
• 2021

In this study, we investigated whether the combined administration of berberine (BBR) and silibinin (SBN) was effective in improving hyperlipidemia and anti-obesity efficacy using a high-fat diet (HFD)-fed obese mouse model. HFD-induced obese mice were supplemented with the BBR and SBN combination (BBR-SBN) along with the HFD administration for 8 weeks. During the experiment, body weight, food intake, and levels of total cholesterol, triglyceride and high-density lipoprotein (HDL)-cholesterol were analyzed. Consumption of HFD in the mice caused rapid increases in body weight and the levels of total cholesterol and triglycerides compared to the normal control (NC) group. However, supplementation of BBR-SBN in these obese mice significantly reduced body weight gain and suppressed the levels of total cholesterol and triglyceride with the increment of HDL cholesterol level. In the HFD-fed group, abdominal fat weight was significantly increased and the adipocytes within the epididymal adipose tissue were found to have expanded sizes compared to the NC group. However, in the BBR-SBN group, the sizes of the adipocytes were comparable to those of the NC group and abdominal fat weight was significantly reduced. Moreover, the deposition of giant vesicular fat cells in liver tissues seen in the HFD-fed group was considerably reduced in the BBR-SBN group. These results suggest that the BBR-SBN combination tends to have synergic potential as an anti-obesity agent by significantly reducing body weight gain as well as lowering serum lipid levels and thus improving anti-obesity efficacy in HFD-induced obese mice.

• Journal of Information Processing Systems
• /
• v.12 no.1
• /
• pp.57-72
• /
• 2016

To provide effective communication in the wireless mesh network (WMN), several algorithms have been proposed. Since the possibilities of numerous failures always exist during communication, resiliency has been proven to be an important aspect for WMN to recover from these failures. In general, resiliency is the diligence of the reliability and availability in network. Several types of resiliency based routing algorithms have been proposed (i.e., Resilient Multicast, ROMER, etc.). Resilient Multicast establishes a two-node disjoint path and ROMER uses a credit-based approach to provide resiliency in the network. However, these proposed approaches have some disadvantages in terms of network throughput and network congestion. Previously, the buffer based routing (BBR) approach has been proposed to overcome these disadvantages. We proved earlier that BBR is more efficient in regards to w.r.t throughput, network performance, and reliability. In this paper, we consider the node/link failure issues and analogous performance of BBR. For these items we have proposed a resilient packet transmission (RPT) algorithm as a remedy for BBR during these types of failures. We also share the comparative performance analysis of previous approaches as compared to our proposed approach. Network throughput, network congestion, and resiliency against node/link failure are particular performance metrics that are examined over different sized WMNs.

• Molecular Medicine Reports
• /
• v.21 no.1
• /
• pp.258-266
• /
• 2020

The major role of inner medullary collecting duct (IMCD) cells is to maintain water and sodium homeostasis. In addition to the major role, it also participates in the protection of renal and systemic inflammation. Although IMCD cells could take part in renal and systemic inflammation, investigations on renal inflammation in IMCD cells have rarely been reported. Although berberine (BBR) has been reported to show diverse pharmacological effects, its anti-inflammatory and protective effects on IMCD cells have not been studied. Therefore, in the present study, we examined the anti-inflammatory and protective effects of BBR in mouse IMCD-3 (mIMCD-3) cells against lipopolysaccharide (LPS). An MTT assay was carried out to investigate the toxicity of BBR on mIMCD-3 cells. Reverse transcription quantitative-PCR and western blotting were performed to analysis pro-inflammatory molecules and cytokines. Mechanisms of BBR were examined by western blotting and immunocytochemistry. According to previous studies, pro-inflammatory molecules, such as inducible nitric oxide synthase and cyclooxygenase-2, and pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6 and tumor necrosis factor-α are increased in LPS-exposed mIMCD-3 cells. However, the production of these pro-inflammatory molecules is significantly inhibited by treatment with BBR. In addition, BBR inhibited translocation of nuclear factor (NF)-κB p65 from the cytosol to the nucleus, and degradation of inhibitory κ-Bα in LPS-exposed mIMCD-3 cells. In conclusion, BBR could inhibit renal inflammatory responses via inhibition of NF-κB signaling and ultimately contribute to amelioration of renal injury during systemic inflammation.

• International Journal of Highway Engineering
• /
• v.6 no.4 s.22
• /
• pp.1-12
• /
• 2004

This study evaluated the asphalt binder characteristics for the hot-recycled asphalt mixture in which RAP was added in ambient temperature for surface course as well as for base course. RAPs were collected from four sources and their physical properties were evaluated. Mix designs were performed using 10 and 20% RAP contents for surface courses and 10, 20 and 30% for base courses. A virgin asphalt with the penetration grade of 60-80 was used for mixing recycled mixtures. Physical properties of recycled binders, including penetration, absolute viscosity, GPC, BBR and penetration after TFO were measured. From the results, regression analysis of absolute viscosity versus LMS in GPC showed $R^2$ being over 0.95, showing that GPC results estimate the absolute viscosity with relative accuracy. In BBR test, the resistance of recycled mixtures at low service temperature was inferior to the control, because the low temperature PG of recycled binder was one grade higher than that of the control binder.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.46 no.1
• /
• pp.1-9
• /
• 2019

The aim of this study was to compare the degree of conversion and polymerization shrinkage of low and high viscosity bulk-fill giomer-based and resin-based composites. Two bulk-fill giomer (Beautifil Bulk Restorative (BBR), Beautifil Bulk Flowable (BBF)), two bulk-fill (Tetric N-Ceram Bulk-fill (TBF), SureFil SDR flow (SDR)) and two conventional resin composites (Tetric N-Ceram (TN), Tetric N-flow (TF)) were selected for this study. The degree of conversion was measured by using Fourier transform infrared spectroscopy. Polymerization shrinkage was measured with the linometer. For all depth, BBR had the lowest degree of conversion and SDR had the highest. At 4 mm, the degree of conversion of low and high viscosity bulk-fill giomer resin composites was lower than that of bulk-fill resin composites (p < 0.05). At the depth between 2 mm and 4 mm, there were significant difference with TBF, TN and TF (p < 0.05), while no significant difference in the degree of conversion was measured for BBR, BBF and SDR. Polymerization shrinkage of six resin composites decreased in the following order: TF > SDR > BBF > TBF > TN and BBR (p < 0.05). Polymerization shrinkage of bulk-fill giomer resin composites was lower than that of bulk-fill resin composites (p < 0.05). From this study, it is found that the bulk-fill giomer resin composites and TBF were not sufficiently cured in 4 mm depth. The degree of conversion of low and high viscosity bulk-fill giomer resin composites was significantly lower than bulk-fill resin composites in both 2 mm and 4 mm depths. Therefore, such features of bulk-fill giomer resin composites should be carefully considered in clinical application.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.37 no.5
• /
• pp.542-547
• /
• 2008

The anti-diabetic effects of water extracts (WE) from medicinal herbs on hepatic glucose-regulating enzymes, such as glucokinase (GCK), pyruvate dehydrogenase (PDH), acetyl-CoA carboxylase (ACC) and ${\alpha}$-glucosidase, were studied using the cytosol fraction in liver and mitochondia fraction in heart of a type II diabetic animal (GK rat, Goto-Kakizaki). The free radical scavenging activity of water extracts by DPPH method was also tested. We found that free radical scavenging activity was strong in Corni fructu (CF), Mokdan Bark (MDB), Chenhwabon (CHB) and Sanyack (SY), while that of Backbocreng (BBR), Shuckgihwang (SGH) and Taecsa (TS) was lower. For GCK activity in cytosol of liver, CF and CHB had a more effective activity than other extracts. PDH activity in mitochondria fraction of heart was higher in all of the extracts, expect for the TS extract, than in the control. ACC activity in cytosol fraction of liver was significantly higher in the CF, CHB, SGH, TS and SY extracts than in the control. CF, BBR and MDB led to a decrease in the ${\alpha}$-glucosidase activity. Therefore, these results suggest that all of the extracts may be used as functional material in the development as anti-diabetic functional food and medicine.

• Journal of Korean Society of Forest Science
• /
• v.98 no.5
• /
• pp.584-592
• /
• 2009

The objective of this study was to examine the impact of pruning intensity on the vigor and cambial growth of the treated trees, and on the closure of pruning wounds for one year after pruning treatment. Two tree species, Pinus strobus and Acer palmatum, planted broadly in the urban forest of Korea were selected for the experiment. Intensity of pruning, which was estimated by proportion of removed branches, was categorized into five levels with about 10% intervals from lowest 8% up to 46%. Following parameters were examined; cambial electrical resistance (CER) and the cambial growth of trunk at 30 cm above the ground for the years before and after pruning, the cambial growth of stem at 1.5 cm above the branch bark ridge (BBR) of the pruned branch, and closure of pruning wound for one year after pruning. Tree vigor inferred from CER had a tendency to be weakened as pruning intensity increased in P. strobus, while that of A. palmatum was not affected. The trunk growth decreased significantly when the pruning intensity was higher than 30% in both species. The closure of individual pruning wound was related more to the cambial growth of stem at 1.5 cm above BBR than to the pruning intensity. Comparing the closure rate of pruning wound for one year, P. strobus with 72.1% was faster than A. palmatum with 39.3%, which corresponded with the rate of cambial growth of the two species.

• Archives of design research
• /
• v.12 no.4
• /
• pp.251-262
• /
• 1999

This article analyzed the building regulations, the guidelines for the people with disabilities, and the interior environment of the transportation facilities of Stockholm and Oslo, which wee capital cities of leading countries in this field. Result showed that Swedish 'BBR 94' was made and based on accessibility, safety, and efficiency. But the mandatory items and detailed recommendations were minimal. 'The Swedish Handicap Institute' provided more detailed requirements. As a result of case studies of 4 facilities, it appeared that these facilities used sufficient dimension, variable color, different material, or adaptable lightings in order to provide easy accessibility, adaptability, safety, support, and mobility for the people with disabilities instead of keeping the building regulations and guidelines reluctantly.

• Korean Journal of Materials Research
• /
• v.31 no.12
• /
• pp.727-731
• /
• 2021

In this study, we have investigated a selective emitter using a UV laser on BBr₃ diffusion doping layer. The selective emitter has two regions of high and low doping concentration alternatively and this structure can remove the disadvantages of homogeneous emitter doping. The selective emitters were fabricated by using UV laser of 355 nm on the homogeneous emitters which were formed on n-type Si by BBr₃ diffusion in the furnace and the heavy boron doping regions were formed on the laser regions. In the optimized laser doping process, we are able to achieve a highly concentrated emitter with a surface resistance of up to 43 Ω/□ from 105 ± 6 Ω/□ borosilicate glass (BSG) layer on Si. In order to compare the characteristics and confirm the passivation effect, the annealing is performed after Al₂O₃ deposition using an ALD. After the annealing, the selective emitter shows a better effect than the high concentration doped emitter and a level equivalent to that of the low concentration doped emitter.

• Journal of Korean Society of Transportation
• /
• v.26 no.6
• /
• pp.49-60
• /
• 2008

The aim of this study was to evaluate the variability of the blood.breath ratio (BBR) value and to rationalize the determination of ethanol in breath for evidential sobriety testing. In the experiment forty eight healthy persons, 24 men and 24 women, took part. The experiment included the experimental condition such as sex(2),the type of alcoholic beverage(2; soju, whisky), the type of food(2;kimchi stew, pork belly) and the amount of ethanol consumed(2; 0.35g/kg, 0.70g/kg, based on body weight ) according to 24 factorial design by orthogonal arrays. Breath and blood sample were taken each 8 times and 5 times after the end of drinking. The blood and breath alcohol measurements were highly correlated (r = 0.973). The Results of four way analyses of variance revealed a significant 'the type of food' effect for maximum BrAC (F (1, 43) =5.1, pp<.029), but no significant effect in the type of alcoholic beverage and sex. The overall blood/breath ratio (${\pm}$ SD) was 2295${\pm}$403 and the 95% confidence interval were 1489 and 3101. In spite of these variations, at this time, it seems to be reasonable that apply 2100:1 conversion factor to breathalyzers, because most of the subjects showed the blood.breath ratio of over 2100:1 at least 30 minutes or more passed from the time of drinking as shown in this study.