• 보존과학회지
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• 제34권2호
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• pp.97-106
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• 2018

회곽묘는 조선시대의 대표적인 묘제로서 당시 사회와 장례문화 이해에 중요한 자료이다. 궁리유적에서 발굴한 회곽묘를 제작방식에 따라 분류하여 초음파속도와 반발경도 측정을 통해 물성을 평가하였다. 층벽식으로 제작한 회곽묘의 강도는 측정방법에 따라 차이가 있다. 초음파속도와 반발경도를 통해 산출한 층벽식 회곽묘의 압축강도는 각각 4.0~355(평균 43.6) $kgf/cm^2$ 및 18.8~538(평균 245.2) $kgf/cm^2$의 범위를 보였다. 이 회곽묘는 발굴과 이장과정에서 벽체에 충격이 발생한 상태로, 벽체의 고유물성에 비해 낮은 초음파속도가 산출된 것으로 보인다. 반면 통벽식으로 제작한 회곽묘의 압축강도는 초음파속도 및 반발경도 측정방법에 따라 각각 5.7~793(평균 281.6) $kgf/cm^2$와 4.5~551(평균 172.4) $kgf/cm^2$로 나타났다. 이처럼 압축강도 값의 차이는 있지만 경향성이 유사한 것으로 보아, 초음파속도와 반발경도 측정을 통한 물성평가는 통벽식 회곽묘에서 더욱 효과적인 것으로 판단된다. 또한 측정면적이 작은 반발경도법이 초음파법보다 더욱 일정한 강도를 보였다.

• 대한소아치과학회지
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• 제23권2호
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• pp.429-449
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• 1996

An objective definition of the anomaly is not avaliable and most investigators define the term differently or fail to describe their criterion. Because dental anomaly may lead to many complications, early detection and diagnosis of dental anomalies are essential steps in the evaluation of the child patient and in treatment planning. These procedures require detailed medical and dental histories, through clinical examination and the use of radiographs. So, this study was designed to find out the prevalence of dental anomalies. The clinical and roentgenographic examination was undertaken for 8,054 children at age from 0 to 15 years and statistical analysis was done. The results were as follows : 1. Among the examined subjects, 2,134 subjects(26.5%) showed dental anomalies. The prevalence of individual dental anomalies were as follows : supernumerary teeth 15.6%, congenitally missing teeth 6.6%, fusion 2.2%, odontoma 0.35%, microdontia 1.2%, macrodontia 0.05%, gemination 0.22%, talon cusp 0.36%, dens evaginatus 0.24%, dens invaginatus 0.15%, dilaceration 0.27%, taurodontism 0.09%, abnormal tooth position 1.7%, natal & neonatal teeth 0.92%, amelogenesis imperfecta 0.01%. 2. Significant correlations between the groups with individual dental anomalies were as follows : between group I and other groups, there was negative correlation, especially group I and group II. And the correlation coefficient between male and female showed differences. 3. For the supernumerary teeth group, the prevalence of male was higher than female(p<0.001). While for the congenitally missing teeth, macrodontia, microdontia, abnormal tooth position group, the prevalence of female was greater than male(p<0.001). 4. For the congenitally missing teeth group, the mandibular primary lateral incisor showed the highest incidence in primary dentiton, while mandibular lateral incisor in permanent dentition. In the mandible(72.5%), this site showed higher prevalence than in maxilla. In the case with deciduous congenitally missing teeth, the prevalence of successive permanent congenitally missing teeth was about 33.9%, the incidence was highest in mandibular lateral incisors. 5. Most supernumerary teeth existed on middle area and showed inverted position and unerupted state. In addition, supernumerary teeth showed higher incidence on maxilla (99.3%). 6. In the case with deciduous fused teeth, the prevalence of successive permanent congenitally missing teeth was 39.9%, while that of successive permanent fused teeth was 2.7%. And the highest rate of the prevalence (40.3%) appeared in fusion of mandibular deciduous lateral incisor and canine. 7. In the case of odontoma, the prevalence was higher in maxilla(78.6%) and anterior region(82.7%) than mandible and posterior region.

• 한국지능시스템학회논문지
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• 제24권1호
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• pp.1-6
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• 2014

본 연구에서 $(2D)^2$ PCA 알고리즘을 이용한 최적 RBFNNs 기반 나이트비전 얼굴인식 시뮬레이터을 설계한다. CCD 카메라로 야간에 이미지를 취득할 경우 조도가 낮기 때문에 인식을 수행하기 어려운 수준의 이미지가 취득되는 문제점이 발생한다. 따라서 본 논문에서는 나이트 비전 카메라를 이용하여 야간 얼굴을 취득하였다. 또한 얼굴과 비얼굴 이미지 영역에서 야간 얼굴 이미지를 검출하기 위해 Ada-Boost 알고리즘을 사용한다. 그리고 히스토그램 평활화를 이용하여 이미지의 왜곡 현상을 최소화 한다. 이렇게 얻어진 고차원 이미지를 저차원으로 축소하기 위해 $(2D)^2$ PCA 알고리즘을 사용했다. 다항식 기반 RBFNNs을 이용한 지능형 패턴 분류 모델을 통하여 얼굴인식을 수행 한다. 마지막으로 차분진화 알고리즘을 사용하여 파라미터를 최적화 한다. $(2D)^2$ PCA를 최적 RBFNNs 기반 나이트비전 얼굴인식 시스템의 성능 평가를 위하여 IC&CI Lab data를 사용하고 실제 얼굴 인식 시스템을 설계한다.

• Archives of Pharmacal Research
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• 제26권1호
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• pp.70-75
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• 2003

The objective of the present study was to investigate the uptake process of 4-Phenylazobenzoxycarbonyl-Pro-Leu-Gly-Pro-D-Arg (Pz-peptide), a hydrophilic and collagenase-labile pentapeptide, by isolated hepatocytes. For comparison, the uptake of Pz-peptide by Caco-2 cells and colonic cells, two known paracellular routes of Pz-peptide, was also evaluated. A simple and sensitive reversed-phase HPLC assay method using UV detection has been developed. The coefficient of variation for all the criteria of validation were less than 15%. The method was, therefore, considered to be sutable for measuring the concentration of Pz-peptide in the biological cells. Pz-peptide was extensively uptaked into hepatocytes. The initial velocity of Pz-peptide uptake assessed from the initial slope of the curve was plotted as Eadie-Hofstee plots. The maximum velocity ($V_{max}$) and the Michaelis constant ($K_m$) were 0.190$\pm$0.020 $nmol/min/10^6$ cells and 12.1$\pm$3.23 $\mu$M, respectively. The permeability-surface area product ($PS{influx}$) was calculated to be 0.0157 ml/min/10^6$ cells. $V_{max}$ and $K_m$ values for Caco-2 cells were calculated to be 6.22$\pm$0.930 pmol/min/10^6$ cells and 82.8$\pm$8.37 $\mu$M, respectively, being comparable with those of colonocytes (6.04$\pm$1.03 pmol/min/10^6$ cells and 87.8$\pm$13.2 $\mu$M, respectively). $PS_{influx}$ values for Caco-2 cells and colonocytes were calculated to be 0.0751 $\mu$l/min/10^6$ cells and 0.0688 $\mu$l/min/10^6$ cells, respectively. The more pronounced uptake of Pz-peptide by hepatocytes, when compared with Caco-2 cells and colonocytes, is probably due to its specific transporter. In conclusion, Pz-peptide, a paracellularly transported pentapeptide in the intestine and ocular epithelia, was uptaked into hepatocytes extensively. Although Pz-peptide is able to be uptaked into the Caco-2 cells and colonocytes, it is less pronounced when compared with hepatocytes. $PS_{influx}$ values of Caco-2 cells and colonocytes for unbound Pz-peptide under linear conditions were less than 0.4% when compared with that of hepatocytes.

• 농촌의학ㆍ지역보건
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• 제23권2호
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• pp.193-204
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• 1998

Cardiovascular diseases are the leading cause of death and disability in Korea. Their risk factors can be classified as either modifiable or nonmodifiable and among modifiable factors are high bood pressure, elevated blood cholesterol, obesity and cigarette smoking. The purpose of this study was to evaluate the risk factors for the cardiovascular diseases in a rural community and to get basic data for the development of a community-based rick reduction intervention program. Evaluation involved population-based, cross-sectional samples of adult residents in a rurual community. We measured blood pressure, body fat percent by bioelectric impedance fatness analyzer and serum cholesterol and interviewed adult residents over 20-year-old age. Blood pressure was checked twice and hypertension was classified by the sixth report of the Joint National Committee on Detection. Evaluation, and Treatment of High Blood Pressure. The Cutpoints for high blood cholesterol was used National Cholesterol Treatment Guidelines and those for obesity was 25% in male. 30% in female. The results were as follows: 1. Prevalence of definitive hypertension was 59.7% in males and 54.4% in female. 2. Prevalence of hypercholesterolemia was 14.3% in male and 18.2% in female. 3. Prevalence of obese was 10.7% in male and 41.1% in female. 4. Among definitive hypertension, hypercholesterolemia, and obesity 52.1% possessed one risk factor, 12.6% two risk factors and 2.5% three risk factors in males. In females 41.4% possessed one risk factor and 27.6%. 5.7% respectively. 5. The smoking rate was 65.8% in males and 5.2% in females. Our results are used effectively for the community-based intervention towards cardiovascukr diseases risk reduction. However, because of limitations in our study design, further datas are needed including other risk factors and in-person clinical datas.

• 농촌의학ㆍ지역보건
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• 제19권1호
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• pp.41-52
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• 1994

The aim of this study was to assess the people's need for visiting health services in a rural area. In recent years, the great concern for the visiting health services has aroused in Korea. Stratified cluster sample for a household survey was used to select 1,255(8.4%) Households from Yonchon county. This study was undertaken from July 26 to August 7 in 1993. Medically defined need, usually expressed by the prevalencies or rates of specific disease, was evaluated with the use of criteria established by medical and nursing professors and expressed by the percent of specific objects for the visiting health services. Perceived need represented by the acceptability for the visiting services and willingness to paying for it, also, evaluated. The major results were as follows : 1. Of the 348 patients with hypertension, 201 were the non-compliant patients, the rate of the non-compliant hypertension patients in 4,577 study population was 7.4%. 2. Of the 141 diabetic patients, 73 were the non-compliant patients, the rate of the non-compliant hypertension patients in 4,577 sample population was 2.7%. 3. The number of patients with severe musculo-skeletal disease was 24, the rate was 0.9% above the age 30. 4. Of the 514 elderly, 33 were the elderly without any family member, the rate was 8.4%. Those with severely decreased activity of daily living were 13. 5. Infants with high risks were 12, pregnant women and neonates were 5, patients discharged within 1 week and with special equipments such as peritoneal dialysis, stoma, TPN etc. were 17, and patients with cancer were 5. Total number of the objects needed visiting health services was 752(18.43%) of the 4,577 study population. Perceived need evaluated were as follows; The acceptance rate of visiting health services was 74.9%, The kinds of visiting health services such as family health protection and promotion, early detection of hypertension, physiotherapy, health education and counseling were needed in the order of high rate The price willing to pay for visiting health services per visit was about 3,000-5,000Won. In conclusion, Visiting health services programme to be developed should have priority to the prevention of complications of chronic disease such as hypertension, diabetes milletus, elderly disease and health promotion.

• 전자공학회논문지CI
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• 제47권3호
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• pp.11-21
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• 2010

최근 웹페이지의 생성 및 웹이 가진 정보량이 기하급수적으로 늘면서 사용자의 검색 목적을 파악하여 효율을 높이기 위한 다양한 방법이 연구되고 있으며, 태깅 시스템이 하나의 대안으로 떠오르고 있다. 태깅 시스템은 인터넷 사용자로 하여금 태그라고 불리는 메타데이터를 글, 사진, 동영상 등에 부여하도록 함으로써 콘텐츠의 검색 및 브라우징을 편리하게 하는 시스템이다. 이처럼 태그는 해당 페이지의 대표 키워드를 의미하므로 콘텐츠 분류의 기준을 마련할 수 있으나, 사용자에 의해 직접 입력되어야 하는 수고가 필요하고, 또한 무분별한 태깅으로 인해 오히려 분류에 방해가 되는 등의 문제점들이 있다. 본 논문에서는 이러한 태깅의 문제를 해결하기 위한 방법으로 얼굴인식 알고리즘을 활용한 영상콘텐츠 내에서의 다중 얼굴 태깅 자동화 방법을 제시한다. 이를 위해 먼저 여러 얼굴검출 방법 중 Haar-like features와 AdaBoost 알고리즘을 이용하여 빠른 속도와 높은 정확도로 영상콘텐츠 내에서 얼굴 영역을 검출한다. 이후 PCA와 고유얼굴을 이용하여, 검출해 낸 얼굴을 데이터베이스에 미리 저장해 놓은 프로필 사진과 비교, 인식해냄으로써 해당 인물에 대한 정보를 불러와서 자동으로 태깅하는 시스템을 구현하였다. 이러한 새로운 방식의 태깅 기술은 현존하는 사진공유, 쇼핑, 검색 등의 수많은 웹서비스에 적용이 가능하며, 특히 소셜네트워크서비스에서의 사진 관리나 인물검색 등에서 활용할 때 큰 효과를 보일 것으로 기대된다.

• 대한전자공학회논문지SP
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• 제46권4호
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• pp.124-131
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• 2009

방사선영상의 신뢰할 만한 영역검출은 용접부위 결함탐지 이전의 중요한 작업 중의 하나이다. 추출되는 특징들은 각 분할된 영상에 대하여 서로 다른 군집으로 분류되어야한다. 그러나 종래의 분할 기법으로는 방사선영상 고유의 색도중첩과 낮은 SN비로 인해 만족할 만한 결과를 얻기가 쉽지 않다. 전체나 국부처리로는 잡음제거에 취약할 뿐만 아니라 영역분류도 어렵다. 이 논문은 산업용 CR 영상에서 영역기반실현의 분할을 위한 적절한 기법을 제시한다. 강판튜브에서 용접과 비용접 구간의 기하학적 차이가 영상화 과정을 통해 배경부, 두께부, 중간부 및 용접부 영역을 생성하고 계층 구조적 배열을 형성한다. 비록 그 구조가 잡음에 훼손되기는 하지만 영역구분 구도 각 영역의 차별된 기하학적 특성에 근거한 국부군집화에 의해 선별이 가능하다. 관련 영역의 기하학적 속성에 의해 그에 따른 영역이 계층별로 선별되어 실제 구분이 영역간 경계를 반영하기 때문에 직경과 길이방향의 군집화는 각 계층의 구별을 명확케 한다. 그리고 산업용 강판튜브 CR영상에 다양한 분할 방식으로 비교 실험을 실시하여 이 기법의 효과를 보였다.

• 한국임상약학회지
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• 제8권2호
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• pp.107-112
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• 1998

Lovastatin is a lipid lowering agent for the treatment of hypercholesterolemia and belongs to a new class of pharmacologic compounds called the 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors. By competitively inhibiting HMG CoA reductase, lovastatin disrupts the biosynthesis of cholesterol in hepatic and peripheral cells and increases the synthesis of high-density-lipoprotein HDL) receptors. Following oral administration, the lactone ring of lovastatin is hydrolysed to the active inhibitor of HMG CoA reductase, lovastatin acid. Lovastatin is known to have poor oral absorption and wide individual variation. In this study, bioequivalence test of two lovastatin formulations, the test drug ($Lovaload^{TM}$, Chong Kun Dang Pharmaceutical Co.) and the reference drug ($Mevacor^{TM}$, Chung Wae Pharmaceutical Co.) were conducted according to the guidelines of Korea Food and Drug Administration (KFDA). A total of 18 healthy male volunteers, $31.90\pm3.60$ years old and $72.17\;7.88$ kg of body weight in average, were evaluated in a randomized crossover manner with a 2-week washout period. Concentrations of lovastatin acid in plasma were measured upto 12 hours following a single oral administration of eight tablets (20 mg of lovastatin per tablet) by high-performance liquid chromatography with UV detection at 238 nm. The area under the concentration-vs-time curve from 0 to 12 hours $(AUC_{0-12h})$ was calculated by the trapezoidal summation method. The statistical analysis showed that there are no significant differences in $AUC_{0-12h),\;C_{max}\;and\;T_{max}$ between the two formulations ($6.72\%,\;1.52\%,\;and\;0.88\$, respectively). The least significant differences between the formulations at $\alpha$=0.05 were less than $20\%\;(11.65\%,\;19.73\%,\;and\;14.81\%\;for\;AUC_{0-12h},\;C_{max}\;and\;T_{max}$, respectively). The $90\%$ confidence intervals for these parameters were also within $\pm20\%\;(-1.50{\leq}{\delta}{\leq}15.00$, $-12.50{\leq}{\delta}{\leq}15.50,\;and\;-9.64{\leq}{\delta]{\leq}11.40{\leq}\;for\;\;AUC_{0-12h}$ ,$C_{max}\;and\;T_{max}$, respectively). In conclusion, the new generic product $Lovaload^{TM}$ was proven to be bioequivalent with the reference drug.

• 콘크리트학회논문집
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• 제22권1호
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• pp.113-122
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• 2010

후 긴장된 PS 강재의 부식과 파단은 프리스트레스 콘크리트 교량의 안전에 매우 심각한 문제를 발생시키고 있다. 따라서 교량의 내하력 평가시 PS 강재의 부식 상태를 조사해야 하며, 부식된 PS 강재가 발견되는 경우, 부식에 의한 강재의 단면적 감소량을 극한강도 평가시 고려해야만 한다. 선행 연구에서는 연속음향감지기법을 그라우팅되고 후 긴장된 PS 강연선의 부식과 파단을 감지할 수 있는 신뢰할 만한 비파괴검사방법으로 평가하였다. 이 연구에서는 긴장재에 도입된 응력 수준이 현행 설계기준에 제시된 수준보다 낮게 도입된 PS 강연선에 대해 부식에 의한 강선 파단을 감지하기 위한 실험적 연구를 수행하였다. 이를 위해 프리스트레스의 크기가 각각 인장강도의 66%와 40%로 도입된 PS 강연선이 포함된 길이 10 m의 PSC 보를 제작하였다. 부식 촉진 장비를 이용하여 긴장재를 인위적으로 부식시켰으며, 7개의 음향센서와 연속음향감지장치를 이용하여 실험부재를 모니터링하였다. 부식 촉진 실험 동안 각 PS 강연선으로부터 2번의 강선 파단음파를 성공적으로 감지하였으며, 또한 오차범위 20 mm 이하로 음원 위치를 표정할 수 있었다. 이상의 실험 결과를 토대로 그라우팅되고 후 긴장된 PSC 보에서 발생되는 PS 강선 파단을 감지하는데 연속음향감지기법을 적용할 수 있다고 판단된다.