• 한국임상약학회지
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• 제29권1호
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• pp.1-8
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• 2019

Background: Alzheimer's dementia is the most common dementia. However, recently, choline alfoscerate is prescribed for treating Alzheimer's dementia, although it is not a treatment for this disease. Purpose: To analyze the prescription patterns of choline alfoscerate as a dementia treatment for patients with Alzheimer's disease and to analyze, as well as the factors affecting choline alfoscerate prescription. Method: The 2016 HIRA-NPS data was used in this study. The code of Alzheimer's dementia is F00 in the ICD-10 disease classification code. We analyzed the demographic, clinical, and regional characteristics associated with donepezil, rivastigmine, galantamine, memantine, and choline alfoscerate prescriptions. All statistical and data analyse were conducted by SAS 9.4 and Excel. Results: For patients with Alzheimer's disease, choline alfoscerate was the second most prescribed after donepezil. Analysis results showed that choline alfoscerate was more likely to be prescribed to men than to women, and more likely to be prescribed by local health centers than by medical institutions. Moreover, choline alfoscerate was highly likely to be prescribed at neurosurgical departments, among medical departments. Conclusions: This study confirmed that choline alfoscerate was prescribed considerably for patients with Alzheimer's dementia. Further studies valuating its clinical validity should be performed to clarify whether choline alfoscerate prescription is appropriate for treating Alzheimer's dementia.

• 수면정신생리
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• 제29권1호
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• pp.1-3
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• 2022

Sleep is associated with Alzheimer's dementia. Many previous researches have shown that inadequate sleep is one of the risk factors that predict Alzheimer's dementia. The causal mechanism of this association is not clear. Slow wave sleep and REM sleep are critical stages in memory consolidation, and by sequential hypothesis both stages are important. Deposition of amyloid beta and tau, the main pathology of Alzheimer's dementia, are also associated with sleep. This review provides the association of sleep and Alzheimer's dementia, and future research is necessary to examine the specific mechanism of this association between sleep and Alzheimer's dementia, which may lead to an early intervention in sleep.

• 동의신경정신과학회지
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• 제25권3호
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• pp.287-296
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• 2014

Objectives: Alzheimer's Dementia is somewhat common in clinical stages, and there are many reports and papers regarding this subject. We explain the present state of Alzheimer's Dementia in JON (The Journal of Oriental Neuropsychiatry) for the benefits of clinical practice. Methods: We searched for articles in JON from 1990 to 2014 and selected ones that were related to Alzheimer's Dementia; then, we analyzed the data and placed it in four categories, like experimental study, case study, Clinical Data-Analysis study, and clinical trial. Results: 1) We found 47 articles relating to Alzheimer's Dementia in JON from 1997 to 2014: 41 experimental studies, 1 case study, 1 Clinical Data-Analysis study, and 4 Clinical trials. 2) There were Chung-kyung Acupuncture Method, Auricular acupuncture, and Cha-rak Acupuncture Method to treat Alzheimer's Dementia. 3) There were many additional treatments, like aroma therapy. 4) In the experimental study, they reported on several herbs, including herbal prescriptions that affected the suppression of related mRNAs and genes. 5) There were 4 clinical trials regarding herbal prescription that was effective for treating Alzheimer's Dementia. Conclusions: In JON, regarding Alzheimer's Dementia, the majority dealt with experimental studies. Therefore, we also have to expand our sight into other fields of study. We need more clinical trials and case studies for the treatment of Alzheimer's Dementia in Oriental Neuropsychiatry.

• 생물정신의학
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• 제18권2호
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• pp.72-79
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• 2011

Recent advances in brain imaging research are remarkable. Among them, many results from a variety of neuroimaging modalities in Alzheimer's dementia accompanied by the development and growing of imaging techniques have been presented in the research field. In this review we are focused on the imaging biomarkers for the Alzheimer's dementia to investigate the pathophysiologic mechanism. Future research on biomarkers for Alzheimer's dementia will provide more diverse and complex mechanisms or hypotheses than have been proposed in the current hypothesis about the pathogenesis of Alzheimer's dementia.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 추계학술대회
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• pp.97-99
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• 2021

최근 고령화 사회가 지속됨에 따라, 치매(Dementia)에 대한 관심이 높아지고 있다. 그 중에서 알츠하이머병(Alzheimer's disease)는 전체 치매 환자의 50~60%로 가장 많은 비율을 차지하는 퇴행성 뇌질환으로, 현재 의료계에선 알츠하이머병에 대한 명확한 예방법 및 치료법에 대해 내놓지 못하고 있으며, 치매 발병 전 조기 치료 및 조기 예방법에 대한 중요성이 강조되고 있다. 본 논문에서는 정상인과 알츠하이머병에 걸린 환자의 MRI 데이터셋을 활용하여 컨볼루션 신경망을 중심으로 여러 가지 활성화 함수를 접목시켜, 가장 효율적인 활성화 함수를 찾고자 한다. 또한 알츠하이머 치매분류 모델링을 통해 향후 의료분야에 적합한 치매 구분 모델링으로 활용하고자 한다.

• 한국엔터테인먼트산업학회논문지
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• 제15권1호
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• pp.181-189
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• 2021

본 연구는 알츠하이머 치매 환자의 MMSE-K, SGDS, NPI-Q, BADL IADL CDR 평가도구 결과를 분석하여 치매평가 도구들 간의 상관관계와 치매중등도 판정에 미치는 영향정도를 확인하고자 하였다. 본 연구는 일개 병원의 알츠하이머대상자의 치매검사자료인 2차 자료를 분석한 서술적 조사 연구이다. 본 연구는 2015년 1월부터 2017년 4월까지 일개 치매검진병원에서 등록 관리되고 있는 알츠하이머 치매 환자 총 617명의 자료를 분석하였으며, 수집된 자료는 SPSS 25.0 통계 프로그램을 이용하여 분석하였다. 치매평가도구 중 치매중등도 판정에 영향력이 큰 유의한 도구로는 CDR, ADL, MMSE-K, SGDS 도구이며, 유의한 영향을 미치지 못하는 도구로는 NPI-Q, IADL로 나타났다.

• 재활치료과학
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• 제9권4호
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• pp.21-31
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• 2020

목적: 회상하기는 알츠하이머 치매 환자에게 심리적 측면에서 안정을 찾는 방안이면서 동시에 자신의 과거를 기억하면서 자신에 대해서 정확하게 표현하면서 의사소통에 대해 접근하는 방법이다. 따라서, 이 연구는 알츠하이머 치매노인에게 회상하기 프로그램에 적응하여 의사소통 능력의 효과를 알아보고자 한다. 연구방법: 본 연구는 70세 노인 중 알츠하이머 치매(Alzheimer's dementia; AD) 노인 4명을 대상으로 사전-치료-사후 평가 단계를 구성하여 실시하였다. 결과: 첫째, 의사소통 요소 중 회화항목 영역에서 중재 후에 향상되었다. 둘째, 의사소통 요소 중 인지력 인식 영역에서 중재 후에 향상되었다. 셋째, 의사소통 요소 중 커뮤니케이션 영역에서 중재 후에 향상되었다. 결론: 이 연구에서는 회상하기 프로그램이 알츠하이머 치매 노인이 의사소통능력의 향상에 긍정적 영향을 미쳤다. 회상하기 프로그램을 바탕으로 추후 치매 노인의 의사소통 능력을 향상시키는데 많은 도움이 될 것으로 사료된다.

• 대한물리치료과학회지
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• 제9권3호
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• pp.171-178
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• 2002

This research recognized about general ancient temple of Alzheimer dementia. Research of cause of Alzheimer dementia is progressing up to now. Age, education, melancholia, estrogen, woman, smoking, thyroid gland disease, aluminum etc. are danger factor of an Alzheimer dementia. Familyish factor was proved in some degree by gene. Medicine in early patient's case imbecility some measure progress late in degree develop. However, ceilinged thing is true in treatment of Alzheimer dementia up to now, and must help so that their quality of life may can rise and laws of physical therapist must help to keep function in everyday life.

• Journal of Preventive Medicine and Public Health
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• 제39권3호
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• pp.243-248
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• 2006

Objectives: The Quality of Life-Alzheimer's Disease (QOL-AD) scale is a reliable and valid tool for assessing the quality of life (QOL) in the elderly with dementia. This study aimed to develop the Korean version of Quality of Life-Alzheimer's Disease (KQOL-AD) scale for the demented elderly living in the community. Methods: KQOL-AD was administered to two groups: 24 demented elderly and 72 cognitively impaired elderly with no dementia (CIND) who were living in the community Each elderly person and their caregiver rated the elderly QOL. The Korean version of mini-mental state examination (MMSE-K), the clinical dementia rating (CDR), the activities of daily living (ADL), and the neuropsychiatric inventory (NPI) were also assessed. The reliability and validity of the KQOL-AD were examined. Results: In the dementia group, the internal consistency (Cronbach's $\alpha$), the split half and the test-retest reliabilities of the KQOL-AD were excellent. Scores on the KQOL-AD were significantly correlated with the scores of the NPI, but they were not significantly correlated with scores of the MMSE-K, CDR and ADL. In addition, the CIND group showed similar results to the dementia group. Conclusions: KQOL-AD might be a reliable and valid instrument for assessing QOL in the elderly with dementia It could be used as an important outcome measure for research on the demented elderly.

• The Journal of Korean Physical Therapy
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• 제33권3호
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• pp.136-141
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• 2021

Purpose: Dementia is a disease in which cognitive function declines, leading to deterioration of body functions and activities of daily living. The purpose of this study is to explore the effects of dual-task training, including cognitive tasks, on cognitive and body function and β-amyloid levels in Alzheimer's dementia patients. Methods: 34 inpatients diagnosed with Alzheimer's dementia at a nursing hospital located in South Korea. The patients were randomly divided into a dual-task group (n=16) and a single-task group (n=18). Each group was trained for 30 minutes three times a week for eight weeks. The MMSE-K was used to measure the patients' cognitive function. To assess the patients' static balance ability, their LOS was measured using BioRescue. while dynamic balance was measured using the BBS. The 10MWT were conducted to evaluate the patients' walking ability. Blood analysis was performed to measure levels of β-amyloid. Results: Both groups exhibited statistically significant improvements in gait function after the training (p<0.05). The dual-task group exhibited statistically significant differences in cognitive function, static and dynamic balance function, and β-amyloid levels after training (p<0.05). A significant difference was observed between the two groups (p<0.05). Conclusion: Dual-task training were found to be effective in improving cognitive and bodily functioning and reducing β-amyloid levels in Alzheimer's dementia patients. Thus, this may be suggested as an effective exercise method for the treatment and early prevention of Alzheimer's dementia.