• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.6
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• pp.1365-1380
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• 2007

Based on the theories and clinical data of oriental medicine, traditional medicinal prescriptions known to be effective to diabetic nephropathy were collected. The prescriptions were carefully examined and analyzed in order to be used as fundamental material for experiments and in clinicals. More than 40 publications related to diabetes were arranged and analyzed. Of the complications, diabetic nephropathy part of the publications were specifically focused during analysis. Data were analyzed and classified according to the quantity, prescription, differentiation of symptoms, signs and addition and subtraction of each medicine. Frequently used medicines were statistically analyzed. The most frequently used prescription was Yukmigihwang-tang(六味地黃湯) based medicine and prescriptions of its addition and subtraction, which was 15% of the total prescriptions cited. The most frequently used medicine was Astragali Radix, mentioned 192 times in the prescriptions. Hoelen was next with 180 citations, followed by Dioscoreae Rhizoma with 147 times, Rehmanniae Radix with 140, Corni Fructus with 131, Salviae Miltiorrhizae Radix with 106, Angelicae Gigantis Radix with 101, Alismatis Rhizoma with 95, Rhei Rhizoma with 90, Atractylodis Rhizoma Alba with 84, Rehmanniae Radix Preparata with 78, Leonuri Herba with 74, Moutan Cortex Radicis with 66, Aconiti Lateralis Preparata Radix with 66 Cnidii Rhizoma with 65, Pseudostellaria heterophylla with 62, Liriopis Tuber with 55, Lycii Fructus with 52, Rhei Rhizoma with 49, Codonopsis Pilosulae Radix with 44, Paeoniae Radix Rubra with 44, Schisandrae Fructus with 42, Polyporus with 42, Achyranthis Radix with 41 and Euryales Semen with 40. Medicines prescribed more than 30 grams a day included Astragali Radix, Imperatae Rhizoma, Benincasae Pericarpium, Leonuri Herba, Dioscoreae Rhizoma, Plantaginis Semen, Polyporus, Hoelen, Halloysitum Rubrum, Achyranthis Radix, Arecae Pericarpium, Phaseoli Angularis Semen, Coicis Semen, Rhei Rhizoma, Salviae Miltiorrhizae Radix, Sargassum, Ostreae Concha, Pseudostellaria heterophylla, Epimedii Herba, Rehmanniae Radix, Scrophulariae Radix and Polygonati Rhizoma. No scientific reports on the traditional medicinal aspects of diabetic nephropathy was searched. This analysis report would be able to provide the basis of developing new drug candidates for the treatment of diabetic nephropathy, as well as securing the EBM for the traditional medicines already being prescribed to the patients.

• Herbal Formula Science
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• v.11 no.2
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• pp.83-94
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• 2003

This study aimed to investigate the effects of each constituent-herb of Sagoonja- Tang on the plasma corticosterone level in mice exposed to cold stress. Sagoonja-Tang is composed of Ginseng Radix, Atractylodis Radix, Poria, and Glycyrrhizae Radix. Each constisuent-herb(0.5g/kg, 1.0g/kg) was administered intragastrically to mice 1hr prior to expose to forced cold water swimming($4{\circ}C$, 3min) before measuring the change of plasma corticosterone level of mice. The results were as follows: 1. At 30 minutes after the cold stress for 3 minutes the most significant increase of corticosterone level was shown. 2. Ginseng group(PGR group) didn't show any significant changes. 3. Atractylodis group(AR group) showed significant decrease at 0.5g/kg dose (P<0.01). But it didn't show significant changes at 1.0g／kg dose. 4. Poria group(P group) didn't show significant changes. But it showed slightly increase at 1.0g/kg dose. 5. Glycyrrhizae group(GR group) didn't show significant changes. These data revealed that Atractylodis macrocephalae Rhizoma might have the anti-stress effect through the control of plasma corticosterone level and the dose of herbs had a different effect on the plasma corticosterone level in mice exposed to cold stress.

• Herbal Formula Science
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• v.25 no.2
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• pp.325-336
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• 2017

Objectives : The purpose of this study is to find out herb-pair prototype composed of Aconiti Radix(烏頭) or Aconiti Lateralis Preparata Radix(附子) written in ancient chinese medical classics. Methods : To search usages of Aconiti Radix and/or Aconiti Lateralis Preparata Radix, we have investigated the classics of herb and prescription such as "Fifty-two kinds of Diseases"("五十二病方"),"WuWeiHanDaiYiJian" ("武威漢代醫簡"),"Treatise on Febrile Caused by Cold"("傷寒論"),"Synopsis of Prescriptions of The Golden Chamber"("金匱要略"). Results : There were three herb pairs of Aconiti Radix and/or Aconiti Lateralis Preparata Radix in "Fifty-two kinds of Diseases", four herb pairs of it in "WuWeiHanDaiYiJian", eight herb pairs of it in "Treatise on Febrile Caused by Cold", and five herb pairs of it in "Synopsis of Prescriptions of The Golden Chamber". Conclusions : 1. Aconiti Radix herb-pairs written in ancient chinese medical classics are as follows ; Cinnamomi Cortex(桂), Arsenopyritum(礜) and Veratri Nigri Rhizoma et Radix(藜蘆). Zanthoxyli Fructus(蜀椒), Aconiti Lateralis Preparata Radix(附子), honey(蜜) and Asari Radix(細辛). 2. Aconiti Lateralis Preparata Radix(附子) herb-pairs written in ancient chinese medical classics are as follows ; Zanthoxyli Fructus(蜀椒), Paeonia Radx(芍藥), Ephedrae Herba(麻黃), Zingiberis Rhizoma(乾薑), Zingiberis Rhizoma(乾薑)-Allii Radix(葱白), Cinnamomi Cortex(桂), Atractylodis Rhizoma White(白朮), Poria(茯苓), Atractylodis Rhizoma White(白朮)-Poria(茯苓) and Gentianae Macrophyllae Radix(秦艽), Coisis semen(薏苡仁), Pinelliae Rhizoma(半夏). 3. In "Fifty-two kinds of Diseases"only Aconiti Radix was used and in "Treatise on Febrile Caused by Cold"only Aconiti Lateralis Preparata Radix was used, but in "WuWeiHanDaiYiJian"and "Synopsis of Prescriptions of The Golden Chamber"both herbs were used. 4. Method for reducing toxicity of Aconiti Radix and Aconiti Lateralis Preparata Radix was found in "Treatise on Febrile Caused by Cold"and "Synopsis of Prescriptions of The Golden Chamber".

• Herbal Formula Science
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• v.10 no.1
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• pp.41-55
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• 2002

There are total 403 prescriptions containing Radix Scutellariae in Donguibogam and among them, 106 prescriptions treat Radix Scutellariae as a principal medicine. This report describes the study on therapeutic range, symptom, pathology and composition of 106 Radix Scutellariae-main blended Prescriptions from Donguibogam. The frequency and percentage of Radix Scutellariae-main blended prescriptions for the therapeutic range are as follows; cold symptom-complex is the most frequent(11 prescriptions, 10.37%) and gynecology is second(10 prescriptions, 9.43%). The symptoms that Radix Scutellariae-main blended prescriptions are made out for are 70 prescriptions of 28 therapeutic ranges, for example, minor Eum physical appearance, fire of triple burners jaundice, etc. The main pathologies that Radix Scutellariae-main blended prescriptions are being affected by cold, fire triple burners, dampness and heat, wind and heat, heat of heart and lung, heat of liver, heat of spleen, etc. Through the research into the composition of Radix Scutellariae-main blended prescriptions, the kind of medicines and certain rules of compounding medicines centering on Radix Scutellariae are deduced as follows: The main combinations of herbal medicines are Radix Scutellariae and Fructus Gardeniae, Radix Scutellariae and Rhizona Rhei, and Radix Scutellariae, Rhizona coptidis and Fructus Gardeniae. The main combinations of prescriptions are Yihwanghwan(Radix Scutellariae, Rhizoma Cotidis, Radix Glycyrrhizae), Boanbaekchulsan(Radix Scutellariae. Rhizoma Atractylodis macrocephalae), Sambohwan(Radix Scutellariae, Rhizoma Cotidis, Cortex Phellodendrj), Samhwangwon(Radix Scutellariae, Rhizoma Cotidis, Rhizoma Rhei), Hwangryeonhaedoktang(Radix Scutellariae, Cortex Phellodendri, Rhizoma Cotidis. Fructus Gardeniae), Daegumhwahwan(Radix Scutellariae, Rhizoma Cotidis, Cortex Phellodendri. Rhizoma Rhei). Sanyeolumja(Radix Scutellariae. Rhizoma Cotidis. Radix Osterici koreani. Radix Ledebouriellae), etc.

• Korean Journal of Pharmacognosy
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• v.14 no.3
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• pp.113-118
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• 1983

Studies were undertaken to develop for the anti-inflammatory analgesic activities of 'Insam-Tang' extract, which composed of four crude drugs; Ginseng Radix, Glycyrrhizae Radix, Atractylodis Rhizoma, and Zingiberis Rhizoma, was known to be applied in edema, convulsion, excremental blood, and cooling pain etc, in oriental herb remedies. It was exhibited significant anti-inflammatory effect on carrageenin inflammation, and preventive and therapeutic effects to chronic inflammation on Freund' complete adjuvant in rats, Especially, therapeutic effect of extract 500mg/kg was observed more effective than that of phenylbutazone 50mg/kg. Also, it was shown significant effect on leakage of dye into the peritoneal cavity and analgesic effect on squirm symptom induced by acetic acid in mice.

• Korean Journal of Pharmacognosy
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• v.30 no.4
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• pp.363-367
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• 1999

Palmultang(PMT) consists of Ginseng Radix Alba, Atractylodis Rhizoma Alba, Hoelen, Glycyrrhizae Radix, Rehmanniae Radix Preparata, Paeoniae Radix, Cnidii Rhizoma and Angelicae Gigantis Radix. PMT enhanced the lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles and inhibited the production of nitric oxide in murine peritoneal macrophage. PMT enhanced the production of ${\gamma}-interferon$, interleukin-2 and the cell viability in murine thymocyte, but did not affect the production of interleukin-4. These results indicate that PMT enhances the phagocytosis of macrophage via the stimulation of ${\gamma}-interferon$ production in $T_H1$ cells and the reduction of nitric oxide production in peritoneal macrophage.

• Korean Journal of Pharmacognosy
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• v.15 no.3
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• pp.115-120
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• 1984

'Bojungikgi-tang' consists of Astragali Radix, Ginseng Radix, Atractylodis Rhizoma alba, Glycyrrhizae Radix, Angelicae gigantis Radix, Aurantii nobilis Pericarpium, Cimicifugae Rhizoma and Bupleuri Radix. It has been widely prescribed in oriental medicine for controlling digestive functions and for health. Experimental studies were implemented on analgesic, sedative and antipyretic actions. The results showed significant analgesic and antipyretic actions were recognized. Sedative actions were significantly noted.

• Journal of Society of Preventive Korean Medicine
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• v.3 no.1
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• pp.101-123
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• 1999

To investigate the documental records of the medi-alcohol theraphy on the Gastrointestinal disease, the 33 kinds of medical books editioned from the old to the present were used. the results were followed Many herbs used on the Gastrointestinal disease were sequently Atractylodis Macrocephalae Rhizoma, Zingiberis Rhizoma, Ginseng Radix. The herbs of invigorating and warming body, regulating the flow of qi etc. were many occupied(used) in treating the Gastrointestinal disease. In analyzing treatment symptom as medi-alcohol theraphy were sequently many used abdominal pain, inappetence, gastrointestinal cancer, indigestion, fatigue, vomiting, diarrhea, abdominal dropsy. The kinds of using medi-alcohol on the Gastrointestinal disease were totally 120 ones.

• The Journal of Pediatrics of Korean Medicine
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• v.32 no.4
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• pp.103-112
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• 2018

Objectives The purpose of this study is to provide clinical evidences on effectiveness of herbal medicine treatment regarding pediatric growth based on recent clinical studies. Methods Selected 17 clinical studies since January 1998 to June 2018 from the Journal of Pediatrics of Korean Medicine and OASIS Traditional Medicine Knowledge Portal were reviewed. Results Medications that strengthening spleen and stomach (健脾胃藥), digestant (消導藥), supplementing kidneys (補 腎藥), and lungs (補肺藥) were frequently used. Frequently used herbs were Hoelen (茯?), Citri Pericarpium (陳皮), Glycyrrhizae Radix (甘草), Atractylodis Rhizoma Alba (白朮), Dioscoreae Rhizoma (山藥), Angelicae Gigantis Radix (當歸), Amomi Fructus (砂仁), Rehmanniae Radix Preparata (熟地黃). Conclusions This study showed that Korean herb medicine treatment can be effective for pediatric growth.

• Herbal Formula Science
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• v.7 no.1
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• pp.167-181
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• 1999

Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae, Radixi, Radix Ledeboutriellae, Rhizoma Atractylodis, Herba Ephedrae, Radix Puerariae and Radi Aconitx Bupleuri have been used in Korea for many centuries as a treatment for various disease. The purpose of the present study is to determine the effect of several herbs on norepinephrine(NE) induced blood vessel contraction in rabbits and pigs. Rabbit(2 kg, male) were killed by $CO_2$ exposure and a segment (8-10mm) of each rabbit was cut into equal segments and mounted in a tissue bath. Contractile force was measured with force displacement transducers under 2-3 g loading tension. The dose of norepinephrine(NE) which evoked 50% of maximal response $(ED_{50})$ was obtained from cumulative dose response curves for NE $(10^{-6}{\sim}10^{-3}M)$. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Rhizoma Arisaematis, Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Folium Perillae, Radix Sophorae Subprostratae and Herba Ephedrae in abdominal aorta. Contractions evoked by NE $(ED_{50})$ were inhibited significantly be Lignum Akebiae, Rhizoma Zedoariae, Cortex Eucommiae, Herba Ephedrae, Radix Puerariae and Radix Bupleuri in femoral artery. Contractions evoked by NE $(ED_{50})$ were inhibited significantly by Radix Sophorae Subprostratae, Radix Aconiti and Herba Ephedrae in renal artery. These results indicate that each herb can relax NE induced contraction of rabbit and pig blood vessel selectively, and that this relaxation relates to Gui-Gyung(歸經).