Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Characterization of Antithrombotic Activity of Lumbrokinase immobilized Polyurethane Heart Valves in Total Artificial Heart Experiment

  • Park, Y.D. (Department of Biomedical Engineering, Seoul National University) ;
  • Jeong, J.S. (Department of Biomedical Engineering, Seoul National University) ;
  • Kim, H.J. (Institute of Biomedical Engineering, Seoul National University) ;
  • Kim, J. (Institute of Biomedical Engineering, Seoul National University) ;
  • Min, B.G. (Department of Biomedical Engineering, Seoul National University)
  • Published : 1997.05.23
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Abstract

Lumbrokinase, potent fibrinolytic enzyme purified from earthworm, was immobilized onto the total artificial heart valves using photoreaction. This valve were implanted into the lamb for three days. After experiments, thrombus was observed in the untreated valves whereas no thrombus was observed in the lumbrokinase immobilized valves. The fibrinolytic activity and proteolytic activity of the implanted valve was examined. The fibrinolytic activity of the valve was remained after the implantation. The lumbrokinase could be a suitable fibrinolytic agents in the vascular contacting devices to reduce the thrombus.

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