• 약학회지
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• 제47권6호
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• pp.422-431
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• 2003

The use of recombinant human erythropoietin (rhEPO), a stimulator of erythropoiesis, banned in sports because of the medical risk associated with thrombosis. Due to analytical difficulties to differentiate between natural human EPO (hEPO) and rhEPO, blood parameters of erythropoiesis such as contents of hemoglobin (cut-off value <17.5 g/d l for man, and < 16.0 g/dl for women), hematocrit and reticulocytes (cut-off value <2.0%) were measured to focus the misuse of rhEPO. We conducted anti-doping test for 122 blood samples of the World Cup athletes. The mean values of key parameters are as follows; 14.5$\pm$1.0 g/dl for hemoglobin, 41.7$\pm$2.8% for hematocrit, and 1.3$\pm$0.4% for reticulocyte. Blood sample was found to be stable up to 8 hours for the reticulocyte measurement. In addition, the soluble transferrin receptor and ferritin levels were measured by immunoassay methods using plasma samples (n=28) in which the mean value was 0.8$\pm$0.5 $\mu\textrm{g}$/$m\ell$ and 54.6$\pm$33.7 ng/$m\ell$, respectively. The results indicate that all samples tested were negative for the blood parameters of indirect anti-doping test for hEPO misuse. The statistical evaluation suggest that several other parameters such as red blood cell, mean corpuscular hemoglobin concentration, mean corpuscular volume, mean corpuscular hemoglobin and white blood cell could be considered as factors influencing hEPO function in addition to five parameters mentioned.

• Mass Spectrometry Letters
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• 제7권3호
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• pp.55-63
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• 2016

Growth hormone (GH)-releasing peptides (GHRPs) and GH secretagogues (GHSs) are listed in the World Anti-Doping Agency (WADA) Prohibited List. In the present study, we developed and validated a method for the simultaneous analysis of seven GHRPs (alexamorelin, GHRP-1, -2, -4, -5, -6, and hexarelin) and three GHSs (anamorelin, ibutamoren, and ipamorelin) in human urine. Method validation was performed at minimum required performance levels specified by WADA technical documents (2 ng/mL) for all substances, and the method was validated with regard to selectivity (no interference), linearity (R2 > 0.9986), matrix effects (50.0%-141.2%), recovery (10.4%-100.8%), and intra- (2.8%-16.5%) and inter-day (7.0%-22.6%) precisions. The limits of detection for screening and confirmation were 0.05-0.5 ng/mL and 0.05-1 ng/mL, respectively.

• 한국세라믹학회지
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• 제56권4호
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• pp.412-420
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• 2019

In this study, the dielectric and polarization properties of manganese (Mn% = 0.0, 0.1, 0.2, 0.5) doped (Pb_0.93La_0.07)(Zr_0.82Ti_0.18)O₃ (PLZT 7/82/18) anti-ferroelectric ceramics were studied for energy storage capacitor and pyroelectric applications. A systematic investigation demonstrated that the electric properties of PLZT 7/82/18 ceramics are affected significantly by the Mn-doping content. A maximum dielectric constant of ~ 2,128 at 1 kHz was found for 0.1% Mn-doped PLZT ceramics with a low dielectric loss of 0.018. The bipolar polarization versus electric field (P-E) hysteresis loops were traced for all compositions showing a typical anti-ferroelectric nature. The breakdown field was found to decrease with Mn-doping. The energy storage density and efficiency were found to be 460 J/㎤ and ~ 63%, respectively, for 0.2% Mn-doped PLZT ceramics. The pyroelectric coefficient of PLZT ceramics shows an increase based on the amount of Mn-doping.

• 한국임상약학회지
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• 제31권1호
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• pp.12-20
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• 2021

The World Anti-Doping Agency has made efforts to promote the safe use of medications and prevent doping in sports globally. International standards have been established and experts have advocate anti-doping education to athletes and healthcare professionals. Pharmacists are expected to participate in the pharmaceutical care activity of sports medicine in protecting the athletes while providing the spirits of clean sports. In this review, we described the pharmacists' roles and functions in six areas of sports pharmaceutical care: awareness, treatment, prevention, optimization, abuse, and monitoring. Sports pharmacists should be able to prevent inappropriate drug use and manage athletes' illness and injury using pharmacotherapy. Further pharmacists should actively involve to educate and counsel athletes, trainers, and healthcare teams. In conclusion, pharmacists are expected to play important roles in sports pharmacy, which is the emerging area of specialized pharmaceutical care services.

• 디지털융복합연구
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• 제17권5호
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• pp.391-398
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• 2019

본 연구는 육상의 세부종목에 따라 성별, 나이범주, 운동경력, 금지약물에 대한 정보 및 교육 여부, 완벽주의성향 및 지각된 동기 분위기가 도핑에 대한 태도에 미치는 영향을 확인하여 육상선수에게 특성화된 도핑예방프로그램 개발에 유용한 정보를 제공하고자 한다. 172명의 국내 육상선수를 대상으로 설문지를 통해 인구통계학적 특성과 도핑정보 관련 질문, 도핑에 대한 태도, 완벽주의성향 및 지각된 동기 분위기에 대한 자료를 수집하였고, 각 요인 중 도핑에 대한 태도에 관한 영향요인을 탐색하기 위해 단계적 다중회귀분석을 실시하였다. 그 결과, 필드종목과 트랙종목의 성인선수는 청소년선수에 비해 도핑에 대한 태도에 더 허용적인 것으로 확인되었고, 트랙종목 선수의 경우에는 완벽주의성향의 하위요인 중 코치의 비판을 더 큰 의미로 받아들일수록 도핑에 대해 더 허용적인 태도를 보이는 반면, 개인적 기준이 중요할수록 도핑에 대해 더 억압적인 태도를 보였다. 이러한 결과는 육상의 세부종목의 특성을 고려한 반도핑 전략 마련에 있어 유용한 정보가 될 것으로 생각된다.

• Journal of Pharmaceutical Investigation
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• 제41권1호
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• pp.31-36
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• 2011

$5HT_{2C}$ receptor among fourteen 5-HT subtypes plays important roles in several disorders such as depression, anxiety, epilepsy, schizophrenia and sleep disorders. The purpose of the study is to investigate pharmacokinetic parameters and bioavailability of a newly synthesized selective agonist of $5-HT_{2C}$ receptor, KOPC-20010 (KP10) in rats after intravenous and oral administration for the development of therapeutic anti-obesity agents. KP10 was administered orally (40 mg/kg) or intravenously (20 mg/kg), blood was collected via a catheter, and analyzed by GC/MSD. The calibration curve of KP10 in plasma and urine showed high linearity ($r^2$ >0.999). The retention times of KP10 in plasma and urine were 8.7 and 9.7 min, respectively. After oral administration of 40 mg/kg, pharmacokinetic parameters were calculated as follows; $C_{max}$ value was $1242.9{\pm}1195.5$ ng/mL at $1.1{\pm}0.6$ hr ($T_{max}$). $AUC_{0->24hr}$ and $AUC_{0>{\infty}}$ were $8034.2{\pm}960.7$ and $10464.1{\pm}681.5\;ng{\cdot}hr/mL$, respectively. The terminal half-life was $21.9{\pm}7.6$ hr. $AUC_{0->24hr}$ and $AUC_{0>{\infty}}$ were $4292.4{\pm}523.0$ and $6111.2{\pm}756.2\;ng{\cdot}hr/mL$, respectively, after 20 mg/kg of intravenous administration. The terminal half-life after intravenous administration was $25.1{\pm}9.4$ hr. Bioavailability of KP10 was determined to 86%. The excretion amount into the urine within 48 hr was approximately 4.7 to 6.7% of the dose administered. These data may be beneficial to the anti-obesity drug development of KP10.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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• pp.287.2-287.2
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• 2014

PV (photovoltaic) has becoming an important industry to invest due to its high robustness and require very little maintenance which goes a long time. Solar cell fabrication involves a few critical processes such as doping to make the N-type and P-type silicon, contact metallization, surface texturization, and anti-reflection coatings. Anti-reflection coating is a kind of surface passivation which ensures the stability, and efficiency of the solar cell. Thus, I will focus on the changes happen to the solar cell due to the reflectance and anti-reflection coating by PC1D. By using the PC1D (solar cell simulation program), I would analysis the effect of reflectance on the N-type cell. At last I will conclude the result regarding what I learned throughout this experiment.

• 한국체육학회지인문사회과학편
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• 제54권5호
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• pp.581-592
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• 2015

이 연구는 스포츠에서의 공정성과 권력이 어떻게 형성되고 변화하였는지에 대한 역사적 고찰을 통해서 스포츠에서 공정성에 위배되는 도핑과 승부조작에 대한 문제점들을 인간 욕망의 산물인 권력과의 관계에 대하여 탐구하였다. 첫째, 도핑과 권력의 탐구이다. 도핑의 역사는 스포츠의 역사처럼 오래전부터 존재하였다. 선수들의 약물복용은 자의든 타의든 간에 권력과의 관계를 형성하였는데, 그 중 승리에 따른 부와 명예 그리고 기득권에 대한 유혹과 갈망은 개인, 사회, 국가에 이르기까지 다양하고 폭넓게 자행되었다. 특히 힘의 표현이 냉전시대에서 스포츠에 투영되어 잘 반영되었으며, 이 당시의 잘못된 사고와 관행들이 아직도 도핑과 반도핑의 관계에 대한 본질을 흐리게 하고 있다. 둘째, 승부조작과 권력의 탐구이다. 승부조작 또한 도핑처럼 스포츠의 역사에서 항상 존재해왔다. 스포츠와 공정성의 관계에서 승부조작은 인위적인 결과를 결정하는 것으로 끝나는 것이 아니라 스포츠 도박이나 다른 범죄로 연결되어 문제가 되며, 이는 다시 스포츠로 영향을 미쳐 악순환의 연속이 되게 한다. 이러한 승부조작의 이유에는 권력의 요소인 자본의 형성과 이익을 위한다는 명확한 원인이 형성되어 있어 공정한 스포츠를 더욱 위협하고 있다. 이처럼 스포츠의 공정성과 권력의 관계에서 도핑과 승부조작은 역사적으로 매우 의미가 있으며, 더 많은 연구와 논의가 필요하다. 스포츠의 물질적 가치에 매몰되어 도핑과 승부조작이 아무렇지 않게 용인하거나 묵인되면서 권력의 요소들에 의해서 스포츠 파이만을 키우기만 한다면 마냥 스포츠의 미래가 밝다고만 장담할 수 없다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2010년도 하계학술대회 논문집
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• pp.244-244
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• 2010

Doping process of crystalline silicon solar cell process is very important which is as influential on efficiency of solar. Doping process consists of pre -deposition and diffusion. Each of these processes is important in the process temperature and process time. Through these process conditions variable, p-n junction depth can be controled to low and high. In this paper, we studied a optimized doping pre-deposition temperature for high solar cell efficiency. Using a $200{\mu}m$ thickness multi-crystalline silicon wafer, fixed conditions are texture condition, sheet resistance($50\;{\Omega}/sq$), ARC thickness(80nm), metal formation condition and edge isolation condition. The three variable conditions of pre-deposition temperature are $790^{\circ}C$, $805^{\circ}C$ and $820^{\circ}C$. In the $790^{\circ}C$ pre-deposition temperature, we achieved a best solar cell efficiency of 16.2%. Through this experiment result, we find a high efficiency condition in a low pre-deposition temperature than the high pre-deposition temperature. We optimized a pre-deposition temperature for high solar cell efficiency.

• Bulletin of the Korean Chemical Society
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• 제31권9호
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• pp.2493-2496
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• 2010

Erythropoietin (EPO) is mainly produced in kidney and stimulates erythropoiesis. The use of recombinant EPOs for doping is prohibited because of its performance enhancing effect. This study investigated whether biosimilar EPOs could be differentiated from endogenous one by iso-electro-focusing plus double blotting and SDS-PAGE for antidoping analysis. The established method was validated with positive control urine. The band patterns were reproducible and meet the criteria, which was made by world anti doping agency (WADA). Isoelectric focusing was conducted in pH range 2 to 6. Recormon (La Roche), Aropotin (Kunwha), Epokine (CJ Pharm Co.), Eporon (Dong-A), Espogen (LG Life Sciences), and Dynepo (Shire Pharmaceuticals) were detected in basic region. All biosimilars showed discriminative isoelectric profiles from endogenous EPO profiles, but they showed different band patterns with the reference one except Epokine (CJ Pharm Co.). Next, SDS-PAGE of biosimilar EPOs resulted in different molecular weight patterns which were distributed higher than endogenous EPO. Commercial immune assay kit as an immune affinity purification tool and immobilized antibody coated magnetic bead were tested for the purification and concentration of EPO from urinary matrix. The antibody-coated magnetic bead gave better purification yield. The IEF plus double blotting and SDS-PAGE with immunoaffinity purification method established can be used to discriminate biosimilar EPOs from endogenous EPO.