• 동국한의학연구소논문집
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• 제8권1호
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• pp.159-169
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• 1999

고령화와 육체적 활동의 감소로 증가 추세에 있는 골연화증(骨軟化症)의 임상치료(臨床治療)에 도움을 얻고자 역대의서(歷代醫書)와 중의서(中醫書), 중의잡지(中醫雜誌)를 중심으로 증상(症狀), 병인(病因), 병리(病理), 치법(治法), 치방(治方) 등을 동서의학적(東西醫學的)으로 고찰하였다. 골연화증(骨軟化症)은 골의 석회화 장애로 골밀도가 감소되는 대사성 골질환으로, 동양의학(東洋醫學)에서는 골위, 골고(骨枯) 등의 골질환(骨疾患)에서 유사한 증상(症狀)이 나타나며, 병인(病因)은 주로 신허(腎虛)로서 서양의학의 신장 질환으로 인한 인(燐)의 재흡수 불량, Vit-D 대사 이상과 유사하다. 증상(症狀)으로는 요통(腰痛), 골통증(骨痛症), 다발성 골절, 동요성 보행 등이 나타난다. 치법(治法)은 보신(補腎)을 위주(爲主)로 하여 건비익신(健脾益腎),자양기혈(滋養氣血), 강장근골(强壯筋骨) 등이 있고, 치방(治方)은 육미지황탕(六味地黃湯)을 위주로 하여, 호잠환(虎潛丸), 제생신기환(濟生腎氣丸), 대보음환(大補陰丸) 등이 활용되고 있으며, 약물(藥物)은 숙지황(熟地黃), 호경골(虎脛骨), 호도육(胡挑肉), 자하차(紫河車), 두충(杜沖), 녹각교(鹿角膠), 녹용(鹿茸) 등의 보신지제(補腎之劑)가 주로 사용되고 있다.

• 대한예방한의학회지
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• 제18권1호
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• pp.93-101
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• 2014

Objective : The aim of this study is to analyze medicinal herbs, the ingredients of traditional Korean liquor, focusing on efficacy in the traditional Korean medicine. Through this study, for vitalizing traditional Korean liquor market, the researchers attempt to explain the superiority of traditional Korean liquor and the advantages of using herbs to brew alcoholic beverages. Method : We conducted a research targeting traditional Korean liquors in domestic market from July through september 2012, and finally 70 kinds of liquor were selected and analyzed. Results : Among traditional liquors, fermented liquors are most common. When comparing regions of brewery, the central region of Korea, Gyeonggi-do and Chungcheongnam-do, is major brew area. 37 liquors contain just one medicinal herb. followed 10 liquors contain two medicinal herbs. The most frequently used medicinal herb is Ginseng Radix. And Lycii Fructus, Schisandrae Fructus, Angelicae Gigantis Radix and Chrysanthemi Indici Flos are well used medicinal herbs to brew traditional liquors. In the classification of efficacy of medicinal herbs, tonifying and replenishing medicinal herbs are most popular as ingredients in the traditional alcohols, astringent medicinal herbs, exterior releasing medicinal herbs and heat clearing medicinal herbs are also frequently used. Investigation of tastes and properties of the herbs, it reached a conclusion as below: sweet taste is most common, followed by sour taste and bitter taste. Warm property is account for 50% approximately, followed by cold property. Conclusion : Medicinal herbs have been widely used in the traditional Korean liquor. It came out into the open that the liquor with medicinal herbs is very good for our body in terms of longevity and invigoration. However, liquor consumers concern about not only the efficacy but also the taste, scent and color. Therefore, further study about these things would be required to demonstrate the superiority of the traditional Korean liquor.

• 한국식품과학회지
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• 제29권6호
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• pp.1113-1118
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• 1997

국내에서 재배 수확되는 토당귀와 일당귀를 한방이나 가공시에 기초 자료로 활용될 수 있도록 기본적인 화학 성분을 분석하였다. 일반성분은 건물기준으로 토당귀와 일당귀의 조단백질은 각각 18,1, 13.4%, 조지방은 8.9, 4.3%, 조섬유는 8.6, 9.4%,조회분은 7.4, 8.2%, 당질은 57.0, 64.7%이었다. 두 종류의 당귀 속에 함유된 무기질 함량은 칼륨이 각각 2,740.0, 2,582.4 mg%로 가장 높았으며, 유리당 조성은 sucrose가 각각 0.4, 0.3%, fructose와 glucose는 검출되지 않았다. 토당귀와 일당귀의 지방산 조성은 linoleic acid가 각각 60.8, 59.9%, palmitic acid는 17.4, 15.3%. oleic acid는 8.8, 7.7%이었는데 두 시료간 뚜렷한 차이점은 발견할 수 없었다. 토당귀와 일당귀의 주요 구성아미산으로 아르기닌이 각각 2599.8, 1543.4 mg% 로 가장 많았고, 티로신이 각각 113.7, 84.9 mg%로 가장 적게 함유되어 있었다. 비타민 $B_1$,는 토당귀와 일당귀에 각각 10.5, 12.2 mg%, 비타민 $B_2$,는 각각 0.1, 0.04 mg%, 지표성분인 decursin은 각각 4.3, 0.8%이었다 탄닌은 토당귀, 일당귀에서 각각 988.0, 900.0 mg%로 분석되었다.

• 대한약침학회지
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• 제18권1호
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• pp.63-71
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• 2015

Objectives: This study was carried out to analyze the single-dose toxicity of Eun-Bi San pharmacopuncture injected into the muscle of Sprague-Dawley (SD) rats. Methods: All experiments were performed at Biotoxtech, an institution certified to conduct non-clinical studies under the Good Laboratory Practice (GLP) regulations. Six week old SD rats reared by ORIENTBIO were chosen for this pilot study. The reason SD rats were chosen is that they have been widely used in safety tests in the field of medicine, so the results can be easily compared with many other databases. The Eun-Bi San pharmacopuncture was made in a clean room at the Korean Pharmacopuncture Institute (KPI, K-GMP). The constituents of the Eun-Bi San pharmacopuncture are Angelicae gigantis radix, Strychni semen and Glycyrrhizae radix. These were extracted at low temperature and low pressure in an aseptic room at the KPI. Doses of Eun-Bi San pharmacopuncture, 0.25, 0.5 and 1.0 mL, were administered to the experimental groups, and a dose of normal saline solution, 1.0 mL, was administered to the control group. This study was performed under the approval of the Institutional Animal Ethics Committee of Biotoxtech Co., Ltd. Results: No deaths or abnormalities occurred in any of the four groups. No significant changes in weight, hematological parameters or clinical chemistry between the control group and the experimental groups were observed. To determine if abnormalities existed in any organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues. Conclusion: The results of this study suggest that treatment with Eun-Bi San pharmacopuncture is relatively safe and that its clinical use may be beneficial. Further evaluations and studies on this subject will be needed to provide more concrete evidence in support of these conclusions.

• 한방안이비인후피부과학회지
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• 제32권3호
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• pp.116-135
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• 2019

Objectives : The purpose of this study is to analyze how purpura and vasculitis have been treated with Korean medicine and potentially to present with future direction of research and treatment. Methods : We searched clinical studies from the Korean databases including Oriental medicine Advanced Searching Integrated System(OASIS), Korean Traditional Knowledge Portal(KTKP), National Discovery for Science Leader(NDSL), Research Information Sharing Service(RISS), using keywords related to "Purpura" and "Vasculitis" from January 2000 to May 2019. Results : A total of 20 studies were selected for analysis. More than half of the patients provided with detailed information were under 19 year-olds, and upper respiratory infection, stress and fatigue, seasonal factor were among the most frequently stated as predisposing factors. Among many treatment modalities, herbal medicine was the most frequently used, followed by acupuncture and herbal acupuncture. 23 basic herbal medicine formulas were retrieved from 20 articles, most frequently used being Guibi-tang(歸脾湯加味), Samul-tang(四物湯加味) and Yukmijihwang-tang(六味地黃湯加味). In total, 122 Korean medicine herbs were used, most frequently used herbs being Glycyrrhizae Radix et Rhizoma(甘草), Angelicae Gigantis Radix(當歸), Poria Sclerotium(茯?) and Paeoniae Radix(芍藥). By its category, herbs were mostly classified into Tonyfying and replenishing medicinal(補益藥), Heat-clearing medicinal(淸熱藥) and Exterior-releasing medicinal(解表藥). Patients with total treatment period of 3 months or under were 2/3 of all cases provided with detailed information. Follow up periods were short in general with only 6 cases of over 6 months. The primary motive of patients to receive Korean medicine treatments was unresponsiveness or adverse effects of western medication. Conclusion : Through this literature review, we could find out tendencies of Korean medicine treatments of purpura and vasculitis up to date and some points that may have clinical significance.

• 대한한의학회지
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• 제43권1호
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• pp.136-153
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• 2022

Objectives: The aim of this study was to find out whether east asian herbal medicine (EAHM) treatment alone is effective in improving pregnancy-related indicators compared to conventional medicine in women with Diminished Ovarian Reserve (DOR). Methods: We searched eligible studies from PubMed, Cochrane Library, EMBASE, Chinese National Knowledge Infrastructure Database, CiNii, Korean Medical Database, Korean Studies Information Service System, Oriental Medicine Advanced Searching Integrated System, ScienceOn. GRADE pro was used to evaluate the current evidence of the study. Result: A total of 5 studies, 325 women with DOR were included. EAHM showed a significant effect on improvement of pregnancy rate (n=270, RR 2.13 [95% CI 1.44 to 3.15], Z=3.78, p=0.0002, I2=0%) and Anti-Mullerian Hormone (AMH) level (n=211, SMD 0.82 [95% CI 0.40 to 1.25], Z=3.80, p=0.0001) compared to conventional medicine. In ovulation rate (n=156, RR 0.86 [95% CI 0.70 to 1.06], Z=1.43, p=0.15, I2=0%), Antral Follicle Count (n=245, SMD 0.27 [95% CI -0.25 to 0.79], Z=1.01, p=0.31), and follicle stimulating hormone (n=245, SMD 0.29 [95% CI -0.13 to 0.70], Z=1.36, p=0.17) level, EAHM showed similar effects to conventional medicine. In this study, the most frequently used herbal medicines were Cuscutae Semen, Dipsaci Radix, and Angelicae Gigantis Radix. Conclusion: This meta-analysis showed that EAHM could improve pregnancy rates and AMH levels in women with DOR. However, more well-designed RCTs will have to be performed further in the future.

• 대한한의학방제학회지
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• 제15권1호
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• pp.49-105
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• 2007

Objectives : Select and analyze the case record of dyspnea and wheezing asthma recorded in Xu Ming Yi Lei An that is the most abundant and wide in contents in existing case records that are systematic, comprehending relatively modern Traditional Chinese Medicine to secure more deep and objective basis of Traditional Chinese Medicine approach for dyspnea and wheezing asthma to analyze and review possibility for clinical application in this study. Methods: The study was conducted with the case records of dyspnea and wheezing asthma in whole Xu Ming Yi Lei An. Pattern identify and classify selected case records and again classified with deficiency syndrome and excess syndrome. Also analyzed prescriptions and herbs used in the case records. Nature of herbs and properties and flavors that were used in the case records were classified and frequency of each nature of herbs were analyzed. Applicable case records were interpreted and suggested prescriptions, pulse feelings, pattern classification were analyzed and described. Results : Among the 5254 case records stated on the complete collection, it is researched that there are 63 case records for the symptom complex of dyspnea as 1.2% of the whole case records, and the case records on the symptom complex of wheezing asthma are 14 as the 0.27% of the total examples. 63 case record examples related with symptom complex of dyspnea were pattern identified and classified. As a result, deficiency syndrome of the Kidney(33 %), deficiency syndrome of the Spleen(26.0%), Wind-Cold(12.3%), phlegm turbidity(12.3%), Heat in the Lung(8.2%), asthenia of the Lung(8.2%) were investigated as above order. 14 case record examples related with wheezing asthma were pattern identified and classified. As a result, phlegm-Heat(26.3%), upper excess and lower deficiency(26.3%), external affections Wind-Cold(15.8%), Dampness-phlegm(10.5%), Lung asthenia(10.5%), Cold phlegm(5.3%), mutual deficiency and detriment of Heart and Kidneys(5.3%) were investigated as above order. Symptom complex of dyspnea has 67.1% of deficiency syndrome, 32.9% of excess syndrome resulting more deficiency syndrome than excess syndrome. Symptom complex of wheezing asthma has 42.1 % of deficiency syndrome and 57.9% of excess syndrome resulting more excess syndrome than deficiency syndrome. In case of symptom complex of dyspnea prescription used in the case record, the order of frequency is as following. Palmijihwang-tang, Bojung-ikgitang, Yungmijihwang-tang, Ijintang, Sojaganggitang, Igongsan. In case of symptom complex of wheezing asthma prescription in the case record, Yungmijihwang-tang, Ohotang, Dodamtang were mostly used. Herbs used in case records of symptom complex of dyspnea are Ginseng Radix, Poria, Glycyrrhizae Radix, Aconiti Iateralis Preparata Radix, Atractylodis Macrocephalae Rhizoma, Dioscoreae Rhizoma, Angelicae Gigantis Radix, Rehmanniae Radix Preparat, Pinelliae Rhizoma, Zingiberis Rhizoma Recens are mostly used. Nature of herb properties used for symptom complex of dyspnea and symptom complex of wheezing asthma are herbs that are warm properties. When the symptom complex of dyspnea and the symptom complex of wheezing asthma were treated. if the patient felt tenderness at Pyesu, doctors conducted pricking blood around the opposite Pyesu or Sipseon acupoint. when the patient didn't have tenderness at Pyesu by soft press, pricking blood was performed both sidees, right and left Pyesu. In case of the treatment of symptom complex of dyspnea and symptom complex of wheezing asthma, when they got treatment, when the symptom complex of disease is severe, a doctor cauterized the opposite Pyesu while the other Pyesu felt tenderness, and decided how the above treatment is performed whether the degree of the symptom compolex of disease is severe or not. In case of the treatment of symptom complex of dyspnea and symptom complex of wheezing asthma, if the person felt tenderness at Pyesu and is caught by the Wind-Cold pathogen, slight acupuncture is treated at relevant Pyesu with Fire needling. When patient with symptom complex of dyspnea and symptom complex of wheezing asthma cannot hawk sputum up from the oral and laryngopharynx, suction method is treated. Conclusion : With this study, actual traditional and clinical pattern identification form and characteristics of symptom complex of dyspnea and symptom complex of wheezing asthma were recognized. Modern case report utilizing in clinical application need to be secured and an incurable disease asthma need to be diagnosed and improvement for treatments have to be searched through other case records.

• 동국한의학연구소논문집
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• 제6권2호
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• pp.145-165
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• 1998

부자(附子)는 흔히 한증(寒證)이나 음증(陰證)을 치료하는 약물로서 화열증(火熱證)을 치료하는 경우는 흔하지 않다. 경악(景岳)은 부자(附子)가 능인화귀원(能引火歸源)하여 제복허열(制伏虛熱)하는 효능이 있다고 하였다. 심계(心系)영역 질환의 치료에 있어서 부대(附子)가 한증(寒證)이나 음증(陰證)의 경우외에 부자(附子)가 화열증(火熱證)을 치료하는데 이용된 예(例)가 있는지 역대(歷代)의 문헌에서 찾아보고 그 처방(處方)에서 부자(附子)의 역할과 그에 따라 배합(配合)되는 약물 및 활용특징을 살펴보는 것은 부자(附子)를 이용한 심계(心系)영역 질환의 치료범위와 이해를 넓히는데 도움이 될 것이다. 심계(心系)영역질환 화열증(火熱證)의 치료에 사용된 부자(附子)의 역할을 살펴보면 크게 네 부류로 나눌 수가 있으며 이들 유형에 따라 배합되는 약물의 종류도 다르다. 특히 많은 경우에서 자음약(滋陰藥)과 배합되므로 이체하지 않도록 하는 약물(藥物)의 배합(配合)에 대하여 많은 임상적 연구가 있어야 할 것으로 사료된다.

• Journal of Animal Science and Technology
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• 제52권5호
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• pp.383-388
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• 2010

In vivo 실험에 의해서 지방축적을 억제할 수 있는 물질을 찾아내는 것은 시간과 비용이 많이 든다. 본 연구는 돼지 지방조직을 이용한 in vitro system을 이용해서 한국의 약용식물 중에서 지방축적 억제 작용을 가지는 것을 조사하고자 수행하였다. 총 183종의 약용식물을 이용하여 이들이 돼지 지방조직의 지방합성과 지방전구세포의 분화에 미치는 작용을 조사하였다. 에탄올 추출물은 72종, 물 추출물은 111종, 이 중에서 65종은 물과 에탄올 모두 이용해서 추출하였다. 돼지 지방조직의 지방합성은 13종류의 약용식물이 영향을 미쳤는데, 그 중 11종은 대조구에 비하여 지방합성을 40% 이상 억제하였고, 4종은 지방합성을 70% 이상 억제하였다. 가장 강력한 지방합성 억제작용을 나타낸 것은 붓꽃과와 고삼(에탄올 추출) 그리고 좁쌀풀(물과 에탄올 추출)이었다. 그러나 소목과 황백은 지방합성을 촉진하였다. 돼지 지방전구세포의 분화에 미치는 결과는 총 28종의 약용식물이 돼지 지방전구세포의 분화에 영향을 미쳤는데, 이 중 16종의 약용식물은 증가시켰고, 12종은 억제시켰다. 목단피와 강활(에탄올 추출) 그리고 당귀, 목향 및 신이(물 추출)는 지방세포의 분화를 두 배 정도 증가시켰다. 10종의 약용식물 즉 감초, 형개 및 구월나무(에탄올 추출) 그리고 비름과, 천문동, 백출, 유자나무, 향부자, 구엽초 및 목단피(물 추출)은 지방세포의 분화를 35% 이상 억제시켰다. 구월나무(에탄올 추출)만이 지방합성뿐만 아니라 세포분화도 억제하였다. 본 연구 결과는 약용식물로부터 가축과 사람의 지방축적 억제효능 후보물질을 발굴하기 위한 기초자료로 활용할 수 있을 것으로 여겨진다.