• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.101.2-101.2
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• 2011

We have developed solar and space weather monitoring system for space weather users since 2007 as a project named 'Construction of Korea Space Weather Prediction Center'. In this presentation we will introduce space weather monitoring system for Geostationary Satellites and Polar Routes. These were developed for satisfying demands of space weather user groups. 'Space Weather Monitoring System for Geostationary Satellites' displays integrated space weather information on geostationary orbit such as magnetopause location, nowcast and forecast of space weather, cosmic ray count rate, number of meteors and x-ray solar flux. This system is developed for space weather customers who are managing satellite systems or using satellite information. In addition, this system provides space weather warning by SMS in which short message is delivered to users' cell phones when space weather parameters reach a critical value. 'Space Weather Monitoring System for Polar Routes' was developed for the commercial airline companies operating polar routes. This provides D-region and polar cap absorption map, aurora and radiation particle distribution, nowcast and forecast of space weather, proton flux, Kp index and so on.

• Publications of The Korean Astronomical Society
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• v.10 no.1
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• pp.127-134
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• 1995

Recent discovery of an Io-related feature in Jupiter's auroral regions prompted us to search for an or multiplet at $1304{\AA}$ in IUE aurora spectra. In three independent IUE spectra taken on January 18, 1981, we found an emission structure at $1304{\AA}$, with a signal-to-noise of about three. If the structure is due to the OI emission, then it is a direct evidence of oxygen ion precipitation, which may originate from Io and Io torus. The emission rates of the $H_2$ band systems and the or multiplet are about 50 kR and 150 R, respectively. We have constructed high resolution model spectra with the estimated emission rates of $H_2$, OI and SI for the Goddard High Resolution Spectrograph (GHRS) onboard the Hubble Space Telescope. The model spectra clearly show the or and SI mulitplets separated from crowded $H_2$ Lyman and Werner band lines, and therefore it is promising to detect the OI and SI multiplets with the GHRS. Given the possibility that the lo-related feature may be caused by ion precipitations from the Io flux tube, it is likely that the OI emission may be detected in the footprint area of the IO flux tube.

• Molecules and Cells
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• v.41 no.5
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• pp.444-453
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• 2018

Aberrations in histone modifications are being studied in mixed-lineage leukemia (MLL)-AF9-driven acute myeloid leukemia (AML). In this study, we focused on the regulation of the differentiation of the MLL-AF9 type AML cell line THP-1. We observed that, upon phorbol 12-myristate 13-acetate (PMA) treatment, THP-1 cells differentiated into monocytes by down-regulating Aurora kinase A (AURKA), resulting in a reduction in H3S10 phosphorylation. We revealed that the AURKA inhibitor alisertib accelerates the expression of the H3K27 demethylase KDM6B, thereby dissociating AURKA and YY1 from the KDM6B promoter region. Using Flow cytometry, we found that alisertib induces THP-1 differentiation into monocytes. Furthermore, we found that treatment with the KDM6B inhibitor GSK-J4 perturbed the PMA-mediated differentiation of THP-1 cells. Thus, we discovered the mechanism of AURKA-KDM6B signaling that controls the differentiation of THP-1 cells, which has implications for biotherapy for leukemia.

• BMB Reports
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• v.48 no.6
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• pp.303-312
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• 2015

Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is an essential protein in the "programmed", or "regulated" necrosis cell death pathway that is activated in response to death receptor ligands and other types of cellular stress. Programmed necrotic cell death is distinguished from its apoptotic counterpart in that it is not characterized by the activation of caspases; unlike apoptosis, programmed necrosis results in plasma membrane rupture, thus spilling the contents of the cell and triggering the activation of the immune system and inflammation. Here we discuss findings, including our own recent data, which show that RIP3 protein expression is absent in many cancer cell lines. The recent data suggests that the lack of RIP3 expression in a majority of these deficient cell lines is due to methylation-dependent silencing, which limits the responses of these cells to pro-necrotic stimuli. Importantly, RIP3 expression may be restored in many cancer cells through the use of hypomethylating agents, such as decitabine. The potential implications of loss of RIP3 expression in cancer are explored, along with possible consequences for chemotherapeutic response. [BMB Reports 2015; 48(6): 303-312]

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.6
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• pp.2781-2800
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• 2016

Emerging attacks aim to access proprietary assets and steal data for business or political motives, such as Operation Aurora and Operation Shady RAT. Skilled Intruders would likely remove their traces on targeted hosts, but their network movements, which are continuously recorded by network devices, cannot be easily eliminated by themselves. However, without complete knowledge about both inbound/outbound and internal traffic, it is difficult for security team to unveil hidden traces of intruders. In this paper, we propose an autonomous anomaly detection system based on behavior profiling and relation mining. The single-hop access profiling model employ a novel linear grouping algorithm PSOLGA to create behavior profiles for each individual server application discovered automatically in historical flow analysis. Besides that, the double-hop access relation model utilizes in-memory graph to mine time-sequenced access relations between different server applications. Using the behavior profiles and relation rules, this approach is able to detect possible anomalies and violations in real-time detection. Finally, the experimental results demonstrate that the designed models are promising in terms of accuracy and computational efficiency.

• Journal of Astronomy and Space Sciences
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• v.21 no.2
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• pp.109-120
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• 2004

STSAT-1 was launched on sep. 2003 with the main payload of Far Ultra-violet Imaging Spectrograph(FIMS). The mission of FIMS is to observe universe and aurora. In this paper, we suggest a simple and reliable strategy adopted in STSAT-1 to synchronize time between On-board Computer(OBC) and FIMS. For the characteristics of STSAT-1, this strategy is devised to maintain reliability of satellite system and to reduce implementation cost by using minimized electronic circuits. We suggested two methods with different synchronization resolutions to cope with unexpected faults in space. The backup method with low resolution can be activated when the main has some problems.

• Journal of Ginseng Research
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• v.45 no.6
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• pp.734-743
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• 2021

Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer. This study explored the regulatory effect of ginsenoside Rh2 on m6A RNA methylation in cancer. Methods: m6A RNA quantification and gene-specific m6A RIP-qPCR assays were applied to assess total and gene-specific m6A RNA levels. Co-immunoprecipitation, fractionation western blotting, and immunofluorescence staining were performed to detect protein interactions and distribution. QRT-PCR, dual-luciferase, and ChIP-qPCR assays were conducted to check the transcriptional regulation. Results: Ginsenoside Rh2 reduces m6A RNA methylation and KIF26B expression in a dose-dependent manner in some cancers. KIF26B interacts with ZC3H13 and CBLL1 in the cytoplasm of cancer cells and enhances their nuclear distribution. KIF26B inhibition reduces m6A RNA methylation level in cancer cells. SRF bound to the KIF26B promoter and activated its transcription. SRF mRNA m6A abundance significantly decreased upon KIF26B silencing. SRF knockdown suppressed cancer cell proliferation and growth both in vitro and in vivo, the effect of which was partly rescued by KIF26B overexpression. Conclusion: ginsenoside Rh2 reduces m6A RNA methylation via downregulating KIF26B expression in some cancer cells. KIF26B elevates m6A RNA methylation via enhancing ZC3H13/CBLL1 nuclear localization. KIF26B-SRF forms a positive feedback loop facilitating tumor growth.

• Safety and Health at Work
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• v.14 no.2
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• pp.201-206
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• 2023

Background: Despite workplaces having policies on fire evacuation, many employees still fail to evacuate when there is a fire alarm. The Reasoned Action Approach is designed to reveal the beliefs underlying people's behavioral decisions and thus suggests causal determinants to be addressed with interventions designed to facilitate behavior. This study is a uses a Reasoned Action Approach salient belief elicitation to identify university employees' perceived advantages/disadvantages, approvers/disapprovers, and facilitators/barriers toward them leaving the office building immediately the next time they hear a fire alarm at work. Methods: Employees at a large public United States Midwestern university completed an online cross-sectional survey. A descriptive analysis of the demographic and background variables was completed, and a six-step inductive content analysis of the open-ended responses was conducted to identify beliefs about leaving during a fire alarm. Results: Regarding consequence, participants perceived that immediately leaving during a fire alarm at work had more disadvantages than advantages, such as low risk perception. Regarding referents, supervisors and coworkers were significant approvers with intention to leave immediately. None of the perceived advantages were significant with intention. Participants listed access and risk perception as significant circumstances with the intention to evacuate immediately. Conclusion: Norms and risk perceptions are key determinants that may influence employees to evacuate immediately during a fire alarm at work. Normative-based and attitude-based interventions may prove effective in increasing the fire safety practices of employees.

• ALGAE
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• v.31 no.3
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• pp.267-276
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• 2016

Microalgae are currently a very promising source of biomass and triacylglycerol (TAG) for biofuels. In a previous study, we identified Chlorella saccharophila as a suitable source of oil for biodiesel production because it showed high biomass and lipid content with an appropriate fatty acid methyl esters profile. To improve the TAG accumulation in C. saccharophila, in this study we evaluated the effect of abscisic acid (ABA) addition on cell concentration, lipid content and TAG production in this microalga. First, we evaluated the effects of four ABA concentrations (1, 4, 10, and 20 μM) added at the beginning of a single-stage cultivation strategy, and found that all concentrations tested significantly increased cell concentration and TAG content in C. saccharophila. We then evaluated the addition of 1 μM ABA during the second stage of a two-stage cultivation strategy and compared it with a nitrogen deficiency treatment (ND) and a combination of ND and ABA (ND + ABA). Although ABA alone significantly increased lipid and TAG contents compared with the control, ND showed significantly higher TAG content, and ND + ABA showed the highest TAG content. When comparing the results of both strategies, we found a superior response in terms of TAG accumulation with the addition of 1 μM ABA at the beginning of a single-stage cultivation system. This strategy is a simple and effective way to improve the TAG content in C. saccharophila and probably other microalgae as a feedstock for biodiesel production.

• Journal of People, Plants, and Environment
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• v.23 no.2
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• pp.179-189
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• 2020

In order to increase the indoor air purification effect of plants, plants need to be placed on 5-10% of indoor spaces. To increase the density and utilization of plants in indoor spaces, studies on bio-wall, a vertical green wall system, have been recently conducted. The purpose of this study was to investigate the growth characteristics of 7 indoor plants introduced to the system and their rooting zones at different irrigation cycles. This study was conducted to investigate a proper irrigation cycle for the continuous maintenance of bio-wall systems. The conditions of their growth environment were maintained as follows: light intensity, 20-50 μmol·m^-2·s^-1 PPFD; and temperature, 20 - 25℃. For fertilization, Hyponex diluted with water at the ratio of 1:1,000 was supplied to plants. Irrigation was treated at intervals of 1, 3, 5, and 7 days for 1 hour at a time. As a result, there was no significant difference in the growth of plants between different irrigation cycles. Dieffenbachia 'Marianne' showed a significant decrease in the number of leaves at the irrigation cycle of 7 days. In addition, the chlorophyll content was relatively low at the irrigation cycle of 7 days. In terms of the color of leaves, a decrease in L value and b value and an increase in a value were observed, resulting in changes in brightness and color. Ardisia pusilla 'Variegata' showed a slightly higher photosynthetic activity and stomatal conductance when it was watered every day and once per 5 days, while Epipremnum aureum showed a relatively higher photosynthetic activity and stomatal conductance at the irrigation cycle of 3 days. In the case of root activity, it was found that the longer irrigation cycle, the higher root activity compared to daily irrigation. The development of roots of Peperomia clusiifolia was promoted by watering at long intervals. However, in the case of Aglaonema 'Siam-Aurora', the total number of roots decreased at the interval of 7 days. In conclusion, a proper irrigation cycle for the sustainable maintenance of vertical bio-wall systems seems to be 3 days.