• Title/Summary/Keyword: Autonomous oscillation

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Biological Clock and Ultradian Metabolic Oscillation in Saccharomyces cerevisiae (Saccharomyces cerevisiae의 생물시계와 초단기 대사진동)

  • Kwon, Chong Suk;Sohn, Ho-Yong
    • Journal of Life Science
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    • v.28 no.8
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    • pp.985-991
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    • 2018
  • Biological clocks are the basis of temporal control of metabolism and behavior. These clocks are characterized by autonomous free-running oscillation and temperature compensation and are found in animals, plants, and microorganisms. To date, various biological clocks have been reported. These include clocks governing hibernation, sleep/wake, heartbeat, and courtship song. These clocks can be differentiated by the period of rhythms, for example, infradian rhythms (> 24-hr period), circadian rhythms (24-hr period), and ultradian rhythms (< 24-hr period). In yeast (Saccharomyces cerevisiae), at least five different autonomous oscillations have been reported; (1) glycolytic oscillations (T = 1~30 min), (2) cell cycle-dependent oscillations (T = 2~16 hr), (3) ultradian metabolic oscillations (T = 15~50 min), (4) yeast colony oscillations (T = a few hours), and (5) circadian oscillations (T = 24 hr). In this review, we discuss studies on oscillators, pacemakers, and synchronizers, in addition to the application of biological clocks, to demonstrate the nature of autonomous oscillations, especially ultradian metabolic oscillations of S. cerevisiae.

Stability Analysis of Nonlinear Pulse-Modulated System Subject to Gaussian Noise (가우스 잡음을 고려한 비선형 펄스 변조 시스템의 안정도 분석)

  • 강영채
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.19 no.6
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    • pp.67-79
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    • 1982
  • The stability of general pulse-width modulation system with Gaussian random disturbance was discussed . General system is divided into nonlinear and linear elements using the conventional describing function method. The concept of the equivalent admittance was used to find the transfer characteristic of the nonlinear element of the system. In this paper the self-sustained oscillation condition in the autonomous system was derived and the results was analyzed with computer simulation.

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Added Mass of Submerged Bodies Obtained by Forced Oscillation Tests and Numerical Calculations of Potential Flow (수중운동체의 강제동요시험 및 포텐셜 계산에 의한 부가질량 추정)

  • Kim, Dong Jin;Lee, Gyeong Joong;Kwon, Chang Seop;Kim, Yeon Gyu;Park, Jin-Yeong;Jun, Bong-Huan
    • Journal of the Society of Naval Architects of Korea
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    • v.59 no.4
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    • pp.214-224
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    • 2022
  • It is necessary to estimate manoeuvring characteristics of submerged bodies at the design stage in order to ensure the safe operations. In this study, added mass coefficients in the mathematical model of submerged bodies are estimated by captive model tests and numerical calculations. Two kinds of models, MARIN 'BB2'submarine model and AUV (Autonomous unmanned vehicle) model are utilized in the forced oscillation tests. Compared to BB2 submarine, AUV with cylindrical type hull form shows relatively small added masses in roll, pitch, and yaw directions. Next, numerical calculations based on potential theory are performed under the assumption that viscous effects on inertia forces are negligible. Added masses obtained by numerical calculations are in good agreements with forced oscillation test results. And if slow manoeuvres of submerged bodies are presumed, some of velocity coupled terms can be approximated by combinations of added mass coefficients.

OSCILLATION AND GLOBAL ATTRACTIVITY IN A PERIODIC DELAY HEMATOPOIESIS MODE

  • Saker, S.H.
    • Journal of applied mathematics & informatics
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    • v.13 no.1_2
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    • pp.287-300
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    • 2003
  • In this paper we shall consider the nonlinear delay differential equation (equation omitted) where m is a positive integer, ${\beta}$(t) and $\delta$(t) are positive periodic functions of period $\omega$. In the nondelay case we shall show that (*) has a unique positive periodic solution (equation omitted), and show that (equation omitted) is a global attractor all other positive solutions. In the delay case we shall present sufficient conditions for the oscillation of all positive solutions of (*) about (equation omitted), and establish sufficient conditions for the global attractivity of (equation omitted). Our results extend and improve the well known results in the autonomous case.

Regulation of Branched-Chain, and Sulfur-Containing Amino Acid Metabolism by Glutathione during Ultradian Metabolic Oscillation of Saccharomyces cerevisiae

  • Sohn Ho- Yong;Kum Eun-Joo;Kwon Gi-Seok;Jin Ingnyol;Kuriyama Hiroshi
    • Journal of Microbiology
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    • v.43 no.4
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    • pp.375-380
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    • 2005
  • Autonomous ultradian metabolic oscillation (T$\simeq$50 min) was detected in an aerobic chemostat culture of Saccharomyces cerevisiae. A pulse injection of GSH (a reduced form of glutathione) into the culture induced a perturbation in metabolic oscillation, with respiratory inhibition caused by $H_2S$ burst pro-duction. As the production of $H_2S$ in the culture was controlled by different amino acids, we attempted to characterize the effects of GSH on amino acid metabolism, particularly with regard to branched chain and sulfur-containing amino acids. During stable metabolic oscillation, concentrations of intra-cellular glutamate, aspartate, threonine, valine, leucine, isoleucine, and cysteine were observed to oscil-late with the same periods of dissolved $O_2$ oscillation, although the oscillation amplitudes and maximal phases were shown to differ. The methionine concentration was stably maintained at 0.05 mM. When GSH (100 $\mu$M) was injected into the culture, cellular levels of branched chain amino acids increased dramatically with continuous $H_2S$production, whereas the cysteine and methionine concentrations were noticeably reduced. These results indicate that GSH-dependent perturbation occurs as the result of the promotion of branched chain amino acid synthesis and an attenuation of cysteine and methionine synthesis, both of which activate the generation of $H_2S$. In a low sulfate medium containing 2.5 mM sulfate, the GSH injections did not result in perturbations of dissolved $O_2$ NAD(P)H redox oscillations without burst $H_2S$ production. This suggests that GSH-dependent perturbation is intimately linked with the metabolism of branched-chain amino acids and $H_2S$ generation, rather than with direct GSH-GSSG redox control.

Vehicle Steering System Analysis for Enhanced Path Tracking of Autonomous Vehicles (자율주행 경로 추종 성능 개선을 위한 차량 조향 시스템 특성 분석)

  • Kim, Changhee;Lee, Dongpil;Yi, Kyongsu
    • Journal of Auto-vehicle Safety Association
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    • v.12 no.2
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    • pp.27-32
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    • 2020
  • This paper presents steering system requirements to ensure the stabilized lateral control of autonomous driving vehicles. The two main objectives of a lateral controller in autonomous vehicles are maintenance of vehicle stability and tracking of the desired path. Even if the desired steering angle is immediately determined by the upper level controller, the overall controller performance is greatly influenced by the specification of steering system actuators. Since one of the major inescapable traits that affects controller performance is the time delay of the steering actuator, our work is mainly focused on finding adequate parameters of high level control algorithm to compensate these response characteristics and guarantee vehicle stability. Actual vehicle steering angle response was obtained with Electric Power Steering (EPS) actuator test subject to various longitudinal velocity. Steering input and output response analysis was performed via MATLAB system identification toolbox. The use of system identification is advantageous since the transfer function of the system is conveniently obtained compared with methods that require actual mathematical modeling of the system. Simulation results of full vehicle model suggest that the obtained tuning parameter yields reduced oscillation and lateral error compared with other cases, thus enhancing path tracking performance.

A Study on a RL-Photocoupler Circuit for Chaos Oscillation (카오스 발진을 위한 RL-광결합기 회로 연구)

  • 정동호;정설희
    • Proceedings of the IEEK Conference
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    • 2003.07c
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    • pp.2835-2838
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    • 2003
  • We study the characteristics of oscillating in non-autonomous condition and the conducted noise generation in a RL-photocoupler circuit. This circuit may be shown a period-doubling and a chaos dynamics under any specific conditions of input circuit. But, the relationship between input signals and output signals is different according to the amplitude of driving input voltage. Then, the oscillation noise was analyzed with respect to both the frequency and the amplitude of an external ac signal and do values. The results show that the noise-induced oscillations for falling and rising cycles induced by kick-back effect in an inductor, nonlinear capacitance, nonlinear resistance and charge storage time in a diode and an LED. We also compared the simulation with the experimental results.

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Nonlinear Oscillation Characteristics in Combination Resonance Region Considering Damping Effects (조합공진 영역에서 감쇠의 영향을 고려한 비선형 진동 응답 특성)

  • Jeong, Tae-Gun
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.20 no.9
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    • pp.849-855
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    • 2010
  • Damping may change the response characteristics of nonlinear oscillations due to the parametric excitation of a thin cantilever beam. When the natural frequencies of the first bending and torsional modes are of the same order of magnitude, we can observe the one-to-one combination resonance in the perturbation analysis depending on the characteristic parameters. The nonlinear behavior about the combination resonance reveals a chaotic motion depending on the natural frequencies and damping ratio. We can analyze the chaotic dynamics by using the eigenvalue analysis of the perturbed components. In this paper, we derived the equations for autonomous system and solved them to obtain the characteristic equation. The stability analysis was carried out by examining the eigenvalues. Numerical integration gave the physical behavior of each mode for given parameters.

Frequency Tracking of Resonance Frequency Variation of L-C Circuits for Wireless Energy Transmission to Medical Devices in Human Organs

  • Gimm, Yoon-Myoung;Ju, Young-Jun;Lee, Yu-Ri;Lee, Dong-Yeol;Wang, Jong-Wook
    • Journal of electromagnetic engineering and science
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    • v.11 no.4
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    • pp.298-303
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    • 2011
  • A capsular endoscope (CE) for inspection of the large intestine requires a motor for backward navigation against the autonomous travel in the intestine. This study proposes an HF power system for generating a magnetic field and for delivering wireless power to the internal or implanted medical devices. The magnetic field is generated by a wound coil (L) around a wooden frame, and the current is driven to the coil through a resonating capacitor (C). The characteristics of the resonance frequency shifting of the L-C series circuit are analyzed. A stable magnetic field intensity in the field coil is maintained by a specially designed frequency tracking system that automatically follows the L-C resonance frequency. Testing confirmed that the oscillation system tracks well the parameter changes of the electric components caused by the operating conditions or environmental variations.