• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제26권3호
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• pp.197-208
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• 2015

Objectives : The purposes of this study were to examine the reliability and validity of the Korean version of Social Communication Questionnaire (K-SCQ) and to determine cut-off scores for diagnosis of autism spectrum disorder (ASD). Methods : A total of 166 subjects with ASD and their 186 unaffected siblings were recruited through child psychiatry clinics of university hospitals. Board certified child psychiatrists screened all probands suspected to have ASD based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. To confirm the diagnoses, the Korean versions of the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview-Revised (K-ADI-R) were administered to all the subjects. All parents completed the K-SCQ and Social Responsiveness Scale (SRS). The non-ASD siblings were evaluated with the same instruments as the probands with ASD. We performed a factor analysis to examine the structure of K-SCQ. For testing the validity of K-SCQ, we compared the difference in Lifetime and Current scores of probands with ASD and their non-ASD siblings using t-test and analysis of covariance. Correlations between the K-SCQ and other measurements of ASD symptomatology, including K-ADI-R totals and domain scores and SRS, were examined. Receiver operation characteristic curve analysis was performed to extract cutoff scores discriminating affection status. Results : Four factors were extracted through factor analysis of K-SCQ ; 1) social relation and play, 2) stereotyped behavior, 3) social behavior, and 4) abnormal language. Cronbach's internal consistency was .95 in K-SCQ Lifetime, and .93 in K-SCQ Current. There were significant differences in total score of K-SCQ, both in Lifetime and Current between the ASD group and non-ASD siblings group (p<.05). K-SCQ scores were significantly correlated with K-ADI-R subdomain scores and SRS total scores (p<.05). The best-estimate cut-off scores of K-SCQ for diagnosis of ASD were 12 for 48 months and over, and 10 for below 47 months. Conclusion : Our findings suggest that the K-SCQ is a reliable and valid instrument for screening autistic symptoms in the Korean population. Lower cut-off scores than the original English version might be considered when using it as a screening instrument of ASD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제17권2호
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• pp.91-97
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• 2006

The effects of the Attachment Promotion Therapy (APT) program for the autistic children were reviewed by 8 papers. The program was consisted with play activity centered mother-child interaction, educational activity for parents, lecture, video-feedback, and support. APT program was effective to improve the attachment behaviors and attachment security. And the mother's behaviors to her child became more child-centered, positively responsive, expressive supportively. Ninety six point seven percent of the mothers were satisfied with the APT program. They described that it was helpful to understand their children's developmental limitation and strength, to learn how to play with their children, to make supportive social network among the mothers, to minimize familial conflicts, and to make them much more comfortable with their children. They thought the APT Program was to be a steppingstone of the further educational program. APT program is an effective early intervention to promote social development and decrease autistic problems.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권6호
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• pp.619-623
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• 2019

We report the case of a seven-year-old boy with an ingested foreign body, which was retained within the appendix for a known duration of ten months, ultimately requiring appendectomy. The ingested foreign body was incidentally discovered by abdominal x-ray at an emergency room visit for constipation. Despite four bowel cleanouts, subsequent x-rays showed persistence of the foreign body in the right lower quadrant. While the patient did not have signs or symptoms of acute appendicitis, laparoscopic appendectomy was performed due to the risk of this foreign body causing appendicitis in the future. A small metallic object was found within the appendix upon removal. This case highlights the unique challenge presented by foreign body ingestions in non-verbal or developmentally challenged children and the importance of further diagnostic workup when concerns arise for potential retained foreign bodies.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제34권4호
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• pp.258-267
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• 2023

Objectives: This study aimed to compare the utility of the Psychoeducational Profile-Revised (PEP-R), Korean Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition (K-WPPSI-IV), and Vineland Adaptive Behavior Scale, Second Edition (VABS-II) for evaluating developmental disabilities (DD) in preschool children. Additionally, we examined the correlations between the PEP-R, K-WPPSI-IV, and VABS-II. Methods: A total of 164 children aged 37-84 months were assessed. Children's development was evaluated using the PEP-R, K-WPPSI-IV, VABS-II, Preschool Receptive-Expressive Language Scale, and Korean Childhood Autism Rating Scale, Second Edition. Results: Of the 164 children, 103 had typical development (TD) and 61 had DD. The mean of the PEP-R Developmental Quotient (DQ), K-WPPSI-IV Full-Scale Intelligence Quotient (FSIQ), and VABS-II Adaptive Behavior Composite (ABC) scores were significantly higher in the TD group than in the DD group (p<0.001). The estimated area under the curve of the PEP-R DQ, K-WPPSI-IV FSIQ, and VABS-II ABC scores was 0.953 (95% confidence interval [CI]=0.915-0.992), 0.955 (95% CI=0.914-0.996), and 0.961 (95% CI=0.932-0.991), respectively, which did not indicate a statistically significant difference. The PEP-R DQ scores were positively correlated with the K-WPPSI-IV FSIQ (r=0.90, p<0.001) and VABS-II ABC scores (r=0.84, p<0.001). A strong correlation was observed between the K-WPPSI-IV FSIQ and VABS-II ABC scores (r=0.89, p<0.001). Conclusion: This study found that the PEP-R, K-WPPSI-IV, and VABS-II effectively distinguished DD from TD in preschool children, and no significant differences in utility were observed between them.

• 대한감각통합치료학회지
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• 제21권1호
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• pp.59-73
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• 2023

목적 : 본 연구는 COVID-19 상황 속 자폐스펙트럼 장애아동의 놀이 활동과 관련된 문헌을 분석하여 재난으로 인한 아동의 놀이 활동 참여 변화를 살펴보고자 하였다. 연구방법 : Arskey와 O'Malley가 제시한 주제범위 문헌고찰의 5단계에 따라 진행되었다. COVID-19가 발표된 2020년 3월부터 2022년 8월까지 CINAHL, PubMed, ERIC, MEDLINE, Google scholar 데이터베이스와 Google 검색엔진을 통해 영문 문헌과 웹사이트 정보를 검색하였다. 문헌의 출판연도, 연구가 이루어진 국가, 연구유형, 대상자 연령, 대상자 수, 연구 결과 등의 10가지 항목에 따라 데이터를 정리하였다. 양적 자료를 통해 관련 주제의 일반적 특성을 알아보았고, 주제 분석을 통해 COVID-19로 인한 아동의 놀이 양상 변화를 확인하였다. 결과 : 437개의 문헌 및 152개의 웹사이트 정보를 검토하여 최종적으로 6개의 문헌이 분석되었다. 분석된 연구는 다양한 나라와 분야의 전문가들에 의해 수행되었다. 문헌에서 공통으로 강조된 5가지 주제는 COVID-19로 인한 자폐스펙트럼 장애아동의 실외 놀이 감소, 스크린 이용 시간 증가, 가족 간 시간 증가, 감각적 어려움, 그리고 연구자가 권고하는 서비스로 나타났다. 결론 : 본 연구에서는 재난 상황 시 자폐스펙트럼 장애아동이 경험하는 놀이 활동 참여의 어려움을 해결하기 위해 주양육자와 자녀가 함께할 수 있는 공동 미디어 참여, 부모 행동 전략 교육 등의 비대면 프로그램을 제안한다. 연구 결과는 향후 재난 상황 시 장애아동의 놀이 활동의 중요성을 강조하고, 이를 지원하기 위한 작업치료사의 역할과 서비스 지침을 체계화하는 데에 기초자료로 활용될 수 있다.

• 대한감각통합치료학회지
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• 제17권2호
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• pp.56-68
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• 2019

목적 : 본 연구는 발달장애 아동과 청소년을 대상으로 한 국내 작업치료의 중재 목표를 International Classification of Functioning, Disability and Health-Children and Youth version(ICF-CY)의 용어를 사용하여 체계적으로 분석하고자 하였다. 연구방법 : Riss, KISS, DBpia를 통하여 2008년 1월부터 2018년 9월까지의 국내 논문을 검색하였다. 검색어는 "아동작업치료", "아동감각통합", "청소년작업치료", "청소년감각통합", "발달장애작업치료", "발달장애감각통합"을 사용하였다. 2차 분류를 통해 최종 7편의 연구를 분석하였다. 연구결과 : 분석 대상 연구의 근거 수준은 개별 실험연구가 가장 많았으며, 중재 대상은 자폐스펙트럼 장애가 가장 많았고, 중재 방법은 감각통합 중재를 가장 많이 적용하였다. ICF-CY의 활동과 참여에 대한 작업치료 목표는 자기관리(33%)와 주요 생활영역(33%), 학습과 지식 적용(11%), 의사소통(11%), 이동(11%) 에서 진행되었다. 결론 : 발달장애 아동과 청소년을 대상으로 한 국내 작업치료 목표는 활동과 참여 영역의 많은 부분에서 진행됨을 확인할 수 있었다. 이를 기반으로 ICF-CY의 활동과 참여 영역에 대한 전문가 중 하나로써 작업치료사의 전문성을 설명할 수 있는 근거가 될 것으로 보인다.

• Mass Spectrometry Letters
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• 제5권2호
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• pp.42-48
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• 2014

A specific and sensitive liquid chromatography-electrospray ionization tandem mass spectrometry method (LC-ESI-MS/MS) was developed and validated for the simultaneous quantification of porphyrins (coproporphyrin, pentacarboxylporphyrin, hexacarboxylporphyrin, heptacarboxylporphyrin, and uroporphyrin) in human plasma and urine. Acidified plasma samples and urine samples were prepared by using liquid-liquid extraction using ethyl acetate and protein precipitation with acetonitrile, respectively. The separation was achieved onto a Synergi Fusion RP column ($150mm{\times}2.0mm$, $4{\mu}m$) with a gradient elution of mobile phase A (0.1% formic acid in 2 mmol/L ammonium acetate, v/v) and mobile phase B (20% methanol in acetonitrile, v/v) at a flow rate of $450{\mu}L$/min. Porphyrins and the internal standard (IS), coproporphyrin I-$^{15}N_4$, were detected by a tandem mass spectrometer equipped with an electrospray ion source operating in positive ion mode. Multiple reaction monitoring (MRM) transitions of the protonated precursor ions and the related product ions were optimized to increase selectivity and sensitivity. The proposed method was validated by assessing selectivity, linearity, limit of quantification (LOQ), precision, accuracy, recovery, and stability. The calibration curves were obtained in the range of 0.1-100 nmol/L and the LOQs were estimated as 0.1 nmol/L for all porphyrins. Results obtained from the validation study of porphyrins showed good accuracy, precision, recovery, and stability. Finally, the proposed method was successfully applied to clinical studies on the autism spectrum disorder (ASD) diagnosis of 203 Korean children.

• 대한지역사회작업치료학회지
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• 제1권2호
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• pp.71-79
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• 2011

목적 : 감각통합에 기반을 둔 작업치료의 효과를 연구한 연구들의 체계적인 고찰을 통하여, 임상에서 치료계획 시 도움이 될 수 있는 정보를 제공하고, 앞으로 감각통합에 기반을 둔 작업치료의 연구 방향을 제시하고자 한다. 연구방법 : MEDLINE/PubMed와 AOTAPress에서 제공되는 연구논문들 중에서 1993년부터 2011년까지 발표된 아동과 청소년을 대상으로 감각통합에 기반을 둔 작업치료 효과를 살펴 본 10개의 논문을 분석하였다. 결과 : 연구대상은 감각조절장애와 자폐스펙트럼의 진단군이었으며, 중재 효과를 증명하기 위에 선택한 다른 중재유형은 여전히 과거의 체계적 고찰연구와 유사하였다. 중재기간은 대체로 감각통합에 기반을 둔 작업치료중재를 10주 이상, 20회기 이상, 적어도 주당 2~3회 정도 실시하였다. 감각통합에 기반을 둔 작업치료중재가 대체로 효과적인 편으로 특히 운동수행영역과 행동개선 영역, 학습과 관련한 교육영역이 효과적인 것으로 나타났고, 최근에는 감각처리 영역이나 작업수행영역에 감각통합중재의 효과가 있음을 GAS를 사용하여 규명하고자 하는 연구노력이 있었다. 결론 : 본 연구를 통하여 임상가들에게 감각통합에 기반을 둔 작업치료중재 효과를 증명할 수 있는 연구디자인의 최소 틀을 알고 연구계획을 실시할 수 있는 근거를 갖게 될 것이다.

• Neonatal Medicine
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• 제25권1호
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• pp.7-15
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• 2018

We need to understand the outcomes into adulthood for survivors born either extremely low birthweight (ELBW; <1,000 g) or extremely preterm (EP; <28 weeks' gestational age), particularly their blood pressure and cardiovascular metabolic status,respiratory function, growth, psychological and mental health performance, and functional outcomes. Blood pressure is higher in late adolescence and early adulthood in ELBW/EP survivors compared with controls. In some studies, expreterm survivors have higher insulin and blood lipid concentrations than controls, which may also increase their risk for later cardiovascular disease. ELBW/EP survivors have more expiratory airflow obstruction than do controls. Those who had bronchopulmonary dysplasia (BPD) in the newborn period have even worse lung function than those who did not have BPD. As a group, they are unlikely to achieve their full lung growth potential, which means that more of them are likely to develop chronic obstructive airway disease in later life. Although they are smaller than term born controls, their weight gradually rises and ultimately reaches a mean z-score close to zero in late adolescence, and they ultimately attain a height z-score close to their mid-parental height z-score. On average, ex-preterm survivors have intelligence quotient (IQ) scores and performance on tests of academic achievement approximately 2/3 SD lower than do controls, and they also perform less well on tests of attention and executive function. They have similar high rates of anxiety and depression symptoms in late adolescence as do controls. They are, however, over-represented in population registries for rarer disorders such as schizophrenia and Autism Spectrum Disorder. In cohort studies, ex-preterm survivors mostly report good quality of life and participation in daily activities, and they report good levels of self-esteem. In population studies, they require higher levels of economic assistance, such as disability pensions, they do not achieve education levels as high as controls, fewer are married, and their rates of reproduction are lower, at least in early adulthood. Survivors born ELBW/EP will present more and more to health carers in adulthood, as they survive in larger numbers.

• 한국콘텐츠학회논문지
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• 제13권7호
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• pp.265-277
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• 2013

본 연구는 정신적 장애인의 경제수준과 직업능력에 따른 취업욕구를 살펴보고 그에 따른 직업재활 활성화 방안을 제안하고자 하였다. 분석자료는 2008년부터 2010년 까지 장애인 고용패널조사에 3년간 참여한 정신적 장애인 298명(가중빈도적용:154,348명)을 대상으로 하였다. 연구결과, 직업교육 참여희망은 남성일 때, 중졸 이상일 때, 자격증을 보유했을 때, 그리고 장애유형중 지적장애일 때 직업교육 참여희망이 높았다. 한편, 취업의사 관련요인은 남성일 때, 가구주일 때, 중등교육 이상 이수하였을 때, 자격증을 보유하고 있을 때, 육체활동 능력이 높아질 때, 그리고 장애유형 중 자폐장애일 때 취업의사가 높았다. 이러한 결과를 토대로 정신적 장애인의 경제활동 참여를 높이기 위하여 정신적 장애인의 의사를 반영한 직업재활 서비스제공 및 사업주 주도적 직업활동 등을 제안하였다.