• Clinical and Experimental Pediatrics
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• 제57권5호
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• pp.205-210
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• 2014

Atopic sensitization is a complex phenomenon that changes dynamically with age throughout childhood; its prevalence increases with age in young children. Additionally, with increasing age, the prevalence of sensitization to inhalant allergens and the prevalence of polysensitization to allergens increase. It is also well established that the development of atopic sensitization is the result of a complex interplay of genetic and environmental factors. However, there is considerable heterogeneity in the literature in terms of the effect of different environmental exposures in young children on the subsequent risk of atopic sensitization and allergic diseases. Previous studies on the relationship, in early life, between pet ownership, sex, exposure to secondhand smoke, exposure to traffic-related air pollution components, and atopic sensitization have yielded different results. Recent studies have highlighted the importance of gene-environment interactions, especially during early childhood, on the risk of subsequent atopic sensitization and allergic diseases. Therefore, pediatricians should consider the genetic and environmental determinants of atopic sensitization in infants and young children when diagnosing and treating patients with allergic diseases. Determining ways in which early exposure to these risk factors in young children may be reduced could be beneficial in preventing the likelihood of developing atopic sensitization.

• 재활간호학회지
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• 제15권2호
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• pp.83-90
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• 2012

Purpose: The purpose of this study was to investigate the factors associated with atopic dermatitis in Korean adults. Methods: The data were obtained from the Korean National Health and Nutrition Survey on 2008. Subjects of this study were 7,280 adults aged older than 18 years. The data were analyzed for demographic characteristics, health status, alcohol drinking, smoking, hypertension, hyperlipidemia, asthma, chronic sinusitis, rhinitis, stress, depression, and suicidal ideation between atopy group and non-atopy group. Results: Among 7,280 subjects, 2.9% of Korean adults had a diagnosis of atopic dermatitis from doctor. Multiple logistic regression identified that the presence of atopic dermatitis was associated with marital status (OR=2.66, CI 1.84~3.86, p<.001), rhinitis (OR=1.52, CI 1.04~2.22, p = .030), and depression (OR=1.89, CI 1.04~3.41, p = .036). Conclusion: Based on these results, marital status, rhinitis, and depression should be considered in addressing individuals with atopic dermatitis. And the other factors contributing to atopic dermatitis need to be specifically identified.

• 지역사회간호학회지
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• 제28권4호
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• pp.504-512
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• 2017

Purpose: This study aims to investigate the effects of atopic dermatitis on suicidal ideation, plans and attempts in young adult. Methods: Data are from the Sixth Korean National Health and Nutrition Examination Survey (KNHANES VI, 2013, 2015) in a sample of 2,983 respondents aged 19 to 39 years. Data were analyzed using Frequency, Percentage, $x^2$ test, Complex sample multivariate binary logistic regression analysis with SPSS version 18.0 software. Results: Firstly, factors affecting suicidal ideation are gender, education level, smoking, self-reported health status, asthma, depression and stress perception. Factors affecting suicidal plan are education level, self-reported health status, asthma and depression. Lastly, factors affecting suicidal attempt are gender, education level, smoking, self-reported health status, depression and stress perception. Compared to non-atopic group, the prevalence of suicidal ideation and plan of atopic group increased from odds ratio 2.14 to 2.48 and 1.90 to 2.50, respectively. Odds ratio for suicidal attempt was odds ratio 2.69 (10% error level). Conclusion: The results show that atopic dermatitis in young adult affects suicidal ideation, plans and attempts. Therefore, it is necessary to identify atopic patients who have suicidal thoughts and plans and develop an intervention program to prevent and manage suicide in young adult.

• 대한한방소아과학회지
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• 제23권2호
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• pp.87-101
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• 2009

Objectives : The purpose of this study is to investigate the effect of JUJSTK on atopic dermatitis in an in-vitro experiment using an NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to the humans in terms of health condition. Methods : We evaluated IL-1$\beta$, IL-6, IL-10, TNF-$\alpha$ mRNA, TGF-$\beta$ mRNA, CD4+/IFN-$\gamma$+ and IL-17+CD4+Th17 cells of NC/Nga atopic dermatitis mouse by real-time PCR and intracellular staining in vitro. Results : JUJSTK medicines supressed the activities of IL-1$\beta$, IL-6, TNF-$\alpha$, TGF-$\beta$ mRNA and IL-17+CD4+Th17 cells and it incresed the activities of IL-10 mRNA in B cells. The level of CD4+/IFN-$\gamma$+ in T cells were increased by JUSSTK. Conclusions : JUJSTK on atopic dermatitis might be incredibly effective to the atopic dermatitis treatment.

• 대한한방소아과학회지
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• 제23권1호
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• pp.23-35
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• 2009

Objectives The purpose of this study is to investigate the effect of Kakamsodokum (KKSDU) on atopic dermatitis in an in-vitro experiment using an NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to the condition in humans. Methods We evaluated $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, $TGF-{\beta}$, IL-10 mRNA, CD4+/$IFN-{\gamma}+$, and CD4+CD25+foxp3+ in B and T cells of NC/Nga atopic dermatitis mouse by real-time PCR and intracellular staining in vitro. Results KKSDU medicines supressed $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, $TGF-{\beta}$ mRNA and increased IL-10 mRNA in B cells. CD4+/$IFN-{\gamma}+$ and CD4+CD25+foxp3+ in T cells were increased by KKSDU. Conclusions KKSDU on atopic dermatitis might be very effective to the atopic dermatitis treatment.

• 대한한방소아과학회지
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• 제15권2호
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• pp.177-188
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• 2001

Background : Atopic Dermatitis is thought to be a common and chronic relapsing inflammatory skin disease that probably results from allergic reaction. Because it make some serious problems in children, it is needed to treat and at least subside symptoms. Objective : The aim of this study was to evaluate the efficacy of GamiYeoldahansotang(加味熱多寒少湯) for treating Atopic Dermatitis and survey the general characteristics in children with Atopic Dermatitis. Method : Atopic Dermatitis with typical clinical symptoms were included in this study. Forty two patients were treated with hot water extract of GamiYeoldahansotang(加味熱多寒少湯) for four weeks. Clinical evaluation were made by Jacob T scoring system before and after treatment. Total Serum IgE, Eosinophil count were also conducted. Results : Reduction in body surface area was not observed. But significant reductions of severity scores before and after adminstration of GamiYeoldahansotang(加味熱多寒少湯) were observed in all of three groups: mind, moderate, severe. specially severe intensity group was very statistically significant.(p<0.05) Conclusion : We speculate that GamiYeoldahansotang(加味熱多寒少湯) has some therapeutic effects in mitigating the symptoms of Atopic Dermatitis.

• 대한상한금궤의학회지
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• 제6권1호
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• pp.71-78
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• 2014

Objective : This study reports the effect of Gamchosasim-tang on atopic dermatitis. Methods : According to shanghanlun six meridian patterns diagnostic system, We diagnosed Taeyang-byung kyeolhyung. The symptoms of atopic dermatitis were worsen when the patient had bad sleeping habits by stress(心煩不得安). So the patient treated with Gamchosasim-tang for 3 months. The severity of atopic dermatitis was evaluated by SCORAD index, EASI and pictures. Results : After the treatment, SCORAD index and EASI decreased $75.9{\rightarrow}27.9$, $19{\rightarrow}5.7$ each. And sleeping habits also improved. Conclusions : Gamchosasim-tang improved the symptoms of atopic dermatitis on this study. Although Gamchosasim-tang is not an usual treatment for atopic dermatitis, we could prescribe the medicine due to shanghanlun six meridian patterns diagnostic system. And Further research would be needed the relation between bad sleeping habits cased by stress(心煩不得安) and Gamchosasim-tang.

• Child Health Nursing Research
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• 제15권4호
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• pp.401-408
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• 2009

Purpose: This study was done to assess the home nursing and quality of life of parents caring for preschool children with atopic dermatitis and to identify the factors which influence quality of life. Methods: Participants in the study were 149 parents of preschool children with atopic dermatitis attending a kindergarten and a nursery school in S city. Parent completed a set of questionnaires (assessing demographic factors, home nursing, quality of life). Descriptive analysis, t-test, ANOVA and multiple regression were used to analyze the data. Results: The mean score for home nursing was $3.06{\pm}0.38$ and for quality of life, $4.18{\pm}0.74$. The lowest scored question in the 13 question on quality of life was that of frustration related to itching sensation. Significant factors that affect quality of life were severity and home care. These variables explained 21% of variance in quality of life (F=21.17, p<.001). Conclusion: The results indicate that severity of childhood atopic dermatitis and home nursing impact on the quality of life of parents. Using the above findings, health professionals who work with children with atopic dermatitis and their parents need to develop specific nursing interventions that will promote health of children with atopic dermatitis and quality of life in their parents.

• 한방안이비인후피부과학회지
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• 제20권2호통권33호
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• pp.230-239
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• 2007

Introduction : Atopic dermatitis is very epidermic disease in these days. Atopic dermatitis is difficult for patient to be treated because there is no specific treatment. The oriental method of atopic dermatitis is varied as patient situation and doctor's view point. The Treatise on Febrile Diseases(傷寒論) may be a hint for atopy disease. Object: Although we use various method such as acupucture, aroma therapy, a medicine for external use, we use the two decoctions in the Treatise on Febrile Diseases according to differentiation of syndromes and abdominal diagnosis. Result : After inpatient treatment in 21 days, the itching, redness, exudation, crust, lichen get better and insomnia and constipation was removed quickly. The SCORAD index is decreased from 84.2 to 25.9. Conclusion : These decoction can treat the atopic dermatitis although there is no symptom in atopy because we cure the all situation of the patient. We can cure the atopic dermatitis not only by routine remedy for various symptoms but also by diagnosis and treatment based on overall analysis of symptoms and signs.

• 한방안이비인후피부과학회지
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• 제29권3호
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• pp.208-216
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• 2016

Objectives : The purpose of this study is to report the effectiveness of Soshiho-tang on the patients who suffered from atopic dermatitis with gastrointestinal disorders.Methods : We diagnosed the symptoms and the signs of the patients who suffered from atopic dermatitis with gastrointestinal disorders as Soshiho-tang syndrome(嘔而發熱) according to 'Treatise on Cold Damage Disease(傷寒論)'. Patients are treated only with Soshiho-tang. The severity of Atopic dermatitis was evaluated by SCORAD index, visual analogue scale(VAS) and pictures. Gastrointestinal disorders(mainly food allergy, indigestion) were evaluated by patients' subjective complaint.Results : After the treatment, not only the severity of atopic dermatitis but gastrointestinal disorders were also improved.Conclusions : Soshiho-tang has improved the symptoms of Atopic dermatitis with gastrointestinal disorders in this study.