• Clinical and Experimental Pediatrics
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• v.52 no.5
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• pp.538-543
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• 2009

Purpose : To report the clinical experience with amitriptyline for managing children with cyclic vomiting syndrome (CVS). Methods : Totally, eleven children (eight males) were diagnosed with CVS. Of these, medical records were reviewed for eight children treated with amitriptyline; three children were not treated because one was not followed up and two were kept under observation to study the natural course without medication, because the frequency of vomiting had recently decreased to less than one episode per year. The eight amitriptyline-treated children were divided into three groups by the therapeutic response: (1) complete remission (CR), with no recurrence of symptoms after treatment; 2) partial remission (PR), in which the frequency of symptoms decreased by almost 50% after treatment; and (3) no response. Results : For the eight amitriptyline-treated children, the mean age of symptom onset was 4.7 (0.3-7) yr and mean age at diagnosis was 8.9 (6.0-11.3) yr. The mean number of vomiting episodes was 8.8 (2-25) per year, and the duration of vomiting in each episode ranged from 3 hours to 5 days. CR was achieved in five (62.5%) of the eight amitriptyline-treated children (0.2-0.8 mg/kg/day orally, at night) and PR was achieved in three children (37.5%). Two children relapsed on discontinuation of amitriptyline by their parents decision but showed improvement on remedication. No adverse effects were noted throughout the study period. Conclusion : Amitriptyline can be used in long-term prophylaxis for the management of children with CVS aged over 6 yr. However, a large-scale study is needed to ascertain its effects.

• The Korean Journal of Pesticide Science
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• v.14 no.4
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• pp.407-414
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• 2010

Bacillus subtilis strains isolated from different regions of Korea were screened for their plant growth promotion and induced systemic resistance (ISR) in tomato and red-pepper. The plant growth promotion on red-pepper and tomato revealed maximum plant height (22.73 cm) on red pepper treated with B. subtilis strain JE 21-1 and 30.18cm in case of tomato treated with B. subtilis strain JE 8-1. There was also significant improvement in root and shoot dry weight in both the plants. The strain JE 21-1 showed better promise for all growth parameters in red-pepper and tomato when compared to other strains and positive check BTH. Different strains screened in square plate method also revealed maximum plant height and leaf width, and suppressed anthracnose on red pepper in case of strain JE 21-1 at $10^6$ and $10^7$ cells/ml when compared to other strains. In all the bacterial inoculations the population was significantly high when compared to untreated check. In plant growth promotion with respect to fruit length and weight, fruit length was maximal in treating with JE 9-4 and ES 2-2, while fruit weight was maximal in treating with JE 3-6, ES4-2, ES2-2 and JE 21-2 on red pepper. In case of tomato, comparatively better fruit weight was in JE 21-1, ES 3-3 and JE 10-2 when compared to BTH and untreated control. The soft rot disease caused by Pectobacterium carotovorum SCCI was completely suppressed in case of transgenic tobacco harboring GUS gene related to PR1a and increased the level of salicylic acid significantly in combined application of JE 9-4 on par with BTH. Thus, this study clarified some potential Bacillus subtilis strains for plant growth promotion and ISR in red-pepper and tomato.

• Resources Recycling
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• v.26 no.4
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• pp.26-33
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• 2017

The behavior on the solvent extraction of heavy rare earths (HRE) by using PC88A was confirmed to demonstrate the possibility of recovery on the HRE from industrial wastewater, which consist of low concentration rare earth. We verified the extraction behavior of the HRE through a change of equilibrium pH, extractant concentration and A/O ratio, and also confirmed the stripping behavior depending on the type of mineral acids. At equilibrium pH 1.0, extraction of rare earth (RE) was completed from 95% to 100%. In all extraction conditions, it tend to be extracted in order of high atomic number. When A/O ratio was 10/1, Yb and Tm were concentrated at the maximum and increased 6-fold and 3-fold compared to initial concentration, respectively. To confirm the stripping behavior of the RE, three mineral acids were applied to the organic phase and consequently rate of stripping was increased in order of $HNO_3$, $H_2SO_4$ and HCl.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.11 no.6
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• pp.26-37
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• 2008

The purpose of the study was to evaluate the effect of pervious pavements on reducing the surface runoff caused by rainfall. The surface runoff from twelve steel experimental beds with different pavement had been recorded every minute from May to September 2008, by the measuring system of tipping buckets(0.1mm/count) and data aquisition systems(National Instrument's Labview and DAQ boards & Autonics PR12-4). The dimension of the experimental bed was $1.5m(W){\times}2.0m(L){\times}0.6m(D)$ and eleven different kinds of vegetational(grass, grass+cubic stone, grass+hole brick), modular(brick, cubic stone, small cubic stone, wood block, interlocking block, clay brick, granular clay brick) and granular(naked soil, gravel) paving materials and concrete were applied for the comparison. Six rain events with depth over 30mm were selected and compared. The maximum depth of the rainfall selected was 137.5mm for 28 hours, and the minimum 30mm for 5 hours. The maximum rainfall per hour was 23mm/hr and the minimum 11.4mm/hr. The major findings were as follows; 1. All pervious pavement applied reduced over 75% of the surface runoff compared with concrete pavement. The grassy and porous pavements were relatively efficient in reducing surface runoff. 2. The grass was the more efficient as intercepting average 69.5mm of initial surface runoff, and maximum 77.8mm at the condition of 13.5mm/hr rainfall. The next was gravel intercepting maximum 65.5mm at the condition of 13.5mm/hr and the 40.9mm at 19.1mm/hr, average 55.7mm. 3. The modular pavements common in urban area were not good in intercepting the runoff except the 'clay granular brick' compared with others. The 'clay granular brick' showed relatively efficient intercepting average 14.1mm, which was the bigger amount than the 'grass+hole brick'. 4. The 'naked soil' were more effective than the 'concrete', 'brick', and 'interlocking block' in reducing the surface runoff, but less efficient than other materials. The capacity of the 'naked soil' to intercept the initial rainfall was similar to the 'brick'. As summary, the more grassy and porous pavement shows more effective in reducing surface runoffs.

• Atmosphere
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• v.24 no.4
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• pp.541-554
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• 2014

Historical, RCP4.5 and RCP8.5 scenarios from HadGEM2-AO are dynamically downscaled over the northeast East Asia with WRFV3.4. The horizontal resolution of the produced data is 12.5 km and the periods of integration are 1979~2010 for historical and 2019~2100 for both RCP4.5 and RCP8.5. We analyze the time series, climatology, EOF and extreme climate in terms of 2 m-temperature and precipitation during 30-year for the Historical (1981~2010) and RCP4.5 and RCP8.5 (2071~2100) scenarios. According to the result, the temperature of the northeast Asia centered at the Korean Peninsula increase 2.9 and $4.6^{\circ}C$ in the RCP4.5 and RCP8.5 scenarios, respectively, by the end of the 21st century. The temperature increases with latitude and the increase is larger in winter rather than in summer. The annual mean precipitation is expected to increase by about $0.3mm\;day^{-1}$ in RCP4.5 scenario and $0.5mm\;day^{-1}$ in RCP8.5 scenario. The EOF analysis is also performed for both temperature and precipitation. For temperature, the EOF $1^{st}$ modes of all scenarios in summer and winter show that temperature increase with latitude. The $2^{nd}$ mode of EOF of each scenario shows the natural variability, exclusive of the global warming. The summer precipitation over the Korean Peninsula projected increases in EOF $1^{st}$ modes of all scenarios. For extreme climate, the increment of the number of days with daily maximum temperature above $30^{\circ}C$ per year ($DAY_{TX30}$) is 25.3 and 49.7 days in RCP4.5 and RCP8.5 respectively over the Korean Peninsula. The number of days with daily precipitation above $20mm\;day^{-1}$ per year ($DAY_{PR20}$) also increases 3.1 and 3.5 days in RCP4.5 and RCP8.5 respectively.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.1
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• pp.23-31
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• 2011

At supercritical pressure, the physical properties of fluid change substantially and the heat transfer at a temperature similar to the critical or pseudo-critical temperature improves considerably; however, the heat transfer may deteriorate due to a sudden increase in the wall temperature at a certain condition of a mass and heat flux. In this study, the heat transfer rates in $CO_2$ flowing vertically upward and downward in a circular tube with a diameter of 4.57 mm under various conditions were calculated by measuring the temperature of the outer wall of the tube. The published heat transfer correlations were analyzed by comparing their prediction values with 7,250 experimental data. By introducing a buoyancy parameter, a heat transfer correlation, which could be applied only to a normal heat transfer regime, was extended such that it can be applied to regime of heat transfer deterioration. The published criteria for heat transfer deterioration were evaluated against the conditions obtained from the experiment in this study.

• Radiation Oncology Journal
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• v.11 no.1
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• pp.97-102
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• 1993

A retrospective analysis of various characteristics in 32 limited stage small cell lung cancer patients treated at the Department of Therapeutic Radiology in Kangnam St. Mary's Hospital, Catholic University Medical College from April 1983 to September 1991, was carried out to identify factors which had prognostic significance for survival from initiation of radiation therapy. There were 26 men and 6 women. Median age was 63 years (range: 24-78 years). The follow up duration was 1.5 to 44 months (median: 9 months). External radiation therapy was done with daily 160-180 cGy,5 fraction/week, total of 1000-6660 cGy (median: 4500 cGy) to the mediastinum by 6 MV linear accelerator. Of 32 Patients, 27 ($84.4{\%}$) patients were treated with combined modality (chemotherapy plus radiation therapy), and 5 ($15.6{\%}$) patients were treated with radiation therapy only. Complete responders were 12 patients ($37.5{\%}$), partial responders were 11 ($34.4{\%}$), and no responders were 9($28.1{\%}$). Karnofsky performance status over 70 (p<0.04), chemotherapy regimen (CAV, PV, and CAV+PV) (p<0.04),6 or more cycles of chemotherapy (p<0.007), radiation therapy over 4500 cGy (p<0.03), and radiation therapy responder (CR+PR) (p<0.003) showed a significantly favorable influence on 1 year survival rate. Age (p=0.545), sex (p=0.666), presence of superior vena cava syndrome (p=0.719), prophylactic cranial irradiation (p=0.217), and radiation therapy duration (p=0.491) had no effect on survival. Radiation induced side effects were transient esophagitis in 11 ($34{\%}$), general weakness in 9($28{\%}$), gastrointestinal symptoms in terms of nausea, vomiting and indigestion in 5 ($15{\%}$) and leukopenia in 1 ($3{\%}$).

• Clinical and Experimental Reproductive Medicine
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• v.32 no.1
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• pp.47-54
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• 2005

Objective: Evaluation of embryos using early cleavage to 2-cell stage has been proposed, but a critical time-point for selecting embryos is unclear. The aim of the present study is to provide a guideline including critical time-point in the selection of early cleaving embryo for the reduction of multiple pregnancies as well as the increase of pregnancy rate in human IVF. Methods: This prospective study was performed in 116 cycles from 85 patients who underwent conventional IVF or ICSI at the infertility clinic of Good Moonhwa Hospital from January 2002 to December 2003. Early cleavage (EC) of embryos to 2-cell stage was assessed at 25 h and 27 h postinsemination/microinjection. Embryos that had early cleaved at each time point were designated as EC-1 and EC-2, respectively, while others were designated as non-early cleavage (NEC). Results: At least one early cleavage embryo was observed in 54 (46.6%) for the EC-1 and 84 (72.4%) for the EC-2 of the 116 cycles assessed. Clinical pregnancy rates (PR) were significantly higher in the EC-1 group (66.7%) compared to the EC-2 group (53.6%) or the NEC group (31.2%) (p<0.05). Significant improvement of the pregnancy rate was found when at least two or more embryos were early cleaved at 25 h postinsemination or when the proportion of early cleavage embryo at 25 h postinsemination was higher than 20% (p<0.05). Conclusion: The critical time-point for the selection of early cleavage embryos with high implantation potential is more effective in 25 h postinsemination/microinjection compared to 27 h. The proportion as well as number of early cleavage embryos is also an important factor for the prediction of pregnancy outcome and the chance of multiple pregnancies. These results demonstrated that the evaluation of early cleavage embryos to 2-cell stage is an easy, simple, and objective method for the selection of good quality embryos suitable for embryo transfer.

• Tuberculosis and Respiratory Diseases
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• v.45 no.1
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• pp.140-152
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• 1998

Background: Prone position improves oxygenation in patients with ARDS probably by reducing shunt Reduction of shunt in prone position is thought to be effected by lowering of the critical opening pressure (COP) of the dorsal lung because the pleural pressure becomes less positive in prone position compared to supine position. It can then be assumed that prone position would bring about greater improvement in oxygenation when PEEP applied in supine position is just beneath COP than when PEEP is above COP. Hemodynamically, prone position is expected to attenuate the lifting of cardiac fossa induced by PEEP. Based on these backgrounds, we investigated whether the effect of prone position on oxygenation differs in magnitude according to the level of PEEP applied in supine position, and whether impaired cardiac output in supine position by PEEP can be restored in prone position. Methods: In seven mongrel dogs, $PaO_2/F_1O_2$(P/F) was measured in supine position and at prone position 30 min. Cardiac output (CO), stroke volume (SV), pulse rate (PR), and pulmonary artery occlusion pressure (PAOP) were measured in supine position, at prone position 5 min, and at prone position 30 min. After ARDS was established with warmed saline lavage(P/F ratio $134{\pm}72$ mm Hg), inflection point was measured by constant flow method($6.6{\pm}1.4cm$ $H_2O$), and the above variables were measured in supine and prone positions under the application of Low PEEP($5.0{\pm}1.2cm$ $H_2O$), and Optimal PEEP($9.0{\pm}1.2cm$ $H_2O$)(2 cm $H_2O$ below and above the inflection point, respectively) consecutively. Results : P/F ratio in supine position was $195{\pm}112$ mm Hg at Low PEEP and $466{\pm}63$ mm Hg at Optimal PEEP(p=0.003). Net increase of P/F ratio at prone position 30 min, however, was far greater at Low PEEP($205{\pm}90$ mm Hg) than at Optimal PEEP($33{\pm}33$ mm Hg)(p=0.009). Compared to CO in supine position at Optimal PEEP($2.4{\pm}0.5$ L/min), CO in prone improved to $3.4{\pm}0.6$ L/min at prone position 5 min (p=0.0180) and $3.6{\pm}0.7$ L/min at prone position 30 min (p=0.0180). Improvement in CO was attributable to the increase in SV: $14{\pm}2$ ml in supine position, $20{\pm}2$ ml at prone position 5 min (p=0.0180), and $21{\pm}2$ ml at prone position 30 min (p=0.0180), but not to change in PR or PAOP. When the dogs were turned to supine position again, MAP ($92{\pm}23$ mm Hg, p=0.009), CO ($2.4{\pm}0.5$ L/min, p=0.0277) and SV ($14{\pm}1$ ml, p=0.0277) were all decreased compared to prone position 30 min. Conclusion: Prone position in a dog with saline-lavaged acute lung injury appeared to augment the effect of relatively low PEEP on oxygenation, and also attenuate the adverse hemodynamic effect of relatively high PEEP. These findings suggest that a PEEP lower than Optimal PEEP can be adopted in prone position to achieve the goal of alveolar recruitment in ARDS avoiding the hemodynamic complications of a higher PEEP at the same time.

• Journal of Energy Engineering
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• v.21 no.1
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• pp.18-25
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• 2012

This work investigated the influence of the chimney dimensions(exit and entrance length, and diameter) on the heat transfer of a vertical cylinder in a duct. The measured mass transfer rates for the natural convection of vertical cylinder in a duct were presented for Prandlt number 2,094, Rayleigh number in the range of $4.55{\times}10^9$, $5.79{\times}10^{10}$, and $1.69{\times}10^{11}$. Experiments were performed using a copper sulfate electroplating system to simulate heat transfer based upon the analogy concept. The diameter of the duct was varied from 0.06 m to 0.14 m, and the heights from 0.30 m to 1.10 m. Nusselt numbers measured at open channel condition agreed well with the existing laminar heat transfer correlations for vertical plate developed by Le Fevre. The increase of the exit length enhanced the heat transfer up to a certain duct height but further increase does not affects the heat transfer. The heat transfer decreased with increasing the entrance length up to a certain duct height and was constant at further increase. The Nusselt number decreased with increasing the diameter of duct, until Nusselt number becomes similar to that at open channel beyond a certain diameter.