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http://dx.doi.org/10.4110/in.2010.10.6.247

Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)  

Noh, Joon-Yong (Department of Animal Biotechnology, College of Animal Bioscience & Technology, Konkuk University)
Choi, Wahn-Soo (Department of Immunology, College of Medicine, Konkuk University)
Noh, Geun-Woong (Division of Allergy and Clinical Immunology, Department of Paediatrics, Chungnam National University Hospital)
Lee, Jae-Ho (Department of Paediatrics, Chungnam National University)
Publication Information
IMMUNE NETWORK / v.10, no.6, 2010 , pp. 247-249 More about this Journal
Abstract
Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs and were found to consist of $8.5{\pm}3.5%$ of CD19(+)CD5(+) B cells. CD19(+)CD5(+)Foxp3(+) B cells showed spontaneous apoptosis. Rare CD19(+)CD5(+) Foxp3(+) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.
Keywords
Foxp3; Regulatory B cell; Breg; CD5; CD19; CD5(+) B;
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