• 대한한방내과학회지
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• 제38권2호
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• pp.270-275
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• 2017

Objective: We describe the case of a patient with a cerebellar infarction, with dizziness and ataxia who was treated with traditional Korean medicine. Methods: The patient was treated with the herbal medicine Jaeumgeonbi-tang. Acupuncture and moxibustion therapy were also administered on a daily basis. Dizziness was evaluated using the Numeric Rating Scale, and spontaneous movement was observed daily. Results: After the administration of Jaeumgeonbi-tang, the patient's dizziness and ataxia improved. Conclusion: This case shows that traditional Korean medicine appears to be effective in improving side effects of a cerebellar infarction.

• Clinical and Experimental Pediatrics
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• 제57권12호
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• pp.542-545
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• 2014

Bickerstaff's brainstem encephalitis is characterized by ophthalmoplegia, ataxia, and disturbance of consciousness. It is similar to Miller Fisher syndrome, a variant of Guillain-Barre syndrome, in that they share features such as ophthalmoplegia and ataxia. The difference is that patients with Bickerstaff's brainstem encephalitis have impaired consciousness, whereas patients with Miller Fisher syndrome have alert consciousness and areflexia. Here, we report the case of a 3-year-old child who was diagnosed with Bickerstaff's brainstem encephalitis presenting typical clinical features and interesting radiological findings. The patient showed ophthalmoplegia, ataxia, and subsequent stuporous mentality. Brain magnetic resonance imaging revealed high signal intensity in the pons and cerebellum around the 4th ventricle on a T2-weighted image. He was successfully treated with intravenous immunoglobulin. Differentiation of Bickerstaff's brainstem encephalitis and Miller Fisher syndrome is often difficult because they possess many overlapping features. Brain magnetic resonance imaging may be helpful in diagnosing Bickerstaff's brainstem encephalitis, especially when lesions are definitely found.

• 사상체질의학회지
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• 제22권4호
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• pp.113-123
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• 2010

1. Objectives This study is about three cerebellar infarction patients with dizziness and ataxia. In this study, we evaluated the effects of Sasang constitutional treatment and suggested using the 'Equilibrium Function Test' as scale. 2. Methods These three patients were treated by Sasang constitutional herbal medications based on "Donguisusebowon". Acupuncture & moxa therapy and west medications were limited as much as possible. We evaluated the symptoms through two methods, the Visual Analogue Scale and the Equilibrium Function Test. 3. Results and Conclusions Dizziness and ataxia that were these three patients' chief complaints were improved. This case study shows that Sasang constitutional herbal medications are an effective treatment for cerebellar infarction patients.

• Journal of Genetic Medicine
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• 제15권2호
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• pp.110-114
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• 2018

Ataxia-telangiectasia (AT; OMIM 208900) is a rare autosomal recessive inherited progressive neurodegenerative disorder, with onset in early childhood. AT is caused by homozygous or compound heterozygous mutations in ATM (OMIM 607585) on chromosome 11q22. The average prevalence of the disease is estimated at 1 of 100,000 children worldwide. The prevalence of AT in the Republic of Korea is suggested to be extremely low, with only a few cases genetically confirmed thus far. Herein, we report a 5-year-old Korean boy with clinical features such as progressive gait and truncal ataxia, both ankle spasticity, dysarthria, and mild intellectual disability. The patient was identified as a compound heterozygote with two novel genetic variants: a paternally derived c.5288_5289insGA p.(Tyr1763*) nonsense variant and a maternally derived c.8363A>C p.(His2788Pro) missense variant, as revealed by next-generation sequencing and confirmed by Sanger sequencing. Based on claims data from the Health Insurance Review and Assessment Service Republic of Korea, we calculated the prevalence of AT in the Republic of Korea to be about 0.9 per million individuals, which is similar to the worldwide average. Therefore, we suggest that multi-gene panel sequencing including ATM should be considered early diagnosis.

• Journal of Genetic Medicine
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• 제17권2호
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• pp.92-96
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• 2020

Hypotonia, Ataxia, and Delayed Development Syndrome (HADDS) is an autosomal-dominant, extremely rare neurodevelopmental disorder caused by the heterozygous EBF3 gene mutation. EBF3 is located on chromosome 10q26.3 and acts as a transcription factor that regulates neurogenesis and differentiation. This syndrome is characterized by dysmorphism, cerebellar hypoplasia, urogenital anomaly, hypotonia, ataxia, intellectual deficit, and speech delay. The current report describes a 3-year-old Korean male carrying a de novo EBF3 mutation, c.589A>G (p.Asn197Asp), which was identified by whole exome sequencing. He manifested facial dysmorphism, hypotonia, strabismus, vermis hypoplasia, and urogenital anomalies, including vesicoureteral reflux, cryptorchidism, and areflexic bladder. This is the first report of a case of HADDS cause by an EBF3 mutation in the Korean population.

• 대한한방내과학회지
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• 제38권2호
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• pp.93-102
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• 2017

Objective: We describe the case of an 84-year-old man with a midbrain infarction causing pupil sparing oculomotor nerve palsy, with ipsilateral cerebellar ataxia diagnosed as Claude's syndrome. Methods: The patient was treated with Korean medicine, including herbal medicine, acupuncture, and electro-acupuncture, during 45 days of hospitalization. Improvements in the patient's symptoms and changes in ptosis were evaluated using the Korean version of the Scale for the Assessment and Rating of Ataxia (SARA). Results: After 45 days of treatment with the Korean medicine, the patient's symptoms, including ataxia and ptosis, improved. Conclusions: This study suggests that the treatment with Korean medicine was effective in aiding the patient's recovery.

• 대한한방내과학회지
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• 제25권2호
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• pp.335-343
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• 2004

The two case reports here presented are based on an inpatient with lateral medullary infarction, known as Wallenberg's syndrome with chief complains of central dizziness and cerebellar ataxia, and an inpatient with infarctions of cerebellar, pontine, and lacunar thalamic region. QSCCII was performed while the patient was hospitalized and, by consultation with the Dept. of Sasang Constitutional Medicine, the patient was diagnosed with Taeumin. Thus, an oriental medical therapy of Cheongsimyeonjatang, acupuncture, and moxibustion was carried out. As a result the degree of dizziness decreased noticeably while other symptoms improved as well. Before leaving the hospital, the degree of cerebellar ataxia also improved and the patient was able to go on foot by himself. In conclusion, significant improvements were observed in cerebellar and a pontine infarction patients who suffered central dizziness and cerebellar ataxia through Sasang medical therapy.

• 대한한방내과학회지
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• 제39권5호
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• pp.994-1003
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• 2018

Objective: The aim of this study was to report a clinical case suggesting the potential effects of traditional Korean medicine for the treatment of sporadic spinocerebellar ataxia in a patient with herniated intervertebral lumbar discs. Methods: The patient was treated with a series of Korean medicine treatments including the herbal medicine Zhenganxifeng-tang-gagam, acupuncture, pharmacoacupuncture, and electroacupuncture along with herniated intervertebral lumbar disc treatments. Results: Improvements of Numeric rating scale (NRS) and European Quality of Life-5 Dimensions (EQ-5D) score were observed after the treatment. Conclusion: Traditional Korean medicine has potential benefits for sporadic spinocerebellar ataxia patients with herniated intervertebral lumbar discs.

• 한국지능시스템학회논문지
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• 제24권6호
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• pp.609-614
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• 2014

소뇌 운동실조는 점차 진행되는 신경퇴행질병이며 운동 조절을 위한 기능의 상실을 동반하기에 환자의 삶을 심각하게 저하시킨다. 소뇌 운동실조 환자는 운동제어 과정에서 부적절한 폐회로 소뇌 반응으로 인해 운동 명령이 제한된다. 본 논문에서는 최근 뇌-컴퓨터 인터페이스 기술을 이용하여 소뇌의 이상으로 인한 운동실조 환자들이 외부기기를 제어할 수 있도록 운동상상 기반의 뇌파의 특성을 분석하고 이를 이용한 뇌-컴퓨터 인터페이스 기법을 제안한다. 뇌파 기반의 뇌-컴퓨터 인터페이스의 효용성을 검증하기 위하여 소뇌 운동실조 환자와 정상인 그룹에서 운동상상에 따른 뮤밴드 파워를 조절하는 능력을 비교하였다. 이를 통하여 소뇌 운동실조 환자에의 뇌-컴퓨터 인터페이스의 가능성을 보여준다.

• Journal of Veterinary Science
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• 제23권5호
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• pp.75.1-75.7
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• 2022

Background: Since 2013, the number of requests for diagnosis for horses based on neurological symptoms has increased rapidly in South Korea. The affected horses have commonly exhibited symptoms of acute seasonal hindlimb ataxia. A previous study from 2015-2016 identified Setaria digitata as the causative agent. Objectives: This study is an epidemiological investigation to find out risk factors related to the rapid increase in hindlimb ataxia of horses due to aberrant parasites in South Korea. Methods: An epidemiological investigation was conducted on 155 cohabiting horses in 41 horse ranches where the disease occurred. The surrounding environment was investigated at the disease-causing horse ranches (n = 41) and 20, randomly selected, non-infected ranches. Results: Hindlimb ataxia was confirmed in nine cohabiting horses; this was presumed to be caused by ectopic parasitism. Environments that mosquitoes inhabit, such as paddy fields within 2 km and less than 0.5 km from a river, had the greatest association with disease occurrence. Conclusions: Most horse ranches in South Korea are situated in favorable environments for mosquitoes. Moreover, the number of mosquitoes in the country has increased since 2013 due to climate change. Additional research is required; however, these data show that it is necessary to establish guidelines for the use of anthelmintic agents based on local factors in South Korea and disinfection of the environment to prevent disease outbreaks.