• BMB Reports
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• v.50 no.12
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• pp.640-646
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• 2017

Regulatory B cells, also well-known as IL-10-producing B cells, play a role in the suppression of inflammatory responses. However, the epigenetic modulation of regulatory B cells is largely unknown. Recent studies showed that the bromodomain and extra-terminal domain (BET) protein inhibitor JQ1 controls the expression of various genes involving cell proliferation and cell cycle. However, the role of BET proteins on development of regulatory B cells is not reported. In this study, JQ1 potently suppressed IL-10 expression and secretion in murine splenic and peritoneal B cells. While bromodomain-containing protein 4 (BRD4) was associated with $NF-{\kappa}B$ on IL-10 promoter region by LPS stimulation, JQ1 interfered the interaction of BRD4 with $NF-{\kappa}B$ on IL-10 promoter. In summary, BRD4 is essential for toll like receptor 4 (TLR4)-mediated IL-10 expression, suggesting JQ1 could be a potential candidate in regulating IL-10-producing regulatory B cells in cancer.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.5 no.5
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• pp.908-915
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• 2001

In this paper, it is analyzed theoretically that the performance degradation, caused by carrier frequency offset, in an OFDM/M-ary PSK system. Then, when Turbo coding is adopted to an OFDM/M-ary PSK system, the degree of performance enhancement is evaluated. Finally, the maximum frequency offset is calculated to satisfy the BER performance required in a Turbo coded OFDM/M-ary PSK system. As results of analysis, it is shown that the more the number of M-ary is, the worse the BER performance is. Moreover, 7dB, 9dB, and 17dB of $E_b/N_o$ are required in QPSK, 8PSK and 16PSK systems, respectively in order to satisfy the error performance, $BER=10^{-3}$ for voice communication. If $E_b/N_o$ are 10㏈ and 15㏈, the frequency offset should be below 0.05 and 0.075, respectively, for voice communication. When Turbo coding is adopted to an OFDM/M-ary PSK system, the less the number of M-ary is, the greater the performance enhancement of Turbo coding is. If the number of a M-ary system of the system is below 16, it is found that required $E_b/N_o$ is about 8dB to satisfy $BER=10^{-5}$ Moreover, in the system the Turbo coding scheme, voice communication is available with greatly low$E_b/N_o$, and 8dB of $E_b/N_o$ is enough for data communication regardless of the permission range of frequency offset.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.7
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• pp.1433-1438
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• 2011

Relative attenuations of Tx and Rx in K-PCS and US-PCS duplexers were about -60dB and -65dB, -51dB and -53dB, respectively. In the case of Rx and Tx in K-PCS and US-PCS bandpass filters, relative attenuations were about -40dB and -14dB, -5dB and -10dB, respectively. From the aboved results, the relative affect between Tx and Rx in K-PCS bands was smaller than that of US-PCS bands. Also, the various capacitances of passband were important role to determine the characterics of bandpass filter.

• YAKHAK HOEJI
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• v.43 no.1
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• pp.11-15
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• 1999

A brief route for regiospecific synthesis of novel 10-Oxodaunomycinone Derivatives (10a, b) is described. Dimethoxy-l-tetralone 4 was converted to acetyl tetralone (5a, b) which was oxidized with oxygen to obtain cis-diol compound (8a, b). The construction of (10a, b) was completed by the condensation of phthaloyl dichloride 9 with cis-diol (8a, b)

• Korean Journal of Crystallography
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• v.18 no.1_2
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• pp.1-6
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• 2007

An Organometallic compound, $C_{16}H_{35}B_{10}IrS_2Si$, was synthesized from o-carborane, $Cp^*Ir(S_2C_2B{10}H_{10})$, and $Me_3SiCHN_2$. The molecular structure of this complex has been determined by X-ray diffraction. Crystallographic data : monoclinic, space group $P2_1/n$, $a=10.1986(12)\;{\AA}$, $b=14.834(5)\;{\AA}$, $c=17.139\;{\AA}$, ${\beta}=92.24(2)^{\circ}$, Z=4, $V=2591.0(14)\;{\AA}^3$. The structure was solved by direct methods and refined by full-matrix leat-squares methods to give a model with a reliability factor R=0.053 for 5080 reflections.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2004.05b
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• pp.664-668
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• 2004

본 논문에서는 고속 이더넷의 고속의 이더넷의 물리계층에서 수신된 비트열로 부터 클록을 복원하고, 이 클록으로부터 동기된 비트열을 10b/8b 디코딩한 다음, 바이트열로 복원하여 데이터 링크계층의 MAC(Media Access controller)로 전송한다. PCS의 디코더는 S비트의 데이터와 제어신호를 추출하여 MAC으로 전달하는 기능을 수행한다. 즉 본 논문에서는 PCS기능 중 가장 중요한 요소인 10b/8b 디코더를 VHDL언어를 사용하여 기술하고 Xilinx ISE5.1를 이용하여 구현하였고, 입력 부분에 DDR인터페이스를 사용하였다. 구현한 결과 1056개의 게이트 사용하였으며, 10Gbps를 지원하기 위해서는 한 블록 당 2.5Gbps의 처리속도가 필요하다. 설계 모듈은 5.1Gbps의 처리 속도를 지원하여 관련 응용분야에서 사용이 가능할 것으로 사료된다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.2
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• pp.50-59
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• 2009

Objectives : The aim of this study was conducted that CRE (Coptidis Rhizoma Extract) induces apoptosis in YD-10B cells, human oral squamous carcinoma cell line. Methods : In this study, YD-10B cells were exposed to CRE (0.03-0.30 mg/ml), for 6-24 hours. We measured the effects of CRE on the changes of cell viability and cell membrane, TUNEL assay of CRE-treated YD-10B cell. Results : In this study, CRE caused a decrease of viability in YD-10B cells, human oral squamous carcinoma cell line. When YD-10B cells were treated with CRE, cells showed dose-dependent manner apoptotic cell death. Conclusions : These results suggest that CRE may be potential therapeutic approach in the clinical management of oral squamous cell carcinoma.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.3
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• pp.51-62
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• 2007

Objective : The aim of this study is to assess the effect of Schizandrae Fructus on melanin synthesis inhibition and whitening effect. Methods : We assessed inhibitory effects of Schizandrae Fructus on melanin-release from B16F10, on melanin production in B16F10, on mushroom tyrosinase activity in vitro, on tyrosinase activity in B16F10 and effect of Schizandrae Fructus on the expression tyrosinase, TRP-1, TRP-2, PKA, ERK-1 ERK-2, AKT-1, MITF in B16F10. Results and Conclusion : 1. Schizandrae Fructus inhibited melanin-release, melanin production in B16F10. 2. Schizandrae Fructus inhibited tyrosinase activity in vitro and in B16F10. 3. Schizandrae Fructus suppressed the expression of tyrosinase, TRP-1, TRP-2, PKA, ERK-2 in B16F10.

• Journal of Radiation Protection and Research
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• v.39 no.4
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• pp.199-205
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• 2014

In the field of neutron detections, $^3He$ gas, the so-called "the gold standard," is the most widely used material for neutron detections because of its high efficiency in neutron capturing. However, from variable causes since early 2009, $^3He$ is being depleted, which has maintained an upward pressure on its cost. For this reason, the demands for $^3He$ replacements are rising sharply. Research into neutron converting materials, which has not been used well due to a neutron detection efficiency lower than the efficiency of $^3He$, although it can be chosen for use in a neutron detector, has been highlighted again. $^{10}B$, which is one of the $^3He$ replacements, such as $BF_3$, $^6Li$, $^{10}B$, $Gd_2O_2S$, is being researched by various detector development groups owing to a number of advantages such as easy gamma-ray discrimination, non-toxicity, low cost, etc. One of the possible techniques for the detection is an indirect neutron detection method measuring secondary radiation generated by interactions between neutrons and $^{10}B$. Because of the mean free path of alpha particle from interactions that are very short in a solid material, the thickness of $^{10}B$ should be thin. Therefore, to increase the neutron detection efficiency, it is important to make a $^{10}B$ thin film. In this study, we fabricated a $^{10}B$ thin film that is about 60 um in thickness for neutron detection using well-known technology for the manufacturing of a thin electrode for use in lithium ion batteries. In addition, by performing simple physical tests on the conductivity, dispersion, adhesion, and flexibility, we confirmed that the physical characteristics of the fabricated $^{10}B$ thin film are good. Using the fabricated $^{10}B$ thin film, we made a proportional counter for neutron monitoring and measured the neutron pulse height spectrum at a neutron facility at KAERI. Furthermore, we calculated using the Monte Carlo simulation the change of neutron detection efficiency according to the number of thin film layers. In conclusion, we suggest a fabrication method of a $^{10}B$ thin film using the technology used in making a thin electrode of lithium ion batteries and made the $^{10}B$ thin film for neutron detection using suggested method.

• Journal of Microbiology and Biotechnology
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• v.17 no.8
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• pp.1308-1315
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• 2007

Lipase B from Candida antarctica (CalB) displayed on the cell surface of H. polymorpha has been functionally improved for catalytic activity by molecular evolution. CalB was displayed on the cell surface by fusing to a cell-wall anchor motif (CwpF). A library of CalB mutants was constructed by in vivo recombination in H. polymorpha. Several mutants with increased whole-cell CalB activity were acquired from screening seven thousand transformants. The two independent mutants CalB 10 and CalB 14 showed an approximately 5 times greater whole-cell activity than the wild-type. When these mutants were made as a soluble form, CalB 10 showed 6 times greater activity and CalB 14 showed an 11 times greater activity compared with the wild-type. Sequence analyses of mutant CALB genes revealed amino acid substitutions of $Leu^{278}Pro$ in CalB10 and $Leu^{278}Pro/Leu^{219}Gln$ in CalB14. The substituted $Pro^{278}$ in both mutants was located near the proline site of the ${\alpha}$10 helix. This mutation was assumed to induce a conformational change in the ${\alpha}$10 helix and increased the $k_{cat}$ value of mutant CalB approximately 6 times. Site-directed mutagenized CalB, LQ ($Leu^{219}Gln$) was secreted into the culture supernatant at an amount of approximately 3 times more without an increase in the CalB transcript level, compared with the wild-type.