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http://dx.doi.org/10.3746/jfn.2007.12.4.217

The Effect of Water-Soluble Calcium Supplements on Calcium Metabolism and Bone Metabolism of Growing Rats  

Jang, Se-Young (Department of Food Science and Technology, Keimyung University)
Jeong, Yong-Jin (Department of Food Science and Technology, Keimyung University)
Kwon, Teak-Kyu (Department of Immunology, College of Medicine, Keimyung University)
Seo, Ji-Hyung (Division of Food, Beverage & Culinary Arts, Yeungnam College of Science & Technology)
Park, Eun-Mi (Efficacy and Safety Research Center for Traditional Oriental Medicine, Daegu Haany University)
Publication Information
Preventive Nutrition and Food Science / v.12, no.4, 2007 , pp. 217-221 More about this Journal
Abstract
Within the elderly population, the use of calcium supplements and the intake of calcium from food are on the rise in order to maintain health. Calcium is absorbed as an ion in vivo, leading to speculation that absorption efficiency is affected by the solubility of the calcium consumed. In our study, the bioavailability of two types of calcium supplements with different solubilities was evaluated. Experimental animals were fed water-soluble or insoluble calcium supplements for 6 weeks. We found that blood alkali phosphatase activity, osteocalcin content, and urine crosslinks values were not different between the groups. Similarly, the degree of apparent calcium absorption between the two calcium supplements was not significantly different. The bone mineral density and bone mineral content of the femur and the tibia increased in the group that consumed insoluble calcium compared with those of the water-soluble calcium supplemented group. However, when considering body weight, the bone mineral density value for all areas, including the spine, was significantly higher in the group that consumed the water-soluble calcium supplement.
Keywords
calcium supplement; water-soluble calcium; calcium absorption; bone mineral density; calcium carbonate;
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Times Cited By KSCI : 4  (Citation Analysis)
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1 Kleerekoper M. 1996. Biochemical markers of bone remodeling. Am J Med Sci 312: 270-277   DOI
2 Hamalainen MM. 1994. Bone repair in calcium-deficient rats: Comparison of xylitol+calcium carbonate with calcium carbonate, calcium lactate and calcium citrate on the repletion of calcium. Am J Nutr 124: 874-881   DOI
3 Choi MJ, Yu TS. 2004. Effects of red-yeast-rice supplementation on bone mineral density and bone mineral content in overiectomized rats. Kor J Nutr 37: 423-430   과학기술학회마을
4 Hanzlik RP, Fowler SC, Fisher DH. 2005. Relative bioavailability of calcium from calcium formate, calcium citrate, and calcium carbonate. J Pharmacol Exp Ther 313: 1217-1222   DOI   ScienceOn
5 Sakhaee K, Bhuket T, Adams-Huet B, Sudhaker Rao D. 1999. Meta-analysis of calcium bioavailability: a comparison of calcium citrate with calcium carbonate. Am J Ther 6: 313-321   DOI   ScienceOn
6 Martini L, Wood RJ. 2002. Relative bioavailability of calcium-rich dietary sources in the elderly. Am J Clin Nutr 76: 1345-1350   DOI
7 Heaney RP, Dowell MS, Bierman J, Hale CA, Bendich A. 2001. Absorbability and cost effectiveness in calcium supplementation. J Am Coll Nutr 20: 239-246   DOI
8 Kind PRN, King ER. 1954. Estimation of plasma phosphatase by determination of hydrolyzed phenol with amino- antipyrine. J Clin Pathol 3: 332-334   DOI
9 Lee YS, Oh JH. 1995. Effects of bovine bone ash and calcium phosphate on calcium metabolism in postmenopausal osteopotosis model rats. Kor J Nutr 28: 434-441
10 Hietala EL. 1993. The effect of ovariectomy on periosteral bone formation and bone resorption in adult rats. Bone Miner 20: 57-65   DOI   ScienceOn
11 Sung CJ. 1995. Effects of calcium intake on calcium, sodium and potassium metabolism in young and adult female rats. Kor J Nutr 28: 309-320
12 Chang YE, Chung HK, Chang NS, Lee HS. 1997. The effects of dietary protein and calcium levels on calcium and bone metabolism in growing rats. Kor J Nutr 30: 266-276
13 Greger JL, Krzykowski CE, Khanzen RR, Krashoc CL. 1987. Mineral utilization by rats fed various commercially available calcium supplements or milk. Am J Nutr 117: 717-724   DOI
14 Eyre DR. 1996. Biochemical markers of bone turnover. In Primer on the metabolic bone diseases and disorder of mineral metabolism. Favus MJ, ed. Raven Press Inc, New York. p114-118
15 Benson JD, Emery RS, Thomas JW. 1969. Effects of previous calcium intake on adaptation to low and high calcium diets in rats. Am J Nutr 97: 53-60   DOI
16 Choi MJ, Ho HJ. 2003. Effects of soy protein and isoflavones on bone mineral density in growing female rat. Kor J Nutr 36: 359-367
17 Heller HJ, Greer LG, Haynes SD, Pondexter JR, Pak CY. 2000. Pharmacokinetic and pharmacodynamic comparison of two calcium supplements in postmenopausal women. J Clin Pharmacol 40: 1237-1244
18 McKane WR, Khosla S, Egan KS, Robins SP. 1996. Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption. Am J Clin Endocrinol Metab 81: 1699-1703   DOI
19 Allen LH. 1982. Calcium bioavailability and adsorption. Am J Clin Nutr 35: 738-808
20 Choi MJ. 2001. Effects of exercise and calcium intake on blood pressure and blood lipids in premenopausal women. Kor J Nutr 34: 62-68   과학기술학회마을
21 Sinha R, Smith JC, Soares JH. 1988. The effect of dietary calcium on bone metabolism in young and aged female rats using a short-term in vivo model. Am J Nutr 118: 1217-1222   DOI
22 Gordon, GS, Vaughn C. 1987. Calcium and osteoporosis. Am J Nutr 116: 319-322