• Journal of Korean Clinical Nursing Research
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• v.22 no.2
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• pp.217-224
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• 2016

Purpose: The purpose of this study was to evaluate the effects of safe handling education of antineoplastic drug on knowledge and performance of clinical nurses. Methods: This was a nonequivalent control-group pretest-posttest study. A total of 49 nurses (25 for the experimental group and 24 for the control group) who dealt with antineoplastic drug within the previous 1 week participated in the study. The guidelines for safe handling of antineoplastic drugs and antineoplastic drugs side effects were provided to the experimental groups whereas only antineoplastic drugs side effects was given to the control groups. Knowledge and performance in reference to antineoplastic drug handling were measured before and 8-week after interventions. Results: The knowledge scores between the pretest and posttest were not statistically significant in both groups. However, the performance scores in the experimental group was significantly higher than that of the control group. Conclusion: The given education of safe handling of antineoplastic drugs had an effect on improving clinical nurses' performance. Thus this education could be routinely administered in practice for those who deal with antineoplastic drugs in their everyday practice.

• Archives of Pharmacal Research
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• v.11 no.3
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• pp.169-174
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• 1988

A new series of substituted phenazone derivatives has been prepared through a series of reactions that are illustrated in Scheme I. The antibacterial and antineoplastic activities of the prepared compounds were evaluated. While none of the synthesized products showed marked antibacterial activity, all of them possessed a significant antitumor effect.

• YAKHAK HOEJI
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• v.17 no.4
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• pp.245-248
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• 1973

Four main components of plants produced in Korea were subjected to the screening test of antineoplastic activity against Ehrlich ascites carcinoma, SN 36 leukemia and sarcoma 180. Of the four components, bilobol showed comparatively active survival effect.

• YAKHAK HOEJI
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• v.17 no.2
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• pp.115-121
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• 1973

Seven ${\beta}$-substituted-2,4-dihydroxy-5-nitropropiophenones were synthesized as potential antineoplastic agents, and subjected to the screening test of survival effect and cell decrease effect. Of the sunthesized compounds, ${\beta}$-(1-methyl-1-hydroxymlethy) ethylamino-2, 4-dihydrocy-5-nitropropiophenone and ${\beta}$(1,1-dihydorxymethyl) ethylamino-2,4-dihydroxy-5-dihyropropiophenone and ${\beta}$-(1,1-dihydroxymethyl) propylamino-2,4-dihydroxy-5-nitropropiophenone were found to be active against both Ehrlich ascites carcinoma and Sarcoma 180.

• Korean Journal of Pharmacognosy
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• v.25 no.2
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• pp.171-177
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• 1994

Antineoplastic activity against human gastric and colon carcinoma cell lines was measured in 100 extracts from 90 plants using MTT (3-[4,5-dimethyl thiazo-2-yl]-2, 5-diphenyl tetrazolium bromide) method. Four extracts from four plants have been reported to have antineoplastic effect. Extracts from remaining 86 plants failed to show significant cytotoxic effect at the concentration of less than $230\;{\mu}/ml$.

• Korean Journal of Pharmacognosy
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• v.24 no.3
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• pp.223-230
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• 1993

Antineoplastic activity against human gastric, colon and hepatocellular carcinoma cell lines were measured in 100 extracts from 80 medicinal plants using MTT (3-[4, 5-dimethyl thiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) method. Seventeen extracts from fourteen plants, all of which have previously been reported to have antineoplastic effect, had $IC_{50}$(50% inhibitory concentration) values of less than $230{\;}{\mu}g/ml$ in at least one of the three cell lines. Extracts from remaining sixty-six medicinal plants failed to show significant cytotoxic effect at the concentration of less than $230{\;}{\mu}g/ml$.

• Korean Journal of Plant Resources
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• v.10 no.4
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• pp.346-350
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• 1997

Antineoplastic activities against human gastric and colon carcinoma cell lines were measured in seventeen methanol extracts of seventeen food and medicinal crops using the MTT(3-[4.5-dimethyl thiazol-2-yl)-2.5-diphenyl tetrazolium bromide) method. Three extracts(Hodeum vulgare, Schizandra chinensis and Zea mays)from seventeen tested crops have been reported to have antineoplastic effects. The extracts obtained from remaining fourteen tested crops failed to show significant cytotoxic effect at the concentration of less than $230{\mu}g/ml$(50% inhibitory concentration).

• Korean Journal of Pharmacognosy
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• v.27 no.2
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• pp.105-110
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• 1996

Antineoplastic activity against human gastric and colon carcinoma cell lines was tested in eighty-three species of Korean plants including Korean medicinal plants which have been frequently used in oriental herb prescriptions. The plant materials were extracted with methanol and the cytotoxic activity was tested using a calorimetric tetrazolium assay (MTT assay). Twenty-six plant extracts against gastric carcinoma cell line, eighteen extracts against colon carcinoma cell line and fourteen plant extracts against both carcinoma cell lines showed antineoplastic activity at the concentration of less than $100{\mu}g/ml$. The effective components from four species have been isolated and reported.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.41 no.4
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• pp.450-455
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• 1996

In this study isolation and identification of squalene from amaranth and antineoplastic activity of its residue extract except squalene were determined to examine the utilization of grain amaranth in Korea. The content of squalene in amaranth grain was about 0.43%. The isolated squalene showed 99% pureness containing the identical molecular weight and structure provisionally in comparison with that of animal squalene from Sigma Co. by means of GC /Mass spectrum. Antineoplastic activity against human gastric and colon carcinoma cell line was measured in extract (except squalene) from Amaranth using MTT method. Extract from remaining plant good showed significant cytotoxic effect at the concentration of less than 230$\mu\textrm{g}$/ml.

• Korean Journal of Pharmacognosy
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• v.25 no.4 s.99
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• pp.382-387
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• 1994

Antineoplastic activity against human gastric and colon carcinoma cell lines was measured in 49 extracts from 46 plants using MTT (3-[4, 5-dimethyl thiazol-2-yl]-2, 5-diphenyl tetrazolium bromide) method. Six extracts from five plants have been reported to have antineoplastic effect. Extracts from remaining 41 plants failed to show significant cytotoxic effect at the concentration of less than $230\;{\mu}g/ml$.