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http://dx.doi.org/10.3746/jkfn.2008.37.5.542

A Study on the Glucose-regulating Enzymes and Antioxidant Activities of Water Extracts from Medicinal Herbs  

Choe, Myeon (Dept. of Plant Biotechnology, Kangwon National University)
Kim, Dae-Jung (Dept. of Plant Biotechnology, Kangwon National University)
Lee, Hyeon-Ju (Dept. of Plant Biotechnology, Kangwon National University)
You, Jin-Kyoun (Dept. of Plant Biotechnology, Kangwon National University)
Seo, Dong-Joo (Dept. of Plant Biotechnology, Kangwon National University)
Lee, Joon-Hee (Division of Biotechnology, Kangwon National University)
Chung, Mi-Ja (The Nutraceutical Bio Brain Korea 21 Project Group, Kangwon National University)
Publication Information
Journal of the Korean Society of Food Science and Nutrition / v.37, no.5, 2008 , pp. 542-547 More about this Journal
Abstract
The anti-diabetic effects of water extracts (WE) from medicinal herbs on hepatic glucose-regulating enzymes, such as glucokinase (GCK), pyruvate dehydrogenase (PDH), acetyl-CoA carboxylase (ACC) and ${\alpha}$-glucosidase, were studied using the cytosol fraction in liver and mitochondia fraction in heart of a type II diabetic animal (GK rat, Goto-Kakizaki). The free radical scavenging activity of water extracts by DPPH method was also tested. We found that free radical scavenging activity was strong in Corni fructu (CF), Mokdan Bark (MDB), Chenhwabon (CHB) and Sanyack (SY), while that of Backbocreng (BBR), Shuckgihwang (SGH) and Taecsa (TS) was lower. For GCK activity in cytosol of liver, CF and CHB had a more effective activity than other extracts. PDH activity in mitochondria fraction of heart was higher in all of the extracts, expect for the TS extract, than in the control. ACC activity in cytosol fraction of liver was significantly higher in the CF, CHB, SGH, TS and SY extracts than in the control. CF, BBR and MDB led to a decrease in the ${\alpha}$-glucosidase activity. Therefore, these results suggest that all of the extracts may be used as functional material in the development as anti-diabetic functional food and medicine.
Keywords
water extracts; medicinal herbs; glucokinase; pyruvate dehydrogenase; acetyl-CoA carboxylase${\alpha}$-glucosidase;
Citations & Related Records
Times Cited By KSCI : 8  (Citation Analysis)
Times Cited By SCOPUS : 8
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