• Korean Chemical Engineering Research
• /
• v.57 no.2
• /
• pp.205-209
• /
• 2019

The exquisite structure and attractive biological properties of biominerals have great potential and increased interest for use in a wide range of medical and industrial applications. Calcium carbonate biomineralization, mainly controlled by shell matrix proteins, has been used as a representative model to understand the biomineralization mechanism. In this study, in vitro calcium carbonate crystallization was carried out under room temperature and atmospheric pressure using recombinant shell matrix protein GRP_BA and artificial shell matrix protein GG1234. Both proteins inhibited the growth of typical rhombohedral calcite crystals in the calcium carbonate crystallization using $CaCl_2$ solution and $(NH_4)_2CO_3$ vapor, and spherulitic calcite crystals with rosette-like structures were synthesized in both the presence of GRP_BA and GG1234. These results might be caused by the properties of block-like domain structure and intrinsically disordered proteins. We expect that this study can contribute to enhance understanding of the calcium carbonate biomineralization controlled by shell matrix proteins.

• Korean Journal of Clinical Laboratory Science
• /
• v.50 no.4
• /
• pp.391-398
• /
• 2018

Mesenchymal stem cells (MSCs) are an attractive resource for refractory patients because of their anti-inflammatory/immunomodulatory capability and multi-lineage differentiation potential. The transplantation of MSCs has led to positive results in preclinical and clinical application to various diseases, including autoimmune disease, cardiovascular disease, cancer, liver cirrhosis, and ischemic stroke. On the other hand, studies have shown that paracrine factors, not direct cell replacement for damaged cells or tissue, are the main contributors in MSC-based therapy. More recently, evidence has indicated that MSC-derived exosomes play crucial roles in regulating the paracrine factors that can mediate tissue regeneration via transferring nucleic acids, proteins, and lipids to the local microenvironment and cell-to-cell communication. The use of these exosomes is likely to be beneficial for the therapeutic application of MSCs because their use can avoid harmful effects, such as tumor formation involved in cell transplantation. Therefore, therapeutic applications using MSC-derived exosomes might be safe and efficient strategies for regenerative medicine and tissue engineering. This review summarizes the recent advances and provides a comprehensive understanding of the role of MSC-derived exosomes as a therapeutic agent.

• The Journal of the Korea Contents Association
• /
• v.18 no.12
• /
• pp.1-13
• /
• 2018

Senior business has been paid attention due to rapid global aging and baby boomers turning 60. However, senior business is not successful as expected because of a lack of understanding of consumers and small size of Korean domestic market. Understanding of senior consumers and overseas markets and providing attractive product and service contents needs to overcome the current challenges. Therefore, this study explores and compares consumers of different generation and different countries. We employ consumption value theory and analyze which consumption values are perceived strongly by each four group(Korean consumers in their 20s, Korean their consumers in 50s, Chinese consumers in their 20s, and Chinese consumers in their 50s). We conducted online survey to compare consumption values among samples of consumers in two countries: Korea and China. There are forty survey instruments in twelve consumption values. The results can be used to develop a strategy for planning, developing, distributing, and promoting product and service contents which consumers, in particular baby boomers, have a strong intention to purchase it.

• International Area Studies Review
• /
• v.13 no.3
• /
• pp.413-438
• /
• 2009

Tourism is an attractive field of industry to many countries due to its strong potentials in increasing employment rates as well as improving the national image. The positive effect of the tourism on the national economy and globalization has been recognized in Korea. A multilateral effort has been made in order to develop its tourist industry. Therefore, it is necessary to analyze the patterns of tourism demand in Korea. The present study analyzes and demonstrates the effects of a nation's characteristics on tourism demand. The study model was based on factors that affected tourism demand, especially emphasizing on the economic size, distance, national income, and language differences from the mother country. In particular, this study highlights the effects of economic relations between the countries and their exchange rate on tourism demand. In summary, this thesis demonstrates that actual national and international panel data enhance the credibility of the research and precisely determine factors that have a direct influence on tourism demand. A corresponding strategy of development and products are required as most tourists show the preference in advanced nations.

• Korean Journal of Heritage: History & Science
• /
• v.43 no.1
• /
• pp.4-27
• /
• 2010

In this article, concepts, types, and aspects of geological heritage with increasing interests as utilization as tourist attractions domestically and internationally are introduced, and the characteristics of the interpretive facilities for geological heritages in western Australia, one of the most famous geotourism areas, are considered. Based on this, the potential geotourism for the Korean Cretaceous geological heritages including dinosaur fossil sites is discussed in diverse aspects including academic values, academic and tourism infrastructures, characteristics of geotourists, systematic devices for conservation of geological heritage, economic value, and sustainability as tourist attractions. Although the Korean Cretaceous geosites are not quite competent in their scale or diversity when compared to world-class geosites, convenient access, world-class unique geographical characteristics of each geosites, and relatively cheaper travelling expenses seems to be able to give the geotourism of the South Korean Cretaceous geosites a competitive edge, attractive for international and domestic tourists seeking unique experience of 'Age of dinosaurs' for short periods with easy access from metropolitan areas and low costs. Likewise, the development of geotourism for the Korean Cretaceous geosites can revitalize the geotourism industry in South Korea, contributing to the growth in job opportunities, including students majoring in geological sciences at University.

• Investigative Magnetic Resonance Imaging
• /
• v.23 no.3
• /
• pp.179-201
• /
• 2019

Portable low-cost magnetic resonance imaging (MRI) systems have the potential to enable "point-of-care" and timely MRI diagnosis, and to make this imaging modality available to routine scans and to people in underdeveloped countries and areas. With simplicity, no maintenance, no power consumption, and low cost, permanent magnets/magnet arrays/magnet assemblies are attractive to be used as a source of static magnetic field to realize the portability and to lower the cost for an MRI scanner. However, when taking the canonical Fourier imaging approach and using linear gradient fields, homogeneous fields are required in a scanner, resulting in the facts that either a bulky magnet/magnet array is needed, or the imaging volume is too small to image an organ if the magnet/magnet array is scaled down to a portable size. Recently, with the progress on image reconstruction based on non-linear gradient field, static field patterns without spatial linearity can be used as spatial encoding magnetic fields (SEMs) to encode MRI signals for imaging. As a result, the requirements for the homogeneity of the static field can be relaxed, which allows permanent magnets/magnet arrays with reduced sizes, reduced weight to image a bigger volume covering organs such as a head. It offers opportunities of constructing a truly portable low-cost MRI scanner. For this exciting potential application, permanent magnets/magnet arrays have attracted increased attention recently. A magnet/magnet array is strongly associated with the imaging volume of an MRI scanner, image reconstruction methods, and RF excitation and RF coils, etc. through field patterns and field homogeneity. This paper offers a review of permanent magnets and magnet arrays of different kinds, especially those that can be used for spatial encoding towards the development of a portable and low-cost MRI system. It is aimed to familiarize the readers with relevant knowledge, literature, and the latest updates of the development on permanent magnets and magnet arrays for MRI. Perspectives on and challenges of using a permanent magnet/magnet array to supply a patterned static magnetic field, which does not have spatial linearity nor high field homogeneity, for image reconstruction in a portable setup are discussed.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.45 no.1
• /
• pp.95-103
• /
• 2019

Lips have a defect in maintenance of moisture due to their thin layer. As aging progresses, lips lose volume and redness, and become wrinkled. Fat grafting and filler surgery have been used to achieve attractive lips, but little research has been reported to develop better materials to replace the present methods. Recently, a study suggests that the increase of adipocyte number can be enhancing the expansion endogenous fat. In previous study, we identified that the efficacy of Magnolia officinalis bark extract (MOBE) was effective on the induction of adipogenic differentiation. In this study, we confirmed that MOBE enhanced the differentiation of human adipose-derived stem cells on the fat mimic 3D structure built by 3D bioprinting method From further experiments in human, we established a method to quantify the severity of lip wrinkle by measurement of standard deviation of gray value using Image J software. Finally, we found that topical treatment with 1% MOBE formulated lip balm significantly improved the lip wrinkle after using for 12 weeks. In conclusion, these findings suggest that MOBE has great potential, as a cosmetic ingredient, to reduce the lip wrinkle through the effect of promoting adipogenic differentiation.

• Journal of Digital Convergence
• /
• v.17 no.1
• /
• pp.159-168
• /
• 2019

The purpose of this study is to propose a strategy for creating an advertisement for Corporate Social Responsibility(CSR) based on the strategy of selecting an advertisement model in order to efficiently execute the advertisement of CSR. Data were analyzed by regression analysis. The results of this study are as follows: First, it is found that the value-relevance factors of the model are important regardless of the theme of CSR. In the economic field, the reliability of the model is important. But, the attractiveness of the model was more important in the environmental field. Second, it is effective to select a model with high value-relevance when selecting CSR advertising model. But, in the case of an expert, it is effective to select not only value addition, but also attractive and reliable models. Third, when producing CSR ads using emotional messages, it is important to consider the value and reliability of the advertising model. But, it is important to select the model considering the importance of the value and attractiveness of the advertisement model when producing the CSR advertisement using the informational message. It was found that it is very important to select a model that has a high relevance to the image of the social responsibility subject and the advertisement model when producing the social responsibility advertisement.

• Journal of Korean Classical Literature and Education
• /
• no.15
• /
• pp.67-88
• /
• 2008

In spite of a few numbers of Hyangga that is handed down today, Hyangga has diverse and abundant contents. So it is possible to survey Hyangga as a journey literature of the middle age. On this purpose we can inquire into the Hwarangs' group journey, because the Hwarang was one of the main enjoying group of Hyangga. Hwarangs' group journey shows many aspects. They made a journey for the public purpose like a tour of inspection of people's daily life and the fortresses of the country's peripheral areas. Also, they made a journey for personal purposes like enjoying the attractive view of the mountains and rivers or seeking pretty girls outside of the palace. On these journeys, Hwarang made and enjoyed Hyanggas. Among Hyanggas that remains today, Hyeseongga and Cheoyongga have a direct relation to Hwarang's journey. Hyeseongga was made to eliminate the calamities that occurred at the time of the start of a journey. It is expressed in this poem that Hwarang could take a peaceful trip with the condition that the celestial objects shed light on the earth path. As such, the trip becomes a sacred ceremony. Cheoyongga reflects the fact that the foreigner Cheoyong became Hwarang and toured the streets of Seorabeol, the capital of Shilla. The Cheoyong's bitterness of broken love is expressed in this poem. SongSadahamga and MoJukjirangga come under a broad category of Hwarang's journey literature. SongSadahamga is a farewell poem for Hwarang who leaves to fight on the battlefield. It was universal to make a journey for the fighting of a battle in Shilla period, so many Hyanggas would be made under those situations. MoJukjirangga has the content of Hwarang's trip for saving his follower who was taken by another senior. It expresses the intimate relationship between Hwarang and the follower. Though the words of the song have not been remained, Hyeongeumpogok, Daedogok, and Mungungok were created on the way of Hwarang's journey. These seem to be a series poems which have the proper characteristic features of the Hwarang's journey literature. In these poems, the king's open mind and liberal political views are reflected. In short, Hwarang created and enjoyed Hyanggas on the way of their journey, so Hyangga has the features of journey literature in Korean middle ages.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.16 no.3
• /
• pp.485-492
• /
• 2021

The wind turbines with a rated capacity of 50kW or less are generally considered as small class. Small wind turbines are an attractive alternative for off-grid power system and electric home appliances, both as stand-alone application and in combination with other energy technologies such as energy storage system, photovoltaic, small hydro or diesel engines. The research objective is to develop the 50kW scale wind turbine blades in ways that resemble as closely as possible with the construction and methods of utility scale turbine blade manufacturing. The mold process based on wooden form is employed to create a hollow, multi-piece, lightweight design using carbon fiber and fiberglass with an epoxy based resin. A hand layup prototyping method is developed using high density foam molds that allows short cycle time between design iterations of aerodynamic platforms. A production process of five blades is manufactured and key components of the blade are tested by IEC 61400-23 to verify the appropriateness of the design. Also, wind system with developed blades is tested by IEC 61400-12 to verify the performance characteristics. The results of blade and turbine system test showed the available design conditions for commercial operation.