• 대한의용생체공학회:의공학회지
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• 제18권1호
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• pp.25-36
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• 1997

To regulate cardiac output of the Total Artificial Heart(TAH) physiologically, the hemodynamic information must be toed back to the controller. So far, our group has developed an automatic cardiac output control algorithm using the motor current waveform, It is, however difficult to detect the preload level such as a filling status of ventricular inflow and the variation of atrial pressures within normal physiologic range(0-15 mmHg) by analyzing the motor current which simultaneously reflects the afterload effect. On the other hin4 the interventricular volume pressure(IVP) which is not influenced by arterload but by preload is a good information source for the estimation of preload states. In order to find the relationship between preload and IVP waveform, we set up the artificial heart system on the Donovan type mock circulatory system and measured the IVP waveform, right and left atrial pressures, inflow and outflow waveforms and the signals represented the information of moving actuator's position. We shows the feasibility of estimating the hemodynamic changes of inflow by using IVP waveform. fife found that the negative peak value of IVP waveform is linearly related to atrial pressures. And we also found that we could use the time to reach the negative peak in IVP waveform, the time to open outflow valve, the area enclosed IVP waveform as unfu parameters to estimate blood filling volume of diastole ventricle. The suggested method has advantages of avoiding thrombogenesis, bacterial niche formation and increasing longterm reliability of sensor by avoiding direct contact to blood.

• 한국음향학회지
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• 제25권3호
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• pp.144-150
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• 2006

심장병이 있는 환자들을 진료할 때 의사들은 청진기를 이용하여 심음 (heart sound)을 듣고 이를 기준으로 환자의 병의 유무나 질환의 종류에 대한 기초적인 판단을 하게 된다. 하지만, 심음은 환자의 상태나 외부 잡음의 영향에 따라서 신호의 특성이 변하고 또한 정상적인 심음과 질병을 나타내는 심음과의 차이가 비교적 구분하기 어려울 정도로 작기 때문에 숙달된 전문의가 아니면, 진단의 정확도가 떨어질 가능성이 있다. 따라서 신호처리 기법을 이용하여 심음을 분석해서 심음이 정상적인지의 유무를 자동으로 판단할 수 있다면, 진단을 하는 의사들에게 유용한 정보가 될 것이라 생각된다. 본 연구에서는 심음의 질병유무와 질병종류를 자동으로 판단하기 위해서 기존에 많이 사용되었던 artificial neural network (ANN) 대신에 hidden Markov model (HMM)을 사용하는 방법을 제안하였으며, 기초적인 실험결과 상당히 우수한 성능을 보임을 알 수 있었다.

• 대한한의진단학회지
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• 제15권1호
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• pp.55-66
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• 2011

Objectives: The purpose of this study is to review the simulator for cardiovascular system. Methods & Results: Simulators were classified according to the structure and function of cardiovascular system. Heart and blood vessel were selected as the represent of structure. Blood pressure and blood flow were chose as the functional index. With the view points of four keywords, four kinds of simulators were selected: artificial heart, pressure simulator, flow simulator, and pulse simulator. Conclusions: This paper discussed the state of the art of research and development of the selected four kinds of simulators.

• 대한의용생체공학회:의공학회지
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• 제8권2호
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• pp.161-170
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• 1987

A new type of motor-driven total artificial heart system with a rolloing-cylinder mechanism has been developed. The prototype system consists of a brushless DC motor inside of a rolling-cylinder, two arc shaped pusher-plate s, and two ventricles of smooth, seamless polyurethane sacs. The motor-driven pump has the advantages of being portable and quiet compared to the present air-driven pump. It can also be controlled more accurately. This rolling-cylinder type electromechanical pump has several structural advantages including small size and weight, as compared to other research groups' motor-driven pumps. The results of mock circulation tests confirm sufficient pump output capacity(cardiac output . 9 L/min, at aortic pressure'120mmHg, with heart rate . 120 BPM) for animal implantation of our prototype system.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.51-54
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• 1997

Lumbrokinase, potent fibrinolytic enzyme purified from earthworm, was immobilized onto the total artificial heart valves using photoreaction. This valve were implanted into the lamb for three days. After experiments, thrombus was observed in the untreated valves whereas no thrombus was observed in the lumbrokinase immobilized valves. The fibrinolytic activity and proteolytic activity of the implanted valve was examined. The fibrinolytic activity of the valve was remained after the implantation. The lumbrokinase could be a suitable fibrinolytic agents in the vascular contacting devices to reduce the thrombus.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1995년도 Proceedings of the Korea Automation Control Conference, 10th (KACC); Seoul, Korea; 23-25 Oct. 1995
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• pp.509-513
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• 1995

A microcontroller-based DC motor control system for a total artificial heart(TAH) was developed. Using a one-chip microcontroller, 87Cl96KB, the design of digital motor speed control system and servo control system is demonstrated. Functionally, the control system consists of a position control unit, a speed control unit, and a communication unit. The performance and the reliability of the developed control system were assessed through a series of mock circulation system experiments.

• Journal of information and communication convergence engineering
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• 제21권2호
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• pp.130-138
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• 2023

The selection of the correct examination variables for diagnosing heart disease provides many benefits, including faster diagnosis and lower cost of examination. The selection of inspection variables can be performed by referring to the data of previous examination results so that future investigations can be carried out by referring to these selected variables. This paper proposes a model for selecting examination variables using an Artificial Bee Swarm Optimization method by considering the variables of accuracy and cost of inspection. The proposed feature selection model was evaluated using the performance parameters of accuracy, area under curve (AUC), number of variables, and inspection cost. The test results show that the proposed model can produce 24 examination variables and provide 95.16% accuracy and 97.61% AUC. These results indicate a significant decrease in the number of inspection variables and inspection costs while maintaining performance in the excellent category.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.59-63
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• 1997

It is needless to say that the hemodynamic variables estimation is a very important study for the artificial heart. Even though its importance there have not been satisfactory results which can be applied to the real-world situations. This paper surveys and recommends how to cope with the problem of hemodynamic variable estimation for the moving-actuator type total artificial heart (MA-TAH).

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.126-130
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• 1997

In the development of the totally implantable artificial heart (TAH), the information of the preload condition is important to ind appropriate condition or the automatic control of the heart. Our TAH configuration consists of two artificial ventricles, and brushless DC motor within actuator. The pressure between ventricles could indicate the preload condition during the TAH operation. If we can measure accurately inspite of the noise induced from TAH and environmental condition. We suggested integrating a feedback loop to remove an unexpected DC drift. NPI 19-series Nova sensor was used which could measure pressure in gas and liquid. This method and sensor enabled us to develop the pressure transducer compact so (that) the systems can be implanted with TAH into patient. This system has been verified in vitro and in vivo test. This results showed that the output waveform of this system was stable irrespective of animal condition.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.125-128
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• 1996

A new type of motor-driven total artificial heart system with a moving-actuator mechanism has been developed. The prototype system consists of a brushless do motor inside of actuator, two polyurethane sacs, and peripheral devices with internal controller. In this research work, the moving-actuator type electromechanical total artificial heart was redesigned for a good anatomical fitting. For total implantation we are developing the internal controller with high reliability and stability, and automatic control algorithm in response to the physiological requirements of animal. Contents and scope of the research work on ";Development of a totally implantable artificial heart of pre-clinical stage"; is summerized below 1) Animal experiment using sheep(55-60kg) 2) Development of implantable controller 3) Automatic control algorithm 4) Improvement of biocompatibility 5) Redesign of Actuator/blood pump.