• 융합정보논문지
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• 제9권12호
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• pp.286-293
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• 2019

본 연구에서는 식약청 고시 원료인 레티놀, 레티닐팔미테이트, 아데노신, 폴리에톡실레이티드레틴아마이드 4종류와 항 노화의 효능을 가진 천연 원료인 금송, 하고초, 맨드라미, 브라질린, 여뀌, 황기, 연교, 자근, 대황, 육종용에 대한 연구 동향을 살펴보았다. 현재까지의 항 노화 연구는 주로 콜라겐 생성과 엘라스타아제 합성 억제 기전을 중심으로 이루어지고 있는 것이 확인되었다. 하지만, 피부의 노화 과정은 여러 가지 원인에 의해서 발생하는 것으로 볼 때, 다양한 기전에 맞춰 피부 항노화에 도움을 줄 수 있는 안전하고 효과적인 천연 원료를 활용한 항노화 연구가 지속적으로 이루어져야할 것으로 사료되어 진다.

• 한국노년학
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• 제36권4호
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• pp.1059-1074
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• 2016

본 연구는 노인의 평생학습활동과 삶의 만족도, 우울의 구조적 관계를 분석하는데 목적이 있다. 본 연구 목적 달성을 위한 분석자료로 제4차(2012) 고령화연구패널(Korean Longitudinal Study of Ageing : KLoSA) 기본 조사 자료를 사용하여, 항 우울제를 복용하지 않는 만65세 이상 노인 4,096명을 대상으로 분석하였으며 분석결과는 다음과 같다. 첫째, 노인의 비형식교육 활동 및 무형식학습 활동은 삶의 만족도에 정의 영향을 미치는 것으로 나타났다. 둘째, 노인의 비형식교육 활동 및 무형식학습 활동은 우울에 부의 영향을 미치는 것으로 나타났다. 셋째, 노인의 우울은 삶의 만족도에 부의 영향을 미치는 것으로 나타났다. 넷째, 노인의 비형식교육 활동 및 무형식학습 활동은 우울을 감소시켜 삶의 만족도에 정의 영향을 미치는 것으로 나타나 우울이 부분 매개효과가 있는 것으로 확인되었으며, 비형식교육보다 무형식학습 활동의 간접효과가 더 큰 것으로 확인되었다. 이러한 연구결과를 바탕으로 실천적 함의를 제안하였다.

• Natural Product Sciences
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• 제25권4호
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• pp.293-297
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• 2019

Policosanol extracted from sugarcane wax is a generic term used for total fatty alcohols obtained from esterification of fatty acids. It has been approved as a health functional food by the Ministry of Food and Drug Safety of Korea in 2006. Policosanol is well-known to aid in lowering blood cholesterol level. Recently, several studies have reported the physiological activities of policosanol, such as anti-inflammatory effects, antioxidant effects, and lowering of the incidence of ageing-related diseases, for example, hypertension, stroke, among others. This review describes the physiological activities of policosanol and its applications in the field of health functional foods.

• 한국작물학회지
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• 제7권1호
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• pp.31-63
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• 1969

A series of experiment was carried out to study on the production of disease-free seed potatoes at the Alpine Experiment Station from 1960 to 1968, which initiated a study of comparison on degeneration of plain warm region and high altitude products and the effect of latent potato virus X (PVX) and potato leaf roll virus(PLRV) on degeneration. Particular observations were made on some aspect of the nature of potato virus disease and its control such as concentrations of PVX, range of host plants, physical properties such as concentrations of PYX, range of host plants, physical properties and carrying effect of insects, by investigating 9 different areas of the main potato producing regions (Kimhae, Taegu, Choongju, Taejoen, Suwon, Kwangju, Chonju, Cheju and Chinju). Highly purified anti-serum was separated and tested for control of the virus disease and also various method of prevention and control of PLRV were observed, using cultivation of sprouted seed tubers, early harvesting method, and systemic chemicals. The results obtained are summarized as follows; 1. Potato yield in the plain region decreased by 32.8~66.3% in the first year cultivation of seed potatoes from colder region, and the rate of virus infection was 92.9 to 95.4%. 2. Plants of three families including, 20 species were susceptible to the PVX, and among the plants Salvia officinalis of a habits only was the carrier while the symptom of Digitalis purpurea of Screphulariaceae was masked. Necrosis and ring spot was occurred in most pJants of the Solanaceae and ring spot symptom also was observed in Nicotiana tabacum L. var. White Burley and in N. glutinosa. 3. The 8$C_2$ strain of virus had the following physical properties; thermal inactivation point, 68-$72^{\circ}C$ : dilution inactivation point, above 1, 000, 000 dilution: ageing in vitro, 240-360 days: and ageing in dry plant tissue, 30 days. 4. Myzus persicae and Oxya spp. did not transmit the 8$C_2$ strain of potato virus. 5. Virus was purified through the ammonium sulphate isolating method, and higher titer value, 1/2048 was obtained through anti-serum test. 6. Inhibition Chenopodiacae on the virus infection of potato was remarkable, and inhibition of local lesion host also was observed. 7, By earlier planting of sprouted seed tubers, growth period could be prolonged by 10 to 12 days. 8. Earlier harvest decreased much the rate of virus infection of seed potatoes. 9. According to the results of aphid control trial using systemic soil insecticides at Kangnung and Taekwanlyung, PSP 204, Disyston and Thimet was effective to aphid control. In particular, control effect of twice treatments of PSP 204 was great. 10. Treatmental effect of those chemicals lasted about 60-70 days. However, single foliar application of emulsified chemicals was not effective to potato virus control. 11. The effect of PSP 204, Disyston, and Thimet on the control of potato leaf roll virus was great, particularly in the case of two treatments of PSP 204, at Kangnung as well as at Taekwanlyung. Higher negative correlationship between the control effect of potato leaf roll virus and potato yield was observed showing the value r=-0.85 at Kangnung, and r=-0.87 at Taekwanlyung. 12. Differences in the control effects among PSP 204, Disyston, and Thimet was not noticed.

• International Journal of Costume and Fashion
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• 제11권1호
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• pp.63-83
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• 2011

This study aims to prove the changes, development and social background of Korean male cosmetics over the period of 2000-2010. There were total 574 articles written about male make-up and cosmetics in Chosun Daily, Joongang Daily and Donga Daily, which are the top three Korean local daily newspapers in terms of sales revenue for that period. These articles were analyzed together with social background research from various books and daily newspapers. The analysis of articles was divided into different categories; such as foundation cosmetics, color cosmetics, hair, and the social background. It was found that the articles related to foundation cosmetics were written the most, the articles related to male appearance management were second, articles on other items including how to manage the skin being the least. As for the social background of Korean male cosmetics, first of all, a change in social recognition can be pointed out. The traditional understanding of gender roles has changed, men's appearance management has started to be regarded as a competitive talent, and at the same time, the esthetic viewpoint for men also has changed. One example is the newly made popular term, "flower-handsome man", which shows the new trend of favoring males with nice skin. Second, the expansion of mass culture can be pointed out. As consumers can get information and fashion trends easier and faster, the fashion spreads fast, and this has led to the generalization and popularization of the sense of beauty. Third, the development of scientific technology and medical science can be pointed out. Thanks to the progress in those areas. the extension of youthfulness has become possible and the cosmetics industry was also affected greatly, as shown in the market spread of functional products for anti-ageing and wrinkle control as the interest in anti-ageing has grown. There are benefits from the development of scientific technology, but the problem of environmental pollution has appeared due to machinery and industrialization and thus the issue of well-being has been raised. Rising interest in naturalism, pro-environmentalism and organic cosmetics has influenced the cosmetics industry. In addition, the quantity of ultraviolet rays exposed to our skin has increased due to the air pollution caused by the destruction of environment, leading to increased usage of sun block lotion. Lastly, the influence of consumer society and the expansion of consumerism culture can be pointed out. In the modern society, consumption acts not only as the use of products and services but it also has an important role of mediating individuals with others and the society. The market for male cosmetics has been expanding and the number of men putting on make-up has been increasing rapidly. Therefore, this study is meaningful in that the analysis of the mode of change and the social background are an essential process in order to provide a direction for the future market for male cosmetics.

• 대한화장품학회지
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• 제40권3호
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• pp.297-305
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• 2014

홍삼(Red Ginseng; RG)은 인삼보다 더 높은 생체 흡수율과 다양한 약리효과를 갖는 특이한 진세노사이드(Rg2, Rg3)를 함유하고 있다. 따라서 오랫동안 많은 사람들의 건강을 위해 이용되어 왔다. 또한 발효는 유효한 생리활성을 갖는 저분자의 물질들을 생성하기 때문에 많은 연구자들이 생물학적 활성에 대해 오랫동안 연구해오고 있다. 본 연구에서는 홍삼을 붉은덕다리버섯 균사체로 7일 동안 발효하였다. HPLC 분석 결과 진세노사이드 Rg1, Re 및 Rb2가 각각 0.24, 0.25, 0.16 mg/g에서 0.12, 0.1, 0.03 mg/g으로 함량 감소를 확인하였고, 홍삼 붉은덕다리 균사체배양액(Fermented Red Ginseng; FRG)의 항염, 세포 이동, 항산화, 콜라겐 타입 I 합성과 MMP-1 억제효능에 대한 생물학적 효능을 확인하였다. 그 결과, FRG는 RG보다 항염 및 cell migration 촉진효과가 더 우수하였다. FRG는 LPS로 유도된 RAW 264.7 대식세포의 NO 생성을 억제하였으며, iNOS와 IL-6의 발현을 mRNA 수준에서 억제하였다. 이 결과로 FRG는 새로운 항염소재로서 제안이 가능하다고 사료된다.

• 한국의류산업학회지
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• 제18권4호
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• pp.531-539
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• 2016

Charcoal dyed fabrics have been widely used in home textiles and functional clothing due to their anti-statics, antibacterial, deodorization, far infrared emitting and anion releasing. Soybean fiber were regenerated from soybean. Soybean fiber have biodegradable, microbiocidal, non-allergic, and anti-ageing properties. The purpose of this study is to investigate the dyeing characteristics of soybean fabric using charcoal as colorants. Soybean fabrics were dyed with charcoal solution according to concentration of charcoal, dyeing temperature, and dyeing time. To improve washing fastness and investigate mordanting condition, soybean fabric and dyed soybean fabric with charcoal were mordanted by mordanting agents such as $CH_3COOH$(acetic acid), NaCl(sodium chloride) and $AlK(SO_4)_2{\cdot}12H_2O$(Aluminium Potassium Sulfate). Dyeability and color characteristics of charcoal dyed soybean fabric were obtained by computer color matching and SEM morphology analysis. Particle size of charcoal and color fastness were also investigated. The results obtained were as follows; Mean average diameter of charcoal was $1.39{\mu}m$. The dyeability of soybean fabric using charcoal as colorants was increased gradually with increasing concentration of charcoal dyeing solution and saturated at about 8%(o.w.b.). The optimum dyeing temperature and dyeing time were $90{\sim}105^{\circ}C$ and 60~90 minutes respectively. The overall wash fastness at dyeing concentration 2~4%(o.w.b.) and 6~10%(o.w.b.) were 4 degree and 3-4 degree respectively. The fastness to washing according to mordanting method indicated good grade result as more than 4 degree in all conditions. On the other hand, the staining of adjacent fabrics, i.e. PET, Acryl, Wool, Acetate, Nylon and Cotton was found to be of grade 4 or 4-5 in all conditions.

• 생명과학회지
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• 제17권7호통권87호
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• pp.915-922
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• 2007

본 연구자들은 동${\cdot}$서양에서 오랫동안 민간요법으로 사용되어져 왔고, 문헌에도 약리적인 작용이 기록되어 있는 Opuntia ficus-indica var. Saboten Makino (손바닥 선인장, 백년초) 줄기 분말을 사용하여 항균생리활성 물질을 규명하고자 하였다. 줄기 분말을 황산으로 가수분해 처리한 후 메탄올, 메틸클로라이드, 에탄올 등의 용매로 추출하였다. 용매추출물 가운데 methylene chloride 추출물의 경우 가장 탁월한 항균활성을 나타내었다. 항균활성을 나타내는 생리활성 물질을 분리 분석하기 위하여 조제용 TLC를 이용하여 산 가수분해 추출물로부터 7개의 분획물을 분리하였다. 7개 분획물 가운데 가장 광범위한 항균활성을 나타내는 유효 분획물로 분리된 것을 MBT-01108이라 명명하였다. 산가수분해로 추출된 분획물 MBT-01108을 구조 분석한 결과 항균 활성을 나타내는 화합물이 levulinic acid임을 밝혀냈다. Opuntia ficus-indica var. Saboten Makino로부터 분리된 levulinic acid는 식품 또는 화장품의 천연 보존제로써 사용가능하리라 판단되며, 또한, 세균성 질병예방, 여드름, 노화 예방, 미백 화장품 성분, 그리고 항생제로도 사용 가능한 물질임을 밝혀냈다.

• Tuberculosis and Respiratory Diseases
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• 제82권1호
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• pp.71-80
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• 2019

Background: Efficacy and safety of tiotropium bromide, a muscarinic receptor antagonist, in treatment of asthma have been reported. However, its effect on airway remodeling in chronic asthma of the elderly has not been clearly verified. The objective of this study was to investigate the effect of tiotropium and expression of muscarinic receptors as its related mechanism in an aged mouse model of chronic asthma with airway remodeling. Methods: BALB/c female mice age 6 weeks, 9 and 15 months were sensitized and challenged with ovalbumin (OVA) for three months. Tiotropium bromide was administered during the challenge period. Airway hyperresponsiveness (AHR) and pulmonary inflammation were measured. Parameters of airway remodeling, and expression levels of $M_2$ and $M_3$ receptors were examined. Results: Total cell with eosinophils, increased in the OVA groups by age, was decreased significantly after treatment with tiotropium bromide, particularly in the age group of 15 months. AHR and levels of interleukin (IL)-4, IL-5, and IL-13 were decreased, after tiotropium administration. In old aged group of 9- and 15-months-treated groups, hydroxyproline contents and levels of ${\alpha}$-smooth muscle actin were attenuated. Tiotropium enhanced the expression of $M_2$ but decreased expression of $M_3$ in all aged groups of OVA. Conclusion: Tiotropium bromide had anti-inflammatory and anti-remodeling effects in an aged mouse model of chronic asthma. Its effects seemed to be partly mediated by modulating expression $M_3$ and $M_2$ muscarinic receptors. Tiotropium may be a beneficial treatment option for the elderly with airway remodeling of chronic asthma.

• Journal of Microbiology and Biotechnology
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• 제14권6호
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• pp.1333-1337
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• 2004

Oxidants such as hydrogen peroxide are powerful inducers of cell damage, ageing, and apoptosis. Since clusterin, a 75-80 kDa mammalian glycoprotein, is frequently found to be inducible in apoptotic cells and tissues, this study inquired into whether this would be a protective mechanism against further cell death. The aim was to find out whether overexpression of clusterin could protect cells from oxidant­induced stress and apoptosis. To clarify this issue, we generated and analyzed stable cell lines expressing fusion proteins of a rat clusterin with an enhanced green fluorescent protein (EGFP). When treated with varying concentrations of hydrogen peroxides, clusterin transfectants indeed showed increased resistance to apoptosis and exhibited a much higher survival rate than mock-transfected cells. On the other hand, neither intracellular re-distribution nor local concentration of clusterin-EGFP was observed, which leaves the question open about its anti-apoptotic mechanism. In conclusion, the overexpression of clusterin provides a means for protecting cells against oxidative stress and subsequent cell death.