IMMUNE NETWORK

The Korean Association of Immunobiologists (대한면역학회)
권호 표지
DOI QR코드

DOI QR Code

Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)

  • Noh, Joon-Yong (Department of Animal Biotechnology, College of Animal Bioscience & Technology, Konkuk University) ;
  • Choi, Wahn-Soo (Department of Immunology, College of Medicine, Konkuk University) ;
  • Noh, Geun-Woong (Division of Allergy and Clinical Immunology, Department of Paediatrics, Chungnam National University Hospital) ;
  • Lee, Jae-Ho (Department of Paediatrics, Chungnam National University)
  • Received : 2010.11.11
  • Accepted : 2010.11.30
  • Published : 2010.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs and were found to consist of $8.5{\pm}3.5%$ of CD19(+)CD5(+) B cells. CD19(+)CD5(+)Foxp3(+) B cells showed spontaneous apoptosis. Rare CD19(+)CD5(+) Foxp3(+) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.

Keywords

References

  1. Mizoguchi A, Bhan AK: A case for regulatory B cells. J Immunol 176;705-710, 2006 https://doi.org/10.4049/jimmunol.176.2.705
  2. Gieni RS, Umetsu DT, DeKruyff RH: Ly1- (CD5-) B cells produce interleukin (IL)-10. Cell Immunol 175;164-170, 1997 https://doi.org/10.1006/cimm.1996.1060
  3. Lee JH, Noh J, Noh G, Kim HS, Mun SH, Choi WS, Cho S, Lee S: Allergen-specific B cell subset responses in cow's milk allergy of late eczematous reactions in atopic dermatitis. Cell Immunol 262;44-51, 2010 https://doi.org/10.1016/j.cellimm.2009.12.006
  4. Noh J, Lee JH, Noh G, Bang SY, Kim HS, Choi WS, Cho S, Lee SS: Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy. Cell Immunol 264;143-149, 2010 https://doi.org/10.1016/j.cellimm.2010.05.013
  5. Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science 299;1057-1061, 2003 https://doi.org/10.1126/science.1079490
  6. Amu S, Saunders SP, Kronenberg M, Mangan NE, Atzberger A, Fallon PG: Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. J Allergy Clin Immunol 125;1114- 1124, 2010 https://doi.org/10.1016/j.jaci.2010.01.018
  7. Lee JH, Noh J, Noh G, Choi WS, Cho S, Lee SS. Allergenspecific TGF-$\beta$-producing CD19(+)CD5(+) Regulatory B-Cell (Br3) Responses in Human Late Eczematous Allergic Reactions to Cow's Milk. J Interferon Cytokine Res 2011 in press
  8. Douglas RS, Woo EY, Capocasale RJ, Tarshis AD, Nowell PC, Moore JS: Altered response to and production of TGF-beta by B cells from autoimmune NZB mice. Cell Immunol 179;126-137, 1997 https://doi.org/10.1006/cimm.1997.1149
  9. Weiner HL: Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect 3;947-954, 2001 https://doi.org/10.1016/S1286-4579(01)01456-3

Cited by

  1. Function of regulatory T-cells improved by dexamethasone in Graves' disease. vol.166, pp.4, 2012, https://doi.org/10.1530/eje-11-0879
  2. Food allergy: management, diagnosis and treatment strategies vol.5, pp.7, 2010, https://doi.org/10.2217/imt.13.63
  3. Aberrant expression of CCR4 in diffuse large B-cell lymphoma, not otherwise specified vol.27, pp.12, 2010, https://doi.org/10.1038/leu.2013.128
  4. Regulatory B-Cells in Transplantation vol.2, pp.4, 2010, https://doi.org/10.3390/antib2040587
  5. Clostridium difficile recurrence is characterized by pro-inflammatory peripheral blood mononuclear cell (PBMC) phenotype vol.63, pp.10, 2014, https://doi.org/10.1099/jmm.0.075382-0
  6. Perioperative changes in peripheral regulatory B cells of patients with esophageal cancer vol.10, pp.3, 2010, https://doi.org/10.3892/mmr.2014.2347
  7. Increased Interleukin 21 and Follicular Helper T-like Cells and Reduced Interleukin 10+ B cells in Patients with New-onset Systemic Lupus Erythematosus vol.41, pp.9, 2010, https://doi.org/10.3899/jrheum.131025
  8. Transient Low-Dose Methotrexate Generates B Regulatory Cells That Mediate Antigen-Specific Tolerance to Alglucosidase Alfa vol.193, pp.8, 2014, https://doi.org/10.4049/jimmunol.1303326
  9. Changes in regulatory B cells and their relationship with rheumatoid arthritis disease activity vol.15, pp.3, 2010, https://doi.org/10.1007/s10238-014-0310-9
  10. Regulatory immune cells in regulation of intestinal inflammatory response to microbiota vol.8, pp.5, 2010, https://doi.org/10.1038/mi.2015.49
  11. Myeloid-Derived Suppressor Cells as an Immune Parameter in Patients with Concurrent Sunitinib and Stereotactic Body Radiotherapy vol.21, pp.18, 2015, https://doi.org/10.1158/1078-0432.ccr-14-2742
  12. Splenic lymphocyte subtypes in immune thrombocytopenia: increased presence of a subtype of B‐regulatory cells vol.173, pp.1, 2010, https://doi.org/10.1111/bjh.13567
  13. Phosphatidylserine Outer Layer Translocation Is Implicated in IL-10 Secretion by Human Regulatory B Cells vol.12, pp.1, 2017, https://doi.org/10.1371/journal.pone.0169755
  14. Advances in the pathophysiology of primary immune thrombocytopenia vol.22, pp.1, 2010, https://doi.org/10.1080/10245332.2016.1219497
  15. Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus vol.2019, pp.None, 2010, https://doi.org/10.1155/2019/7948687
  16. CD5+ B lymphocytes secrete IL-10 rather than TGF-β1 which control the immune response in autoimmune haemolytic anaemia/Evans syndrome vol.52, pp.1, 2010, https://doi.org/10.1080/08916934.2019.1576644
  17. The Multiple Functions of B Cells in Chronic HBV Infection vol.11, pp.None, 2010, https://doi.org/10.3389/fimmu.2020.582292
  18. Characterization and antiproliferative activity of glioma-derived extracellular vesicles vol.15, pp.10, 2010, https://doi.org/10.2217/nnm-2019-0431
  19. Connection of BANK1, Tolerance, Regulatory B cells, and Apoptosis: Perspectives of a Reductionist Investigation vol.12, pp.None, 2010, https://doi.org/10.3389/fimmu.2021.589786
  20. Effects of Peptide-Induced Immune Tolerance on Murine Lupus vol.12, pp.None, 2010, https://doi.org/10.3389/fimmu.2021.662901
  21. The Role of Regulatory B cells in Kidney Diseases vol.12, pp.None, 2021, https://doi.org/10.3389/fimmu.2021.683926