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http://dx.doi.org/10.14374/HFS.2013.21.1.091

Skin Whitening Effects of Extracts from Angelicae Gigantis Radix and Lycii fructus Ethanol Extracts  

Hwang, Sung Yeoun (Department of Korean Medical Prescription, Woosuk University)
Lee, Jeong Tak (Department of Korean Medical Prescription, Woosuk University)
Kim, Yeong Uk (Department of Korean Medical Prescription, Woosuk University)
Kim, Hong Jun (Department of Korean Medical Prescription, Woosuk University)
Publication Information
Herbal Formula Science / v.21, no.1, 2013 , pp. 91-98 More about this Journal
Abstract
Objective : The purpose of this study was to investigate the synergistic effect of Angelicae gigantis Radix (AG) and Lycii fructus (LF) ethanol extracts on skin-whitening effects. Method : LFAG extracts were prepared by extracting with 80% ethanol. The efficacy of LFAG was judged by measurement of cell viability, tyrosinase activity, melanin production, tyrosinase and microphthalmia-associated transcription factor (MITF) expression in B16F10 murine melanoma cells by lipopolysaccharides (LPS) treatment. Results : Each extract (LF or AG) inhibited the tyrosinase activity in a dose-dependent manner. The co-treatment of LFAG extracts ($25{\mu}g/mL$ LF plus $25{\mu}g/mL$ AG) markedly suppressed the LPS-induced cellular tyrosine activity, melanin production, tyrosinase and MMP-1 expression in B16F10 murine melanoma cells. These suppressive effects were synergistically increased by their combination. Conclusions : With these observations, we suggest that the extracts from Lycii fructus and Angelica gigantis Radix could be potent natural materials for whitening skin.
Keywords
Lycii fructus; Angelicae gigantis Radix; Tyrosinase; Melanin; Skin whitening; UVB protection;
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Times Cited By KSCI : 2  (Citation Analysis)
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