• Title/Summary/Keyword: Angelicae gigantis radix

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Effect of Angelicae gigantis Radix Extract on Experimentally Induced Hyperlipemia in Rats (한국당귀(Angelicae gigantis Radix) 엑스가 흰쥐의 실험적 고지혈증에 미치는 영향)

  • Lim, Jong-Hoon;Oh, Hyung-Soo;Chung, Myung-Hyun
    • Korean Journal of Pharmacognosy
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    • v.29 no.4
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    • pp.300-311
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    • 1998
  • This study was attempted to investigate the effects of "Angelicae gigantis Radix extract" (AG.EX.) on the activities of GOT and GPT, the contents of total lipid, triglyceride, total cholesterol, phospholipid and ${\beta}-lipoprotein$ in serum, and the weight change ratio of body, liver and spleen in the experimentally induced hyperlipemic rats by administering the extract of 300 and 500 mg/kg p.o.. Significant test was performed by comparision with the biochemical values between control group and experimentally hyperlipemic rats. In the activities of s-GOT and s-GPT inhibition effects were significantly appeared in all dose of AG.EX. (especially more excellent in ethanol extract) and Angelicae acutilobae Radix extract (AA.EX.) as compared with the control group. The content of total lipid was remarkably decreased in all sample group when compared with the control group, and AA.EX. showed more excellent decreasing effect than AG.EX. The contents of triglyceride and total cholesterol were significantly lowered in all sample group, and more significantly decreased in water extract of AG.EX. and ethanol extract of AA.EX. The content of phospholipid was significantly decreased in all sample group and AG.EX. was more significantly decreased than AA.EX. The increasing rate of body weight in all sample groups except AA.EX. 500 mg/kg was increased more than control group and more significantly remarkable in dose of 300 mg/kg than 500 mg/kg. The increasing rate of liver weight in all sample groups was increased more than control group, and AG.EX. was more increased than AA.EX.

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Anti-allergic Effect of the Fermented Angelicae Gigantis Radix in Human Mast Cell Line HMC-1 (발효처리한 당귀의 항알레르기 효능에 대한 연구)

  • Seo, Min-Jun;Park, Jin-Han;Lee, Je-Hyun
    • The Korea Journal of Herbology
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    • v.28 no.5
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    • pp.39-44
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    • 2013
  • Objectives : Allergy is an immune dysfunction caused by degranulation from mast cells in the early phase of allergic disease. The purpose of this study was to investigate the anti-allergic effect of fermented Angelicae gigantis Radix in human mast cell line, HMC-1. Method : The Angelicae gigantis Radix was fermented by Lactobacillus acidophilus. The cell toxicity of fermented Angelicae gigantis Radix(FAGR) was determined by MTT assay. The release of ${\beta}$-hexosaminidase from HMC-1 stimulated by phorbol-12-myristate 13-acetate (PMA) plus A23187 was determined by ${\beta}$-hexosaminidase assay. Also, the concentrations of cytokines (interleukin-$1{\beta}$, -6, -8 and tumor necrosis factor-alpha) were measured by enzyme-linked immunosorbent assay. The gene expression of COX-2 from HMC-1 stimulated by phorbol-12-myristate 13-acetate (PMA) plus A23187 was determined by reverse transcription polymerase chain reaction. The release of histamine on substance P-stimulated HMC-1 was measured by histamine assay. Result : The FAGR suppressed the release of ${\beta}$-hexosaminidase, a marker of degranulation, from HMC-1 stimulated by PMA plus A23187. The FAGR inhibited the production of interleukin-$1{\beta}$, -6, -8 and tumor necrosis factor-alpha. The FAGR inhibited the expression of COX-2 mRNA. The FAGR suppressed the release of histamine on substance P-stimulated HMC-1. Conclusion : These results provide that FAGR may be beneficial in the treatment of allergic inflammatory disease.

A Study on the Anti-Condensing Effect of ChondroT Components (ChondroT 구성 약재의 항응고 효과에 관한 연구)

  • Kim, Sun-Gil;Jeong, Ji-Won;Lim, Young-Ha;Kim, Ji-Hoon;Na, Chang-Su;Kim, Seon-Jong
    • Journal of Korean Medicine Rehabilitation
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    • v.28 no.2
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    • pp.47-60
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    • 2018
  • Objectives The objective of this study was to investigate the effect of Anti-condensing on the composition of ChondroT Methods Specimens are divided in 7 groups (Control, ChondroT, Lonicerae Folium (Gumenhwa, GEH), Angelicae Gigantis Radix(Danggui, DG), Phellodendri Cortex(HwangBaek, HB), Osterici Radix(Kanghwal, KH), Clematidis Radix(Weeryungsun, WRS)) Each specimen is subjected to a concentration of 20 %, 10 %, and 5 %, and is administered to collagen and thrombin-stimulated platelets. Results In the anticoagulance effect test, Lonicerae Folium and ChondroT very well. The effect was high in order of Lonicerae Folium-Angelicae Gigantis-Phellodendri Cortex-Osterici Radix and Clematidis Radix. Conclusions ChondroT has anti-condensing effects on blood platelet.

Effect of the Constituents of Angelicae gigantis Radix on Hepatic Drug Metabolizing Enzymes (참당귀근 성분이 간의 약물대사효소에 미치는 효과)

  • Han, Jung-Mee;Lee, Ihn-Ran;Shin, Kuk-Hyun
    • Korean Journal of Pharmacognosy
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    • v.27 no.4
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    • pp.323-327
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    • 1996
  • The ether soluble fraction of the roots of Angelicae gigantis Radix caused a significant prolongation of hexobarbital(HB) induced sleeping time in mice. Through systematic fractionation of the ether fraction monitored by bioassays, two pyranocoumarins, decursinol angelate and decursin were isolated as active principles. Decursin, as a main component, exhibited significant prolongation of HB-induced hypnosis as well as significant inhibition of hepatic microsomal drug metabolizing enzyme(DME) activities at relatively high dose which indicated that it is a weak DME inhibitor.

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The Effect of Angelicae gigantis Radix on the Benzo(a)pyrene-induced Hepatotoxicity in Rats (Benzo(a)pyrene에 의해 유도된 간기능 장해에 미치는 당귀의 효과)

  • 윤수홍;조수열;이윤경;하두현
    • Environmental Analysis Health and Toxicology
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    • v.7 no.1_2
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    • pp.45-51
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    • 1992
  • This study was performed to investigate the effect of Angelicae gigantis Radix extract oil the hepatic detoxifying enzyme activities and lipids. Male sprague-dawley rats were administrated the extracts with benzo(a)pyrene, a hepatotoxic agent, inducing liver damages. Results obtained from this study were as follows: 1. The markedly increased enzyme activities (AST, ALT, LDH, ALP, ${\gamma}$-GTP, GSH-Px) in B(a)P induced groups tended to be decreased by the treatment of the Angelicae gigantis Radix extract. 2. Liver GSH content and lipid peroxide activity were decreased by the administration of the extracts. 3. It tended that the curative effects were better than the protective effects of the extracts.

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Comparative Studies on the Discrimination of Angelicae Gigantis Radix by Near-infrared Spectroscopy, Electronic Nose and X-ray Fluorescence Spectrometry (근적외선분광법, 전자코 및 엑스선형광법을 이용한 당귀의 기원판별법 비교 연구)

  • 조창희;김수정;김효진
    • YAKHAK HOEJI
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    • v.46 no.3
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    • pp.161-167
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    • 2002
  • Angelicae gigantis radix is the root of the perennial plant, which belongs to the family Umbelliferae. However, this herbal drug is represented quite different chemical components according to its different genus name, though other herbal drugs (i.e. Leonuri Herba, Xanthii Fructus and so on) show similar constituents on the same name. The root of Angelica gigas containing the coumarin compounds is commonly used in Korea, while Angelica sinensis and Angelica acutiloba including phthalide compounds are used in China and Japan, respectively as Angelicae gigantis radix. In this paper, a nearinfrared spectroscopic method was developed to determine genus name of Angelica spp., especially A. gigas and A. sinensis which are commonly misused in herbal markets. X-ray fluorescence spectrometry and electronic nose have been also applied as nondestructive methods to discriminate A. gigas from A. sinensis according to their specific properties.

Validation of Analysis Methods of Decursin and Decursin angelate from Angelicae gigantis Radix by Reversed-phase Liquid Chromatography

  • Ze, Keum-Ryon;Park, Sang-Young;Cho, Chang-Hee;Sung, Rak-Sun;Lee, Jong-Pil;Park, Ju-Young;Cho, So-Yean;Jin, Zhexiong;Kim, Jun-Hyuk
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.288.1-288.1
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    • 2003
  • The determination method of decursin and decursin angelate from Angelicae gigantis Radix, an important crude drug in oriental medicine, was developed and validated by a reverse-phase liquid chromatography. The decursin and decursin angelate, the structural isomer aspyranocoumarin each other, are the main organic constituents in Angelicae gigantis Radix. (omitted)

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Protective Effects of Angelicae gigantis Radix Extract on Hepatic Injury Induced by Toxic Drugs in Rats (한국당귀(Angelicae gigantis Radix) 엑스가 흰쥐의 약물성 간장해에 대한 보호 효과)

  • Oh, Hyung-Soo;Lim, Jong-Hoon;Chung, Myung-Hyun
    • Korean Journal of Pharmacognosy
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    • v.29 no.4
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    • pp.402-412
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    • 1998
  • This study was attempted to investigate the effect of 'Angelicae gigantis Radix extract (AG.EX.)' and 'Angelicae acutilobae Radix extract (AA.EX.)' on the activities of GOT, GPT and alkaline phosphatase (A1.P), the contents of total cholesterol in serum of $CCl_4$ and D-galactosamine intoxicated rats, and the weight change ratio of body, liver and spleen in $CCl_4-intoxicated-rats$ by administering the extract of 300 and 500 mg/kg P.O.. Significant test was performed by comparision with the biochemical values between intoxicated-control group and extract-administered group. The activities of s-GOT, s-GPT and the contents of total cholesterol elevated by $CCl_4-intoxication$ were significantly decreased in all dose (300, 500 mg/kg) of Angelicae gigantis Radix-water extract (AG.WEX.) and alcohol extract (AG.AEX), and Angelica acutilobae Radix-water extract (AA.WEX.) and alcohol extract (AA.AEX.), respectively, as compared with the control group. And administered group of 300 mg/kg showed more significant decreasing effect than 500 mg/kg, and more significantly decreased in water extract of AG.EX. and ethanol extract of AA.EX. But in the activities of s-A1.P. inhibition effect were significantly decreased only in a dose of 300 mg/kg of AA.WEX. and AA.AEX. The activities of s-GOT and s-GPT elevated by D-galactosamine were not decreased in all samples, as compared to intoxicated-control group. But the activities of s-Al.p was significantly decreased as compared with control groups, in all samples and administration of 300 mg/kg was more significantly decreased than 500 mg/kg. The contents of total cholesterol remarkably decreased than the normal groups by D-galactosamine intoxication was not recovered in all samples. The increasing rate of the body weight increased by $CCl_4-intoxication$ were not decreased than the $CCl_4-control$ group in all sample groups. The increasing rate of liver weight increased by $CCl_4-intoxication$ were significantly decreased in 300 mg/kg of AA.AEX.AG.WEX. and AA.WEX., respectively, as compared with $CCl_4-control$ group.

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Skin Whitening Effects of Extracts from Angelicae Gigantis Radix and Lycii fructus Ethanol Extracts (당귀와 구기자 에탄올 추출물의 피부 미백작용)

  • Hwang, Sung Yeoun;Lee, Jeong Tak;Kim, Yeong Uk;Kim, Hong Jun
    • Herbal Formula Science
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    • v.21 no.1
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    • pp.91-98
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    • 2013
  • Objective : The purpose of this study was to investigate the synergistic effect of Angelicae gigantis Radix (AG) and Lycii fructus (LF) ethanol extracts on skin-whitening effects. Method : LFAG extracts were prepared by extracting with 80% ethanol. The efficacy of LFAG was judged by measurement of cell viability, tyrosinase activity, melanin production, tyrosinase and microphthalmia-associated transcription factor (MITF) expression in B16F10 murine melanoma cells by lipopolysaccharides (LPS) treatment. Results : Each extract (LF or AG) inhibited the tyrosinase activity in a dose-dependent manner. The co-treatment of LFAG extracts ($25{\mu}g/mL$ LF plus $25{\mu}g/mL$ AG) markedly suppressed the LPS-induced cellular tyrosine activity, melanin production, tyrosinase and MMP-1 expression in B16F10 murine melanoma cells. These suppressive effects were synergistically increased by their combination. Conclusions : With these observations, we suggest that the extracts from Lycii fructus and Angelica gigantis Radix could be potent natural materials for whitening skin.

Environmental Variation of Decursin Content in Angelica gigas (재배지역에 따른 참당귀의 Decursin 함량변이)

  • 성낙술;이순우;김관수;이승택
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.38 no.1
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    • pp.60-65
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    • 1993
  • This experiment was conducted to understand the effects of climatic environment on the useful components in Angelicae gigantis radix. The variation of decursin contents in different seven cultivated regions and the relationship between decursin contents and meteorological factors were investigated. The appropriate analytical methods for decursin and decursinol angelate of Angelicae gigantis radix were HPLC method used normal phase column($\mu$-Porasil) and GC method. In different cultivated regions, the variation of decursin contents of Angelicae gigantis radix was relatively great, which were high with 4.86%, 4.75% in Bongwha, Yongcheon respectively and was low with 2.33% in Suwon. There was no significant relationship between decursin contents of Angelicae radix and meteorological factors during growing periods, but was negative correlation in average temperature and precipitation, and positive correlation in diurnal change of temperature, radiation and sunshine hours.

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