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A Case of Idiopathic Renal Hypouricemia with SLC22A12 Gene Mutation Showing General Weakness and Incidental Renal Stone

  • Joung, Jin Woon;Song, Young Wha;Kim, Jong Dae;Cheon, Eun Jung
    • Childhood Kidney Diseases
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    • v.25 no.1
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    • pp.44-48
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    • 2021
  • Idiopathic renal hypouricemia (iRHUC) is a rare hereditary disease caused by a defect in urate handling of renal tubules. Type 1 renal hypouricemia (RHUC1) is diagnosed with confirmation of a mutation in SLC22A12 gene which encodes a renal urate-anion exchanger (URAT1). The majority of iRHUC patients are asymptomatic, especially during childhood, and thus many cases go undiagnosed or they are diagnosed late in older age with complications of hematuria, renal stones, or acute kidney injury (AKI). We report a case of a 7-year-old boy with subtle symptoms such as general weakness and dizziness and revealed hypouricemia and incidental nephrolithiasis. Homozygous mutations were detected in the SLC22A12 (c.774G>A) by molecular analysis. The present case suggests that fractional excretion of uric acid (FEUA) screening could be better followed by the coincidental discovery of hypouricemia, to prevent conflicting complications of iRHUC, even with normal urine uric acid to creatinine ratio (UUA/UCr), and sequential genetic analysis if needed.

Study on functional elevations of sperm-host glands in domestic hens 2. Storage level of spermatozoa (닭의 정자선(精子腺) 기능(機能) 향상(向上)을 위한 연구(硏究) 2. 정자(精子) 저장(貯藏) 상태에 대하여)

  • Kwak, Soo-Dong;Ahn, Dong-Won
    • Korean Journal of Veterinary Research
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    • v.31 no.1
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    • pp.11-18
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    • 1991
  • The purpose of this study was designed to investigate the methods for the functional elevations of sperm-host (utero-vaginal, U-V) glands in domestic hens. The laying hens were assigned to five groups of low-, medium-, high- fecundity, gonadotrophin-, and caffeinetreated hen groups, these group hens were sacrified at interval after last artificial inseminations (AI). Number of U-V gland observed in tissue preparation of each hen U-V region were investigated, and also the appearance rates of spermatozoa-contained U-V glands were calculated. 1. In low-fecundity hen groups, the appearance rates of spermatozoa-contained U-V glands were found to be 13.5, 15.6, 11.8, 13.6, 2.3, 0, and 0% respectively at the hens of 1, 3, 7, 10, 13, 16, and 19 days after AI. 2. In medium-fecunditiy hen groups, the appearance rates of spermatozoa-contained U-V glands were found to be 21.7, 22.7, 13.4, 10.4, 10.0, 7.7 and 0% respectively at the hens of 1, 3, 7, 10, 13, 16, and 19 days after AI. 3. In high-fecundity hen groups, the appearance rates of spermatozoa-contained U-V glands were found to be 30.8, 31.8, 28.9, 13.0, 10.3, 10.8, and 0.9 respectively at the hen of 1, 3, 7, 10, 13, 16, and 19 days after AI. 4. In gonadotrophin-treated hen groups, the appearance rates of spermatozoa-contained U-V glands were found to be 31.8, 33.7, 32.3, 17.3, 12.0, 5.0, and 1.0% respectively at hens of 1, 3, 7, 10, 13, 16, and 19 days after AI. 5. In caffeine-treated hen groups, the appearance rates of spermatozoa-contained U-V glands were found to be 33.2, 29.2, 22.4, 17.8, 12.7, 0, and 1.1% respectively at hens of 1, 3, 7, 10, 13, 16, and 19 days after AI. 6. The appearance rates of completely filled U-V glands and partially filled U-V glands of spermatozoa-contained U-V glands were found to be 3.8:1. So we suggested as follows: The appearance rates of spermatozoa-contained glands tend to be high from 1 day after AI to 7 days and tend to declined rapidly from 10 days. Also higher fecundity hen groups tend to be higher in the appearance rates and longer in spermatozoa-contained duration in U-V glands than in lower fecundity hen groups. Gonadotrophin hormone tend to increase the appearance rates of spermatozoa-contained U-V glands than those in control group, whereas caffeine tend to increase those rates at 1 day and to declined more rapidly from 3 day than in control group.

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The Comparative Study of the Modalities of '-keyss' and '-(u)l kes' in Korean (`-겠`과 `-을 것`의 양태 비교 연구)

  • Yeom Jae-Il
    • Language and Information
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    • v.9 no.2
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    • pp.1-22
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    • 2005
  • In this paper I propose the semantics of two modality markers in Korean, keyss and (u)1 kes. I compare the two modality markers with respect to some properties. First, keyss is used to express logical necessity while (u)1 kes can be used to express a simple prediction as well. Second, keyss expresses some logical conclusion from the speaker's own information state without claiming it is true. On the other hand, (u)1 kes expresses the claim that the speaker's prediction will be true. Third, the prediction of keyss is non-monotonic: it can be reversed without being inconsistent. However, that of (u)1 kes cannot. Fourth, (u)1 kes can be used freely in epistemic conditionals, but keyss cannot. Finally, when keyss is used, the prediction cannot be repeated. The prediction from the use of (u)1 kes can be repeated. To account for these differences, I propose that keyss is used when the speaker makes a purely logical presumption based on his/her own information state, and that (u)1 kes is used to make a prediction which is asserted to be true. This proposal accounts for all the differences of the two modality markers.

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Effect of AC Electric Field on Decreasing Liftoff Height in Laminar Lifted Jet Flames (층류 부상 화염의 화염부상 높이 감소 구간에서 교류 전기장이 인가된 화염에 관한 영향)

  • Seo, B.H.;Van, K.H.;Kim, G.T.;Park, J.;Keel, S.I.;Kim, S.W.;Chung, S.H.
    • Journal of the Korean Society of Combustion
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    • v.22 no.3
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    • pp.17-22
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    • 2017
  • An experimental study has been conducted to elucidate the effect of AC electric field on behaviors of laminar lifted flame in nitrogen-diluted methane coflow-jets. Our concerns are focued on the regime to show a decrease in liftoff height, $H_L$ with increasing nozzle exit velocity, $U_O$ (hereafter, $decreasing-H_L$). The $H_L$ with $U_O$ near flame extinction were measured by varying the applied AC voltage, $V_{AC}$ and frequency, $f_{AC}$ in a single electrode configuration. The behavior of $H_L$ with a functional dependency of $V_{AC}$ and $f_{AC}$ was categorized into two regime : (I) $H_L$ decreased for nozzle diameter, D = 1.0 mm, and (II) $H_L$ increased in the increase of $f_{AC}$ for a fixed $V_{AC}$ in a D = 4.0, 8.4 mm. The lifted flames in $decreasing-H_L$ region was unstable in high voltage regimes while the $H_L$ showed a decreasing tendency with $U_O$ except them. Such behaviors in $H_L$ were also characterized by functional dependencies of related physical parameters such as $V_{AC}$, $f_{AC}$, $U_O$, fuel mole fraction ($X_{F.O}$) and D.

SHRIMP U-Pb Ages of the Namwon and Sunchang Granites (남원화강암과 순창화강암의 SHRIMP U-Pb 연령)

  • Jo, Hui Je;Park, Kye-Hun;Yi, Keewook
    • The Journal of the Petrological Society of Korea
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    • v.22 no.2
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    • pp.197-208
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    • 2013
  • The Namwon and Sunchang granites are neighbouring plutons intruding the Yeongnam massif and the Okcheon metamorphic belt, respectively in the southwestern part of the Korean peninsula. In this study, SHRIMP zircon U-Pb ages are determined from these plutons. The results show that the emplacement age of the Namwon granite is $185.8{\pm}0.9(2{\sigma})$ Ma. We obtained $175.0{\pm}2.0(2{\sigma})$ Ma from the northern part and $179.8{\pm}0.9(2{\sigma})$ Ma from the central part of the Sunchang granite, yielding $177.4{\pm}1.3(2{\sigma})$ Ma as the average age of the pluton. Such age results confirm that the Honam shear zone, which cause marked deformation of the Sunchang granite, was active after ca. 175 Ma.

Synthesis and Properties of Uranium Compounds (I). Salts of Bis(undecatungstophosphato)uranate(Ⅳ) Anion, $[U(PW_{11}O_{39})_2]^{10-}$ (우라늄 화합물의 합성과 성질에 관한 연구 (제1보). 비스(운데카텅스토포스파토)우라늄(IV) 산 이온, $[U(PW_{11}O_{39})_2]^{10-}$의 염)

  • Chul Wee Lee;Hyunsoo So
    • Journal of the Korean Chemical Society
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    • v.26 no.3
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    • pp.160-164
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    • 1982
  • A guanidinium salt of $[U(PW_{11}O_{39})_2]^{10-}$, the solubility of which is adequate for crystal growing, has been synthesized. Using this salt or potassium salt, we have measured the stability of $[U(PW_{11}O_{39})_2]^{10-}$as a function of pH of the solution and found that the anion is stable for the pH range 3~7. We have developed a colorimetric method for determining the concentration of $U^{4+}$. In this method$PW_{11}O_{39}^{7-}$ is added to$U^{4+}$ in such a quantity that the mole ratio $PW_{11}O_{39}^{7-}/ U^{4+}$exceeds 2 and the intensity of the 22.7kK band (${\varepsilon}$1030 M-1cm-1) is measured. In order to develop a continuous method to recover uranium, we have determined the amount of recoverd$PW_{11}O_{39}^{7-}$ after decomposing $[U(PW_{11}O_{39})_2]^{10}$- by adding either a base or an oxidizing agent. The percentage of $PW_{11}O_{39}^{7-}$recovered was approximately 70% when a base was used and approximately 80% when$K_2S_2O_8$ was used. A colorimetric method for determining $PW_{11}O_{39}^{7-}$ has also been developed.

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The Effects of Distance-Accessibility to the Complex Shopping Mall of 'Lotte Mall-Suwon' on the Prices of Its Neighboring Apartments within the Gwonseon-gu of Suwon City (복합쇼핑몰 '롯데몰 수원점'에 대한 거리 접근성이 수원시 권선구 내 인근 아파트가격에 미친 효과)

  • Jeong, Jun Ho
    • Journal of the Economic Geographical Society of Korea
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    • v.22 no.4
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    • pp.576-591
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    • 2019
  • This study attempts to analyze the effects of distance-accessibility to the complex shopping mall of 'Lotte Mall-Suwon', located at the old central and catchment district of the Suwon station in the Province of Gyeonngi, on the prices of its neighboring apartments within the Gwonseon-gu of Suwon City by using the hierarchical and linear-difference in difference regression method. The results of the analysis are as follows. First, before construction the effects of distance-accessibility show the U-shaped pattern, suggesting that the negative external effects of noise and traffic congestion around the Suwon Station affected the prices of its neighboring apartments within the Gwonseon-gu of Suwon City. Second, the effects of distance-accessibility at different times, such as the construction period and after the opening, are statistically significant only in the latter, indicating the reverse U-shaped pattern unlike before the opening. This means that after the opening of the complex shopping mall its external effects as a leisure and convenience space have a positive effect on the prices of its neighboring apartments within the Gwonseon-gu of Suwon City. Third, the effects of distance-accessibility is at an inflection point around 1.6-1.7 kilometers, which means that the U-shaped distance-decay pattern before construction, while the reverse U-shaped pattern is shown after the opening of opening. The latter implies that apartments that are very close to the mall within the Gwonseon-gu of Suwon City enjoy relatively small positive externalities. Therefore, they are exposed to some negative external effects of noise and traffic congestion, but apartments with some distance apart within the Gwonseon-gu of Suwon City maximize those positive externalities. These results suggest that the effects to distance-accessibility are different from location to location.

THE BASES OF PRIMITIVE NON-POWERFUL COMPLETE SIGNED GRAPHS

  • Song, Byung Chul;Kim, Byeong Moon
    • Korean Journal of Mathematics
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    • v.22 no.3
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    • pp.491-500
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    • 2014
  • The base of a signed digraph S is the minimum number k such that for any vertices u, v of S, there is a pair of walks of length k from u to v with different signs. Let K be a signed complete graph of order n, which is a signed digraph obtained by assigning +1 or -1 to each arc of the n-th order complete graph $K_n$ considered as a digraph. In this paper we show that for $n{\geq}3$ the base of a primitive non-powerful signed complete graph K of order n is 2, 3 or 4.

Fast Detection of Forgery Image using Discrete Cosine Transform Four Step Search Algorithm

  • Shin, Yong-Dal;Cho, Yong-Suk
    • Journal of Korea Multimedia Society
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    • v.22 no.5
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    • pp.527-534
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    • 2019
  • Recently, Photo editing softwares such as digital cameras, Paintshop Pro, and Photoshop digital can create counterfeit images easily. Various techniques for detection of tamper images or forgery images have been proposed in the literature. A form of digital forgery is copy-move image forgery. Copy-move is one of the forgeries and is used wherever you need to cover a part of the image to add or remove information. Copy-move image forgery refers to copying a specific area of an image itself and pasting it into another area of the same image. The purpose of copy-move image forgery detection is to detect the same or very similar region image within the original image. In this paper, we proposed fast detection of forgery image using four step search based on discrete cosine transform and a four step search algorithm using discrete cosine transform (FSSDCT). The computational complexity of our algorithm reduced 34.23 % than conventional DCT three step search algorithm (DCTTSS).

The Effect of Quantitative Easing on Inflation in Korea

  • Nam, Min-Ho
    • East Asian Economic Review
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    • v.22 no.4
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    • pp.507-529
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    • 2018
  • This paper evaluates the whole impact of quantitative easing on inflation in Korea implemented by the central banks in four major advanced economies, the U.S., Euro Area, U.K. and Japan. According to the analysis employing a VAR-X model with the security holdings of those central banks an exogenous variable, quantitative easing is estimated to exert downward pressures on inflation in Korea. Considering the impulse responses of Korean macroeconomic variables to a quantitative easing shock, the spillover effect is transmitted through exchange rate channel while trade channel turns out to be ineffective. In an additional analysis assessing the impact of each quantitative easing program of the central banks, only those of the Fed and European Central Bank are estimated to be significant. The empirical results prove to be robust even if using long-term interest rates as an alternative indicator of quantitative easing.