• 한방재활의학과학회지
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• 제21권2호
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• pp.1-13
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• 2011

Objectives : We investigated the effect of Haein-tang(Hairen-tang) on short-term memory and apoptosis in dentate gyrus of the gerbils with transient global ischemia. Methods : For the induction of cerebral ischemia model in mice, common carotid arteries of gerbils were occluded with aneurysm clips for 5 min. One day after operation, Haein-tang(Hairen-tang) was administrated orally injected once a day for 15 consecutive days. Gerbils were randomly divided into four group(n=10 in each group): sham-operation group, ischemia-induction group, ischemia-induction and 50 mg/kg Haein-tang(Hairen-tang)-treated group, ischemia-induction and 100 mg/kg Haein-tang(Hairen-tang)-treated group, and ischemia-induction and 200 mg/kg Haein-tang(Hairen-tang)-treated group. The effect of Haein-tang(Hairen-tang) on memory function was investigated by using step-down avoidance task. Apoptosis was confirmed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling(TUNEL) staining and immunohistochemistry for caspase-3. Western blot analysis for the expressions of Bax and Bcl-2 protein was also conducted. Results : 1. Haein-tang extract significantly enhanced short-term memory in step-down avoidance task and 100 mg/kg, 200 mg/kg Haein-tang-treated group. 2. Haein-tang extract significantly suppressed TUNEL-positive cells after transient global ischemia and 50 mg/kg, 100 mg/kg, 200 mg/kg Haein-tang-treated group. 3. Haein-tang extract significantly increased caspase-3 positive cells in the hippocampal dentate gyrus after transient global ischemia and 50 mg/kg, 100 mg/kg, 200 mg/kg Haein-tang-treated group. 4. Haein-tang extract significantly decreased Bax protein expressions in the hippocampus after transient global ischemia and 100 mg/kg, 200 mg/kg, Haein-tang-treated group. Haein-tang extract significantly increased Bcl-2 protein expressions in the hippocampal dentate gyrus after transient global ischemia and 50 mg/kg, 100 mg/kg, 200 mg/kg, Haein-tang-treated group. Haein-tang extract significantly decreased Ratio of Bax protein to Bcl-2 protein in the hippocampus after transient global ischemia and 100 mg/kg, 200 mg/kg Haein-tang-treated group. Conclusions : While Haein-tang(Hairen-tang) treatment improved short-term memory by suppressing on ischemia-induction apoptosis. In the present study, Haein-tang(Hairen-tang) shows protective effect on transient global ischemia.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권4호
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• pp.2002-2019
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• 2017

RPL routing protocol for low-power and lossy networks is an Internet Engineering Task Force (IETF) recommended IPv6 based protocol for routing over Low power Lossy Networks (LLNs). RPL is proposed for networks with characteristics like small packet size, low bandwidth, low data rate, lossy wireless links and low power. RPL is a proactive routing protocol that creates a Directed Acyclic Graph (DAG) of the network topology. RPL is increasingly used for Internet of Things (IoT) which comprises of heterogeneous networks and applications. RPL proposes a single path routing strategy. The forwarding technique of RPL does not support multiple paths between source and destination. Multipath routing is an important strategy used in both sensor and ad-hoc network for performance enhancement. Multipath routing is also used to achieve multi-fold objectives including higher reliability, increase in throughput, fault tolerance, congestion mitigation and hole avoidance. In this paper, M-RPL (Multi-path extension of RPL) is proposed, which aims to provide temporary multiple paths during congestion over a single routing path. Congestion is primarily detected using buffer size and packet delivery ratio at forwarding nodes. Congestion is mitigated by creating partially disjoint multiple paths and by avoiding forwarding of packets through the congested node. Detailed simulation analysis of M-RPL against RPL in both grid and random topologies shows that M-RPL successfully mitigates congestion and it enhances overall network throughput.

• 생물정신의학
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• 제18권2호
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• pp.101-108
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• 2011

Objectives The aim of this study is to explore the association among DRD4 polymorphism, temperament and alcohol drinking behavior of Koreans in their early adulthood. Method Participants were 172 healthy Korean adults (mean age $28.1{\pm}0.8$). Their temperament was assessed with the Temperament and Character Inventory (TCI) and their alcohol drinking behavior were evaluated with a self-reported questionnaire including the CAGE and the Korean version of Alcohol Use Disorder Identification Test (AUDIT-K). DRD4 exon III 48 base pair variable number of tandem repeats (VNTR) was genotyped by PCR. Results No significant association was found between DRD4 polymorphism and TCI temperament dimension (novelty seeking, harm avoidance, reward dependence, and persistence) as well as alcohol drinking behavior scales. However, novelty seeking was significantly associated with alcohol drinking behavior. The higher level of novelty seeking was associated with the higher severity index of drinking (B = -0.225, p < 0.001) and problematic alcohol use on the CAGE and AUDIT-K [Odds Ratio (OR) = 1.111, 95% Confidence Interval (CI) 1.021-1.209, p = 0.015, OR = 1.087, 95% CI 1.009-1.170, p = 0.028]. Conclusion In our study, while there is no significant association of DRD4 polymorphism with temperament and alcohol drinking behavior, novelty seeking affects problematic alcohol use. Results suggest that novelty seeking may play an important role in problematic alcohol use in young Korean adults.

• 인터넷정보학회논문지
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• 제3권6호
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• pp.43-51
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• 2002

본 논문은 능동적인 큐 관리를 이용한 새로운 패킷 탈락 알고리즘에 대해 연구이다. 능동적인 큐 관리 기법은 기존의 Drop Tail과 다른데, Drop Toil은 버퍼 오버플로우가 발생하면 패킷 탈락되는 반면, 능동적인 큐 관리 기법인 RED는 폭주가 발생하기 전에 패킷이 탈락된다는 것이다. 그러나 능동적인 큐 관리 기법은 버퍼 크기가 충분히 크지 않을 때 높은 패킷 손실률을 초래한다. 폭주를 탐지하고 무작위로 선택된 연결에 이를 통보함에 의한 글로벌 동기화와 공정성 문제를 야기하며, 최적의 평균 큐 길이를 찾기 위해서는 네트워크 트래픽 특성이 미리 알려져야 한다는 커다란 문제가 있다. 본 논문에서는 폭주제어를 위한 새로운 큐 관리 기법 기반의 효율적인 패킷 탈락 기법을 제안한다. 제안된 기법은 플로우별 도착률과 추정된 공정한 대역을 사용한다. 이를 이용하여 플로우 도착률과 링크 대역을 계산하기 위한 추정 알고리즘을 제안한다. 제안된 기법은 패킷 손실을 가져오는 패킷에 의한 큐 길이의 급속한 진동을 초래하지 않기 때문에 네트워크 성능을 향상시킬 수 있음을 보인다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권12호
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• pp.4819-4834
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• 2015

The spectral efficiency of cellular networks can be improved when proximate users engage in device-to-device (D2D) communications to communicate directly without going through a base station. However, D2D communications that are not properly designed may generate interference with existing cellular networks. In this paper, we study resource allocation and power control to minimize the probability of an outage and maximize the overall network throughput. We investigate three power control-based schemes: the Partial Co-channel based Overlap Resource Power Control (PC.OVER), Fractional Frequency Reuse based Overlap Resource Power Control (FFR.OVER) and Fractional Frequency Reuse based Adaptive Power Control (FFR.APC) and also compare their performance. In PC.OVER, a certain portion of the total bandwidth is dedicated to the D2D. The FFR.OVER and FFR.APC schemes combine the FFR techniques and the power control mechanism. In FFR, the entire frequency band is partitioned into two parts, including a central and edge sub-bands. Macrocell users (mUEs) transmit using uniform power in the inner and outer regions of the cell, and in all three schemes, the D2D receivers (D2DRs) transmit with low power when more than one D2DRs share a resource block (RB) with the macrocells. For PC.OVER and FFR.OVER, the power of the D2DRs is reduced to its minimum, and for the FFR.APC scheme, the transmission power of the D2DRs is iteratively adjusted to satisfy the signal to interference ratio (SIR) threshold. The three schemes exhibit a significant improvement in the overall system capacity as well as in the probability of a user outage when compared to a conventional scheme.

• Molecules and Cells
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• 제40권10호
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• pp.714-730
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• 2017

Pre-mRNA splicing further increases protein diversity acquired through evolution. The underlying driving forces for this phenomenon are unknown, especially in terms of gene expression. A rice alternatively spliced transcript detection microarray (ASDM) and RNA sequencing (RNA-Seq) were applied to differentiate the transcriptome of 4 representative organs of Oryza sativa L. cv. Ilmi: leaves, roots, 1-cm-stage panicles and young seeds at 21 days after pollination. Comparison of data obtained by microarray and RNA-Seq showed a bell-shaped distribution and a co-lineation for highly expressed genes. Transcripts were classified according to the degree of organ enrichment using a coefficient value (CV, the ratio of the standard deviation to the mean values): highly variable (CVI), variable (CVII), and constitutive (CVIII) groups. A higher index of the portion of loci with alternatively spliced transcripts in a group (IAST) value was observed for the constitutive group. Genes of the highly variable group showed the characteristics of the examined organs, and alternatively spliced transcripts tended to exhibit the same organ specificity or less organ preferences, with avoidance of 'organ distinctness'. In addition, within a locus, a tendency of higher expression was found for transcripts with a longer coding sequence (CDS), and a spliced intron was the most commonly found type of alternative splicing for an extended CDS. Thus, pre-mRNA splicing might have evolved to retain maximum functionality in terms of organ preference and multiplicity.

• 한국강구조학회 논문집
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• 제28권2호
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• pp.75-83
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• 2016

기존 콘크리트충전 각형강관(CFT) 구조에 사용하는 각형강관은 4개의 판을 용접하여 제작하는 박스칼럼이 일반적이다. 그러나 이러한 강관은 제작효율이 저하되며, 또한 기둥-보 접합부에는 내측 다이아프램과 관통 다이아프램을 용접하는데 특수한 용접기술이 필요하다. 따라서, 얇은 강판을 절곡하는 방식으로 응력집중 위치의 용접을 피하고, 단면효율이 극대화된 내부앵커 돌출형의 용접조립 각형강관을 개발하게 되었다. 용접조립 각형강관은 강관내부에 스티프너가 설치되어 내측 다이아프램과 관통 다이아프램과 간섭이 발생하게 되므로 본 연구에서는 용접조립 각형CFT 기둥-보 접합부로 외다이아프램형식을 채택하고 외다이아프램의 설계식을 제안하였으며, 기둥-보 접합부의 거동을 파악하기 위해 실대형 4개 실험체를 제작하여 구조거동 및 내력을 분석하였다.

• 한국항공우주학회지
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• 제39권9호
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• pp.848-857
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• 2011

영상센서 기반의 충돌회피 시스템을 구성하기 위해서는 수 픽셀 이내의 낮은 신호대잡음비 환경에서 다수의 표적을 탐지할 수 있는 알고리듬이 필요하다. 이처럼 영상 내에서 희미하게 나타나는 잠재적인 표적과 잡음을 구분하기 위한 방법으로서 연속적인 영상 정보를 효율적으로 처리하는 Track-Before-Detect (TBD) 알고리듬이 연구되고 있다. 본 논문에서는 기존의 TBD 알고리듬을 확장하여 다수 표적 탐지 요구조건을 만족시키기 위한 두 가지 방식의 기법을 제시하였다. 첫 번째 방식은 동적 계획법과 K-평균 클러스터링 기법에 기반을 두고 있으며 두 번째 방식은 은닉 마르코프 모델에 Sub-Window 기법을 적용하였다. 제안한 방식의 성능 및 차이점은 수치해석 결과를 통해 분석하였다.

• 생명과학회지
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• 제6권2호
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• pp.142-148
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• 1996

Aloe(Aloe arborescens M$_{ILL}$) has been used as a home medicine for the past several thousand in the world, and has been studied on anti-bacterial and anti-fungal activities, hypotension, atherosclerosis, myocardiac infartion, apoplexy, diabetes as a chronic digenerative disease, tumors, gastrointestinal tract, liver and pancreas' diseases, and genitourinary tract etc. SAMP8 as a learing and memory impairment animal model were fed basic and/or experimental diets with 1.0% freezing dried(FD)-aloe for 8 months. The passive avoidance tests such as acqusition trial and retention test were significantly higher in aloe group than in control group. Grading score of senescence resulted in a marked decreases in aloe group compared with control group. Acetylcholinesterase(AChE) activity was remarkably increased in aloe group compared with control group. Neurotransmitters such as dopamine(DA) and serotonin(5-HT) almost did not change by the feeding of aloe-added diet, but their metabolites such as homovanillic acid(HVA) and 5-hydroxy-indole acetic acid(5-HIAA) in aloe group were significantly increased compared with control group. Therefore, the ratios of HVA/DA and 5-HIAA/5-HT as a ratio of metabolite on neurotransmitter were significantly increased by the feeding of aloe-added diet. These results suggest that aloe vara may be activated acetylcholinesterase, the metabolite of neurotransmitter, and ratios of metabolite on neurotransmitter, resulting ina greater prevention of learning and memory impairments such as Alzheimertype dementia.

• 한국통신학회논문지
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• 제42권1호
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• pp.64-76
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• 2017

MANET (Mobile Ad hoc Network)에서 라우팅은 네트워크 토폴로지의 동적인 변화에 큰 영향을 받는다. AntHocNet은 집단 개미가 최적 경로를 통해 먹이를 찾아가는 원리를 모방한 집단생태 특성 기반 MANET 라우팅 프로토콜이다. 하지만, AntHocNet은 다른 MANET 라우팅 프로토콜과 달리 단방향 경로만을 지원하여 양방향 통신이 요구되는 다양한 응용 환경에서 사용하기에 많은 제약이 따른다. 또한, AntHocNet은 다중 경로를 통한 확률적 라우팅으로 인해 루핑 문제 (looping problems)를 빈번히 발생시킨다. 본 논문에서는 AntHocNet에서 양방향 경로 수립을 위한 향상된 경로 수립 방안을 제안한다. 또한, 다양한 시나리오별 루핑 문제의 발생 원인을 분석하고 루프 방지를 위한 해결 방안을 제시한다. NS-2 시뮬레이션을 통해 기존 AntHocNet과의 성능을 비교하였으며, 제안 방안이 라우팅 오버헤드, 종단간 지연 시간, 패킷 전달률 측면에서 기존 방안에 비해 우수한 성능을 보임을 확인하였다.