Sleep Medicine and Psychophysiology (수면정신생리)

KOREAN ACADEMY OF SLEEP MEDICINE (대한수면의학회)
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Relationship Between Sleep and Alzheimer's Dementia

수면과 알츠하이머 치매의 관계

  • Kyoung Hwan Lee (Department of Psychiatry, Bong Seng Memorial Hospital) ;
  • Ho Chan Kim (Department of Psychiatry, Gosin University Gospel Hospital)
  • 이경환 (김원묵기념 봉생병원 정신건강의학과) ;
  • 김호찬 (고신대학교 복음병원 정신건강의학과)
  • Received : 2022.06.03
  • Accepted : 2022.06.16
  • Published : 2022.06.30
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Abstract

Sleep is associated with Alzheimer's dementia. Many previous researches have shown that inadequate sleep is one of the risk factors that predict Alzheimer's dementia. The causal mechanism of this association is not clear. Slow wave sleep and REM sleep are critical stages in memory consolidation, and by sequential hypothesis both stages are important. Deposition of amyloid beta and tau, the main pathology of Alzheimer's dementia, are also associated with sleep. This review provides the association of sleep and Alzheimer's dementia, and future research is necessary to examine the specific mechanism of this association between sleep and Alzheimer's dementia, which may lead to an early intervention in sleep.

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References

  1. Di MA, Joshi YB, Pratico D. Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles. Neurobiol Aging 2014;35: 1813-1820. https://doi.org/10.1016/j.neurobiolaging.2014.02.011
  2. Diekelmann S, Born J. The memory function of sleep. Nature 2010; 11:114-126.
  3. Driscoll HC, Serody I, Patrick S, Maurer J, Benssasi S, Houck PR, et al. Sleeping well, aging well: a descriptive and cross-sectional study of sleep in "successful ahers" 75 and older. Am J Geriatr Psychiatry 2008;16:74-82.
  4. Durmer JS, Dinges DF. Neurocognitive consequences of sleep deprivation. Semin Neurol 2005;25:117-129. https://doi.org/10.1055/s-2005-867080
  5. Fogel SM, Smith CT, Cote KA. Dissociable learning-dependent changes in REM and non-REM sleep in declarative and procedural memory systems. Bahav Brain Res 2007;180:48-61. https://doi.org/10.1016/j.bbr.2007.02.037
  6. Giuditta A, Ambrosini MV, Montagnese P, Mandile P, Cotugno M, Zucconi GG, et al. The sequential hypothesis of the function of sleep. Bahv Brain Res 1995;69:157-166. https://doi.org/10.1016/0166-4328(95)00012-I
  7. Hoch CC, Dew MA, Reynold CF III, Monk TH, Buysse DJ, Houck PR, et al. A longitudinal study of laboratory- and diary-based sleep measures in healthy "old old" and "young old" volunteers. Sleep 1994;17:489-496. https://doi.org/10.1093/sleep/17.6.489
  8. Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, et al. Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle. Science 2009;326:1005-1007. https://doi.org/10.1126/science.1180962
  9. Lee YM, Choi WJ, Park MS, Kim ES. Biochemical biomarkers for Alzheimer's disease in cerebrospinal fluid and peripheral blood. J Korean Geriatric Psychiatry 2012;16:17-23.
  10. Lim ASP, Yu L, Costa MD, Leurgans SE, Buchman AS, Bennett DA, et al. Increased fragmentation of rest-activity patterns is associated with a characteristic pattern of cognitive impairment in older individuals. Sleep 2012;35:633-640. https://doi.org/10.5665/sleep.1820
  11. Luengo E, Buendia I, Fernandez-Mendivil C, Trigo-Alonso P, Negredo P, Michalska P et al. Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux. J Pineal Res 2019;67:e12578.
  12. Mestre H, Mori Y, Nedergaard M. The brain's glymphatic system: current controversies. Trends in Neurosciences 2020;43:458-466. https://doi.org/10.1016/j.tins.2020.04.003
  13. Morris RG. Short-term forgetting in senile dementia of the Alzheimer's type. Cogn Neuropsychol 1986;3:77-97. https://doi.org/10.1080/02643298608252670
  14. Musiek ES, Holtzman DM. Mechanism linking circadian clocks, sleep, and neurodegeneration. Science 2016;354:1004-1008. https://doi.org/10.1126/science.aah4968
  15. Ju YS, Lucey BP, Hotzman DM. Sleep and alzheimer disease pathology-a bidirectional relationship. Nat Rev Neurol 2014;10:115-119. https://doi.org/10.1038/nrneurol.2013.269
  16. Kamel NS, Gammack JK. Insomnia in the elderly: cause, approach, and treatment. Am J Med 2006;119:463-469. https://doi.org/10.1016/j.amjmed.2005.10.051
  17. Maquet P. The role of sleep in learning and memory. Science 2001; 294:1048-1052. https://doi.org/10.1126/science.1062856
  18. Plihal W, Born J. Effects of early and late nocturnal sleep on declarative and procedural memory. J Cogn Neurosci 1997;9:534-547. https://doi.org/10.1162/jocn.1997.9.4.534
  19. Osorio RS, Ducca EL, Wohlleber ME, Tanzi EB, Gumb T, Twumasi A, et al. Orexin-a is associated with increases in cerebrospinal fluid phosphorylated-tau in cognitively normal elderly subjects. Sleep 2016;39:1253-1260. https://doi.org/10.5665/sleep.5846
  20. Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease. J Exp Med 2014;211:2487-2496. https://doi.org/10.1084/jem.20141788
  21. Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature 2005;437:1257-1263. https://doi.org/10.1038/nature04284
  22. Srinivasan V, Kaur C, Pandi-Perumal S, Brown GM, Cardinali DP. Melatonin and its agonist ramelteon in Alzheimer's disease: possible therapeutic value. Int J Alzheimer's Dis 2011;741974.