• Title/Summary/Keyword: Assessing

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Assessing Average Bioequivalence for 2×2 Crossover Design with Covariates (공변량을 고려한 2×2 교차설계법에 평균 생물학적 동등성 평가)

  • Jeong, Gyu-Jin;Park, Sang-Gue;Kim, Kwan-Yup
    • The Korean Journal of Applied Statistics
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    • v.24 no.1
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    • pp.161-167
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    • 2011
  • The primary variables are often systematically related to other influences apart from drug effect. For instance, there may be relationships to covariates such as health conditions or prognostic factors. When a $2{\times}2$ crossover experiment for bioequivalence is designed, the statistical adjustment for the influence of covariates should be considered if some covariates influence the drug effect. Statistical inference for assessing average bioequivalence for a $2{\times}2$ crossover design with covariates is given and an illustrated example is presented with discussion.

A Study on the Risk based RAMS Assessment for Railway Rolling Stock Systems (철도차량시스템의 위험기반 RAMS 평가에 관한 연구)

  • Park, Mun-Gyu;Han, Seong-Ho
    • The Transactions of the Korean Institute of Electrical Engineers P
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    • v.64 no.4
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    • pp.220-230
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    • 2015
  • Rolling stock RAMS is a field of engineering which integrates reliability, availability, maintainability and safety (RAMS) characteristics into an inherent product design property through rolling stock system engineering process. It is implemented to achieve operational objectives successfully, and recently the RAMS has become a rapidly growing engineering discipline because it has a great potential to ensure safety and improve cost effectiveness. However, the Korean rolling stock industry has not yet implemented RAMS management in the rolling stock engineering process, despite the issue having been addressed since the introduction of the KTX. Thus, this paper discusses the processes, methods and techniques for RAMS assessment in three parts. Firstly, it outlines a process of the overall RAMS performance assessment for achieving technical RAMS design criteria. Secondly, it discusses a process for assessing the operational RAM and allocating the RAM. This paper also proposes a model for assessing safety-based risk management, which includes five analytic techniques for identifying the causes and consequences of a system failure. Finally, a case example is provided for the risk assessment of the pneumatic braking device.

A Study on Process Capability Index using Reflected Normal Loss Function (역정규 손실함수를 이용한 공정능력지수에 관한 연구)

  • 정영배;문혜진
    • Journal of Korean Society for Quality Management
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    • v.30 no.3
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    • pp.66-78
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    • 2002
  • Process capability indices are being used as indicators for measurements of process capability for SPC of quality assurance system in industries. In view of the enhancement of customer satisfaction, process capability indices in which loss functions are used to deal with the economic loss In the processes deviated from the target, are in an adequate representation of the customer's perception of quality In this connection, the loss function has become increasingly important in quality assurance. Taguchi uses a modified form of the quadratic loss function to demonstrate the need to consider the proximity to the target while assessing its quality. But this traditional quadratic loss function is inadequate to assessing the quality and quality improvement since different processes have different sets of economic consequences on the manufacturing, Thereby, a flexible approach to the development of the loss function needs to be desired. In this paper, we introduce an easily understood loss function, based on reflection of probability density function of the normal distribution. That is, the Reflected Normal Loss function can be adapted to an asymmetric loss as well as to a symmetric loss around the target. We propose that, instead of the process variation, a new capability index, CpI using the Reflected Normal Loss Function that can accurately reflect the losses associated with the process and a new capability index CpI Is compared with the classical indices as $C_{p}$ , $C_{pk}$, $C_{pm}$ and $C_{pm}$ $^{+}$.>.+/./.

A Preliminary Study on the Korean Version of Quality of Life-Alzheimer's Disease (QOL-AD) Scale in Community-dwelling Elderly with Dementia (지역사회 거주 치매환자에서 한국판 삶의 질 -알쯔하이머병 척도 개발을 위한 예비연구)

  • Shin, Hee-Young
    • Journal of Preventive Medicine and Public Health
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    • v.39 no.3
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    • pp.243-248
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    • 2006
  • Objectives: The Quality of Life-Alzheimer's Disease (QOL-AD) scale is a reliable and valid tool for assessing the quality of life (QOL) in the elderly with dementia. This study aimed to develop the Korean version of Quality of Life-Alzheimer's Disease (KQOL-AD) scale for the demented elderly living in the community. Methods: KQOL-AD was administered to two groups: 24 demented elderly and 72 cognitively impaired elderly with no dementia (CIND) who were living in the community Each elderly person and their caregiver rated the elderly QOL. The Korean version of mini-mental state examination (MMSE-K), the clinical dementia rating (CDR), the activities of daily living (ADL), and the neuropsychiatric inventory (NPI) were also assessed. The reliability and validity of the KQOL-AD were examined. Results: In the dementia group, the internal consistency (Cronbach's $\alpha$), the split half and the test-retest reliabilities of the KQOL-AD were excellent. Scores on the KQOL-AD were significantly correlated with the scores of the NPI, but they were not significantly correlated with scores of the MMSE-K, CDR and ADL. In addition, the CIND group showed similar results to the dementia group. Conclusions: KQOL-AD might be a reliable and valid instrument for assessing QOL in the elderly with dementia It could be used as an important outcome measure for research on the demented elderly.

A Methodology for Assessing Risk from Released Hydrocarbon (탄화수소 누출로 인한 위험분석 평가 방법론 연구)

  • Keun-Won Lee
    • Journal of the Korean Society of Safety
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    • v.13 no.2
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    • pp.170-180
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    • 1998
  • This study presents a method for calculating the concentration of hydrocarbon releases in enclosed areas using empirical equations of evaporation rate. The approach of the method is to estimate the hydrocarbon exposure concentration in the air under conditions assumed. A methodology for assessing risk was suggested to individual risk assessment to exposed workers or others by probit expressions. The toxicity criteria and available human exposure data were examined and guidelines for risk assessment suggested for benzene-air and toluene-air systems. The value of probit constants with mole fractions of lethal concentrations in a mixture of hydrocarbons and a non-toxic substance was predicted. The probit values calculated with mole fractions can be used to estimate guidelines to prevent toxicity within enclosed working areas.

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Lightning Risk Assessment for Structures Lower than 20m High (높이 20미터 미만인 구조물의 낙뢰리스크 평가)

  • Lee, Ju-Chul;Kim, Gi-Hyun;Lee, Young-Chul
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.26 no.12
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    • pp.21-27
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    • 2012
  • Korean Industrial Standards for lightning protection system complies with IEC standards. However, the standards are applicable only to buildings and structures more than 20 meters in high. Therefore, it is necessary to determine whether lightning protection system should be installed on structures lower than 20 meters high. This paper proposes an efficient method of assessing risk against lightning of structures lower than 20 meters high. The method suggests simplified lightning protection system and provides selecting an appropriate protection level. The suggested method assumes that structure under assessment has no lightning protection system and there is no person around the structure at the moment of lightning stroke. A simplified method of assessing the risk to human within the structure is developed by adopting the general assessment factor. The selection of a protection level is possible by comparing tolerable risk with physical damage risk caused by a direct lightning. Finally, this paper gives ways to establish surge protection measures when a structure with lightning risk is within a radius of 2km from the assessed structure even if this structure requires no lightning protection system.

Ratio of Torsion (ROT): An index for assessing the global induced torsion in plan irregular buildings

  • Stathi, Chrysanthi G.;Bakas, Nikolaos P.;Lagaros, Nikos D.;Papadrakakis, Manolis
    • Earthquakes and Structures
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    • v.9 no.1
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    • pp.145-171
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    • 2015
  • Due to earthquakes, many structures suffered extensive damages that were attributed to the torsional effect caused by mass, stiffness or strength eccentricity. Due to this type of asymmetry torsional moments are generated that are imposed by means of additional shear forces developed at the vertical resisting structural elements of the buildings. Although the torsional effect on the response of reinforced concrete buildings was the subject of extensive research over the last decades, a quantitative index measuring the amplification of the shear forces developed at the vertical resisting elements due to lateral-torsional coupling valid for both elastic and elastoplastic response states is still missing. In this study a reliable index capable of assessing the torsional effect is proposed. The performance of the proposed index is evaluated and its correlation with structural response quantities like displacements, interstorey drift, base torque, shear forces and upper diaphragm's rotation is presented. Torsionally stiff, mass eccentric single-story and multistory structures, subjected to bidirectional excitation, are considered and nonlinear dynamic analyses are performed using natural records selected for three hazard levels. It was found that the proposed index provides reliable prediction of the magnitude of torsional effect for all test examples considered.

Statistical division of compressive strength results on the aspect of concrete family concept

  • Jasiczak, Jozef;Kanoniczak, Marcin;Smaga, Lukasz
    • Computers and Concrete
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    • v.14 no.2
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    • pp.145-161
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    • 2014
  • The article presents the statistical method of grouping the results of the compressive strength of concrete in continuous production. It describes the method of dividing the series of compressive strength results into batches of statistically stable strength parameters at specific time intervals, based on the standardized concept of "concrete family". The article presents the examples of calculations made for two series of concrete strength results, from which sets of decreased strength parameters were separated. When assessing the quality of concrete elements and concrete road surfaces, the principal issue is the control of the compressive strength parameters of concrete. Large quantities of concrete mix manufactured in a continuous way should be subject to continuous control. Standardized approach to assessing the concrete strength proves to be insufficient because it does not allow for the detection of subsets of the decreased strength results, which in turn makes it impossible to make adjustments to the concrete manufacturing process and to identify particular product or area on site with decreased concrete strength. In this article two independent methods of grouping the test results of concrete with statistically stable strength parameters were proposed, involving verification of statistical hypothesis based on statistical tests: Student's t-test and Mann - Whitney - U test.

Reliability-based assessment of damaged concrete buildings

  • Sakka, Zafer I.;Assakkaf, Ibrahim A.;Qazweeni, Jamal S.
    • Structural Engineering and Mechanics
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    • v.65 no.6
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    • pp.751-760
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    • 2018
  • Damages in concrete structures due to aging and other factors could be a serious and immense matter. Making the best selection of the most viable and practical repairing and strengthening techniques are relatively difficult tasks using traditional methods of structural analyses. This is due to the fact that the traditional methods used for assessing aging structure are not fully capable when considering the randomness in strength, loads and cost. This paper presents a reliability-based methodology for assessing reinforced concrete members. The methodology of this study is based on probabilistic analysis, using statistics of the random variables in the performance function equations. Principles of reliability updating are used in the assessment process, as new information is taken into account and combined with prior probabilistic models. The methodology can result in a reliability index ${\beta}$ that can be used to assess the structural component by comparing its value with a standard value. In addition, these methods result in partial safety factor values that can be used for the purpose of strengthening the R/C elements of the existing structure. Calculations and computations of the reliability indices and the partial safety factors values are conducted using the First-order Reliability Method and Monte Carlo simulation.

A Study of the Nutritional Status, Nutritional Knowledge, and Dietary Habits of the Hemodialysis Patients (혈액투석 환자의 영양상태, 영양지식도 및 식습관에 대한 연구)

  • 김양하;서혜정;김성록
    • Journal of Nutrition and Health
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    • v.34 no.8
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    • pp.920-928
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    • 2001
  • Malnutrition is a common problem in patients undergoing maintenance hemodialysis(HD) and compromised food intake is an important cause. Malnutrition is one of the important factors influencing mortality in chronic HD patients. We investigated the nutritional parameters of 50 Korean HD patients(mean age: 46.9 $\pm$ 10.3y, men : 23, women : 27) by measuring anthropometric and biochemical blood indices and assessing food intake using 24-h recall method. Also we administered two questionnaires, one for assessing nutritional knowledge about renal disease and dietary therapy, the other for measuring dietary habits related to dietary therapy. According to the distribution of BMI, 21.3% of HD patients were underweight. The hematological values of HD patients, such as plasma hemoglobin, hematocrit, and total lymphocyte count were below the normal range. The serum cholesterol levels were 133.2 $\pm$ 30.5mg/dl. HD patients took energy and protein only 77.5% and 83.1%, respectively, of their RDA. There were significantly positive correlations between nutritional knowledge and intake of nutrients, such as energy, fat, cholesterol, iron, potassium, vitamin B$_1$, vitamin B$_2$, and niacin. Also, there was a significantly positive correlation between nutritional knowledge and dietary habits(r = 0.317, p < 0.05). In conclusion, Korean HD patients showed mild malnutrition and suboptimal nutrition intake. It can be postulated that the dietary intake can be increased by nutrition education improving nutritional knowledge and correcting the dietary habits of HD patients.

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