• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.1336-1340
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• 2003

The compressed fracture of spine caused by osteoporosis is one of the most frequent diseases in bone fracture. Recently the vertebroplasty has drawn much attention as a medical treatment for the compressed fracture of spine, which strengthens the vertebral body and corrects deformity, and relieves pain in patients by injecting bone cement. The purpose of this research is to provide the theoretical background for the vertebroplasty by employing scientific methods and thus to find out the improvements of the conventional surgical method. By applying the engineering analysis tools to clinical study, new application fields can also be obtained

• Journal of Biomedical Engineering Research
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• v.22 no.5
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• pp.419-424
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• 2001

We intended to evaluate the Young's modulus of trabecular bone of a human distal femur by spherical Indentation test and CT images and to quantify relationships between the direction of load, density. and Young's modulus. The specimens were scanned at 1 mm intervals on CT scanner After scanning the bones were sectioned with diamond saw. producing 8mm cubes of trabecular bone. The tubes were mechanically tested in inferior-superior(IS), anterior-posterior(AP). and medial-lateral(ML) direction with custom-made device. After testing, the real apparent density of specimens were measured. The results of this study showed that the IS modulus was significant1y greater than both the AP and ML modulus and the AP modulus was also greater than ML modulus significantly(p〈0.01) A significant Power relationship between the apparent density and the modulus was also found.

• Nutritional Sciences
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• v.7 no.3
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• pp.151-157
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• 2004

The aim of this study was to investigate the effects of chicory fructan fiber supplementation on bone mineral density, apparent absorption of minerals and serum parameters related to bone turnover in postmenopausal women. Twenty-six healthy Korean postmenopausal women participated in the study. 1be participants were randomly divided into two groups in a double-blind parallel design and took one of the supplements for 3 months; either a placebo of 8g maltodextrins/sucrose mixture (control group) or 8g chicory fructan fiber (fructan group). During the 3-month experimental period no differences were found in bone mineral density (BMD) between the two groups. Apparent calcium absorption significantly increased by 42% in the fructan group, while that of the control group decreased by 29% as compared to the values at baseline. Urinary calcium excretion was not significantly different between the group;;. After 3 months, the level of serum alkaline phosphatase (ALP) was significantly lower in the fructan group than in the control group and deoxypyridinolin showed a trend toward a slight reduction. In conclusion, intake of chicory fructan fiber with a regular increases apparent calcium absorption in postmenopausal women.

• Journal of the Korean Society for Nondestructive Testing
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• v.32 no.5
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• pp.502-508
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• 2012

Quantitative ultrasound technologies for osteoporosis diagnosis measure ultrasonic parameters such as speed of sound(SOS) and normalized broadband ultrasound attenuation(nBUA) in the calcaneus (heel bone). In the present study, the dependences of SOS and nBUA on bone mineral density in the proximal femur with high risk of fracture were investigated by using 20 trabecular bone samples extracted from bovine femurs. SOS and nBUA in the femoral trabecular bone samples were measured by using a transverse transmission method with one matched pair of ultrasonic transducers with a center frequency of 1.0 MHz. SOS and nBUA measured in the 20 trabecular bone samples exhibited high Pearson's correlation coefficients (r) of r = 0.83 and 0.72 with apparent bone density, respectively. The multiple regression analysis with SOS and nBUA as independent variables and apparent bone density as a dependent variable showed that the correlation coefficient r = 0.85 of the multiple linear regression model was higher than those of the simple linear regression model with either parameter SOS or nBUA as an independent variable. These high linear correlations between the ultrasonic parameters and the bone density suggest that the ultrasonic parameters measured in the femur can be useful for predicting the femoral bone mineral density.

• The Journal of the Acoustical Society of Korea
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• v.32 no.2
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• pp.181-189
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• 2013

The purpose of the present study is to investigate the effect of cortical bone on acoustic properties of trabecular bone, such as speed of sound (SOS) and normalized broadband ultrasound attenuation (nBUA), in bovine femur in vitro. Twelve trabecular bone samples and three cortical bone plates with thicknesses of 1.00, 1.47, and 2.00 mm were extracted from the proximal end of two bovine femurs. The correlations between acoustic properties and trabecular apparent bone density were also examined before and after attaching a cortical bone plate to the trabecular bone samples. SOS increased linearly with increasing thickness of the cortical plate attached to one side of ultrasonic incidence of the trabecular bone samples, whereas nBUA showed a nonlinear dependence on the thickness of the cortical plate. All the SOS (r = 0.95-0.97) and nBUA (r = 0.53-0.73) measurements with and without the cortical bone plate with various thicknesses were found to exhibit high correlations with the trabecular apparent bone density. These results imply that the acoustic properties measured in the femur with lateral cortical layers in vitro can be useful indices for the prediction of trabecular bone mineral density.

• Preventive Nutrition and Food Science
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• v.12 no.4
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• pp.217-221
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• 2007

Within the elderly population, the use of calcium supplements and the intake of calcium from food are on the rise in order to maintain health. Calcium is absorbed as an ion in vivo, leading to speculation that absorption efficiency is affected by the solubility of the calcium consumed. In our study, the bioavailability of two types of calcium supplements with different solubilities was evaluated. Experimental animals were fed water-soluble or insoluble calcium supplements for 6 weeks. We found that blood alkali phosphatase activity, osteocalcin content, and urine crosslinks values were not different between the groups. Similarly, the degree of apparent calcium absorption between the two calcium supplements was not significantly different. The bone mineral density and bone mineral content of the femur and the tibia increased in the group that consumed insoluble calcium compared with those of the water-soluble calcium supplemented group. However, when considering body weight, the bone mineral density value for all areas, including the spine, was significantly higher in the group that consumed the water-soluble calcium supplement.

• Journal of Nutrition and Health
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• v.34 no.8
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• pp.887-895
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• 2001

This study was designed to investigate the effect of dietary boron supplementation and calcium levels on calcium and bone metabolism in ovariectomized female rats. The experimental group classified ovariectomized group(O) and sham operation group (S). The two groups were then each randomly divided into flour sub-groups and fed experimental diets consisting in two levels of calcium and at each level of calcium, there were boron supplemented group and non-supplemented group. Calcium levels were either 0.2%(low calcium group: L) or 1.2%(high calcium group: H). The level of boron in the diet for the boron supplemented groups(B) was 100$\mu\textrm{g}$/g diet. The experimental period was six weeks. The average food intake were not statistically significantly different in all of eight groups. The increase in weights of rats was observed only in ovariectonized and sham control rats(low ca without boron supplemented). The rest of the groups lost weight significantly during the experimental period ranging from 26.94g to 44.34g. Significant higher calcium intakes were observed in high calcium groups, regardless of boron supplementation during experimental period. Urinary calcium excretion was not affected either by ovariectomy or diets on the first, third and sixth week of feeding. Apparent calcium absorption rates were not different among the groups on first week, whereas noticeable increase was observed in low calcium groups at third and sixth weeks. Femur wet and dry weight, and calcium contents of femur were higher in low calcium groups. whereas femur bone density was higher low calcium with boron supplementation groups than low calcium groups. Scapular density did not show any significant differences among all groups. Despite there were no differences in the activities of alkaline phosphatase by boron supplementation, boron supplemetation appeared to cause higher femur density. There results suggest that in both of sham-operated and ovariectomized rats low calcium did not influence greatly bone status of rats and boron increased bone density.

• Proceedings of the Acoustical Society of Korea Conference
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• spring
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• pp.525-528
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• 2002

The speed of sound, transmission coefficient, and attenuation are measured around the center frequency 1 and 2 MHz in solid materials such as bone, sediment, rubber, and Lucite materials. Common and different characteristics of such materials in the sound speed, transmission coefficient, and attenuation are discussed. Ambiguities in estimating such acoustic characteristics we also addressed. Ultrasonic properties of the first and second kind waves are clarified for different materials. Discussions are concentrated on classes of sound speed, broadband ultrasonic attenuation (BUA), and correlations of sound speed and BUA with apparent density. New correlations of inverse sound speed square and BUA with apparent density are suggested.

• Journal of Nutrition and Health
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• v.31 no.4
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• pp.716-728
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• 1998

To investigate the effect of dietary Ca levels on metabolic changes of Ca and skeleton in postmenopausal women, 10-month-old ovariectomized female rats were compared with 2 month old rats. The rats were fed either 0.2% or 1.2% Ca diets for 16 weeks. Food intake and weight gain as higher in rats fed high Ca diets and in ovariectomized rats. Apparent Ca absorption as higher, and Ca balance was lower in the low Ca groups. Vertebrae density was higher in old rats or those fed a high Ca diets. The old rats and ovariectomized rats showed decreased bone formation, increased bone resorption and kidney function deterioration resulting in increased urinary Ca excretion. Contradictory to the above observation, old rats and ovariectomized rats still showed higher bone mass and bone ash content. Therefore aging was not fully onging in 10-month-old rats. Bone weights, mineral contents, and mineral/wt ratio were lower in ovariectomized rats. Dietary Ca level did not affect urinary Ca excretion, urinary protein excretion, GFR, serum alkaline phosphatase, or urinary hydroxyporline excretion. This means that dietary Ca level did not influence kidney function or bone turnover. However Ca content and the ash content of femur, 4th vertebra, and scapula were increased in high Ca groups. Therefore, it is considered that decreased bone formation and accelerated bone resorption may account for the increased osteoporotic risk in women in menopause after middle age. However, Ca metabolism can be improved and bone components can be maintained if Ca is supplemented.

• Korean Journal of Poultry Science
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• v.44 no.3
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• pp.151-159
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• 2017

The experiment was carried out on 648 Ross 308 broilers ($40.4{\pm}0.2$ g; 1 d) chickens. It lasted for 28 days to evaluate the effects of phytogenic feed additive (PFA) on growth performance, nutrient digestibility, cecum microbiota, bone minerals contents, meat quality and internal organ weights. The chickens were haphazardly divided into any 1 of 6 dietary treatments (6 replicate pens/treatment; 18 broilers/pen). The experimental diets were: CON, control; T1, CON + 150 ppm PFA; T2, CP 0.5% reduced from basal diet; T3, T2 + 150 ppm PFA; T4, Ca 0.07% reduced + available P (aP) 0.065% reduced from basal diet; T5, T4 + 150 ppm PFA. Overall, broilers fed with T3 diet tended to have higher (P=0.08) body weight gain (BWG), and lower (P=0.05) feed conversion ratio (FCR) than T2 diet. The apparent total tract digestibility (ATTD) of P was lower (P=0.03) in T2 as compared to CON and it was higher (P=0.02) in T3 as compared to T2. There were no differences in meat quality, relative organ weight, and cecum microbiota (P>0.05). The supplementation of PFA showed trends in improvement in ash content in the bone of birds fed T1, T2 and T4 diets compared with CON. Likewise, the supplementation of PFA tended to increase (P=0.07) Ca content in the bone of birds fed T1 diet compared to CON. In conclusion, dietary supplementation with 150 ppm PFA could improve BWG in birds fed protein reduced diet, improve apparent total tract digestibility (ATTD) of P, and the bone Ca contents in broilers.