• IMMUNE NETWORK
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• 제10권3호
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• pp.81-84
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• 2010

B cells, by virtue of their diverse roles in immune responses to foreign and self antigens, have become of increasing interest to the clinician as well as the basic immunologist. In particular, it is now apparent that the development of B cell unresponsiveness in antibody and T cell mediated autoimmune disorders and the transplant setting is both worthwhile and achievable.

• 한국통신학회논문지
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• 제26권7A호
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• pp.1152-1161
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• 2001

본 논문에서는 이동국 수신 신호의 SINR을 최대화하는 빔 성형 알고리듬을 이용하여, 폐쇄 루프 송신 빔 성형기술을 적용한 순방향 링크 CDMA 시스템에서의 안테나 수, 귀환 채널의 구조, 귀환 지연 등과 시스템 성능과의 상관관계를 연구하였다. 폐쇄 루프 전송 빔 성형에서는 이동국이 각 안테나가 겪는 채널을 추정하여 수신 SINR을 최대화시키는 가중치 벡터를 계산하고, 귀환채널을 통해 가중치 벡터의 양자화된 진폭과 위상정보를 전송한다. 컴퓨터 모의 실험 결과는 송신 안테나가 2개, 3개, 4개로 늘어남에 따라 빔 성형 이득은 단일 송신 안테나와 비교해 $10^{-5}$ BER 근방에서 4.2dB, 5.8dB, 7dB로 증가하지만 양자화 오류에 의한 성능 저하 또한 0.1dB, 0.6dB, 1.3dB로 커지는 것을 보여준다. 또한 순방향 채널의 최대 도플러 주파수가 100Hz일 때에는 귀환 채널을 통한 소신 가중치 벡터를 보다 빠르게 갱신하는 것이 가중치 벡터의 양자화 레벨의 수를 늘여주는 것보다 $10^{-5}$ BER 근방에서 0.6dB 더 좋은 성능을 보이며, 최대 도플러 주파수가 10Hz일 때에는 가중치 벡터의 갱신 속도를 늘이기 보다 양자화 레벨의 수를 늘여주어 정확한 가중치 벡터를 전송하는 편이 0.9dB의 성능 향상을 보인다. 두 전력제어 그룹 길이의 귀환지연으로 인한 성능저하는 채널의 최대 도플러 주파수가 50Hz인 경우가 채널의 최대 도플러 주파수가 100Hz인 경우보다 $10^{-5}$ BER 근방에서 0.3dB 정도 더 작다. 또한 AOS가 3$^{\circ}$인 경우가 AOS가 $10^{\circ}$인 경우보다 $10^{-5}$ BER 근방에서 1.9dB 정도, 주파수 선택적 페이딩 채널이 주파수 비선택적 페이딩 채널보다 $10^{-5}$ BER 근방에서 1dB 정도 귀환 지연으로 인한 성능의 저하가 작다.

• 한국응급구조학회지
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• 제20권3호
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• pp.57-67
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• 2016

Purpose: The purpose of this study was to investigate the knowledge and attitudes towards hepatitis B among paramedic students. Methods: A self-reported questionnaire was completed by 395 paramedic students in Daejeon and Chungnam from May 10 to June 10, 2016. The questionnaire consisted of general characteristics of the subjects (9 items), knowledge of hepatitis B (20 items), and attitudes towards hepatitis B (7 items). Data were analyzed by t test, ANOVA, post hoc Duncan test, and Pearson's correlation analysis using SPSS v. 23.0. Results: The knowledge of hepatitis B was 10.52(${\pm}5.18$) out of 20 points and was significantly correlated with grade, vaccination, or antibody-positive irerspective of education. The positive attitude toward hepatitis B was 3.15(${\pm}.43$) and there was a significant correlation with family history irrespective of education. There was a statistically positive correlation between the knowledge and attitudes towards hepatitis B (r=.104, p=.039). Conclusion: Precise knowledge delivery and full understanding of hepatitis B should be incorporated into the education of paramedic students. Active infection control by emergency medical technicians should be maintained by hepatitis B prevention practices.

• 약학회지
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• 제52권6호
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• pp.488-493
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• 2008

2-Aminothiazole ring as a bioisoster of catechol in dopamine has provided with good oral availability and lipophilic property. 2-Aminoindan, is a rigid form of dopamine, was evaluated as a dopamine D3 agonist with low neurotoxicity. Dopamine D3 agonist was evaluated as selective for the treatment of Parkinson's disease. In order to develop a novel dopamine D3 agonist, we tried to synthesize the aminothiazoloindenoxazine derivative that is a hybrid structure of aminoindenoxazine and thiazole ring. cis-2-Amino-1-indanol (2) was synthesized from 1,2-indandione-2-oxime by catalytic hydrogenation and it was treated with chloroacetyl chloride and NaH in benzene solution to give (${\pm}$)-cis-4,4a,5,9b-tetrahydroindeno[1,2-b][1,4]oxazin-3(2H)-one (6). Nitration of 6 by the mixed acid gave 8-nitro compound (7) and the carbonyl group of 7 was reduced with $LiAlH_4$ to afford compound (8). 8 was reduced to form (${\pm}$)-cis-8-amino-2,3,4,4a,5,9b-hexahydroindeno[1,2-b][1,4]oxazine (9) and finally it was cyclized with KSCN in glacial acetic acid to yield (${\pm}$)-cis-8-amino-2,3,4,4a,5,10b-hexahydrothiazolo[4,5-f]indeno[1,2-b][1,4]oxazine (10).

• 한국정보통신학회논문지
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• 제12권10호
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• pp.1731-1736
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• 2008

본 논문은 위성 DMB 수신을 위하여 2단 저잡음 증폭기를 결합한 단일급전 원편파 패치 안테나를 설계 및 제작하였다. 제작된 안테나의 크기는 $40{\times}40{\times}15mm$로서 상대유전율이 2.2인 테플론 기판으로 제작하였다. 측정 된 안테나의 입력 반사손실(10 dB 대역폭)과 3dB 축비의 대역폭은 각각 22 MHz와 28 MHz로 양호한 특성을 나타내었다. 제작된 2단 LNA는 각각 이득이 27.5[dB], 잡음지수는 1.27[dB], 입력 반사손실은 -15.4[dB], 출력 반사손실은 -18.9[dB]인 값을 갖는다. 시뮬레이션 결과와 실험 결과가 잘 일치하였다. 제안된 안테나 구조는 위성 DMB 단말기 수신안테나로 적용 가능하다.

• 한국식품과학회지
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• 제39권3호
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• pp.323-329
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• 2007

가시오가피의 면역활성 증진 효과를 알아보기 위하여 선발된 수컷 마우스를 대상으로 하여 발효유에 가시오가피와 더덕 열수추출건조물(가시오가피 :더덕 =8:2)을 혼합하여 투여한 그룹 1 mg/mL(A), 3 mg/mL(B), 9 mg/mL(C)의 3그룹으로 나누어 임상적용 경로인 경구투여를 선택하여 발효유을 각각 3 mL/kg씩 위내로 직접 투여하였다. 대조군은 발효유만 먹인 그룹(D)과 식염수만 먹인 그룹(E)을 두었다. 오가피의 함량이 ICR계 수컷 마우스의 면역기능에 미치는 영향에 대해 알아본 결과 모든 군에서 마우스의 증체량과 체중 증가는 유의성 있는 차이를 보이지 않았고, 7주와 10주령에 안락사 시킨 마우스의 각 장기의 무게에서도 유의성 있는 차이를 보이지 않았다. 비장계수는 7주령에서는 B군이, 10주령에는 C군이 유의성 있는 증가가 관찰되었다(p<0.05). 항체생산세포수는 식이급여 7주에 B와 C군이, 10주에 C군이 각각 대조군에 비해 통계적인 유의성이 있었다(p<0.05). 양적혈구에 대한 응집소가는 식이의 급여기간이 길어질수록 감소하였는데, 7주차에는 A, B, C 군에서, 10주차에서는 B와 C군에서 유의성이 있었다(p<0.05). 혈중 면역글로불린(IgG)의 수치는 7주에서는 C군이, 10주에서는 B와 C군이 유의성이 있었다. 림프구는 B와 C군이 대조군보다 증가하였고, 비장 및 흉선조직에서도 B와 C군이 활발한 면역반응을 보였다. 이상의 결과 가시오가피와 더덕 열수추출건조물이 생체 내에서 면역력을 증강시킬 수 있을 것으로 사료되었다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2009년도 제40회 하계학술대회
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• pp.1252_1253
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• 2009

The composites were fabricated by adding 0, 15, 20, 25[vol.%] Zirconium Diboride(hereafter, $ZrB_2$) powders as a second phase to Silicon Carbide(hereafter, SiC) matrix. The physical, mechanical and electrical properties of electroconductive SiC ceramic composites by spark plasma sintering(hereafter, SPS) were examined. Reactions between $\beta$-SiC and $ZrB_2$ were not observed in the XRD analysis The relative density of mono SiC, SiC+15[vol.%]$ZrB_2$, SiC+20[vol.%]$ZrB_2$ and SiC+25[vol.%]$ZrB_2$ composites are 90.97[%], 74.62[%], 77.99[%] and 72.61[%] respectively. The XRD phase analysis of the electroconductive SiC ceramic composites reveals high of SiC and $ZrB_2$ and low of ZrO2 phase. The electrical resistivity of mono SiC, SiC+15[vol.%]$ZrB_2$, SiC+20[vol.%]$ZrB_2$ and SiC+25[vol.%]$ZrB_2$ composites are $4.57{\times}10^{-1}$, $2.13{\times}10^{-1}$, $1.53{\times}10^{-1}$ and $6.37{\times}10^{-2}[{\Omega}{\cdot}cm]$ at room temperature, respectively. The electrical resistivity of mono SiC, SiC+15[vol.%]$ZrB_2$, SiC+20[vol.%]$ZrB_2$ and SiC+25[vol.%]$ZrB_2$ are Negative Temperature Coefficient Resistance(hereafter, NTCR) in temperature ranges from 25[$^{\circ}C$] to 100[$^{\circ}C$]. It is convinced that SiC+20[vol.%]$ZrB_2$ composite by SPS can be applied for heater above 1000[$^{\circ}C$].

• 약학회지
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• 제41권6호
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• pp.789-796
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• 1997

The purpose of this study was to determine the effect of sulfinpyrazone on fumonisin $B_1$-induced elevation of free sphingoid bases in LLC-$PK_1$ cells. Fumonis ins are a family of mycotoxins produced by the fungi Fusarium moniliforme which is common contaminant in corn. Fumonisins are also potent inhibiors of sphingosine and sphinganine N-acyltransferases (ceramide synthases), key enzymes in sphingolipid metabolism resulting in the elevation of free sphinganine. The cytosolic concentration of fumonisin B1 was known to be closely proportional to the elevation of free sphinganine in LLC-PK1 cells [Yoo, H.-S., Norred, W.P., Wang, E., Merrill, A.H., Jr., and Riley, R.T. (1992) Toxicol. Appl.Pharmacol. 114. 9-15]. Sulfinpyrazone, an anion transport inhibitor, reduced the elevated level of free sphinganine resulting from fumonisin B1 inhibition of de novo sphingolipid biosynthesis. Fumonisin B1 at a concentration of 20${\mu}$M showed approximately 120pmol/$10^6$ cells relative to 3-10pmol/$10^6$ cells in control cultures, and sulfinpyrazone at a concentration of 200${\mu}$M partially reversed the increased level of free sphinganine induced by fumonisin $B_1$ down to normal level after exposure to fumonisin $B_1$ for 8 to 24hr. However, the reduced effect of sulfinpyrazone on the fumonisin $B_1$-induced elevation of intracellular sphinganine was not shown after 24hr. Fumonisin $B_1$ exposure to LLC-PK1 cells for 36 and 48hr showed approximately 74 and 80pmol per $10^6$ cells relative to 82 and 76pmol,respectively, in fumonisin $B_1$ plus sulfinpyrazone-treated cultures. Sulfinpyrazone-induced less elevation of free sphinganine in confluent cells after exposure to fumonisin $B_1$ suggested that either sulfinpyrazone may block the availability of fumonisin $B_1$ to cells or act on the fumonisin $B_1$ interaction with ceramide synthase.

• IMMUNE NETWORK
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• 제10권6호
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• pp.247-249
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• 2010

Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs and were found to consist of $8.5{\pm}3.5%$ of CD19(+)CD5(+) B cells. CD19(+)CD5(+)Foxp3(+) B cells showed spontaneous apoptosis. Rare CD19(+)CD5(+) Foxp3(+) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.

• 대한의생명과학회지
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• 제20권1호
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• pp.14-24
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• 2014

Hypoxia is one of the main reasons for islet apoptosis after transplantation as well as during isolation. In this study, we attempted to determine the potential usefulness of NF-${\kappa}B$ inhibitor for suppression of hypoxia-induced ${\beta}$-cell apoptosis as well as the relationship between IP-10 induction and ${\beta}$-cell apoptosis in hypoxia. To accomplish this, we cultured the mouse pancreatic ${\beta}$-cell line MIN6 in hypoxia (1% $O_2$). Among several examined chemokines, only IP-10 mRNA expression was induced under hypoxia, and this induced IP-10 expression was due to NF-${\kappa}B$ activity. Since a previous study suggested that IP-10 mediates ${\beta}$-cell apoptosis, we measured hypoxia-induced IP-10 protein and examined the effect of anti-IP-10 neutralizing Ab on hypoxia-induced ${\beta}$-cell apoptosis. However, IP-10 protein was not detected, and anti-IP-10 neutralizing Ab did not rescue hypoxia-induced MIN6 apoptosis, indicating that there is no relationship between hypoxia-induced IP-10 mRNA expression and hypoxia-induced ${\beta}$-cell apoptosis. Since it was still not clear if NF-${\kappa}B$ functions as an apoptotic or anti-apoptotic mediator in hypoxia-induced ${\beta}$-cell apoptosis, we examined possible involvement of NF-${\kappa}B$ in hypoxia-induced ${\beta}$-cell apoptosis. Treatment with 1 ${\mu}M$ NF-${\kappa}B$ inhibitor suppressed hypoxiainduced apoptosis by more than 50%, while 10 ${\mu}M$ AP-1 or 4 ${\mu}M$ NF-AT inhibitor did not, indicating involvement of NF-${\kappa}B$ in hypoxia-induced ${\beta}$-cell apoptosis. Overall, these results suggest that IP-10 is not involved in hypoxia-induced ${\beta}$-cell apoptosis, and that NF-${\kappa}B$ inhibitor can be useful for ameliorating hypoxia-induced ${\beta}$-cell apoptosis.