Korean Journal of Pharmacognosy (생약학회지)
- Volume 27 Issue 4
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- Pages.323-327
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- 1996
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Effect of the Constituents of Angelicae gigantis Radix on Hepatic Drug Metabolizing Enzymes
참당귀근 성분이 간의 약물대사효소에 미치는 효과
- Han, Jung-Mee (College of Pharmacy, Ewha Woman's University) ;
- Lee, Ihn-Ran (College of Pharmacy, Ewha Woman's University) ;
- Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
- Published : 1996.12.30
Abstract
The ether soluble fraction of the roots of Angelicae gigantis Radix caused a significant prolongation of hexobarbital(HB) induced sleeping time in mice. Through systematic fractionation of the ether fraction monitored by bioassays, two pyranocoumarins, decursinol angelate and decursin were isolated as active principles. Decursin, as a main component, exhibited significant prolongation of HB-induced hypnosis as well as significant inhibition of hepatic microsomal drug metabolizing enzyme(DME) activities at relatively high dose which indicated that it is a weak DME inhibitor.
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