• Title/Summary/Keyword: Analytical Methodology

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Glycoscience aids in biomarker discovery

  • Hua, Serenus;An, Hyun-Joo
    • BMB Reports
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    • v.45 no.6
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    • pp.323-330
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    • 2012
  • The glycome consists of all glycans (or carbohydrates) within a biological system, and modulates a wide range of important biological activities, from protein folding to cellular communications. The mining of the glycome for disease markers represents a new paradigm for biomarker discovery; however, this effort is severely complicated by the vast complexity and structural diversity of glycans. This review summarizes recent developments in analytical technology and methodology as applied to the fields of glycomics and glycoproteomics. Mass spectrometric strategies for glycan compositional profiling are described, as are potential refinements which allow structure-specific profiling. Analytical methods that can discern protein glycosylation at a specific site of modification are also discussed in detail. Biomarker discovery applications are shown at each level of analysis, highlighting the key role that glycoscience can play in helping scientists understand disease biology.

Cogging Torque Reduction Design of Permanent Magnet Motor Using Analytical Method (해석적인 방법을 이용한 Cogging Torque 저감을 위한 영구자석형 전동기 형상 설계)

  • Fang, Liang;Lee, Byeong-Hwa;Hong, Jung-Pyo
    • Proceedings of the KIEE Conference
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    • 2009.07a
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    • pp.676_677
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    • 2009
  • In this paper, an analytical method used for predicting the magnetic field distribution and cogging torque characteristic in a permanent magnet synchronous motor (PMSM) is presented. The magnetic field is analyzed with the space harmonic analysis, and the cogging torque is calculated based on the air-gap field distribution and slot-opening effect considered by relative permeance. The validity of the presented analytical method is confirmed by 2-dimensional finite element analysis (FEA). Then this analytical method combines with response surface methodology (RSM) is applied to the prototype PMSM model rebuilding in order to minimize the cogging torque. Finally, an optimized PMSM model is built and the cogging torque reduction is confirmed by FEA.

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Recent Methodology in Ginseng Analysis

  • Baek, Seung-Hoon;Bae, Ok-Nam;Park, Jeong-Hill
    • Journal of Ginseng Research
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    • v.36 no.2
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    • pp.119-134
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    • 2012
  • As much as the popularity of ginseng in herbal prescriptions or remedies, ginseng has become the focus of research in many scientific fields. Analytical methodologies for ginseng, referred to as ginseng analysis hereafter, have been developed for bioactive component discovery, phytochemical profiling, quality control, and pharmacokinetic studies. This review summarizes the most recent advances in ginseng analysis in the past half-decade including emerging techniques and analytical trends. Ginseng analysis includes all of the leading analytical tools and serves as a representative model for the analytical research of herbal medicines.

A novel analytical solution of the deformed Doppler broadening function using the Kaniadakis distribution and the comparison of computational efficiencies with the numerical solution

  • Abreu, Willian V. de;Martinez, Aquilino S.;Carmo, Eduardo D. do;Goncalves, Alessandro C.
    • Nuclear Engineering and Technology
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    • v.54 no.4
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    • pp.1471-1481
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    • 2022
  • This paper aims to present a new method for obtaining an analytical solution for the Kaniadakis Doppler broadening (KDB) function. Also, in this work, we report the computational efficiencies of this solution compared with the numerical one. The solution of the differential equation achieved in this paper is free of approximations and is, consequently, a more robust methodology for obtaining an analytical representation of ψk. Moreover, the results show an improvement in efficiency using the analytical approximation, indicating that it may be helpful in different applications that require the calculation of the deformed Doppler broadening function.

A New Methodology for Software Module Characterization

  • Shin, Miyoung;Nam, Yunseok
    • Proceedings of the IEEK Conference
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    • 1999.11a
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    • pp.434-437
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    • 1999
  • The primary aim of this paper is to introduce and illustrate a radial basis function (RBF) modeling approach fur software module characterization, as an alternative to current techniques. The RBF model has been known to provide a rich analytical framework fur a broad class of so-called pattern recognition problems. Especially, it features both nonlinearity and linearity which in general are treated separately by its learning algorithm, leading to offer conceptual and computational advantages. Furthermore, our new modeling methodology fer determining model parameters has a sound mathematical basis and showed very interesting results in terms of model consistency as well as performance.

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Application of Dynamic Reliability Analysis Method to the CANDU Pressurizer System

  • Lee, Sook-Hyung;Oh, Se-Ki
    • Nuclear Engineering and Technology
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    • v.30 no.3
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    • pp.194-201
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    • 1998
  • DYLAM (Dynamic Logical Analytical Methodology) and its related methodologies are reviewed and found to have many favorable characteristics. Previous studies have shown that the DYLAM methodology represents an appropriate tool to study dynamic analysis. A hybrid model which is a synthesis of the DYLAM model, a system thermodynamic simulation model and a neural network predicative model, is implemented and used to analyze dynamically the CANDU pressurizer system. This study demonstrates that the hybrid model for system reliability analyses is effective.

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Analysis of Visual Perception of Cinemagraph Images: Focusing on Q Methodology

  • Kim, Young Il
    • Journal of Multimedia Information System
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    • v.6 no.4
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    • pp.251-258
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    • 2019
  • In the image methodology, cinemagraphs are needed to find out how to think through the empirical studies of the audiences in actual empirical theory. Therefore, this study analyzes what cinemagraph images represent and what groups are inclined to see them. The analytical study aims to reveal the grouping categorized as a preference survey according to the subjectivity study by Q methodology. Research reveals how images should be read and how disparities tend to differ from or agree with those in understanding images. Therefore, four types categorized into Q analysis through 1: 1 interview using a sample group and using samples showed that human interpretation and cinemagraph images were represented in understanding cinemagraphs.

MaRMI-III: A Methodology for Component-Based Development

  • Ham, Dong-Han;Kim, Jin-Sam;Cho, Jin-Hee;Ha, Su-Jung
    • ETRI Journal
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    • v.26 no.2
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    • pp.167-180
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    • 2004
  • As component-based development (CBD) rapidly spread throughout the software industry, a comprehensive methodology is needed to apply it more systematically. For this purpose, a new CBD methodology named Magic & Robust Methodology Integrated III (MaRMI-III) has been developed. The purpose of this paper is to present MaRMI-III by its constituent processes and claim that it can be used to support system developers conduct CBD in a consistent manner. First, we review the CBD approach to system development and the role of CBD methodology, and then we explain the several characteristics of MaRMI-III which are considered necessary to the CBD environment. Next, we explain a process model of MaRMI-III which separates the development process from the project management process and prescribes well-ordered activities and tasks that the developer should conduct. Each phase forming the Process Model is explained in terms of its objectives and main constituent activities. Some techniques and workproducts related to each phase are also explained. Finally, to examine the usefulness of MaRMI-III, an analytical comparison with other CBD methodologies and the results of a questionnaire survey are described.

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Analytical model of isolated bridges considering soil-pile-structure interaction for moderate earthquakes

  • Mohammad Shamsi;Ehsan Moshtagh;Amir H. Vakili
    • Geomechanics and Engineering
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    • v.34 no.5
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    • pp.529-545
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    • 2023
  • The coupled soil-pile-structure seismic response is recently in the spotlight of researchers because of its extensive applications in the different fields of engineering such as bridges, offshore platforms, wind turbines, and buildings. In this paper, a simple analytical model is developed to evaluate the dynamic performance of seismically isolated bridges considering triple interactions of soil, piles, and bridges simultaneously. Novel expressions are proposed to present the dynamic behavior of pile groups in inhomogeneous soils with various shear modulus along with depth. Both cohesive and cohesionless soil deposits can be simulated by this analytical model with a generalized function of varied shear modulus along the soil depth belonging to an inhomogeneous stratum. The methodology is discussed in detail and validated by rigorous dynamic solution of 3D continuum modeling, and time history analysis of centrifuge tests. The proposed analytical model accuracy is guaranteed by the acceptable agreement between the experimental/numerical and analytical results. A comparison of the proposed linear model results with nonlinear centrifuge tests showed that during moderate (frequent) earthquakes the relative differences in responses of the superstructure and the pile cap can be ignored. However, during strong excitations, the response calculated in the linear time history analysis is always lower than the real conditions with the nonlinear behavior of the soil-pile-bridge system. The current simple and efficient method provides the accuracy and the least computational costs in comparison to the full three-dimensional analyses.