• Journal of Society of Preventive Korean Medicine
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• v.12 no.1
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• pp.73-87
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• 2008

In recent years, there has been a globally increasing application of herbal medicines and dietary supplements to treat various chronic diseases and to promote health. However, there are increasing clinical reports on the organ toxicities associated with consumption of herbal medicines. In general, most xenobiotics are metabolized by Phase I reaction(the main enzyme : cytochrome P450) and Phase II reaction. However, reactive oxygen species, free radicals and electrophils are produced inevitably during xenobiotics metabolism. These toxic species and metabolites are increased whenever the endogenous substances and enzymes for Phase II reaction not available. In addition, herbal-drug interactions are pharmacokinetic, with most actually or theoretically affecting the metabolism of the affected product by way of the cytochrome P450 enzymes. This review updated the knowledge on metabolic activation of herbal components and its clinical and toxicological implications. Also, the possible way for preventing the side-effects by herbal-medicine use was suggested.

• Geomechanics and Engineering
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• v.37 no.1
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• pp.21-29
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• 2024

The effective management of damage in tunnels is crucial for ensuring their safety, longevity, and operational efficiency. In this paper, we propose an educational management model tailored specifically for addressing damage in tunnels, utilizing numerical solution techniques. By leveraging advanced computational methods, we aim to develop a comprehensive understanding of the factors contributing to tunnel damage and to establish proactive measures for mitigation and repair. The proposed model integrates principles of tunnel engineering, structural mechanics, and numerical analysis to facilitate a systematic approach to damage assessment, diagnosis, and management. Through the application of numerical solution techniques, such as finite element analysis, we demonstrate the efficacy of the proposed model in simulating various damage scenarios and predicting their impact on tunnel performance. Additionally, the educational component of the model provides valuable insights and training opportunities for tunnel management personnel, empowering them to make informed decisions and implement effective strategies for ensuring the structural integrity and safety of tunnel infrastructure. Overall, the proposed educational management model represents a significant advancement in tunnel management practices, offering a proactive and knowledge-driven approach to addressing damage and enhancing the resilience of tunnel systems.

• Journal of the Korea Safety Management & Science
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• v.25 no.2
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• pp.167-174
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• 2023

Currently, the budget for vocational competency development training has been expanded, but the number of participants has decreased. As the budget for the Vocational Competency Development Project increases, the participation of a large number of people becomes necessary. This study aims to derive factors that affect satisfaction by selecting factors related to respondent characteristics, training institutions, training types, and job performance for satisfaction with vocational competency development training, and to study ways to improve satisfaction. Data were collected through focus group interviews (FGI), and logistic regression analysis was conducted through feasibility review and reliability analysis. As a result, in the case of the model, it was confirmed that the degree of agreement between the case actually measured and the case predicted by the model was low in the Hosmer and Lemeshow test, but the overall classification accuracy was classified as 96.0% in the classification accuracy table. As for the influence of the factors, the result was derived that the application of knowledge technology, training institution facility equipment, Business Collaboration, long-term work plan, and satisfaction with work performed have an influence in the order.

• The Journal of Korean Academic Society of Nursing Education
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• v.18 no.3
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• pp.474-485
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• 2012

Purpose: The Quality and Safety Education for Nurses [QSEN] initiative group has identified six competencies (patient-centered care, teamwork and collaboration, evidence-based practice, quality improvement, safety, and informatics) for pre-licensure nursing education along with related knowledge, skills, and attitudes for each competency. The purpose of this article is to illustrate a teaching strategy that uses films to demonstrate the QSEN competencies in undergraduate nursing students. Method: A literature review was conducted to define QSEN competencies, and six feature-length commercial movies were selected through a systematic process. We provided film titles and their synopses that can be useful in teaching the QSEN six competencies to undergraduate nursing students. Results: Patch Adams for patient-centered care, Wit for teamwork and collaboration, Lorenzo's Oil for evidence-based practice, Am$\acute{e}$lie for quality improvement, Blindness and The Island for informatics can be applied in nursing classroom practices. Conclusion: Establishing the connection between QSEN competencies and cinenurducation is novel, yet it would provide a unique opportunity for nurse educators seeking to overcome the challenge of better preparing future nurses. In future studies, additional films should be considered to enhance nursing educational strategies.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.21 no.4
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• pp.489-502
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• 2023

This article presents the crucial role played by the French underground research laboratory (URL) in initiating the deep geological repository project Cigéo. In January 2023, Andra finalized the license application for the initial construction of Cigéo. Depending on Government's decision, the construction of Cigéo may be authorized around 2027. Cigéo is the result of a National program, launched in 1991, aiming to safely manage high-level and intermediate level long-lived radioactive wastes. This National program is based on four principles: 1) excellent science and technical knowledge, 2) safety and security as primary goals for waste management, 3) high requirements for environment protection, 4) transparent and open-public exchanges preceding the democratic decisions and orientations by the Parliament. The research and development (R&D) activities carried out in the URL supported the design and the safety demonstration of the Cigéo project. Moreover, running the URL has provided an opportunity to gain practical experience with regard to the security of underground operations, assessment of environmental impacts, and involvement of the public in the preparation of decisions. The practices implemented have helped gradually build confidence in the Cigéo project.

• Korean Journal of Culture and Social Issue
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• v.9 no.spc
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• pp.35-55
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• 2003

The purpose of this study is to review the previous studies on the safety problems in Korea and to propose a psychological total safety system model. The model consisted of four agents; the government as the safety management agent, the suppliers of safety goods and services, consumer of safety goods and services, and civil movement institutions for safety. It was emphasized that the culture specific social representations of safety and accident have emerged in the course of rapid industrialization process in Korea during last 30 years. We delineated the social representations of the Korean people on safety and accident according to the model. A psychological analysis of drinking and driving behavior was performed as an application of the model. It was emphasized that safety psychologists have to develope and to apply the knowledge and the information from human engineering psychology and applied social psychology on safety and accidents.

• Journal of Korea Multimedia Society
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• v.13 no.12
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• pp.1843-1854
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• 2010

The utilization of underground space has recently increased with the complication of road, the rise of the land price, and the development of green technology. Underground space ranges from classical excavations to subway, underground cities, and shopping malls where there are crowds of people. At this time, government has spent a lot of money in installing various types of safety facilities for preparations of increasing potential disasters. Therefore, an effective facility management system is required. In this paper, we propose an information retrieval process to effectively extract the facilities' information based on the ontology and spatial analysis in underground space. The ontology-based searching supports hierarchical and associated results as well as knowledge sharing with hierarchy concepts. The spatial analysis based searching has "Buffer" and "Near" functions to operate on a map without understanding any property of the facility information.

• Toxicological Research
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• v.17
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• pp.17-24
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• 2001

Risk assessment is useful tool making good decisions on the risks of certain hazardous com-pound and suggests safe margin through scientific process using toxicological data, statistical tool, exposure value and relevant variants. The goal of risk management is to protect the public health from hazardous compound based on result of risk assessment having reality. For the suggestion of exact man-aging information, risk assessment must be designed to represent a "plausible estimate" of the exposure to the individuals and to minimize uncertainty. Risk assessment methodology and knowledge are expected to change more rapidly than before and up-to-date methodology should be applied in regulatory aspects through the Agency. For the useful application of risk assessment, the communication between the risk assessor and the risk manager is needed before the initiation of the risk assessment and upon its completion. Generally, the risk assessment itself as a practical tool in the regulatory decision making process would be regarded with social economic impact.ic impact.

• Korean Journal of Veterinary Service
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• v.39 no.1
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• pp.41-49
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• 2016

In the present study, fast and robust methods for the next generation sequencing (NGS) were developed for analysis of PRRSV full genome sequences, which is a positive sensed RNA virus with a high degree of genetic variability among isolates. Two strains of PRRSVs (VR2332 and VR2332-R) which have been maintained in our laboratory were used to validate our methods and to compare with the sequence registered in GenBank (GenBank accession no. EF536003). The results suggested that both of strains had 100% coverage with the reference; the VR2332 had the coverage depth from minimum 3 to maximum 23,012, for the VR2332-R from minimum 3 to maximum 41,348, and 22,712 as an average depth. Genomic data produced from the massive sequencing capacities of the NGS have enabled the study of PRRSV at an unprecedented rate and details. Unlike conventional sequence methods which require the knowledge of conserved regions, the NGS allows de novo assembly of the full viral genomes. Therefore, our results suggested that these methods using the NGS massively facilitate the generation of more full genome PRRSV sequences locally as well as nationally in regard of saving time and cost.

• Journal of Veterinary Science
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• v.24 no.1
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• pp.12.1-12.10
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• 2023

Background: Arthroscopic exploration of ventromedial part of canine coxofemoral joint is limited in conventional dorsal approach. Objectives: We evaluated the efficacy of a medial arthroscopic approach to the coxofemoral joint of dogs by analyzing the joint visible area and performing a safety analysis. Methods: Arthroscopic approaches to the coxofemoral joint were made in five cadavers using a traditional (dorsal) and novel (medial) approach. Three observers scored the visible area of images and videos of the acetabulum and femur. A safety analysis was performed via dissection of the medial hind limb. The distance between neurovascular structures and arthroscopic portals was measured. Results: The acetabulum was more visible in the dorsal than in the medial approach, with mean visualization scores of 16 ± 0.00 and 11.83 ± 1.26, respectively. The medioventral side of the femur was significantly more visible in the medial than in the dorsal approach, with mean visualization scores of 3.9 ± 0.99 and 6.93 ± 0.58, respectively. Safety analysis confirmed the medial portal site was safe, provided that the surgeon has comprehensive knowledge of the joint. The minimum distance from the arthroscopic medial portals to the nearest neurovascular structures was 2.5 mm. Conclusions: A medial arthroscopic approach to the canine coxofemoral joint has potential clinical application. Dorsal and medial approaches differ significantly and have distinct purposes. The medial approach is useful to access the ventromedial joint, making it an eligible diagnostic method for an arthroscopic evaluation of this area.